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Volumn 97, Issue 9, 2012, Pages 3068-3078

Central hypothyroidism: Pathogenic, diagnostic and therapeutic challenges

Author keywords

[No Author keywords available]

Indexed keywords

THYROTROPIN; THYROXINE; THYROID HORMONE;

EID: 84866149947     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2012-1616     Document Type: Review
Times cited : (207)

References (106)
  • 1
    • 56649111212 scopus 로고    scopus 로고
    • Mechanisms related to the pathophysiology and management of central hypothyroidism
    • Yamada M, Mori M 2008 Mechanisms related to the pathophysiology and management of central hypothyroidism. Nat Clin Pract Endocrinol Metab 4:683-694
    • (2008) Nat Clin Pract Endocrinol Metab , vol.4 , pp. 683-694
    • Yamada, M.1    Mori, M.2
  • 3
    • 0035320622 scopus 로고    scopus 로고
    • Cranial irradiation and central hypothyroidism
    • PII S1043276000003593
    • Rose SR 2001 Cranial irradiation and central hypothyroidism. Trends Endocrinol Metab 12:97-104 (Pubitemid 33714196)
    • (2001) Trends in Endocrinology and Metabolism , vol.12 , Issue.3 , pp. 97-104
    • Rose, S.R.1
  • 4
    • 84866149659 scopus 로고    scopus 로고
    • Central hypothyroidism
    • Braverman LE, Cooper D, eds. 10th ed. Chap 38. Philadelphia: Lippincott Williams, Wilkins/Wolters Kluwer Health
    • Persani L, Beck-Peccoz P 2012 Central hypothyroidism. In: Braverman LE, Cooper D, eds. Werner and Ingbar's the thyroid: a fundamental and clinical text. 10th ed. Chap 38. Philadelphia: Lippincott Williams, Wilkins/Wolters Kluwer Health; 560-568
    • (2012) Werner and Ingbar's the Thyroid: A Fundamental and Clinical Text , pp. 560-568
    • Persani, L.1    Beck-Peccoz, P.2
  • 5
    • 0035978012 scopus 로고    scopus 로고
    • Screening for central hypothyroidism is unjustified
    • Price A, Weetman AP 2001 Screening for central hypothyroidism is unjustified. BMJ 322:798
    • (2001) BMJ , vol.322 , pp. 798
    • Price, A.1    Weetman, A.P.2
  • 6
    • 0036196352 scopus 로고    scopus 로고
    • Hypothalamo-pituitary hypothyroidism detected by neonatal screening for congenital hypothyroidism using measurement of thyroid-stimulating hormone and thyroxine
    • DOI 10.1080/080352502317285171
    • Asakura Y, Tachibana K, Adachi M, Suwa S, Yamagami Y 2002 Hypothalamo-pituitary hypothyroidism detected by neonatal screening for congenital hypothyroidism using measurement of thyroid-stimulating hormone and thyroxine. Acta Paediatr 91:172-177 (Pubitemid 34252526)
    • (2002) Acta Paediatrica, International Journal of Paediatrics , vol.91 , Issue.2 , pp. 172-177
    • Asakura, Y.1    Tachibana, K.2    Adachi, M.3    Suwa, S.4    Yamagami, Y.5
  • 7
    • 77952291903 scopus 로고    scopus 로고
    • Newborn screening results in children with central hypothyroidism
    • Nebesio TD, McKenna MP, Nabhan ZM, Eugster EA 2010 Newborn screening results in children with central hypothyroidism. J Pediatr 156:990-993
    • (2010) J Pediatr , vol.156 , pp. 990-993
    • Nebesio, T.D.1    McKenna, M.P.2    Nabhan, Z.M.3    Eugster, E.A.4
  • 9
    • 0027966921 scopus 로고
    • Variable biological activity of thyroid-stimulating hormone
    • Beck-Peccoz P, Persani L 1994 Variable biological activity of thyroid-stimulating hormone. Eur J Endocrinol 131:331-340 (Pubitemid 24309260)
    • (1994) European Journal of Endocrinology , vol.131 , Issue.4 , pp. 331-340
    • Beck-Peccoz, P.1    Persani, L.2
  • 10
    • 0028899107 scopus 로고
    • Bioactivity of thyrotropin (TSH) in patients with central hypothyroidism: Comparison between in vivo 3,5,3-triiodothyronine response to TS Hand in vitro bioactivity of TSH
    • Horimoto M, Nishikawa M, Ishihara T, Yoshikawa N, Yoshimura M, Inada M 1995 Bioactivity of thyrotropin (TSH) in patients with central hypothyroidism: comparison between in vivo 3,5,3-triiodothyronine response to TS Hand in vitro bioactivity of TSH. J Clin Endocrinol Metab 80:1124-1128
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 1124-1128
    • Horimoto, M.1    Nishikawa, M.2    Ishihara, T.3    Yoshikawa, N.4    Yoshimura, M.5    Inada, M.6
  • 12
    • 34249030660 scopus 로고    scopus 로고
    • Congenital thyrotropin deficiency - From discovery to molecular biology, postgenome and preventive medicine
    • DOI 10.1507/endocrj.KR-107
