-
1
-
-
17244376814
-
Wnt signalling in stem cells and cancer
-
Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature. 2005;434(7035):843-850.
-
(2005)
Nature
, vol.434
, Issue.7035
, pp. 843-850
-
-
Reya, T.1
Clevers, H.2
-
2
-
-
33745187852
-
Expression of beta-catenin by acute myeloid leukemia cells predicts enhanced clonogenic capacities and poor prognosis
-
Ysebaert L, Chicanne G, Demur C, et al. Expression of beta-catenin by acute myeloid leukemia cells predicts enhanced clonogenic capacities and poor prognosis. Leukemia. 2006;20(7):1211-1216.
-
(2006)
Leukemia
, vol.20
, Issue.7
, pp. 1211-1216
-
-
Ysebaert, L.1
Chicanne, G.2
Demur, C.3
-
3
-
-
16444374026
-
Constitutive activation of the Wnt/beta-catenin signalling pathway in acute myeloid leukaemia
-
Simon M, Grandage VL, Linch DC, Khwaja A. Constitutive activation of the Wnt/beta-catenin signalling pathway in acute myeloid leukaemia. Oncogene. 2005;24(14):2410-2420.
-
(2005)
Oncogene
, vol.24
, Issue.14
, pp. 2410-2420
-
-
Simon, M.1
Grandage, V.L.2
Linch, D.C.3
Khwaja, A.4
-
4
-
-
0037434982
-
Wnt signaling in B-cell neoplasia
-
Qiang YW, Endo Y, Rubin JS, Rudikoff S. Wnt signaling in B-cell neoplasia. Oncogene. 2003;22(10):1536-1545.
-
(2003)
Oncogene
, vol.22
, Issue.10
, pp. 1536-1545
-
-
Qiang, Y.W.1
Endo, Y.2
Rubin, J.S.3
Rudikoff, S.4
-
5
-
-
12144287598
-
Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells
-
Müller-Tidow C, Steffen B, Cauvet T, et al. Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells. Mol Cell Biol. 2004;24(7):2890-2904.
-
(2004)
Mol Cell Biol
, vol.24
, Issue.7
, pp. 2890-2904
-
-
Müller-Tidow, C.1
Steffen, B.2
Cauvet, T.3
-
6
-
-
11144355530
-
Gamma-catenin contributes to leukemogenesis induced by AML-associated translocation products by increasing the self-renewal of very primitive progenitor cells
-
Zheng X, Beissert T, Kukoc-Zivojnov N, et al. Gamma-catenin contributes to leukemogenesis induced by AML-associated translocation products by increasing the self-renewal of very primitive progenitor cells. Blood. 2004;103(9):3535-3543.
-
(2004)
Blood
, vol.103
, Issue.9
, pp. 3535-3543
-
-
Zheng, X.1
Beissert, T.2
Kukoc-Zivojnov, N.3
-
7
-
-
3943088431
-
Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML
-
Jamieson CH, Ailles LE, Dylla SJ, et al. Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med. 2004;351(7):657-667.
-
(2004)
N Engl J Med
, vol.351
, Issue.7
, pp. 657-667
-
-
Jamieson, C.H.1
Ailles, L.E.2
Dylla, S.J.3
-
8
-
-
34948817707
-
Notch1 co-opts lymphoid enhancer factor 1 for survival of murine T-cell lymphomas
-
Spaulding C, Reschly EJ, Zagort DE, et al. Notch1 co-opts lymphoid enhancer factor 1 for survival of murine T-cell lymphomas. Blood. 2007;110(7):2650-2658.
-
(2007)
Blood
, vol.110
, Issue.7
, pp. 2650-2658
-
-
Spaulding, C.1
Reschly, E.J.2
Zagort, D.E.3
-
9
-
-
33749510883
-
LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia
-
Skokowa J, Cario G, Uenalan M, et al. LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia. Nat Med. 2006;12(10):1191-1197.
-
(2006)
Nat Med
, vol.12
, Issue.10
, pp. 1191-1197
-
-
Skokowa, J.1
Cario, G.2
Uenalan, M.3
-
10
-
-
41149125490
-
A novel role for Lef-1, a central transcription mediator of Wnt signaling, in leukemogenesis
-
Petropoulos K, Arseni N, Schessl C, et al. A novel role for Lef-1, a central transcription mediator of Wnt signaling, in leukemogenesis. J Exp Med. 2008;205(3):515-522.
