Quantification of MRI signal of transgenic grafts overexpressing ferritin in murine myocardial infarcts

NMR in Biomedicine

Volumn 25, Issue 10, 2012, Pages 1187-1195

  Naumova, Anna V ^a,b   Yarnykh, Vasily L ^a,b   Balu, Niranjan ^a,b   Reinecke, Hans ^b   Murry, Charles E ^b,c   Yuan, Chun ^a,b,c  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c University of Washington   (United States)

Author keywords

Animal model study; Cell tracking; Cellular and molecular cardiovascular imaging

Indexed keywords

ANIMAL MODEL; C2C12 CELLS; CELL FATES; CELL IMAGING; CELL THERAPY; CELL TRACKING; DATA SUPPORT; GRADIENT ECHO; HIGHLY-CORRELATED; IN-VIVO; MOUSE HEART; MYOBLASTS; NATURAL IRON; NON-INVASIVE DETECTION; OVER-EXPRESSION; PULSE SEQUENCE; SIGNAL INTENSITIES; SIZE MEASUREMENTS; SYSTEMATIC EVALUATION; TRANSGENIC GRAFTS; TRANSGENICS; TRANSPLANTED CELLS; TURBO SPIN ECHOS; WILD TYPES;

CYTOLOGY; GRAFTING (CHEMICAL); HEART; MAMMALS; SIGNAL SYSTEMS; STEM CELLS;

BLOOD;

FERRITIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIAC GATED IMAGING; CARDIAC IMAGING; CELL GROWTH; CELL MIGRATION; CELL SURVIVAL; COMPUTED TOMOGRAPHY SCANNER; CONTROLLED STUDY; HEART GRAFT; HEART INFARCTION; IMAGE ANALYSIS; IN VIVO STUDY; MOUSE; MYOBLAST; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL TRANSPLANTATION;

ANIMALS; CELL LINE; FERRITINS; MAGNETIC RESONANCE IMAGING; MICE; MICE, TRANSGENIC; MYOCARDIAL INFARCTION; REPRODUCIBILITY OF RESULTS; SIGNAL PROCESSING, COMPUTER-ASSISTED; STEM CELL TRANSPLANTATION;

ANIMALIA; MURINAE;

EID: 84866281870     PISSN: 09523480     EISSN: 10991492     Source Type: Journal    
DOI: 10.1002/nbm.2788     Document Type: Article

References (43)

