Development of a stability-indicating LC method for determination of a synthetic chalcone derivative in a nanoemulsion dosage form and identification of the main photodegradation product by LC-MS

Journal of Pharmaceutical and Biomedical Analysis

Volumn 70, Issue , 2012, Pages 652-656

  Mattos, Cristiane B ^a   Deponti, Vânia B ^a   Barreto, Fabiano ^a   Simões, Cláudia M O ^b   Andrighetti Frohner, Carla R ^b   Nunes, Ricardo J ^b   Steindel, Mário ^b   Teixeira, Helder F ^a   Koester, Letícia S ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

Author keywords

Chalcone; Kinetics study; LC method; LC MS MS; Nanoemulsion

Indexed keywords

5 (2 BENZOYLETHENYL)N BENZYL 2 METHOXYBENZENESULFONAMIDE; CHALCONE DERIVATIVE; METHANOL; SILICON DIOXIDE; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG;

ABSORPTION; ARTICLE; DEGRADATION KINETICS; DRUG FORMULATION; DRUG STRUCTURE; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NANOEMULSION; PH MEASUREMENT; PHOTODEGRADATION; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; ULTRAVIOLET RADIATION;

CALIBRATION; CHALCONE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSAGE FORMS; DRUG STABILITY; EMULSIONS; KINETICS; LINEAR MODELS; METHANOL; NANOPARTICLES; NANOTECHNOLOGY; PHOTOLYSIS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SILICON DIOXIDE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET; TRIFLUOROACETIC ACID; ULTRAVIOLET RAYS; WATER;

EID: 84866251780     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2012.07.021     Document Type: Article

References (12)

1. Boeck P., Falcão C.A.B., Leal P.C., Yunes R.A., Filho V.C., Torres-Santos E.C., Rossi-Bergmann B.R. Synthesis of chalcone analogues with increased antileishmanial activity. Bioorg. Med. Chem. 2006, 14:1538-1545.
2. Andrighetti-Frohner C.R., Oliveira K.N., Silva D.G., Pacheco L.K., Joussef A.C., Steindel M., Simões C.M.O., Souza A.M.T., Magalhaes U.O., Afonso I.F., Rodrigues C.R., Nunes R.J., Castro H.C. Synthesis, biological evaluation and SAR of sulfonamide 4-methoxychalcone derivates with potential antileishmanial activity. Eur. J. Med. Chem. 2009, 44:755-763.
3. Fernandez C., Marti-Mestres G., Ramos J., Maillols H. LC analysis of benzophenone-3: II application to determination of in vitro and in vivo skin penetration from solvents, coarse and submicron emulsions. J. Pharm. Biomed. Anal. 2000, 24:155-165.
4. Puglia C., Rizza L., Drechsler M., Bonina F. Nanoemulsions as vehicles for topical administration of glycyrrhetic acid: characterization and in vitro and in vivo evaluation. Drug Deliv. 2010, 17:123-129.
5. ICH Harmonized Tripartite Guideline: Stability Testing of New Drug Substance and Products: Methodology Q1A (R2) 2003.
6. Andrighetti-Frohner C.R., Joussef A.C., Simões C.M.O., Nunes R.J., Bortoluzzi A.J. 5-(2-Benzoylethenyl)-N-benzyl-2-methoxybenzenesulfonamide 2007, Acta Crystallogr. Sect. E: Struct. Rep. Online.
7. Bakshi M., Singh S. Development of validated stability-indicating assay methods-critical review. J. Pharm. Biomed. Anal. 2002, 28:1011-1040.
8. Nudelman N.E.S. Estabilidad de medicamentos 1975, El Ateno, Buenos Aires, Argentina.
9. Zhao Y., Sukbunthrng J., Antonian L. Simultaneous determination of Z-SU5416 and its interconvertible geometric E-isomer in rat plasma by LC/MS/MS. J. Pharm. Biomed. Anal. 2004, 35:513-522.
10. Liang Y., Zhang R., Adarayan E., Adamson G., Zhao J., Kassahun K., Emary W. Quantitation of geometric isomers of a phosphodiesterase inhibitor in a rat and monkey plasma using liquid chromatography-tandem mass spectrometry. J. Pharm. Biomed. Anal. 2006, 41:1293-1298.
11. Tunell H., Selo M., Skarp K., Hilborn J. Synthesis and characterization of main chain polyimides containing chalcone derivatives for LC alignment. Polym. J. 2006, 38:716-723.
12. Braun R.U., Ansorge M., Muller T.J.J. Coupling-isomerization synthesis of chalcones. Chem. Eur. J. 2006, 12:9081-9094.