Agmatine induces gastric protection against ischemic injury by reducing vascular permeability in rats

World Journal of Gastroenterology

Volumn 18, Issue 18, 2012, Pages 2188-2196

  Al Masri, Abeer A ^a   El Eter, Eman ^a  

^a KING KHALID UNIVERSITY HOSPITAL   (Saudi Arabia)

Author keywords

Agmatine; Ischemia reperfusion injury; Monocyte chemoattractant protein 1; Stomach; Vascular endothelial growth factor; Vascular permeability; Wortmannin

Indexed keywords

AGMATINE; ANGIOPOIETIN 1; ANGIOPOIETIN 2; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; VASCULOTROPIN; WORTMANNIN; ANDROSTANE DERIVATIVE; CCL2 PROTEIN, RAT; PROTECTIVE AGENT; PROTEIN KINASE INHIBITOR; VASCULAR ENDOTHELIAL GROWTH FACTOR A, RAT; VASCULOTROPIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REPERFUSION INJURY; SIGNAL TRANSDUCTION; STOMACH INJURY; STOMACH PROTECTION; TISSUE HOMOGENATE; TREATMENT OUTCOME; TREATMENT RESPONSE; ANIMAL; CAPILLARY PERMEABILITY; CELL PROTECTION; DISEASE MODEL; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; PATHOLOGY; RAT; STOMACH; VASCULARIZATION; WISTAR RAT;

AGMATINE; ANDROSTADIENES; ANGIOPOIETIN-1; ANGIOPOIETIN-2; ANIMALS; CAPILLARY PERMEABILITY; CHEMOKINE CCL2; CYTOPROTECTION; DISEASE MODELS, ANIMAL; DOWN-REGULATION; IMMUNOHISTOCHEMISTRY; MALE; PHOSPHATIDYLINOSITOL 3-KINASE; PROTECTIVE AGENTS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; REPERFUSION INJURY; STOMACH; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84866250838     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v18.i18.2188     Document Type: Article

References (48)

