-
1
-
-
67650385302
-
-
Atlanta (GA): American Cancer Society. Available from
-
American Cancer Society. Atlanta (GA): American Cancer Society. Cancer Facts and Figures 2011. Available from: http://www.cancer. org/acs/groups/ content/@epidemiologysurveilance/documents/document/acspc-029771.pdf.
-
Cancer Facts and Figures 2011
-
-
-
2
-
-
0026069885
-
Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin: Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data
-
Bai RL, Paull KD, Herald CL, Malspeis L, Pettit GR, Hamel E. Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data. J Biol Chem 1991;266:15882-9. (Pubitemid 21907740)
-
(1991)
Journal of Biological Chemistry
, vol.266
, Issue.24
, pp. 15882-15889
-
-
Bai, R.1
Paull, K.D.2
Herald, C.L.3
Malspeis, L.4
Pettit, G.R.5
Hamel, E.6
-
3
-
-
0035110756
-
In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B
-
Towle MJ, Salvato KA, Budrow J, Wels BF, Kuznetsov G, Aalfs KK, et al. In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B. Cancer Res 2001;61:1013-21. (Pubitemid 32174419)
-
(2001)
Cancer Research
, vol.61
, Issue.3
, pp. 1013-1021
-
-
Towle, M.J.1
Salvato, K.A.2
Budrow, J.3
Wels, B.F.4
Kuznetsov, G.5
Aalfs, K.K.6
Welsh, S.7
Zheng, W.8
Seletsky, B.M.9
Palme, M.H.10
Habgood, G.J.11
Singer, L.A.12
DiPietro, L.V.13
Wang, Y.14
Chen, J.J.15
Quincy, D.A.16
Davis, A.17
Yoshimatsu, K.18
Kishi, Y.19
Yu, M.J.20
Littlefield, B.A.21
more..
-
4
-
-
0026774529
-
Total synthesis of halichondrin B and norhalichondrin B
-
Aicher TD, Buszek KR, Fang FG, Forsyth CJ, Jung SH, Kishi Y, et al. Total synthesis of halichondrin B and norhalichondrin B. J Am Chem Soc 1992;114:3162-4.
-
(1992)
J Am Chem Soc
, vol.114
, pp. 3162-3164
-
-
Aicher, T.D.1
Buszek, K.R.2
Fang, F.G.3
Forsyth, C.J.4
Jung, S.H.5
Kishi, Y.6
-
5
-
-
0033791649
-
Structural insights into microtubule function
-
Nogales E. Structural insights into microtubule function. Annu Rev Biochem 2000;69:277-302.
-
(2000)
Annu Rev Biochem
, vol.69
, pp. 277-302
-
-
Nogales, E.1
-
6
-
-
4143052665
-
Induction of morphological and biochemical apoptosis following prolonged mitotic blockage by halichondrin B macrocyclic ketone analog E7389
-
DOI 10.1158/0008-5472.CAN-04-1169
-
Kuznetsov G, Towle MJ, Cheng H, Kawamura T, TenDyke K, Liu D, et al. Induction of morphological and biochemical apoptosis following prolonged mitotic blockage by halichondrin B macrocyclic ketone analog E7389. Cancer Res 2004;64:5760-6. (Pubitemid 39095575)
-
(2004)
Cancer Research
, vol.64
, Issue.16
, pp. 5760-5766
-
-
Kuznetsov, G.1
Towle, M.J.2
Cheng, H.3
Kawamura, T.4
TenDyke, K.5
Liu, D.6
Kishi, Y.7
Yu, M.J.8
Littlefield, B.A.9
-
7
-
-
23144433687
-
The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth
-
DOI 10.1158/1535-7163.MCT-04-0345
-
Jordan MA, Kamath K, Manna T, Okouneva T, Miller HP, Davis C, et al. The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth. Mol Cancer Ther 2005;4:1086-95. (Pubitemid 41079102)
-
(2005)
Molecular Cancer Therapeutics
, vol.4
, Issue.7
, pp. 1086-1095
-
-
Jordan, M.A.1
Kamath, K.2
Manna, T.3
Okouneva, T.4
Miller, H.P.5
Davis, C.6
Littlefield, B.A.7
Wilson, L.8
-
8
-
-
69049106647
-
Macromolecular interaction of halichondrin B analogues eribulin (E7389) and ER-076349 with tubulin by analytical ultracentrifugation
-
Alday PH, Correia JJ. Macromolecular interaction of halichondrin B analogues eribulin (E7389) and ER-076349 with tubulin by analytical ultracentrifugation. Biochemistry 2009;48:7927-38.
