The effect of structural design on mechanical properties and cellular response of additive manufactured titanium scaffolds

Materials

Volumn 5, Issue 8, 2012, Pages 1336-1347

  Wieding, Jan ^a   Jonitz, Anika ^a   Bader, Rainer ^a  

^a ROSTOCK UNIVERSITY MEDICAL CENTER   (Germany)

Author keywords

Additive manufacturing; Bone scaffold; Compressive strength; Elastic modulus; Human osteoblasts; In vitro; Mechanical properties; Titanium

Indexed keywords

ADDITIVE MANUFACTURING; ADDITIVE MANUFACTURING PROCESS; ARTIFICIAL MATERIAL; BONE CELLS; BONE DEFECT; BONE SCAFFOLDS; CELLULAR RESPONSE; CIRCULAR CROSS-SECTIONS; GOLD STANDARDS; HUMAN CORTICAL BONE; HUMAN OSTEOBLAST; IN-VITRO; LOAD DIRECTION; LONG BONE; MANUFACTURING PROCESS; MATERIAL PROPERTY; ORTHOPEDIC SURGERY; PORE GEOMETRY; STRESS-STRAIN RELATIONSHIPS; TI-6AL-4V; TITANIUM SCAFFOLDS; ULTIMATE COMPRESSIVE STRENGTH;

BIOCOMPATIBILITY; BONE; CALCIUM PHOSPHATE; COMPRESSION TESTING; COMPRESSIVE STRENGTH; ELASTIC MODULI; INDUSTRIAL ENGINEERING; MECHANICAL PROPERTIES; PRODUCTION ENGINEERING; STRESS-STRAIN CURVES; STRUCTURAL DESIGN; STRUTS; TITANIUM;

SCAFFOLDS (BIOLOGY);

EID: 84866170081     PISSN: None     EISSN: 19961944     Source Type: Journal    
DOI: 10.3390/ma5081336     Document Type: Article

References (37)