-
(2008)
J Exp Med
, vol.205
, Issue.3
, pp. 515-522
-
-
Petropoulos, K.1
Arseni, N.2
Schessl, C.3
-
11
-
-
1542753653
-
6-Thioguanine, cytarabine, and daunorubicin (TAD) and high-dose cytarabine and mitoxantrone (HAM) for induction, TAD for consolidation, and either prolonged maintenance by reduced monthly TAD or TAD-HAM-TAD and one course of intensive consolidation by sequential HAM in adult patients at all ages with de novo acute myeloid leukemia (AML): A randomized trial of the German AML Cooperative Group
-
Büchner T, Hiddemann W, Berdel WE, et al. 6-Thioguanine, cytarabine, and daunorubicin (TAD) and high-dose cytarabine and mitoxantrone (HAM) for induction, TAD for consolidation, and either prolonged maintenance by reduced monthly TAD or TAD-HAM-TAD and one course of intensive consolidation by sequential HAM in adult patients at all ages with de novo acute myeloid leukemia (AML): a randomized trial of the German AML Cooperative Group. J Clin Oncol. 2003;21(24):4496-4504.
-
(2003)
J Clin Oncol
, vol.21
, Issue.24
, pp. 4496-4504
-
-
Büchner, T.1
Hiddemann, W.2
Berdel, W.E.3
-
12
-
-
33745003472
-
Double induction containing either two courses or one course of high-dose cytarabine plus mitoxantrone and postremission therapy by either autologous stem-cell transplantation or by prolonged maintenance for acute myeloid leukemia
-
Büchner T, Berdel WE, Schoch C, et al. Double induction containing either two courses or one course of high-dose cytarabine plus mitoxantrone and postremission therapy by either autologous stem-cell transplantation or by prolonged maintenance for acute myeloid leukemia. J Clin Oncol. 2006;24(16):2480-2489.
-
(2006)
J Clin Oncol
, vol.24
, Issue.16
, pp. 2480-2489
-
-
Büchner, T.1
Berdel, W.E.2
Schoch, C.3
-
13
-
-
57449103508
-
An 86-probe-set gene-expression signature predicts survival in cytogenetically normal acute myeloid leukemia
-
Metzeler KH, Hummel M, Bloomfield CD, et al. An 86-probe-set gene-expression signature predicts survival in cytogenetically normal acute myeloid leukemia. Blood. 2008;112(10):4193-4201.
-
(2008)
Blood
, vol.112
, Issue.10
, pp. 4193-4201
-
-
Metzeler, K.H.1
Hummel, M.2
Bloomfield, C.D.3
-
14
-
-
67149084950
-
NPM1 but not FLT3-ITD mutations predict early blast cell clearance and CR rate in patients with normal karyotype AML(NK-AML) or high-risk myelodysplastic syndrome (MDS)
-
Schneider F, Hoster E, Unterhalt M, et al. NPM1 but not FLT3-ITD mutations predict early blast cell clearance and CR rate in patients with normal karyotype AML(NK-AML) or high-risk myelodysplastic syndrome (MDS). Blood. 2009;113(21):5250-5253.
-
(2009)
Blood
, vol.113
, Issue.21
, pp. 5250-5253
-
-
Schneider, F.1
Hoster, E.2
Unterhalt, M.3
-
15
-
-
52649181031
-
Rapid and sensitive screening for CEBPA mutations in acute myeloid leukaemia
-
Benthaus T, Schneider F, Mellert G, et al. Rapid and sensitive screening for CEBPA mutations in acute myeloid leukaemia. Br J Haematol. 2008;143(2):230-239.
-
(2008)
Br J Haematol
, vol.143
, Issue.2
, pp. 230-239
-
-
Benthaus, T.1
Schneider, F.2
Mellert, G.3
-
16
-
-
78851470101
-
Rapid identification of IDH1 and IDH2 mutations in acute myeloid leukaemia using high resolution melting curve analysis
-
Noordermeer SM, Tonnissen E, Vissers I, et al. Rapid identification of IDH1 and IDH2 mutations in acute myeloid leukaemia using high resolution melting curve analysis. Br J Haematol. 2011;152(4):493-496.