1. Ramakrishna S, Adiga PR. Arginine decarboxylase from Lathyrus sativus seedlings. Purification and properites. Eur J Biochem 1975; 59: 377-386
2. Tabor CW, Tabor H. Polyamines. Annu Rev Biochem 1984; 53: 749-790
3. Chou HT, Kwon DH, Hegazy M, Lu CD. Transcriptome analysis of agmatine and putrescine catabolism in Pseudomonas aeruginosa PAO1. J Bacteriol 2008; 190: 1966-1975
4. Raasch W, Regunathan S, Li G, Reis DJ. Agmatine, the bac-terial amine, is widely distributed in mammalian tissues. Life Sci 1995; 56: 2319-2330
5. Utkan T, Ulak G, Yildiran HG, Yardimoglu M, Gacar MN. Investigation on the mechanism involved in the effects of agmatine on ethanol-induced gastric mucosal injury in rats. Life Sci 2000; 66: 1705-1711
6. Lortie MJ, Novotny WF, Peterson OW, Vallon V, Malvey K, Mendonca M, Satriano J, Insel P, Thomson SC, Blantz RC. Agmatine, a bioactive metabolite of arginine. Production, degradation, and functional effects in the kidney of the rat. J Clin Invest 1996; 97: 413-420
7. Cabella C, Gardini G, Corpillo D, Testore G, Bendino S, Solinal SP, Cravanzola C, Vargiu C, Grillo MA, and Colombatto S. Transport and metabolism of agmatine in rat hepatocyte cultures. Eur J Biochem 2001; 268: 940-947
8. Satriano J, Isome RA, Casero RA, Thomson SC, and Blantz RC. Polyamine transport system mediates agmatine transport in mammalian cells. Am J Physiol Cell Physiol 2001; 281: C329-C334. (A copy is attached) Available from: URL: http: //ajpcell.org/content/281/1/c329.full.pdf
9. Molderings GJ, Heinen A, Menzel S, Göthert M. Exposure of rat isolated stomach and rats in vivo to [(14)C]agmatine: accumulation in the stomach wall and distribution in various tissues. Fundam Clin Pharmacol 2002; 16: 219-225
10. Raasch W, Regunathan S, Li G, Reis DJ. Agmatine is widely and unequally distributed in rat organs. Ann N Y Acad Sci 1995; 763: 330-334
11. Stickle D, Bohrer A, Berger R, Morrissey J, Klahr S, Turk J. Quantitation of the putative neurotransmitter agmatine as the hexafluoroacetylacetonate derivative by stable isotope dilution gas chromatography and negative-ion chemical ionization mass spectrometry. Anal Biochem 1996; 238: 129-136
12. Regunathan S, Youngson C, Raasch W, Wang H, Reis DJ. Imidazoline receptors and agmatine in blood vessels: a novel system inhibiting vascular smooth muscle proliferation. J Pharmacol Exp Ther 1996; 276: 1272-1282
13. Feng Y, Halaris AE, and Piletz JE. Determination of agmatine in brain and plasma using high-performance liquid chromatography with fluorescence detection. J Chromatogr B Biomed Sci Appl 1997; 691: 277-286
14. Regunathan S, and Reis DJ. Characterization of arginine decarboxylase in rat brain and liver: distinction from ornithine decarboxylase. J Neurochem 2000; 74: 2201-2208
15. Halaris A, Plietz J. Agmatine: metabolic pathway and spectrum of activity in brain. CNS Drugs 2007; 21: 885-900
16. Isome M, Lortie MJ, Murakami Y, Parisi E, Matsufuji S, Satriano J. The antiproliferative effects of agmatine correlate with the rate of cellular proliferation. Am J Physiol Cell Physiol 2007; 293: C705-C711
17. Galea E, Regunathan S, Eliopoulos V, Feinstein DL, Reis DJ. Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine. Biochem J 1996; 316 ( Pt 1): 247-249
18. Mun CH, Lee WT, Park KA, Lee JE. Regulation of endothelial nitric oxide synthase by agmatine after transient global cerebral ischemia in rat brain. Anat Cell Biol 2010; 43: 230-240
19. Wang CC, Chio CC, Chang CH, Kuo JR, Chang CP. Beneficial effect of agmatine on brain apoptosis, astrogliosis, and edema after rat transient cerebral ischemia. BMC Pharmacol 2010; 10: 11
20. Dastan A, Kocer I, Erdogan F, Ates O, Kiziltunc A. Agmatine as retinal protection from ischemia-reperfusion injury in guinea pigs. Jpn J Ophthalmol 2009; 53: 219-224
21. Sugiura T, Kobuchi S, Tsutsui H, Takaoka M, Fujii T, Hayashi K, Matsumura Y. Preventive mechanisms of agmatine against ischemic acute kidney injury in rats. Eur J Pharmacol 2009; 603: 108-113
22. Greenberg S, George J, Wollman Y, Shapira I, Laniado S, Keren G. The effect of agmatine administration on ischemicreperfused isolated rat heart. J Cardiovasc Pharmacol Ther 2001; 6: 37-45
23. Steer H. The source of carbon dioxide for gastric acid production. Anat Rec (Hoboken) 2009; 292: 79-86
24. Glavin GB, Smyth DD. Effects of the selective I1 imidazoline receptor agonist, moxonidine, on gastric secretion and gastric mucosal injury in rats. Br J Pharmacol 1995; 114: 751-754