1. De Coster, T.A.; Gehlert, R.J.; Mikola, E.A.; Pirela-Cruz, M.A. Management of posttraumatic segmental bone defects. J. Am. Acad. Orthop. Surg. 2004, 12, 28-38.
2. Attias, N.; Lehman, R.E.; Bodell, L.S.; Lindsey, R.W. Surgical management of a long segmental defect of the humerus using a cylindrical titanium mesh cage and plates: A case report. J. Orthop. Trauma 2005, 19, 211-216.
3. Schieker, M.; Mutschler, W. Bridging posttraumatic bony defects. Established and new methods. Unfallchirurg 2006, 109, 715-732.
4. Dumont, C.E.; Exner, U.G. Reconstruction of large diaphyseal defects of the femur and the tibia with autologous bone. Eur. J. Trauma Emerg. Surg. 2009, 35, 17-25.
5. Niedhart, C.; Pingsmann, A.; Jurgens, C.; Marr, A.; Blatt, R.; Niethard, F.U. Complications after harvesting of autologous bone from the ventral and dorsal iliac crest-A prospective, controlled study. Z. Orthop. Grenzgeb. 2003, 141, 481-486.
6. Younger, E.M.; Chapman, M.W. Morbidity at bone graft donor sites. J. Orthop. Trauma 1989, 3, 192-195.
7. Hutmacher, D.W.; Schantz, J.T.; Lam, C.X.; Tan, K.C.; Lim, T.C. State of the art and future directions of scaffold-based bone engineering from a biomaterials perspective. J. Tissue Eng. Regen. Med. 2007, 1, 245-260.
8. Reichert, J.C.; Wullschleger, M.E.; Cipitria, A.; Lienau, J.; Cheng, T.K.; Schutz, M.A.; Duda, G.N.; Noth, U.; Eulert, J.; Hutmacher, D.W. Custom-made composite scaffolds for segmental defect repair in long bones. Int. Orthop. 2011, 35, 1229-1236.
9. Mueller, U.; Imwinkelried, T.; Horst, M.; Sievers, M.; Graf-Hausner, U. Do human osteoblasts grow into open-porous titanium? Eur. Cells Mater. 2006, 11, 8-15.
10. Antonialli, A.I.S.; Bolfarini, C. Numerical evaluation of reduction of stress shielding in laser coated hip prostheses. Mater. Res. 2011, 14, 331-334.
11. Niinomi, M.; Nakai, M. Titanium-based biomaterials for preventing stress shielding between implant devices and bone. Int. J. Biomater. 2011, 2011, 1-10.
12. Li, J.P.; Wijn, J.R.; van Blitterswijk, C.A.; de Groot, K. Comparison of porous Ti6Al4V made by sponge replication and directly 3D fiber deposition and cancellous bone. Key Eng. Mater. 2007, 330-332, 999-1002.
13. Karageorgiou, V.; Kaplan, D. Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials 2005, 26, 5474-5491.
14. Ryan, G.; Pandit, A.; Apatsidis, D.P. Fabrication methods of porous metals for use in orthopaedic applications. Biomaterials 2006, 27, 2651-2670.
15. Takemoto, M.; Fujibayashi, S.; Neo, M.; Suzuki, J.; Kokubo, T.; Nakamura, T. Mechanical properties and osteoconductivity of porous bioactive titanium. Biomaterials 2005, 26, 6014-6023.
16. Spoerke, E.D.; Murray, N.G.; Li, H.; Brinson, L.C.; Dunand, D.C.; Stupp, S.I. A bioactive titanium foam scaffold for bone repair. Acta Biomater. 2005, 1, 523-533.
17. Koike, M.; Greer, P.; Owen, K.; Lilly, G.; Murr, L.E.; Gaytan, S.M.; Martinez, E.; Okabe, T. Evaluation of titanium alloys fabricated using rapid prototyping technologies-Electron beam melting and laser beam melting. Materials 2011, 4, 1776-1792.
18. Ponader, S.; von Wilmowsky, C.; Widenmayer, M.; Lutz, R.; Heinl, P.; Koerner, C.; Singer, R.F.; Nkenke, E.; Neukam, F.W.; Schlegel, K.A. In vivo performance of selective electron beam-melted Ti-6Al-4V structures. J. Biomed. Mater. Res. A 2010, 92, 56-62.
19. Li, J.P.; Habibovic, P.; van den Doel, M.; Wilson, C.E.; de Wijn, J.R.; van Blitterswijk, C.A.; de Groot, K. Bone ingrowth in porous titanium implants produced by 3D fiber deposition. Biomaterials 2007, 28, 2810-2820.
20. Murr, L.E.; Gaytan, S.M.; Medina, F.; Lopez, H.; Martinez, E.; Machado, B.I.; Hernandez, D.H.; Martinez, L.; Lopez, M.I.; Wicker, R.B.; Bracke, J. Next-generation biomedical implants using additive manufacturing of complex, cellular and functional mesh arrays. Phil. Trans. Roy. Soc. A Math. Phys. Eng. Sci. 2010, 368, 1999-2032.
