Long-term treatment with l-isoleucine or l-leucine in AIN-93G diet has promoting effects on rat bladder carcinogenesis

Food and Chemical Toxicology

Volumn 50, Issue 11, 2012, Pages 3934-3940

  Xie, Xiao Li ^a   Wei, Min ^a   Yunoki, Takayuki ^a   Kakehashi, Anna ^a   Yamano, Shotaro ^a   Kato, Minoru ^a   Wanibuchi, Hideki ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Bladder carcinogenesis; L Isoleucine; L Leucine

Indexed keywords

ISOLEUCINE; LEUCINE;

AMINO ACID ANALYSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER CARCINOGENESIS; BLADDER MUCOSA; BLADDER PAPILLOMA; BODY WEIGHT; CANCER INCIDENCE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIET SUPPLEMENTATION; DIETARY INTAKE; MALE; MULTIPLE CANCER; NODULAR HYPERPLASIA; NONHUMAN; RAT; TUMOR PROMOTION; URINE PH; UROTHELIUM;

ANIMALS; BODY WEIGHT; BUTYLHYDROXYBUTYLNITROSAMINE; DIET; DIETARY SUPPLEMENTS; HYDROGEN-ION CONCENTRATION; ISOLEUCINE; LEUCINE; MALE; PAPILLOMA; RATS; RATS, INBRED F344; URINALYSIS; URINARY BLADDER; URINARY BLADDER NEOPLASMS; UROTHELIUM;

RATTUS;

EID: 84866169000     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.07.063     Document Type: Article

References (24)

1. Arnold L.L., Cano M., St John M., Eldan M., van Gemert M., Cohen S.M. Effects of dietary dimethylarsinic acid on the urine and urothelium of rats. Carcinogenesis 1999, 20:2171-2179.
2. Baracos V.E., Mackenzie M.L. Investigations of branched-chain amino acids and their metabolites in animal models of cancer. J. Nutr. 2006, 136:237S-242S.
3. Boorman, G.A., Eustis, S.L., Elwell, M.R., Montgomery, C.A., MacKenzie, W.F., 1990. Pathology of the Fisher Rat, Reference and Atlas. Academic Press Inc., 24-28 Oval Road, London.
4. Cai Y.Z., Luo Q., Sun M., Corke H. Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer. Life Sci. 2006, 74:2157-2184.
5. Clayson D.B., Fishbein L., Cohen S.M. Effects of stones and other physical factors on the induction of rodent bladder cancer. Food Chem. Toxicol. 1995, 33:771-784.
6. Doering C.B., Williams I.R., Danner D.J. Controlled overexpression of BCKD kinase expression: metabolic engineering applied to BCAA metabolism in a mammalian system. Metab. Eng. 2000, 2:349-356.
7. Fukuchi Y., Hiramitsu M., Okada M., Hayashi S., Nabeno Y., Osawa T., Naito M. Lemon Polyphenols Suppress Diet-induced Obesity by Up-Regulation of mRNA Levels of the Enzymes Involved in beta-Oxidation in Mouse White Adipose Tissue. J Clin Biochem Nutr 2008, 43:201-209.
8. Fukushima S., Shibata M.A., Kurata Y., Hasegawa R. The roles of l-ascorbic acid, urinary pH, and Na or K ion concentration in rat bladder epithelial cell proliferation with special reference to tumor promotion. Prog. Clin. Biol. Res. 1991, 369:195-208.
9. Henning S.M., Wang P., Said J., Magyar C., Castor B., Doan N., Tosity C., Moro A., Gao K., Li L., Heber D. Polyphenols in brewed green tea inhibit prostate tumor xenograft growth by localizing to the tumor and decreasing oxidative stress and angiogenesis. J. Nutr. Biochem. 2012, 10.1016/j.jnutbio.2011.10.007.
10. Kakizoe T., Komatsu H., Honma Y., Niijima T., Sugimura T. Detection of amino acids as possible promoters of bladder cancer in rats by measuring their enhancement of agglutination of bladder cells by concanavalin A. Gann 1982, 73:870-873.
11. Kakizoe T., Nishio Y., Honma Y., Niijima T., Sugimura T. l-Isoleucine and l-leucine are promoters of bladder cancer in rats. Princess Takamatsu Symp. 1983, 14:373-380.
12. Moriwaki H., Shiraki M., Fukushima H., et al. Long-term outcome of branched-chainamino acid treatment in patients with liver cirrhosis. Hepatol Res 2008, 38:S102-S106.
13. Muto Y., Sato S., Watanabe A., et al. Effects of oral branched-chain amino acid granules on event-free survival in patients with liver cirrhosis. Clin Gastroenterol Hepatol 2005, 3:705-713.
14. Muto Y., Sato S., Watanabe A., et al. Overweight and obesity increase the risk for liver cancer in patients with liver cirrhosis and long-term oral supplementation with branched-chain amino acid granules inhibits liver carcinogenesis in heavier patients with liver cirrhosis. Hepatol Res 2006, 35:204-214.
15. Nishio Y., Kakizoe T., Ohtani M., et al. l-Isoleucine and l-Leucine: Tumor Promoters of Bladder Cancer in Rats. Science 1986, 232:307.
16. Norman H.A., Butrum R.R., Feldman E., Heber D., Nixon D., Picciano M.F., Rivlin R., Simopoulos A., Wargovich M.J., Weisburger E.K., Zeisel S.H. The role of dietary supplements during cancer therapy. J. Nutr. 2003, 133:3794S-3799S.
17. Okamura T., Garland E.M., Masui T., Sakata T., St John M., Cohen S.M. Lack of bladder tumor promoting activity in rats fed sodium saccharin in AIN-76A diet. Cancer Res. 1991, 51:1778-1782.
18. Parkin D.M., Pisani P., Ferlay J. Global cancer statistics. CA-A Cancer J Clin 1999, 49:33-64.
19. Piscopo P., Crestini A., Adduci A., Ferrante A., Massari M., Popoli P., Vanacore N., Confaloni A. Altered oxidative stress profile in the cortex of mice fed an enriched branched-chain amino acids diet: possible link with amyotrophic lateral sclerosis?. J. Neurosci. Res. 2011, 89:1276-1283.
20. Siddiqui R., Pandya D., Harvey K., et al. Nutrition modulation of cachexia/proteolysis. Nutr Clin Pract 2006, 21:155-167.
21. Shen J., Wanibuchi H., Waalkes M.P., Salim E.I., Kinoshita A., Yoshida K., Endo G., Fukushima S. A comparative study of the sub-chronic toxic effects of three organic arsenical compounds on the urothelium in F344 rats; gender-based differences in response. Toxicol. Appl. Pharmacol. 2006, 210:171-180.
22. Shibata M., Tamano S., Shirai T., Kawabe M., Fukushima S. Inorganic alkalizers and acidifiers under conditions of high urinary Na+ or K+ on cell proliferation and two-stage carcinogenesis in the rat bladder. Jpn. J. Cancer Res. 1992, 83:821-829.
23. Tayek J.A., Bistrian B.R., Hehir D.J., Martin R., Moldawer L.L., Blackburn G.L. Improved protein kinetics and albumin synthesis by branched chain amino acid-enriched total parenteral nutrition in cancer cachexia. A prospective randomized crossover trial. Cancer-Am Cancer Soc 1986, 58:147-157.
24. World Cancer Research Fund American Institute for Cancer Research, 2007. Food, Nutrition, Physical Activity, and the Prevention of Cancer: A Global Perspective. AICR, Washington.