Gene expression profiling of primary and metastatic colon cancers identifies a reduced proliferative rate in metastatic tumors

Clinical and Experimental Metastasis

Volumn 27, Issue 1, 2010, Pages 1-9

  Ganepola, Ganepola A P ^a   Mazziotta, Robert M ^a   Weeresinghe, Dilendra ^a   Corner, Georgia A ^c   Parish, Cheryl J ^a,b   Chang, David H ^a,b   Tebbutt, Niall C ^d   Murone, Carmel ^d   Ahmed, Naseem ^c   Augenlicht, Leonard H ^c   Mariadason, John M ^a  

^a VALLEY HOSPITAL   (United States)

^b Valley Hospital   (United States)

^c MONTEFIORE MEDICAL CENTER   (United States)

^d AUSTIN HOSPITAL   (Australia)

Author keywords

Gene expression of colon tumor; Gene expression profiling; Immunohistochemical validation; Metastatic colorectal cancer; Metastatic process; Metastatic proliferation; Microarray analysis of colon cancer; Primary and metastatic colon cancer

Indexed keywords

BRCA2 PROTEIN; CELL CYCLE PROTEIN; CELL NUCLEUS ANTIGEN; CYCLIN D1; CYCLIN D2; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 3; KI 67 ANTIGEN; PROTEIN MAD2; PROTEIN TYROSINE PHOSPHATASE;

ANTIGEN DETECTION; ARTICLE; CANCER TISSUE; CELL PROLIFERATION; COLON TUMOR; CONTROLLED STUDY; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER METASTASIS; MICROARRAY ANALYSIS; TISSUE MICROARRAY; TISSUE SECTION; TRANSCRIPTION REGULATION; TUMOR GENE;

CELL CYCLE; CELL PROLIFERATION; COLONIC NEOPLASMS; GENE EXPRESSION PROFILING; HUMANS; NEOPLASM METASTASIS; TISSUE ARRAY ANALYSIS;

EID: 74849137748     PISSN: 02620898     EISSN: 15737276     Source Type: Journal    
DOI: 10.1007/s10585-009-9295-2     Document Type: Article

References (22)