-
(2009)
Biochemistry
, vol.48
, pp. 7927-7938
-
-
Alday, P.H.1
Correia, J.J.2
-
9
-
-
33744979610
-
Sensitivity to halichondrin analog E7389 and hemiasterlin analog E7974 correlates with bIII tubulin isotype expression in human breast cancer cell lines
-
Agoulnik S, Kuznetsov G, Tendyke K, Parent LA, Marsh JP, Twine N, et al. Sensitivity to halichondrin analog E7389 and hemiasterlin analog E7974 correlates with bIII tubulin isotype expression in human breast cancer cell lines. J Clin Oncol 2005;23(16S):2012.
-
(2005)
J Clin Oncol
, vol.23
, Issue.16
, pp. 2012
-
-
Agoulnik, S.1
Kuznetsov, G.2
Tendyke, K.3
Parent, L.A.4
Marsh, J.P.5
Twine, N.6
-
10
-
-
33745000162
-
A phase I pharmacokinetic and target validation study of the novel anti-tubulin agent E7389: A California Cancer consortium trial
-
Synold TW, Morgan RJ, Newman EM, Lenz HJ, Gandara DR, Colevas AD, et al. A phase I pharmacokinetic and target validation study of the novel anti-tubulin agent E7389: a California Cancer consortium trial. J Clin Oncol 2005;23[Suppl]:3036.
-
(2005)
J Clin Oncol
, vol.23
, Issue.SUPPL.
, pp. 3036
-
-
Synold, T.W.1
Morgan, R.J.2
Newman, E.M.3
Lenz, H.J.4
Gandara, D.R.5
Colevas, A.D.6
-
11
-
-
67449147109
-
A phase I study of eribulin mesylate (E7389), a mechanistically novel inhibitor of microtubule dynamics, in patients with advanced solid malignancies
-
Goel S, Mita AC, Mita M, Rowinsky EK, Chu QS, Wong N, et al. A phase I study of eribulin mesylate (E7389), a mechanistically novel inhibitor of microtubule dynamics, in patients with advanced solid malignancies. Clin Cancer Res 2009;15:4207-12.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 4207-4212
-
-
Goel, S.1
Mita, A.C.2
Mita, M.3
Rowinsky, E.K.4
Chu, Q.S.5
Wong, N.6
-
12
-
-
67449123315
-
Phase I study of eribulin mesylate administered once every 21 days in patients with advanced solid tumors
-
Tan AR, Rubin EH, Walton DC, Shuster DE, Wong YN, Fang F, et al. Phase I study of eribulin mesylate administered once every 21 days in patients with advanced solid tumors. Clin Cancer Res 2009;15: 4213-9.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 4213-4219
-
-
Tan, A.R.1
Rubin, E.H.2
Walton, D.C.3
Shuster, D.E.4
Wong, Y.N.5
Fang, F.6
-
13
-
-
79551555821
-
Eribulin mesylate pharmacokinetics in patients with hepatic impairment
-
Witteveen P, Marchetti S, Mergui-Roelvink M, Reyderman L, Copalu W, Wanders J, et al. Eribulin mesylate pharmacokinetics in patients with hepatic impairment. J Clin Oncol 2010;28 (suppl):2582.
-
(2010)
J Clin Oncol
, vol.28
, Issue.SUPPL.
, pp. 2582
-
-
Witteveen, P.1
Marchetti, S.2
Mergui-Roelvink, M.3
Reyderman, L.4
Copalu, W.5
Wanders, J.6
-
14
-
-
80455138386
-
Eribulin mesylate pharmacokinetics in patients with solid tumors receiving repeated oral ketoconazole
-
abstract 574
-
Devriese L, Wanders J, Jenner A, Edwards G, Reyderman L, Copalu W, et al. Eribulin mesylate pharmacokinetics in patients with solid tumors receiving repeated oral ketoconazole [abstract 574]. EORTC-NCI- AACR Symposium 2010;8:181.
