Synthesis and evaluation of novel anti-proliferative pyrroloazepinone and indoloazepinone oximes derived from the marine natural product hymenialdisine

European Journal of Medicinal Chemistry

Volumn 56, Issue , 2012, Pages 246-253

  White, Alex W ^a   Carpenter, Nicholas ^a   Lottin, Jerome R P ^a   McClelland, Richard A ^a   Nicholson, Robert I ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Hymenialdisine; Kenpaullone; Marine natural products; Oximes; Tetrahydroazepinone

Indexed keywords

2,3 DIBROMO 4 (CYCLOHEXYLMETHOXYIMINO) 1 METHYL 4,5,6,7 TETRAHYDROPYRROLO[2,3 C]AZEPIN 8(1H) ONE; 4 (BENZYLOXYIMINO) 2,3 DIBROMO 1 METHYL 4,5,6,7 TETRAHYDROPYRROLO[2,3 C]AZEPIN 8(1H) ONE; 4 (BENZYLOXYIMINO) 2,3 DIBROMO 4,5,6,7 TETRAHYDROPYRROLO[2,3 C]AZEPIN 8(1H) ONE; 5 (BENZYLOXYIMINO) 2,3,4,5 TETRAHYDROPYRROLO[3,4 B]INDOL 1(10H) ONE; 5 (CYCLOHEXYLMETHOXYIMINO) 10 METHYL 2,3,4,5 TETRAHYDROAZEPINO[3,4 B]INDOL 1(10H) ONE; 7 BROMO 5 (HYDROXYIMINO) 2,3,4,5 TETRAHYDROPYRROLO[3,4 B]INDOL 1(10H) ONE; AZEPINE DERIVATIVE; HYMENIALDISINE; INDOLOAZEPINONE OXIME DERIVATIVE; KENPAULLONE; PYRROLOAZEPINONE OXIME DERIVATIVE; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANTINEOPLASTIC AGENTS; AZEPINES; BIOLOGICAL AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDOLES; MCF-7 CELLS; MOLECULAR STRUCTURE; OXIMES; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84866152057     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.08.022     Document Type: Article

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