1. Laflamme MA, Murry CE. Heart regeneration. Nature 2011; 473(7347): 326-335.
2. Bulte JW, Arbab AS, Douglas T, Frank JA. Preparation of magnetically labeled cells for cell tracking by magnetic resonance imaging. Methods Enzymol. 2004; 386: 275-299.
3. Bulte JW, Kraitchman DL. Monitoring cell therapy using iron oxide MR contrast agents. Curr. Pharm. Biotechnol. 2004; 5: 567-584.
4. Shapiro EM, Sharer K, Skrtic S, Koretsky AP. In vivo detection of single cells by MRI. Magn. Reson. Med. 2006; 55(2): 242-249.
5. Amsalem Y, Mardor Y, Feinberg MS, Landa N, Miller L, Daniels D, Ocherashvilli A, Holbova R, Yosef O, Barbash IM, Leor J. Iron-oxide labeling and outcome of transplanted mesenchymal stem cells in the infarcted myocardium. Circulation, 2007; 116: I38-I45.
6. Terrovitis J, Stuber M, Youssef A, Preece S, Leppo M, Kizana E, Schär M, Gerstenblith G, Weiss RG, Marbán E, Abraham MR. Magnetic resonance imaging overestimates ferumoxide-labeled stem cell survival after transplantation in the heart. Circulation 2008; 117(12): 1555-1562.
7. Ahrens E. Contrast agents for magnetic resonance imaging and methods related thereto. US Patent Application: USPTO US 0219385, 2003.
8. Crichton RR, Wilmet S, Legssyer R, Ward RJ. Molecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cells. J. Inorg. Biochem. 2002; 91: 9-18.
9. Cohen B, Dafni H, Meir G, Harmelin A, Neeman M. Ferritin as an endogenous MRI reporter for noninvasive imaging of gene expression in C6 glioma tumors. Neoplasia 2005; 7(2): 109-117.
10. Genove G, DeMarco U, Xu H, Goins WF, Ahrens ET. A new transgene reporter for in vivo magnetic resonance imaging. Nat. Med. 2005; 11(4): 450-454.
11. Kim HS, Cho HR, Choi SH, Woo JS, Moon WK. In vivo imaging of tumor transduced with bimodal lentiviral vector encoding human ferritin and green fluorescent protein on a 1.5t clinical magnetic resonance scanner. Cancer Res. 2010; 70: 7315-7324.
12. Ono K, Fuma K, Tabata K, Sawada M. Ferritin reporter used for gene expression imaging by magnetic resonance. Biochem. Biophys. Res. Commun. 2009; 388(3): 589-594.
13. Cohen B, Ziv K, Plaks V, Israely T, Kalchenko V, Harmelin A, Benjamin LE, Neeman M. MRI detection of transcriptional regulation of gene expression in transgenic mice. Nat. Med. 2007; 13(4): 498-503.
14. Ziv K, Meir G, Harmelin A, Shimoni E, Klein E, Neeman M. Ferritin as a reporter gene for MRI: chronic liver over expression of h-ferritin during dietary iron supplementation and aging. NMR Biomed. 2010; 23: 523-531.
15. Uchida M, Terashima M, Cunningham CH, Suzuki Y, Willits DA, Willis AF, Yang PC, Tsao PS, McConnell MV, Young MJ, Douglas T. A human ferritin iron oxide nano-composite magnetic resonance contrast agent. Magn. Reson. Med. 2008; 60: 1073-1081.
16. Terashima M, Uchida M, Kosuge H, Tsao PS, Young MJ, Conolly SM, Douglas T, McConnell MV. Human ferritin cages for imaging vascular macrophages. Biomaterials 2011; 32: 1430-1437.
17. Naumova AV, Reinecke H, Yarnykh V, Deem J, Yuan C, Murry CE. Ferritin overexpression for noninvasive MRI-based tracking of stem cells transplanted into the heart. Mol. Imaging 2010; 9: 201-210.
18. Edelman RR, Chien D, Kim D. Fast selective black blood MR imaging. Radiology 1991; 181: 655-660.
19. Simonetti OP, Finn JP, White RD, Laub G, Henry DA. 'Black blood' T2-weighted inversion-recovery MR imaging of the heart. Radiology 1996; 199: 49-57.
20. Wang J, Yarnykh VL, Yuan C. Enhanced image quality in black-blood MRI using the improved motion-sensitized driven-equilibrium (iMSDE) sequence. J. Magn. Res. Imaging 2010; 31(5): 1256-1263.
21. Wang J, Yarnykh VL, Hatsukami T, Chu B, Balu N, Yuan C. Improved suppression of plaque-mimicking artifacts in black-blood carotid atherosclerosis imaging using a multislice motion-sensitized driven-equilibrium (MSDE) turbo spin-echo (TSE) sequence. Magn. Reson. Med. 2007; 58: 973-981.
22. Silberstein L, Webster SG, Travis M, Blau HM. Developmental progression of myosin gene expression in cultured muscle cells. Cell 1986; 46(7): 1075-1081.