-
(2010)
EORTC-NCI- AACR Symposium
, vol.8
, pp. 181
-
-
Devriese, L.1
Wanders, J.2
Jenner, A.3
Edwards, G.4
Reyderman, L.5
Copalu, W.6
-
15
-
-
84940373672
-
Structure-activity relationships of synthetic halicondrin B analog E7389: In vitro susceptibility to PgP- Mediated drug efflux
-
Zheng W, Seletsky B, Palme M, Habgood G, Singer L, Dipietro L. Structure-activity relationships of synthetic halicondrin B analog E7389: in vitro susceptibility to PgP- mediated drug efflux. Proc Am Assoc Cancer Res 2003;7:2751.
-
(2003)
Proc Am Assoc Cancer Res
, vol.7
, pp. 2751
-
-
Zheng, W.1
Seletsky, B.2
Palme, M.3
Habgood, G.4
Singer, L.5
Dipietro, L.6
-
17
-
-
67449159949
-
A phase I study of eribulin mesylate (E7389) in patients with refractory cancers
-
Minami H, Mukohara T, Nagai S, Mukai H, Namiki M. A phase I study of eribulin mesylate (E7389) in patients with refractory cancers. Eur J Cancer 2008;6(Suppl):140.
-
(2008)
Eur J Cancer
, vol.6
, Issue.SUPPL.
, pp. 140
-
-
Minami, H.1
Mukohara, T.2
Nagai, S.3
Mukai, H.4
Namiki, M.5
-
18
-
-
67649908927
-
Phase II study of eribulin mesylate, a halichondrin B analog, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane
-
Vahdat LT, Pruitt B, Fabian CJ, Rivera RR, Smith DA, Tan-Chiu E, et al. Phase II study of eribulin mesylate, a halichondrin B analog, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane. J Clin Oncol 2009;27:2954-61.
-
(2009)
J Clin Oncol
, vol.27
, pp. 2954-2961
-
-
Vahdat, L.T.1
Pruitt, B.2
Fabian, C.J.3
Rivera, R.R.4
Smith, D.A.5
Tan-Chiu, E.6
-
19
-
-
77957594393
-
Phase II study of the halichondrin B analog eribulin mesylate in patients with locally advanced or metastatic breast cancer previously treated with an anthracycline, a taxane, and capecitabine
-
Cortes J, Vahdat L, Blum JL, Twelves C, Campone M, Roché H, et al. Phase II study of the halichondrin B analog eribulin mesylate in patients with locally advanced or metastatic breast cancer previously treated with an anthracycline, a taxane, and capecitabine. J Clin Oncol 2010;28:3922-8.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3922-3928
-
-
Cortes, J.1
Vahdat, L.2
Blum, J.L.3
Twelves, C.4
Campone, M.5
Roché, H.6
-
20
-
-
79551553908
-
Efficacy and safety of eribulin in Japanese patients (pts) with advanced breast cancer
-
abstract
-
Iwata H, Aogi K, Masuda N, Mukai H, Yoshida M, Rai Y, et al. Efficacy and safety of eribulin in Japanese patients (pts) with advanced breast cancer [abstract]. J Clin Oncol 2010;28:1081.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1081
-
-
Iwata, H.1
Aogi, K.2
Masuda, N.3
Mukai, H.4
Yoshida, M.5
Rai, Y.6
-
21
-
-
79952487463
-
EMBRACE (Eisai Metastatic Breast Cancer Study Assessing Physician's Choice Versus E7389) investigators. Eribulin monotherapy versus treatment of physician's choice in patients with metastatic breast cancer (EMBRACE): A phase 3 open-label randomised study
-
Cortes J, O'Shaughnessy J, Loesch D, Blum JL, Vahdat LT, Petrakova K, et al. EMBRACE (Eisai Metastatic Breast Cancer Study Assessing Physician's Choice Versus E7389) investigators. Eribulin monotherapy versus treatment of physician's choice in patients with metastatic breast cancer (EMBRACE): a phase 3 open-label randomised study. Lancet 2011;377:914-23.
