Ccdc94 Protects Cells from Ionizing Radiation by Inhibiting the Expression of p53

PLoS Genetics

Volumn 8, Issue 8, 2012, Pages

  Sorrells, Shelly ^a   Carbonneau, Seth ^b   Harrington, Erik ^a   Chen, Aye T ^c   Hast, Bridgid ^d   Milash, Brett ^e   Pyati, Ujwal ^b   Major, Michael B ^d   Zhou, Yi ^c   Zon, Leonard I ^c   Stewart, Rodney A ^a   Look, A Thomas ^b   Jette, Cicely ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

^e UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MULTIPROTEIN COMPLEX; PROTEIN; PROTEIN CCDC94; PROTEIN P53; PROTEIN PRP19 COMPLEX; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CANCER INHIBITION; CCDC94 GENE; CONTROLLED STUDY; DOUBLE STRANDED DNA BREAK; EMBRYO; GENE; GENE EXPRESSION REGULATION; GENE MUTATION; GENE SEQUENCE; GENETIC CODE; GENETIC CONSERVATION; IMMUNOHISTOCHEMISTRY; IONIZING RADIATION; LOSS OF FUNCTION MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; RADIOSENSITIZATION; REAL TIME POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE;

ANIMALS; APOPTOSIS; DNA BREAKS, DOUBLE-STRANDED; EMBRYONIC DEVELOPMENT; GENE EXPRESSION REGULATION; GENES, RECESSIVE; MUTATION; NEURONS; RADIATION TOLERANCE; RADIATION, IONIZING; TUMOR SUPPRESSOR PROTEIN P53; ZEBRAFISH; ZEBRAFISH PROTEINS;

DANIO RERIO;

EID: 84866152306     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002922     Document Type: Article

References (46)