23. Stevens KR, Rolle MW, Minami E, Ueno S, Nourse MB, Virag JI, Reinecke H, Murry CE. Chemical dimerization of fibroblast growth factor receptor-1 induces myoblast proliferation, increases intracardiac graft size, and reduces ventricular dilation in infarcted hearts. Hum. Gene Therapy 2007; 18(5): 401-412.
24. Balu N, Yarnykh VL, Chu B, Wang J, Hatsukami T, Yuan C. Carotid plaque assessment using fast 3D isotropic resolution black-blood MRI. Magn. Reson. Med. 2011; 65(3): 627-637.
25. Iordanova B, Robison CS, Ahrens ET. Design and characterization of a chimeric ferritin with enhanced iron loading and transverse NMR relaxation rate. J. Biol. Inorg. Chem. 2010; 15: 957-965.
26. Liu J, Cheng EC, Long RC Jr, Yang SH, Wang L, Cheng PH, Yang JJ, Wu D, Mao H, Chan AW. Noninvasive monitoring of embryonic stem cells in vivo with MRI transgene reporter. Tissue Eng. 2009; 15(4): 739-747.
27. Vande Velde G, Rangarajan JR, Toelen J, Dresselaers T, Ibrahimi A, Krylychkina O, Very R, der Linden AV, Maes F, Debyser Z, Himmelreich U, Baekelandt V. Evaluation of the specificity and sensitivity of ferritin as an MRI reporter gene in the mouse brain using lentiviral and adeno-associated viral vectors. Gene Ther. 2011; 18(6): 594-605.
28. Deans AE, Wadghiri YZ, Bernas LM, Yu X, Rutt BK, Turnbull DH. Cellular MRI contrast via coexpression of transferrin receptor and ferritin. Magn. Reson. Med. 2006; 56(1): 51-59.
29. Aung W, Hasegawa S, Koshikawa-Yano M, Obata T, Ikehira H, Furukawa T, Aoki I, Saga T. Visualization of in vivo electroporation-mediated transgene expression in experimental tumors by optical and magnetic resonance imaging. Gene Ther. 2009; 16: 830-839.
30. Arosio P, Levi S. Cytosolic and mitochondrial ferritins in the regulation of cellular iron homeostasis and oxidative damage. Biochim. Biophys. Acta 2010; 1800(8): 783-792.
31. Arosio P, Levi S. Ferritin, iron homeostasis, and oxidative damage. Free Rad. Biol. Med. 2002; 33(4): 457-463.
32. De Domenico I, Ward DM, Kaplan J. Specific iron chelators determine the route of ferritin degradation. Blood 2009, 114: 4546-4551.
33. Iancu TC. Ferritin and hemosiderin in pathological tissues. Electron Microsc. Rev. 1992; 5: 209-229.
34. Miyazaki E, Kato J, Kobune M, Okumura K, Sasaki K, Shintani N, Arosio P, Niitsu Y. Denatured Hferritin subunit is a major constituent of haemosiderin in the liver of patients with iron overload. Gut 2002; 50: 413-419.
35. Harrison PM, Arosio P. The ferritins: molecular properties, iron storage function and cellular regulation. Biochim. Biophys. Acta 1996; 1275(3): 161-203.
36. Loncar R, Flesche CW, Deussen A. Ischemia results in an enhanced ferritin content in relation to the degree of ischemia. Acta Physiol. Scand. 2004; 180: 21-28.
37. Adams CW. Perivascular iron deposition and other vascular damage in multiple sclerosis. J. Neurol. Neurosurg. Psychiatry 1988; 51(2): 260-265.
38. Rigol M, Solanes N, Roqué M, Farré J, Batlle M, Roura S, Bellera N, Prat-Vidal C, Sionis A, Ramírez J, Sitges M, Sanz G, Bayés-Genís A, Heras M. Hemosiderin deposits confound tracking of iron-oxide-labeled stem cells: an experimental study. Transplant. Proc. 2008; 40(10): 3619-3622.
39. Jensen JH, Chandra R. Theory of nonexponential NMR signal decay in liver with iron overload or superparamagnetic iron oxide particles. Magn. Reson. Med. 2002; 47: 1131-1138.
40. Wu EX, Kim D, Tosti CL, Tang H, Jensen JH, Cheung JS, Feng L, Au W-Y, Ha S-Y, Sheth SS, Brown TR, Brittenham GM. Magnetic resonance assessment of iron overload by separate measurement of tissue ferritin and hemosiderin iron. Ann. N. Y. Acad. Sci. 2010; 1202: 115-122.
41. Mills PH, Ahrens ET. Enhanced positive-contrast visualization of paramagnetic contrast agents using phase images. Magn. Reson. Med. 2009; 62: 1349-1355.
42. Gossuin Y, Muller RN, Gillis P. Relaxation induced by ferritin: a better understanding for an improved MRI iron quantification. NMR Biomed. 2004; 17(7): 427-432.
43. Vymazal J, Brooks RA, Zak O, McRill C, Shen C, Di Chiro G. T1 and T2 of ferritin at different field strengths: effect on MRI. Magn. Reson. Med. 1992; 27: 368-374.