25. Glavin GB, Carlisle MA, Smyth DD. Agmatine, an endogenous imidazoline receptor agonist, increases gastric secretion and worsens experimental gastric mucosal injury in rats. J Pharmacol Exp Ther 1995; 274: 741-744
26. Bulhak AA, Jung C, Ostenson CG, Lundberg JO, Sjöquist PO, Pernow J. PPAR-alpha activation protects the type 2 diabetic myocardium against ischemia-reperfusion injury: involvement of the PI3-Kinase/Akt and NO pathway. Am J Physiol Heart Circ Physiol 2009; 296: H719-H727
27. Yoshikawa T, Yusuda M, Ueda S, Naito Y, Tanigawa T, Oyamada H, Kondo M. Vitamin E in gastric mucosal injury induced by ischemia reperfusion. Am J Clin Nutr 1991; 53: 210S-214S
28. Szabo S, Trier JS, Brown A, Schnoor J. Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat. Gastroenterology 1985; 88: 228-236
29. Woods KL, Smith JL, Graham DY. Intragastric accumulation of Evan's blue as a method for assessing aspirin-induced acute gastric mucosal injury in humans. Dig Dis Sci 1988; 33: 769-773
30. Lange S, Delbro DS, Jennische E. Evans blue permeation of intestinal mucosa in the rat. Scand J Gastroenterol 1994; 29: 38-46
31. Kageyama T, Takahashi K. Isolation of an activation intermediate and determination of the amino acid sequence of the activation segment of human pepsinogen A. J Biochem 1980; 88: 571-582
32. Steer H. Acid/base changes in the stomach. In Howard W Steer editor. The stomach, Helicobacter pylori and acid secretion. UK Amazon, 2005: 193-217
33. Molderings GJ, Burian M, Homann J, Nilius M, Göthert M. Potential relevance of agmatine as a virulence factor of Helicobacter pylori. Dig Dis Sci 1999; 44: 2397-2404
34. Fang Y, Jayaram H, Shane T, Kolmakova-Partensky L, Wu F, Williams C, Xiong Y, Miller C. Structure of a prokaryotic virtual proton pump at 3.2 A resolution. Nature 2009; 460: 1040-1043
35. Solligard E, Juel IS, Spigset O, Romundstad P, Grønbech JE, Aadahl P. Gut luminal lactate measured by microdialysis mirrors permeability of the intestinal mucosa after ischemia. Shock 2008; 29: 245-251
36. Takahashi K, Saishin Y, Saishin Y, Silva RL, Oshima Y, Oshima S, Melia M, Paszkiet B, Zerby D, Kadan MJ, Liau G, Kaleko M, Connelly S, Luo T, Campochiaro PA. Intraocular expression of endostatin reduces VEGF-induced retinal vascular permeability, neovascularization, and retinal detachment. FASEB J 2003; 17: 896-898
37. Tsuchihashi S, Ke B, Kaldas F, Flynn E, Busuttil RW, Briscoe DM, Kupiec-Weglinski JW. Vascular endothelial growth factor antagonist modulates leukocyte trafficking and protects mouse livers against ischemia/reperfusion injury. Am J Pathol 2006; 168: 695-705
38. Reinders ME, Sho M, Izawa A, Wang P, Mukhopadhyay D, Koss KE, Geehan CS, Luster AD, Sayegh MH, Briscoe DM. Proinflammatory functions of vascular endothelial growth factor in alloimmunity. J Clin Invest 2003; 112: 1655-1665
39. Ke B, Shen XD, Gao F, Tsuchihashi S, Farmer DG, Briscoe D, Busuttil RW, Kupiec-Weglinski JW. The CD154-CD40 T-cell co-stimulation pathway in liver ischemia and reperfusion inflammatory responses. Transplantation 2005; 79: 1078-1083
40. Roviezzo F, Tsigkos S, Kotanidou A, Bucci M, Brancaleone V, Cirino G, Papapetropoulos A. Angiopoietin-2 causes inflammation in vivo by promoting vascular leakage. J Pharmacol Exp Ther 2005; 314: 738-744
41. Portillo JA, Van Grol J, Zheng L, Okenka G, Gentil K, Garland A, Carison EC, Kern TS, Subauste CS. CD40 mediates retinal inflammation and neurovascular degeneration. J Immunol 2008; 181: 8719-8726
42. Jo N, Wu GS, Rao NA. Upregulation of chemokine expression in the retinal vasculature in ischemia-reperfusion injury. Invest Ophthalmol Vis Sci 2003; 44: 4054-4060
43. Frangogiannis NG. Chemokines in ischemia and reperfusion. Thromb Haemost 2007; 97: 738-747
44. Gilad GM, Salame K, Rabey JM, Gilad VH. Agmatine treatment is neuroprotective in rodent brain injury models. Life Sci 1996; 58: PL 41-46
45. Regunathan S, Piletz JE. Regulation of inducible nitric oxide synthase and agmatine synthesis in macrophages and astrocytes. Ann N Y Acad Sci 2003; 1009: 20-29
46. El Eter E, Al Tuwaijiri A, Hagar H, Arafa M. In vivo and in vitro antioxidant activity of ghrelin: Attenuation of gastric ischemic injury in the rat. J Gastroenterol Hepatol 2007; 22: 1791-1799
47. Ozyazgan S, Bicakci B, Ozaydin A, Denizbasi A, Unluer EE, Akkan AG. The effect of agmatine on the vascular reactivity in streptozotocin-diabetic rats. Pharmacol Res 2003; 48: 133-138
48. Yang MZ, Mun CH, Choi YJ, Baik JH, Park KA, Lee WT, Lee JE. Agmatine inhibits matrix metalloproteinase-9 via endothelial nitric oxide synthase in cerebral endothelial cells. Neurol Res 2007; 29: 749-754