Quantitation of geometric isomers of a phosphodiesterase inhibitor in rat and monkey plasma using liquid chromatography-tandem mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis

Volumn 41, Issue 4, 2006, Pages 1293-1298

  Liang, Yuexia ^a   Zhang, Rena ^a   Adarayan, Emily ^a   Adamson, Gary ^a   Zhao, Jamie J ^a   Kassahun, Kelem ^a   Emary, W Bart ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Bioanalytical assay; Geometric isomers; LC MS MS; Reverse phase chromatography; Tandem mass spectrometry

Indexed keywords

6 [1 METHYL 1 METHYLSULFONYLETHYL 8 [3 [2 [3 METHYL 1,2,4 OXADIAZOL 5 YL] 2 [4 (METHYLSULFONYL)PHENYL]ETHYNYL]PHENYL]QUINOLINE]; PHOSPHODIESTERASE INHIBITOR; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GEOMETRY; ISOMERIZATION; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; NONHUMAN; PRIORITY JOURNAL; RAT; SEPARATION TECHNIQUE; TANDEM MASS SPECTROMETRY; ANIMAL; BLOOD; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MACACA; MASS SPECTROMETRY; METHODOLOGY; SPRAGUE DAWLEY RAT; STEREOISOMERISM;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MACACA MULATTA; MASS SPECTROMETRY; PHOSPHODIESTERASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM;

EID: 33746644815     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2006.02.016     Document Type: Article

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