-
(2011)
Br J Haematol
, vol.152
, Issue.4
, pp. 493-496
-
-
Noordermeer, S.M.1
Tonnissen, E.2
Vissers, I.3
-
17
-
-
78049502442
-
Prospective evaluation of allogeneic hematopoietic stem-cell transplantation from matched related and matched unrelated donors in younger adults with high-risk acute myeloid leukemia: German-Austrian trial AMLHD98A
-
Schlenk RF, Dohner K, Mack S, et al. Prospective evaluation of allogeneic hematopoietic stem-cell transplantation from matched related and matched unrelated donors in younger adults with high-risk acute myeloid leukemia: German-Austrian trial AMLHD98A. J Clin Oncol. 2010;28(30):4642-4648.
-
(2010)
J Clin Oncol
, vol.28
, Issue.30
, pp. 4642-4648
-
-
Schlenk, R.F.1
Dohner, K.2
Mack, S.3
-
18
-
-
23644438883
-
Global approach to the diagnosis of leukemia using gene expression profiling
-
Haferlach T, Kohlmann A, Schnittger S, et al. Global approach to the diagnosis of leukemia using gene expression profiling. Blood. 2005;106(4):1189-1198.
-
(2005)
Blood
, vol.106
, Issue.4
, pp. 1189-1198
-
-
Haferlach, T.1
Kohlmann, A.2
Schnittger, S.3
-
19
-
-
77649096189
-
ERG expression is an independent prognostic factor and allows refined risk stratification in cytogenetically normal acute myeloid leukemia: A comprehensive analysis of ERG, MN1, and BAALC transcript levels using oligonucleotide microarrays
-
Metzeler KH, Dufour A, Benthaus T, et al. ERG expression is an independent prognostic factor and allows refined risk stratification in cytogenetically normal acute myeloid leukemia: a comprehensive analysis of ERG, MN1, and BAALC transcript levels using oligonucleotide microarrays. J Clin Oncol. 2009;27(30):5031-5038.
-
(2009)
J Clin Oncol
, vol.27
, Issue.30
, pp. 5031-5038
-
-
Metzeler, K.H.1
Dufour, A.2
Benthaus, T.3
-
20
-
-
77954569665
-
Gene expression profiling in AML with normal karyotype can predict mutations for molecular markers and allows novel insights into perturbed biological pathways
-
Kohlmann A, Bullinger L, Thiede C, et al. Gene expression profiling in AML with normal karyotype can predict mutations for molecular markers and allows novel insights into perturbed biological pathways. Leukemia. 2010;24(6):1216-1220.
-
(2010)
Leukemia
, vol.24
, Issue.6
, pp. 1216-1220
-
-
Kohlmann, A.1
Bullinger, L.2
Thiede, C.3
-
21
-
-
47149115310
-
An FLT3 gene-expression signature predicts clinical outcome in normal karyotype AML
-
Bullinger L, Dohner K, Kranz R, et al. An FLT3 gene-expression signature predicts clinical outcome in normal karyotype AML. Blood. 2008;111(9):4490-4495.
-
(2008)
Blood
, vol.111
, Issue.9
, pp. 4490-4495
-
-
Bullinger, L.1
Dohner, K.2
Kranz, R.3
-
22
-
-
0036081355
-
Gene expression omnibus: NCVI gene expression and hybridization array data repository
-
Edgar R, Domrachev M, Lash AE. Gene expression omnibus: NCVI gene expression and hybridization array data repository. Nucleic Acids Res. 2002;30(1):207-210.
-
(2002)
Nucleic Acids Res
, vol.30
, Issue.1
, pp. 207-210
-
-
Edgar, R.1
Domrachev, M.2
Lash, A.E.3
-
23
-
-
9144271651
-
Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time' quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR)-a Europe against cancer program
-
Beillard E, Pallisgaard N, van der Velden VHJ, et al. Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time' quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR)-a Europe against cancer program. Leukemia. 2003;17(12):2474-2486.
-
(2003)
Leukemia
, vol.17
, Issue.12
, pp. 2474-2486
-
-
Beillard, E.1
Pallisgaard, N.2
Van Der Velden, V.H.J.3
-
24
-
-
44949231424
-
Analyzing real-time PCR data by the comparative CT method
-
Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative CT method. Nature Protocols. 2008;3(6):1101-1108.