1. S Jones WD Chen G Parmigiani, et al. 2008 Comparative lesion sequencing provides insights into tumor evolution Proc Natl Acad Sci U S A 105 11 4283 4288 10.1073/pnas.0712345105 1:CAS:528:DC%2BD1cXkt1WktLg%3D 18337506 (Pubitemid 351754372)
2. BH O'Neil RM Goldberg 2008 Innovations in chemotherapy for metastatic colorectal cancer: an update of recent clinical trials Oncologist 13 10 1074 1083 10.1634/theoncologist.2008-0083 18922828
3. A Chiappa M Makuuchi NJ Lygidakis, et al. 2009 The management of colorectal liver metastases: expanding the role of hepatic resection in the age of multimodal therapy Crit Rev Oncol Hematol 72 1 65 75 10.1016/j.critrevonc. 2008.11.003 1:STN:280:DC%2BD1MrptVOrtQ%3D%3D 19147371
4. DX Nguyen PD Bos J Massague 2009 Metastasis: from dissemination to organ-specific colonization Nat Rev Cancer 9 4 274 284 10.1038/nrc2622 1:CAS:528:DC%2BD1MXjsFSrsr4%3D 19308067
5. RM Goldberg 2006 Therapy for metastatic colorectal cancer Oncologist 11 9 981 987 10.1634/theoncologist.11-9-981 1:CAS:528:DC%2BD28XhtFOrsb3P 17030638 (Pubitemid 44564805)
6. S Goyle A Maraveyas 2005 Chemotherapy for colorectal cancer Dig Surg 22 6 401 414 10.1159/000091441 1:CAS:528:DC%2BD28XjslKksbo%3D 16479107
7. CS Karapetis S Khambata-Ford DJ Jonker, et al. 2008 K-ras mutations and benefit from cetuximab in advanced colorectal cancer N Engl J Med 359 17 1757 1765 10.1056/NEJMoa0804385 1:CAS:528:DC%2BD1cXht12nu77J 18946061
8. M Jhawer S Goel AJ Wilson, et al. 2008 PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab Cancer Res 68 6 1953 1961 10.1158/0008-5472.CAN-07- 5659 1:CAS:528:DC%2BD1cXjtFOhtro%3D 18339877
9. JM Mariadason D Arango Q Shi, et al. 2003 Gene expression profiling-based prediction of response of colon carcinoma cells to 5-fluorouracil and camptothecin Cancer Res 63 24 8791 8812 1:CAS:528:DC%2BD3sXhtVSqtb%2FE 14695196
10. RC Gentleman VJ Carey DM Bates, et al. 2004 Bioconductor: open software development for computational biology and bioinformatics Genome Biol 5 10 R80 10.1186/gb-2004-5-10-r80 15461798
11. MB Eisen PT Spellman PO Brown, et al. 1998 Cluster analysis and display of genome-wide expression patterns Proc Natl Acad Sci U S A 95 25 14863 14868 10.1073/pnas.95.25.14863 1:CAS:528:DyaK1cXotVGmurk%3D 9843981 (Pubitemid 29003722)
12. SB Kim S Yang SK Kim, et al. 2007 GAzer: gene set analyzer Bioinformatics 23 13 1697 1699 10.1093/bioinformatics/btm144 1:CAS:528:DC%2BD2sXos1yqsrs%3D 17468122 (Pubitemid 47244463)
13. JQ Li H Miki M Ohmori, et al. 2001 Expression of cyclin E and cyclin-dependent kinase 2 correlates with metastasis and prognosis in colorectal carcinoma Hum Pathol 32 9 945 953 10.1053/hupa.2001.27116 1:CAS:528: DC%2BD3MXnslSlt7g%3D 11567224 (Pubitemid 32911317)
14. T Agui DJ McConkey N Tanigawa 2002 Comparative study of various biological parameters, including expression of survivin, between primary and metastatic human colonic adenocarcinomas Anticancer Res 22 3 1769 1776 1:CAS:528:DC%2BD38XmsFWkt7s%3D 12168867
15. HH Backus CJ Van Groeningen W Vos, et al. 2002 Differential expression of cell cycle and apoptosis related proteins in colorectal mucosa, primary colon tumours, and liver metastases J Clin Pathol 55 3 206 211 1:STN:280: DC%2BD387msVemtg%3D%3D 11896073
16. A Anjomshoaa S Nasri B Humar, et al. 2009 Slow proliferation as a biological feature of colorectal cancer metastasis Br J Cancer 101 5 822 828 10.1038/sj.bjc.6605229 1:STN:280:DC%2BD1MrnvVaktg%3D%3D 19654572
17. P Perrin F Pierre Y Patry, et al. 2001 Only fibres promoting a stable butyrate producing colonic ecosystem decrease the rate of aberrant crypt foci in rats Gut 48 1 53 61 10.1136/gut.48.1.53 1:CAS:528:DC%2BD3MXntFKntg%3D%3D 11115823 (Pubitemid 32042642)
18. SE Fleming MD Fitch S DeVries, et al. 1991 Nutrient utilization by cells isolated from rat jejunum, cecum and colon J Nutr 121 6 869 878 1:CAS:528:DyaK3MXktVGltbY%3D 1903440
19. MR Clausen PB Mortensen 1995 Kinetic studies on colonocyte metabolism of short chain fatty acids and glucose in ulcerative colitis Gut 37 684 689 10.1136/gut.37.5.684 1:CAS:528:DyaK28XktVWhsQ%3D%3D 8549946
20. DH Ki HC Jeung CH Park, et al. 2007 Whole genome analysis for liver metastasis gene signatures in colorectal cancer Int J Cancer 121 9 2005 2012 10.1002/ijc.22975 1:CAS:528:DC%2BD2sXhtFSjsL%2FE 17640062 (Pubitemid 47463164)
21. R Blatt S Srinivasan 2008 Defining disease with laser precision: laser capture microdissection in gastroenterology Gastroenterology 135 2 364 369 10.1053/j.gastro.2008.06.054 18619446
22. P Ruminy C Gangneux S Claeyssens, et al. 2001 Gene transcription in hepatocytes during the acute phase of a systemic inflammation: from transcription factors to target genes Inflamm Res 50 8 383 390 10.1007/PL00000260 1:CAS:528:DC%2BD3MXnsFCrsr0%3D 11556518