Validation of an LC-ESI-MS/MS method for the quantitation of phosphodiesterase-5 inhibitors and their main metabolites in rat serum and brain tissue samples

Journal of Pharmaceutical and Biomedical Analysis

Volumn 70, Issue , 2012, Pages 529-533

  Unceta, Nora ^a   Echeazarra, Leire ^a,b   Montaña, Mario ^a,b   Sallés, Joan ^a,b   Gómez Caballero, Alberto ^a   Goicolea, M Aránzazu ^a   Barrio, Ramón J ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE SALUD MENTAL CIBERSAM   (Spain)

Author keywords

LC ESI ITMS; Metabolites; Phosphodiesterase 5 inhibitors; Rat brain tissue; Rat serum

Indexed keywords

ACETONITRILE; AMMONIUM FORMATE; DRUG METABOLITE; N DESETHYLVARDENAFIL; N DESMETHYLSILDENAFIL; O DESETHYLSILDENAFIL; PHOSPHOLIPID; SILDENAFIL; TADALAFIL; UNCLASSIFIED DRUG; VARDENAFIL;

ANIMAL TISSUE; ARTICLE; BRAIN; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; ELECTROSPRAY MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VALIDATION PROCESS;

ACETONITRILES; ANIMALS; BIOTRANSFORMATION; BRAIN; CALIBRATION; CARBOLINES; CHROMATOGRAPHY, LIQUID; DEALKYLATION; FORMATES; IMIDAZOLES; INJECTIONS, INTRAPERITONEAL; LIMIT OF DETECTION; MALE; PHOSPHODIESTERASE 5 INHIBITORS; PIPERAZINES; PURINES; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SULFONES; TANDEM MASS SPECTROMETRY; TRIAZINES;

EID: 84866261374     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2012.04.030     Document Type: Article

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