-
(2008)
Nature Protocols
, vol.3
, Issue.6
, pp. 1101-1108
-
-
Schmittgen, T.D.1
Livak, K.J.2
-
25
-
-
77449159028
-
Diagnosis and management of acute myeloid leukemia in adults: Recommendations from an international expert panel, on behalf of the European LeukemiaNet
-
Döhner H, Estey EH, Amadori S, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood. 2010;115(3):453-474.
-
(2010)
Blood
, vol.115
, Issue.3
, pp. 453-474
-
-
Döhner, H.1
Estey, E.H.2
Amadori, S.3
-
26
-
-
33644830601
-
Overexpression of the ETS-related gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: A Cancer and Leukemia Group B study
-
Marcucci G, Baldus CD, Ruppert AS, et al. Overexpression of the ETS-related gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: a Cancer and Leukemia Group B study. J Clin Oncol. 2005;23(36):9234-9242.
-
(2005)
J Clin Oncol
, vol.23
, Issue.36
, pp. 9234-9242
-
-
Marcucci, G.1
Baldus, C.D.2
Ruppert, A.S.3
-
27
-
-
0022712686
-
Censoring distributions as a measure of follow-up in survival analysis
-
Korn EL. Censoring distributions as a measure of follow-up in survival analysis. Stat Med. 1986;5(3):255-260.
-
(1986)
Stat Med
, vol.5
, Issue.3
, pp. 255-260
-
-
Korn, E.L.1
-
28
-
-
84863116398
-
Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia
-
Marcucci G, Metzeler KH, Schwind S, et al. Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia. J Clin Oncol. 2012;30(7):742-750.
-
(2012)
J Clin Oncol
, vol.30
, Issue.7
, pp. 742-750
-
-
Marcucci, G.1
Metzeler, K.H.2
Schwind, S.3
-
29
-
-
25444486426
-
Gene expression levels assessed by oligonucleotide microarray analysis and quantitative real-time RT-PCR-how well do they correlate?
-
Dallas PB, Gottardo NG, Firth MJ, et al. Gene expression levels assessed by oligonucleotide microarray analysis and quantitative real-time RT-PCR-how well do they correlate? BMC Genomics. 2005;6(1):59.
-
(2005)
BMC Genomics
, vol.6
, Issue.1
, pp. 59
-
-
Dallas, P.B.1
Gottardo, N.G.2
Firth, M.J.3
-
30
-
-
66949150560
-
Marked downregulation of the granulopoiesis regulator LEF1 is associated with disease progression in the myelodysplastic syndromes
-
Pellagatti A, Marafioti T, Paterson JC, et al. Marked downregulation of the granulopoiesis regulator LEF1 is associated with disease progression in the myelodysplastic syndromes. Br J Haematol. 2009;146(1):86-90.
-
(2009)
Br J Haematol
, vol.146
, Issue.1
, pp. 86-90
-
-
Pellagatti, A.1
Marafioti, T.2
Paterson, J.C.3
-
31
-
-
42949142189
-
Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia
-
Schlenk RF, Dohner K, Krauter J, et al. Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. N Engl J Med. 2008;358(18):1909-1918.
-
(2008)
N Engl J Med
, vol.358
, Issue.18
, pp. 1909-1918
-
-
Schlenk, R.F.1
Dohner, K.2
Krauter, J.3
-
32
-
-
34249810897
-
Acute myeloid leukemia and myelodysplastic syndromes in older patients
-
Estey E. Acute myeloid leukemia and myelodysplastic syndromes in older patients. J Clin Oncol. 2007;25(14):1908-1915.
-
(2007)
J Clin Oncol
, vol.25
, Issue.14
, pp. 1908-1915
-
-
Estey, E.1
-
33
-
-
77950287628
-
The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML
-
Wang Y, Krivtsov AV, Sinha AU, et al. The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. Science. 2010;327(5973):1650-1653.
-
(2010)
Science
, vol.327
, Issue.5973
, pp. 1650-1653
-
-
Wang, Y.1
Krivtsov, A.V.2
Sinha, A.U.3
-
34
-
-
0037737728
-
A role for Wnt signalling in self-renewal of haematopoietic stem cells
-
Reya T, Duncan AW, Ailles L, et al. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature. 2003;423(6938):409-414.