21. Harrysson, O.L.A.; CansiZoglu, O.; Marcellin-Little, D.J.; Cormier, D.R.; West, H.A. Direct metal fabrication of titanium implants with tailored materials and mechanical properties using electron beam melting technology. Mater. Sci. Eng. C Biomim. Supramol. Syst. 2008, 28, 366-373.
22. Chahine, G.; Koike, M.; Okabe, T.; Smith, P.; Kovacevic, R. The design and production of Ti-6Al-4V ELI customized dental implants. JOM 2008, 60, 50-55.
23. Mangano, C.; de Rosa, A.; Desiderio, V.; d'Aquino, R.; Piattelli, A.; de Francesco, F.; Tirino, V.; Mangano, F.; Papaccio, G. The osteoblastic differentiation of dental pulp stem cells and bone formation on different titanium surface textures. Biomaterials 2010, 31, 3543-3551.
24. Parthasarathy, J.; Starly, B.; Raman, S.; Christensen, A. Mechanical evaluation of porous titanium (Ti6Al4V) structures with electron beam melting (EBM). J. Mech. Behav. Biomed. Mater. 2010, 3, 249-259.
25. Gibson, L.J.; Ashby, M.F. mechanics of three-dimensional cellular materials. Proc. R Soc. Lond. Ser. A 1982, 382, 43-59.
26. Li, X.; Wang, C.T.; Zhang, W.G.; Li, Y.C. Fabrication and compressive properties of Ti6Al4V implant with honeycomb-like structure for biomedical applications. Rapid Prototyping J. 2010, 16, 44-49.
27. Fassina, L.; Saino, E.; Visai, L.; Magenes, G. Electromagnetically enhanced coating of a sintered titanium grid with human SAOS-2 osteoblasts and extracellular matrix. In Proceedings of 30th Annual International Conference of the IEEE, Vancouver, Canada, 20-25 August 2008.
28. Hollander, D.A.; von Walter, M.; Wirtz, T.; Sellei, R.; Schmidt-Rohlfing, B.; Paar, O.; Erli, H.J. Structural, mechanical and in vitro characterization of individually structured Ti-6Al-4V produced by direct laser forming. Biomaterials 2006, 27, 955-963.
29. Frosch, K.H.; Barvencik, F.; Lohmann, C.H.; Viereck, V.; Siggelkow, H.; Breme, J.; Dresing, K.; Sturmer, K.M. Migration, matrix production and lamellar bone formation of human osteoblast-like cells in porous titanium implants. Cells Tissues Organs 2002, 170, 214-227.
30. Warnke, P.H.; Douglas, T.; Wollny, P.; Sherry, E.; Steiner, M.; Galonska, S.; Becker, S.T.; Springer, I.N.; Wiltfang, J.; Sivananthan, S. Rapid prototyping: Porous titanium alloy scaffolds produced by selective laser melting for bone tissue engineering. Tissue Eng. Part C Methods 2009, 15, 115-124.
31. Jonitz, A.; Wieding, J.; Lochner, K.; Cornelsen, M.; Seitz, H.; Hansmann, D.; Bader, R. Migration capacity and viability of human primary osteoblasts in synthetic three-dimensional bone scaffolds made of tricalciumphosphate. Materials 2011, 4, 1249-1259.
32. Merle, C.; Streit, M.R.; Volz, C.; Pritsch, M.; Gotterbarm, T.; Aldinger, P.R. Bone remodeling around stable uncemented titanium stems during the second decade after total hip arthroplasty: A DXA study at 12 and 17 years. Osteoporos. Int. 2011, 22, 2879-2886.
33. Suzuki, Y.; Nomura, N.; Hanada, S.; Kamakura, S.; Anada, T.; Fuji, T.; Honda, Y.; Masuda, T.; Sasaki, K.; Kokubun, S.; Suzuki, O. Osteoconductivity of porous titanium having young's modulus similar to bone and surface modification by OCP. Key Eng. Mater. 2007, 330-332, 951-954.
34. Ohman, C.; Baleani, M.; Pani, C.; Taddei, F.; Alberghini, M.; Viceconti, M.; Manfrini, M. Compressive behaviour of child and adult cortical bone. Bone 2011, 49, 769-776.
35. Grimal, Q.; Haupert, S.; Mitton, D.; Vastel, L.; Laugier, P. Assessment of cortical bone elasticity and strength: Mechanical testing and ultrasound provide complementary data. Med. Eng. Phys. 2009, 31, 1140-1147.
36. Cahill, S.; Lohfeld, S.; McHugh, P.E. Finite element predictions compared to experimental results for the effective modulus of bone tissue engineering scaffolds fabricated by selective laser sintering. J. Mater. Sci. Mater. Med. 2009, 20, 1255-1262.
37. Frosch, K.H.; Barvencik, F.; Viereck, V.; Lohmann, C.H.; Dresing, K.; Breme, J.; Brunner, E.; Sturmer, K.M. Growth behavior, matrix production, and gene expression of human osteoblasts in defined cylindrical titanium channels. J. Biomed. Mater. Res. A 2004, 68, 325-334.