Protective effects of 5-methoxypsoralen against acetaminophen-induced hepatotoxicity in mice

World Journal of Gastroenterology

Volumn 18, Issue 18, 2012, Pages 2197-2202

  Liu, Wei Xia ^a   Jia, Feng Lan ^a   He, Yue Ying ^a   Zhang, Bao Xu ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

5 Methoxypsoralen; Acetaminophen; Antioxidation; Hepatotoxicity; Protection

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BERGAPTEN; GLUTATHIONE; GLUTATHIONE DISULFIDE; LACTATE DEHYDROGENASE; MALONALDEHYDE; PARACETAMOL; ANTIOXIDANT; BIOLOGICAL MARKER; DRUG DERIVATIVE; METHOXSALEN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL INFILTRATION; CONTROLLED STUDY; ENZYME BLOOD LEVEL; LACTATE DEHYDROGENASE BLOOD LEVEL; LIVER NECROSIS; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; ANIMAL; BLOOD; C57BL MOUSE; CELL PROTECTION; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECT; LIVER; METABOLISM; ORAL DRUG ADMINISTRATION; OXIDATIVE STRESS; PATHOLOGY; TOXIC HEPATITIS;

ACETAMINOPHEN; ADMINISTRATION, ORAL; ALANINE TRANSAMINASE; ANIMALS; ANTIOXIDANTS; ASPARTATE AMINOTRANSFERASES; BIOLOGICAL MARKERS; CYTOPROTECTION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; GLUTATHIONE; GLUTATHIONE DISULFIDE; L-LACTATE DEHYDROGENASE; LIVER; MALE; MALONDIALDEHYDE; METHOXSALEN; MICE; MICE, INBRED C57BL; OXIDATIVE STRESS;

EID: 84866261598     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v18.i18.2197     Document Type: Article

References (35)