-
(2011)
Lancet
, vol.377
, pp. 914-923
-
-
Cortes, J.1
O'Shaughnessy, J.2
Loesch, D.3
Blum, J.L.4
Vahdat, L.T.5
Petrakova, K.6
-
22
-
-
77950475001
-
Phase III trials of eribulin mesylate (E7389) in extensively pretreated patients with locally recurrent or metastatic breast cancer
-
Twelves C, Cortes J, Vahdat LT, Wanders J, Akerele C, Kaufman PA. Phase III trials of eribulin mesylate (E7389) in extensively pretreated patients with locally recurrent or metastatic breast cancer. Clin Breast Cancer 2010;10:160-3.
-
(2010)
Clin Breast Cancer
, vol.10
, pp. 160-163
-
-
Twelves, C.1
Cortes, J.2
Vahdat, L.T.3
Wanders, J.4
Akerele, C.5
Kaufman, P.A.6
-
23
-
-
34548157209
-
Efficacy and safety of ixabepilone (BMS-247550) in a phase II study of patients with advanced breast cancer resistant to an anthracycline, a taxane, and capecitabine
-
DOI 10.1200/JCO.2006.09.3849
-
Perez EA, Lerzo G, Pivot X, Thomas E, Vahdat L, Bosserman L, et al. Efficacy and safety of ixabepilone (BMS-247550) in a phase II study of patients with advanced breast cancer resistant to an anthracycline, a taxane, and capecitabine. J Clin Oncol 2007;25:3407-14. (Pubitemid 47310876)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.23
, pp. 3407-3414
-
-
Perez, E.A.1
Lerzo, G.2
Pivot, X.3
Thomas, E.4
Vahdat, L.5
Bosserman, L.6
Viens, P.7
Cai, C.8
Mullaney, B.9
Peck, R.10
Hortobagyi, G.N.11
-
24
-
-
77954752064
-
Randomized phase III trial of ixabepilone plus capecitabine versus capecitabine in patients with metastatic breast cancer previously treated with an anthracycline and a taxane
-
Sparano JA, Vrdoljak E, Rixe O, Xu B, Manikhas A, Medina C, et al. Randomized phase III trial of ixabepilone plus capecitabine versus capecitabine in patients with metastatic breast cancer previously treated with an anthracycline and a taxane. J Clin Oncol 2010;28:3256-63.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3256-3263
-
-
Sparano, J.A.1
Vrdoljak, E.2
Rixe, O.3
Xu, B.4
Manikhas, A.5
Medina, C.6
-
25
-
-
32944482677
-
Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer
-
DOI 10.1200/JCO.2005.04.937
-
Gradishar WJ, Tjulandin S, Davidson N, Shaw H, Desai N, Bhar P, et al. Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer. J Clin Oncol 2005;23: 7794-803. (Pubitemid 46657376)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.31
, pp. 7794-7803
-
-
Gradishar, W.J.1
Tjulandin, S.2
Davidson, N.3
Shaw, H.4
Desai, N.5
Bhar, P.6
Hawkins, M.7
O'Shaughnessy, J.8
-
26
-
-
84856520235
-
Medicare Part B Drugs Average Sales Price
-
Jul ASP Pricing File 061611.xls. [Accessed June 21, 2011]
-
Medicare Part B Drugs Average Sales Price. 2011 ASP Drug Pricing Files. www.cms.gov/home/medicare.asp. Jul 2011. ASP Pricing File 061611.xls. [Accessed June 21, 2011].
-
(2011)
2011 ASP Drug Pricing Files
-
-
-
27
-
-
84856528631
-
-
ClinicalTrials.gov. Bethesda (MD): National Library of Medicine. Available from
-
ClinicalTrials.gov. Bethesda (MD): National Library of Medicine. Available from: www.ClinicalTrials.gov.
-
-
-
-
28
-
-
65249107203
-
Microtubule assembly, organization and dynamics in axons and dendrites
-
Conde C, Cáceres A. Microtubule assembly, organization and dynamics in axons and dendrites. Nat Rev Neurosci 2009;10:319-32.
-
(2009)
Nat Rev Neurosci
, vol.10
, pp. 319-332
-
-
Conde, C.1
Cáceres, A.2
|