Gut luminal lactate measured by microdialysis mirrors permeability of the intestinal mucosa after ischemia

Shock

Volumn 29, Issue 2, 2008, Pages 245-251

  Solligård, Erik ^a,b   Juel, Ingebjørg S ^a,b   Spigset, Olav ^a,c   Romundstad, Pål ^b   Grønbech, Jon Erik ^a,b   Aadahl, Petter ^a,b  

^a TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^c Children's and Women's Health ^*  (Norway)

Author keywords

Glycerol; I R; Polyethylene glycol; Splanchnic circulation; Tonometry

Indexed keywords

CARBON DIOXIDE; GLUCOSE; GLYCEROL; LACTIC ACID; MACROGOL; OXYGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTERIAL CARBON DIOXIDE TENSION; ARTERY CLAMP; ARTICLE; CONTROLLED STUDY; INTESTINE ISCHEMIA; INTESTINE MUCOSA PERMEABILITY; LACTATE BLOOD LEVEL; MALE; MICRODIALYSIS; NONHUMAN; SUPERIOR MESENTERIC ARTERY; SWINE; TONOMETRY;

ANIMALS; GLYCEROL; HEMODYNAMICS; INTESTINAL MUCOSA; INTESTINES; ISCHEMIA; LACTIC ACID; MALE; MICRODIALYSIS; PERMEABILITY; POLYETHYLENE GLYCOLS; REPERFUSION INJURY; SWINE;

EID: 38349094196     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/shk.0b013e3180cab3ce     Document Type: Article

References (27)

1. Wattanasirichaigoon S, Menconi MJ, Delude RL, Fink MP: Effect of mesenteric ischemia and reperfusion or hemorrhagic shock on intestinal mucosal permeability and ATP content in rats. Shock 12:127-133, 1999.
2. Wattanasirichaigoon S, Menconi MJ, Fink MP: Lisofylline ameliorates intestinal and hepatic injury induced by hemorrhage and resuscitation in rats. Crit Care Med 28:1540-1549, 2000.
3. Fink MP, Antonsson JB, Wang HL, Rothschild HR: Increased intestinal permeability in endotoxic pigs. Mesenteric hypoperfusion as an etiologic factor. Arch Surg 26:211-218, 1991.
4. Ziegler TR, Smith RJ, O'Dwyer ST, Demling RH, Wilmore DW: Increased intestinal permeability associated with infection in burn patients. Arch Surg 123:1313-1319, 1988.
5. De-Souza DA, Greene LJ: Intestinal permeability and systemic infections in critically ill patients: effect of glutamine. Crit Care Med 33:1125-1135, 2005.
6. Ammori BJ, Leeder PC, King RF, Barclay GR, Martin IG, Larvin M, McMahon MJ: Early increase in intestinal permeability in patients with severe acute pancreatitis: correlation with endotoxemia, organ failure, and mortality. J Gastrointest Surg 3:252-262, 1999.
7. Faries PL, Simon RJ, Martella AT, Lee MJ, Machiedo GW: Intestinal permeability correlates with severity of injury in trauma patients. J Trauma 44:1031-1035, 1998.
8. Doig CJ, Sutherland LR, Sandham JD, Fick GH, Verhoef M, Meddings JB: Increased intestinal permeability is associated with the development of multiple organ dysfunction syndrome in critically ill ICU patients. Am J Respir Crit Care Med 158:444-451, 1998.
9. Swank GM, Deitch EA: Role of the gut in multiple organ failure: bacterial translocation and permeability changes. World J Surg 20:411-417, 1996.
10. Murry CE, Jennings RB, Reimer KA: Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74:1124-1136, 1986.
11. Hotter G, Closa D, Prados M, Fernandez-Cruz L, Prats N, Gelpi E, Rosello-Catafau J: Intestinal preconditioning is mediated by a transient increase in nitric oxide. Biochem Biophys Res Commun 222:27-32, 1996.
12. Mallick IH, Yang W, Winslet MC, Seifalian AM: Ischemia-reperfusion injury of the intestine and protective strategies against injury. Dig Dis Sci 49:1359-1377, 2004.
13. Pasupathy S, Homer-Vanniasinkam S: Ischaemic preconditioning protects against ischaemia/reperfusion injury: emerging concepts. Eur J Vasc Endovasc Surg 29:106-115, 2005.
14. McCallion K, Wattanasirichaigoon S, Gardiner KR, Fink MP: Ischemic preconditioning ameliorates ischemia- and reperfusion-induced intestinal epithelial hyperpermeability in rats. Shock 14:429-434, 2000.
15. Solligård E, Wahba A, Skogvoll E, Stenseth R, Grønbech JE, Aadahl P: Endoluminal microdialysis shows increased rectal lactate in routine coronary surgery. Anaesthesia 62:250-258, 2007.
16. Solligård E, Juel IS, Bakkelund K, Jynge P, Tvedt KE, Johnsen H, Aadahl P, Gronbech JE: Gut luminal microdialysis of glycerol as a marker of intestinal ischemic injury and recovery. Crit Care Med 33:2278-2285, 2005.
17. Solligard E, Juel IS, Bakkelund K, Johnsen H, Saether OD, Gronbech JE, Aadahl P: Gut barrier dysfunction as detected by intestinal luminal microdialysis. Int Care Med 30:1188-1194, 2004.
18. Yavuz Y, Rønning K, Lyng O, Marvik R, Gronbech JE: Effect of increased intraabdominal pressure on cardiac output and tissue blood flow assessed by color-labeled microspheres in the pig. Surg Endosc 15:149-155, 2001.
19. Blikslager AT, Roberts MC, Rhoads JM, Argenzio RA: Is reperfusion injury an important cause of mucosal damage after porcine intestinal ischemia? Surgery 121:526-534, 1997.
20. Juel IS, Solligard E, Lyng O, Stromholm T, Tvedt KE, Johnsen H, Jynge P, Saether OD, Aadahl P, Gronbech JE: Intestinal injury after thoracic aortic cross-clamping in the pig. J Surg Res 117:283-295, 2004.
21. Takala J: Determinants of splanchnic blood flow. Br J Anaesth 77:50-58, 1996.
22. Granger DN, Richardson PD, Kvietys PR, Mortillaro NA: Intestinal blood flow. Gastroenterology 78:837-863, 1980.
23. Lundgren O, Haglund U: The pathophysiology of the intestinal countercurrent exchanger. Life Sci 23:1411-1422, 1978.
24. Tenhunen JJ, Kosunen H, Alhava E, Tuomisto L, Takala JA: Intestinal luminal microdialysis: a new approach to assess gut mucosal ischemia. Anesthesiology 91:1807-1815, 1999.
25. Poole RC, Halestrap AW: Transport of lactate and other monocarboxylates across mammalian plasma membranes. Am J Physiol 264:C761-C782, 1993.
26. Menconi MJ, Salzman AL, Unno N, Ezzell RM, Casey DM, Brown DA, Tsuji Y, Fink MP: Acidosis induces hyperpermeability in Caco-2BBe cultured intestinal epithelial monolayers. Am J Physiol 272:G1007-G1021, 1997.
27. Gutierrez G: A mathematical model of tissue-blood carbon dioxide exchange during hypoxia. Am J Respir Crit Care Med 169:525-533, 2004.