1. Larson AM, Polson J, Fontana RJ, Davern TJ, Lalani E, Hynan LS, Reisch JS, Schiødt FV, Ostapowicz G, Shakil AO, Lee WM. Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Hepatology 2005; 42: 1364-1372
2. Lee WM, Squires RH, Nyberg SL, Doo E, Hoofnagle JH. Acute liver failure: Summary of a workshop. Hepatology 2008; 47: 1401-1415
3. Murray KF, Hadzic N, Wirth S, Bassett M, Kelly D. Drugrelated hepatotoxicity and acute liver failure. J Pediatr Gastroenterol Nutr 2008; 47: 395-405
4. Norris W, Paredes AH, Lewis JH. Drug-induced liver injury in 2007. Curr Opin Gastroenterol 2008; 24: 287-297
5. Craig DG, Ford AC, Hayes PC, Simpson KJ. Systematic review: prognostic tests of paracetamol-induced acute liver failure. Aliment Pharmacol Ther 2010; 31: 1064-1076
6. Dahlin DC, Miwa GT, Lu AY, Nelson SD. N-Acetyl-P-benzoquinone imine; a cytochrome P-450-mediated oxidation product of acetaminophen. Proc Nat Acad Sci USA 1984; 81: 1327-1331
7. Ramachandran A, Lebofsky M, Weinman SA, Jaeschke H. The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity. Toxicol Appl Pharmacol 2011; 251: 226-233
8. Agarwal R, MacMillan-Crow LA, Rafferty TM, Saba H, Roberts DW, Fifer EK, James LP, Hinson JA. Acetaminophen-induced hepatotoxicity in mice occurs with inhibition of activity and nitration of mitochondrial manganese superoxide dismutase. J Pharmacol Exp Ther 2011; 337: 110-116
9. Acharya M, Lau-Cam CA. Comparison of the protective actions of N-acetylcysteine, hypotaurine and taurine against acetaminophen-induced hepatotoxicity in the rat. J Biomed Sci 2010; 17 Suppl 1: S35
10. Bessems JG, Vermeulen NP. Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches. Crit Rev Toxicol 2001; 31: 55-138
11. Avila DS, Palma AS, Colle D, Scolari R, Manarin F, da Silveira AF, Nogueira CW, Rocha JB, Soares FA. Hepatoprotective activity of a vinylic telluride against acute exposure to acetaminophen. Eur J Pharmacol 2011; 661: 92-101
12. Ng TB, Liu F, Wang ZT. Antioxidative activity of natural products from plants. Life Sciences 2000; 66: 709-723
13. Yu J, Wang L, Walzem RL, Miller EG, Pike LM, Patil BS. Antioxidant activity of citrus limonoids, flavonoids, and coumarins. J Agric Food Chem 2005; 53: 2009-2014
14. Lee YM, Wu TH. Effects of 5-methoxypsoralen (5-MOP) on arylamine N-acetyltransferase activity in the stomach and colon of rats and human stomach and colon tumor cell lines. In Vivo 2005; 19: 1061-1069
15. Viola G, Vedaldi D, Dall'Acqua F, Fortunato E, Basso G, Bianchi N, Zuccato C, Borgatti M, Lampronti I, Gambari R. Induction of gamma-globin mRNA, erythroid differentiation and apoptosis in UVA-irradiated human erythroid cells in the presence of furocumarin derivatives. Biochem Pharmacol 2008; 75: 810-825
16. Guerrini A, Lampronti I, Bianchi N, Zuccato C, Breveglieri G, Salvatori F, Mancini I, Rossi D, Potenza R, Chiavilli F, Sacchetti G, Gambari R, Borgatti M. Bergamot (Citrus bergamia Risso) fruit extracts as γ-globin gene expression inducers: phytochemical and functional perspectives. J Agric Food Chem 2009; 57: 4103-4111
17. Salvador A, Dall'Acqua S, Sardo MS, Caffieri S, Vedaldi D, Dall'Acqua F, Borgatti M, Zuccato C, Bianchi N, Gambari R. Erythroid induction of chronic myelogenous leukemia K562 cells following treatment with a photoproduct derived from the UV-A irradiation of 5-methoxypsoralen. ChemMedChem 2010; 5: 1506-1512
18. Panno ML, Giordano F, Mastroianni F, Palma MG, Bartella V, Carpino A, Aquila S, Andò S. Breast cancer cell survival signal is affected by bergapten combined with an ultraviolet irradiation. FEBS Lett 2010; 584: 2321-2326
19. Lee YM, Wu TH, Chen SF, Chung JG. Effect of 5-methoxypsoralen (5-MOP) on cell apoptosis and cell cycle in human hepatocellular carcinoma cell line. Toxicol In vitro 2003; 17: 279-287
20. Souetre E, Salvati E, Belugou JL, de Galeani B, Krebs B, Ortonne JP, Darcourt G. 5-Methoxypsoralen increases the plasma melatonin levels in humans. J Invest Dermatol 1987; 89: 152-155
21. Souêtre E, Salvati E, Belugou JL, Robert P, Brunet G, Darcourt G. Antidepressant effect of 5-methoxypsoralen: a preliminary report. Psychopharmacology (Berl) 1988; 95: 430-431
22. Souêtre E, Salvati E, Belugou JL, Krebs B, Darcourt G. 5-Methoxypsoralen increases evening sleepiness in humans: possible involvement of the melatonin secretion. Eur J Clin Pharmacol 1989; 36: 91-92
23. Souetre E, Salvati E, Belugou JL, Krebs B, Darcourt G. 5-Methoxypsoralen as a specific stimulating agent of melatonin secretion in humans. J Clin Endocrinol Metab 1990; 71: 670-674
24. Darcourt G, Feuillade P, Bistagnin Y, Robert P, Pringuey D, Touari M, Merdji Y, Bensmaïl B. Antidepressant effect of 5-methoxypsoralen: The melatonin synchronizer hypothesis. Eur Psychiatry 1995; 10: 142-154
25. Tosun F, Kizilay CA, Erol K, Kiliç FS, Kürkçüoǧlu M, Başer KHC. Anticonvulsant activity of furanocoumarins and the essential oil obtained from the fruits of Heracleum crenatifolium. Food Chemistry 2008; 107: 990-993
26. Nicolis E, Lampronti I, Dechecchi MC, Borgatti M, Tamanini A, Bezzerri V, Bianchi N, Mazzon M, Mancini I, Giri MG, Rizzotti P, Gambari R, Cabrini G. Modulation of expression of IL-8 gene in bronchial epithelial cells by 5-methoxypsoralen. Int Immunopharmacol 2009; 9: 1411-1422
27. Bose SK, Dewanjee S, Sahu R, Dey SP. Effect of bergapten from Heracleum nepalense root on production of proinflammatory cytokines. Nat Prod Res 2011; 25: 1444-1449
28. Berg M, Ros AM. Treatment of psoriasis with psoralens and ultraviolet A. A double-blind comparison of 8-methoxypsoralen and 5-methoxypsoralen. Photodermatol Photoimmunol Photomed 1994; 10: 217-220
29. Stephens RB, Cooper A. Hepatitis from 5-methoxypsoralen occurring in a patient with previous flucloxacillin hepatitis. Australas J Dermatol 1999; 40: 217-219
30. Diawara MM, Williams DE, Oganesian A, Spitsbergen J. Dietary psoralens induce hepatotoxicity in C57 mice. J Nat Toxins 2000; 9: 179-195
31. Pang ZJ, Zhou M, Chen A. Medical Methods of Free Radicals. Beijing: People's Health Publishing House, 2000: 61-64
32. Shen HQ, Zhao LY, Qu QS, Jiang QG. Fluorescent method for determination of glutathione in tissue. Zhonghua Laodong Weisheng Zhiyebing Zazhi 1988; 6: 103-108
33. Zhang BX, Jia FL, Ruan M. Mechanism investigation of acetaminophen induced hepatotoxicity in mice. Weisheng Dulixue Zazhi 2003; 17: 31-33
34. Giboney PT. Mildly elevated liver transaminase levels in the asymptomatic patient. Am Fam Physician 2005; 71: 1105-1110
35. Laine JE, Auriola S, Pasanen M, Juvonen RO. Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes. Xenobiotica 2009; 39: 11-21