-
(2003)
Nature
, vol.423
, Issue.6938
, pp. 409-414
-
-
Reya, T.1
Duncan, A.W.2
Ailles, L.3
-
35
-
-
58849147900
-
Small molecule inhibitors of WNT signaling effectively induce apoptosis in acute myeloid leukemia cells
-
Minke KS, Staib P, Puetter A, et al. Small molecule inhibitors of WNT signaling effectively induce apoptosis in acute myeloid leukemia cells. Eur J Haematol. 2009;82(3):165-175.
-
(2009)
Eur J Haematol
, vol.82
, Issue.3
, pp. 165-175
-
-
Minke, K.S.1
Staib, P.2
Puetter, A.3
-
36
-
-
38349183265
-
Clinical significance of nuclear non-phosphorylated beta-catenin in acute myeloid leukaemia and myelodysplastic syndrome
-
Xu J, Suzuki M, Niwa Y, et al. Clinical significance of nuclear non-phosphorylated beta-catenin in acute myeloid leukaemia and myelodysplastic syndrome. Br J Haematol. 2008;140(4):394-401.
-
(2008)
Br J Haematol
, vol.140
, Issue.4
, pp. 394-401
-
-
Xu, J.1
Suzuki, M.2
Niwa, Y.3
-
37
-
-
33746808398
-
Wnt/beta-catenin signaling in development and disease
-
Clevers H. Wnt/beta-catenin signaling in development and disease. Cell. 2006;127(3):469-480.
-
(2006)
Cell
, vol.127
, Issue.3
, pp. 469-480
-
-
Clevers, H.1
-
38
-
-
20944450265
-
Flt3 tandem duplication mutations cooperate with Wnt signaling in leukemic signal transduction
-
Tickenbrock L, Schwable J, Wiedehage M, et al. Flt3 tandem duplication mutations cooperate with Wnt signaling in leukemic signal transduction. Blood. 2005;105(9):3699-3706.
-
(2005)
Blood
, vol.105
, Issue.9
, pp. 3699-3706
-
-
Tickenbrock, L.1
Schwable, J.2
Wiedehage, M.3
-
39
-
-
34548416774
-
LEF-1 is a decisive transcription factor in neutrophil granulopoiesis
-
Skokowa J, Welte K. LEF-1 is a decisive transcription factor in neutrophil granulopoiesis. Ann N Y Acad Sci. 2007;1106:143-151.
-
(2007)
Ann N Y Acad Sci
, vol.1106
, pp. 143-151
-
-
Skokowa, J.1
Welte, K.2
-
40
-
-
0033711624
-
Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism
-
Reya T, O'Riordan M, Okamura R, et al. Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism. Immunity. 2000;13(1):15-24.
-
(2000)
Immunity
, vol.13
, Issue.1
, pp. 15-24
-
-
Reya, T.1
O'Riordan, M.2
Okamura, R.3
-
41
-
-
0031883962
-
Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1
-
Okamura RM, Sigvardsson M, Galceran J, Verbeek S, Clevers H, Grosschedl R. Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1. Immunity. 1998;8(1):11-20.
-
(1998)
Immunity
, vol.8
, Issue.1
, pp. 11-20
-
-
Okamura, R.M.1
Sigvardsson, M.2
Galceran, J.3
Verbeek, S.4
Clevers, H.5
Grosschedl, R.6
-
42
-
-
77951015381
-
Inactivation of LEF1 in T-cell acute lymphoblastic leukemia
-
Gutierrez A, Sanda T, Ma W, et al. Inactivation of LEF1 in T-cell acute lymphoblastic leukemia. Blood. 2010;115(14):2845-2851.
-
(2010)
Blood
, vol.115
, Issue.14
, pp. 2845-2851
-
-
Gutierrez, A.1
Sanda, T.2
Ma, W.3
-
43
-
-
83455196188
-
Overexpression of LEF1 predicts unfavorable outcome in adult patients with B-precursor acute lymphoblastic leukemia
-
Kühnl A, Gökbuget N, Kaiser M, et al. Overexpression of LEF1 predicts unfavorable outcome in adult patients with B-precursor acute lymphoblastic leukemia. Blood. 2011;118(24):6362-6367.
-
(2011)
Blood
, vol.118
, Issue.24
, pp. 6362-6367
-
-
Kühnl, A.1
Gökbuget, N.2
Kaiser, M.3
|