1. Lord CJ, Ashworth A, (2012) The DNA damage response and cancer therapy. Nature 481: 287-294.
2. Gudkov AV, Komarova EA, (2003) The role of p53 in determining sensitivity to radiotherapy. Nat Rev Cancer 3: 117-129.
3. Kratz E, Eimon PM, Mukhyala K, Stern H, Zha J, et al. (2006) Functional characterization of the Bcl-2 gene family in the zebrafish. Cell Death Differ 13: 1631-1640.
4. Sidi S, Sanda T, Kennedy RD, Hagen AT, Jette CA, et al. (2008) Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell 133: 864-877.
5. Villunger A, Michalak EM, Coultas L, Mullauer F, Bock G, et al. (2003) p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science 302: 1036-1038.
6. Gallenne T, Gautier F, Oliver L, Hervouet E, Noel B, et al. (2009) Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members. J Cell Biol 185: 279-290.
7. Kirkin V, Joos S, Zornig M, (2004) The role of Bcl-2 family members in tumorigenesis. Biochim Biophys Acta 1644: 229-249.
8. McKinnon PJ, (2009) DNA repair deficiency and neurological disease. Nat Rev Neurosci 10: 100-112.
9. Taylor AM, Harnden DG, Arlett CF, Harcourt SA, Lehmann AR, et al. (1975) Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity. Nature 258: 427-429.
10. Savitsky K, Bar-Shira A, Gilad S, Rotman G, Ziv Y, et al. (1995) A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 268: 1749-1753.
11. Shiloh Y, (2003) ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer 3: 155-168.
12. Jette CA, Flanagan AM, Ryan J, Pyati UJ, Carbonneau S, et al. (2008) BIM and other BCL-2 family proteins exhibit cross-species conservation of function between zebrafish and mammals. Cell Death Differ 15: 1063-1072.
13. Jackson SP, Bartek J, (2009) The DNA-damage response in human biology and disease. Nature 461: 1071-1078.
14. Liu YC, Chen HC, Wu NY, Cheng SC, (2007) A novel splicing factor, Yju2, is associated with NTC and acts after Prp2 in promoting the first catalytic reaction of pre-mRNA splicing. Mol Cell Biol 27: 5403-5413.
15. Chan SP, Kao DI, Tsai WY, Cheng SC, (2003) The Prp19p-associated complex in spliceosome activation. Science 302: 279-282.
16. Cheng SC, Tarn WY, Tsao TY, Abelson J, (1993) PRP19: a novel spliceosomal component. Mol Cell Biol 13: 1876-1882.
17. Legerski RJ, (2009) The Pso4 complex splices into the DNA damage response. Cell Cycle 8: 3448-3449.
18. Abdelilah S, Mountcastle-Shah E, Harvey M, Solnica-Krezel L, Schier AF, et al. (1996) Mutations affecting neural survival in the zebrafish Danio rerio. Development 123: 217-227.
19. Furutani-Seiki M, Jiang YJ, Brand M, Heisenberg CP, Houart C, et al. (1996) Neural degeneration mutants in the zebrafish, Danio rerio. Development 123: 229-239.
20. Liu TX, Howlett NG, Deng M, Langenau DM, Hsu K, et al. (2003) Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis. Dev Cell 5: 903-914.
21. Bladen CL, Navarre S, Dynan WS, Kozlowski DJ, (2007) Expression of the Ku70 subunit (XRCC6) and protection from low dose ionizing radiation during zebrafish embryogenesis. Neurosci Lett 422: 97-102.
22. Miyashita T, Reed JC, (1992) bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs. Cancer Res 52: 5407-5411.
23. Miyashita T, Reed JC, (1993) Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. Blood 81: 151-157.
24. Sentman CL, Shutter JR, Hockenbery D, Kanagawa O, Korsmeyer SJ, (1991) bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67: 879-888.
25. Robu ME, Larson JD, Nasevicius A, Beiraghi S, Brenner C, et al. (2007) p53 activation by knockdown technologies. PLoS Genet 3: e78 doi:10.1371/journal.pgen.0030078.
26. Berghmans S, Murphey RD, Wienholds E, Neuberg D, Kutok JL, et al. (2005) tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors. Proc Natl Acad Sci U S A 102: 407-412.
27. Biswas AK, Johnson DG, (2012) Transcriptional and nontranscriptional functions of E2F1 in response to DNA damage. Cancer Res 72: 13-17.
28. Lee KC, Goh WL, Xu M, Kua N, Lunny D, et al. (2008) Detection of the p53 response in zebrafish embryos using new monoclonal antibodies. Oncogene 27: 629-640.
29. Jeffers JR, Parganas E, Lee Y, Yang C, Wang J, et al. (2003) Puma is an essential mediator of p53-dependent and-independent apoptotic pathways. Cancer Cell 4: 321-328.
30. Gavin AC, Bosche M, Krause R, Grandi P, Marzioch M, et al. (2002) Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature 415: 141-147.
31. Grote M, Wolf E, Will CL, Lemm I, Agafonov DE, et al. (2010) Molecular architecture of the human Prp19/CDC5L complex. Mol Cell Biol 30: 2105-2119.
32. Ren L, McLean JR, Hazbun TR, Fields S, Vander Kooi C, et al. (2011) Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19. PLoS ONE 6: e16719 doi:10.1371/journal.pone.0016719.
33. Benathen IA, Beam CA, (1977) The genetic control of X-ray resistance in budding yeast cells. Radiat Res 69: 99-116.
34. Henriques JA, Vicente EJ, Leandro da Silva KV, Schenberg AC, (1989) PSO4: a novel gene involved in error-prone repair in Saccharomyces cerevisiae. Mutat Res 218: 111-124.
35. Mahajan KN, Mitchell BS, (2003) Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase. Proc Natl Acad Sci U S A 100: 10746-10751.
36. Revers LF, Cardone JM, Bonatto D, Saffi J, Grey M, et al. (2002) Thermoconditional modulation of the pleiotropic sensitivity phenotype by the Saccharomyces cerevisiae PRP19 mutant allele pso4-1. Nucleic Acids Res 30: 4993-5003.
37. Zhang N, Kaur R, Lu X, Shen X, Li L, et al. (2005) The Pso4 mRNA splicing and DNA repair complex interacts with WRN for processing of DNA interstrand cross-links. J Biol Chem 280: 40559-40567.
38. Kleinridders A, Pogoda HM, Irlenbusch S, Smyth N, Koncz C, et al. (2009) PLRG1 is an essential regulator of cell proliferation and apoptosis during vertebrate development and tissue homeostasis. Mol Cell Biol 29: 3173-3185.
39. Amsterdam A, Nissen RM, Sun Z, Swindell EC, Farrington S, et al. (2004) Identification of 315 genes essential for early zebrafish development. Proc Natl Acad Sci U S A 101: 12792-12797.
40. Kruse JP, Gu W, (2009) Modes of p53 regulation. Cell 137: 609-622.
41. Raff MC, Barres BA, Burne JF, Coles HS, Ishizaki Y, et al. (1993) Programmed cell death and the control of cell survival: lessons from the nervous system. Science 262: 695-700.
42. Ni Chonghaile T, Sarosiek KA, Vo TT, Ryan JA, Tammareddi A, et al. (2011) Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy. Science 334: 1129-1133.
43. Hanahan D, Weinberg RA, (2011) Hallmarks of cancer: the next generation. Cell 144: 646-674.
44. Westerfield M (1993) The Zebrafish Book.: University of Oregon Press, Eugene, OR.
45. Nix DA, Di Sera TL, Dalley BK, Milash BA, Cundick RM, et al. (2010) Next generation tools for genomic data generation, distribution, and visualization. BMC Bioinformatics 11: 455.
46. Fujita PA, Rhead B, Zweig AS, Hinrichs AS, Karolchik D, et al. (2011) The UCSC Genome Browser database: update 2011. Nucleic Acids Res 39: D876-882.