    • Miyai K 2007 Congenital thyrotropin deficiency-from discovery to molecular biology, postgenome and preventive medicine. Endocr J 54:191-203 (Pubitemid 46798640)
    • (2007) Endocrine Journal , vol.54 , Issue.2 , pp. 191-203
    • Miyai, K.1
  • 13
    • 0035029983 scopus 로고    scopus 로고
    • Hyperplastic pituitary gland, high serum glycoprotein hormone α-subunit, and variable circulating thyrotropin (TSH) levels as hallmark of central hypothyroidism due to mutations of the TSHβ gene
    • DOI 10.1210/jc.86.4.1600
    • Bonomi M, Proverbio MC, Weber G, Chiumello G, Beck-Peccoz P, Persani L 2001 Hyperplastic pituitary gland, high serum glycoprotein hormone α-subunit, and variable circulating thyrotropin (TSH) levels as hallmark of central hypothyroidism due to mutations of the TSHβ gene. J Clin Endocrinol Metab 86:1600-1604 (Pubitemid 32374910)
    • (2001) Journal of Clinical Endocrinology and Metabolism , vol.86 , Issue.4 , pp. 1600-1604
    • Bonomi, M.1    Proverbio, M.C.2    Weber, G.3    Chiumello, G.4    Beck-Peccoz, P.5    Persani, L.6
  • 14
    • 0018758211 scopus 로고
    • Thyrotropin secretion in patients with central hypothyroidism: Evidence for reduced biological activity of immunoreactive thyrotropin
    • Faglia G, Bitensky L, Pinchera A, Ferrari C, Paracchi A, Beck-Peccoz P, Ambrosi B, Spada A 1979 Thyrotropin secretion in patients with central hypothyroidism: evidence for reduced biological activity of immunoreactive thyrotropin. J Clin Endocrinol Metab 48:989-998 (Pubitemid 9190852)
    • (1979) Journal of Clinical Endocrinology and Metabolism , vol.48 , Issue.6 , pp. 989-998
    • Faglia, G.1    Bitensky, L.2    Pinchera, A.3
  • 15
    • 0021928235 scopus 로고
    • Decreased receptor binding of biologically inactive thyrotropin in central hypothyroidism. Effect of treatment with thyrotropin-releasing hormone
    • Beck-Peccoz P, Amr S, Menezes-Ferreira MM, Faglia G, Weintraub BD 1985 Decreased receptor binding of biologically inactive thyrotropin central hypothyroidism: effect of treatment with thyrotropin-releasing hormone. N Engl J Med 312:1085-1090 (Pubitemid 15121217)
    • (1985) New England Journal of Medicine , vol.312 , Issue.17 , pp. 1085-1090
    • Beck-Peccoz, P.1    Amr, S.2    Menezes-Ferreira, M.3
  • 16
    • 0029619433 scopus 로고
    • Thyrotropin with decreased biological activity, a delayed consequence of cranial irradiation for nasopharyngeal carcinoma
    • Lee KO, Persani L, Tan M, Sundram FX, Beck-Peccoz P 1995 Thyrotropin with decreased bioactivity, a delayed consequence of cranial irradiation for nasopharyngeal carcinoma. J Endocrinol Invest 18:800-805 (Pubitemid 26031643)
    • (1995) Journal of Endocrinological Investigation , vol.18 , Issue.10 , pp. 800-805
    • Lee, K.-O.1    Persani, L.2    Tan, M.3    Suhdram, F.X.4    Beck-Peccoz, P.5
  • 17
    • 0031788132 scopus 로고    scopus 로고
    • Hypothalamic thyrotropin-releasing hormone and thyrotropin biological activity
    • Persani L 1998 Hypothalamic thyrotropin-releasing hormone and thyrotropin biological activity. Thyroid 8:941-946 (Pubitemid 28514188)
    • (1998) Thyroid , vol.8 , Issue.10 , pp. 941-946
    • Persani, L.1
  • 18
    • 0035042136 scopus 로고    scopus 로고
    • Investigating the paradox of hypothyroidism and increased serum thyrotropin (TSH) levels in Sheehan's syndrome: Characterization of TSH carbohydrate content and bioactivity
    • DOI 10.1210/jc.86.4.1694
    • Oliveira JH, Persani L, Beck-Peccoz P, Abucham J 2001 Investigating the paradox of hypothyroidism and increased serum thyrotropin (TSH) levels in Sheehan's syndrome: characterization of TSH carbohydrate content and bioactivity. J Clin Endocrinol Metab 86:1694-1699 (Pubitemid 32374925)
    • (2001) Journal of Clinical Endocrinology and Metabolism , vol.86 , Issue.4 , pp. 1694-1699
    • Oliveira, J.H.A.1    Persani, L.2    Beck-Peccoz, P.3    Abucham, J.4
  • 19
    • 0027261228 scopus 로고
    • Variable carbohydrate structures of circulating thyrotropin as studied by lectin affinity chromatography in different clinical conditions
    • DOI 10.1210/jc.77.2.393
    • Papandreou MJ, Persani L, Asteria C, Ronin C, Beck-Peccoz P 1993 Variable carbohydrate structures of circulating thyrotropin as studied by lectin affinity chromatography in different clinical conditions. J Clin Endocrinol Metab 77:393-398 (Pubitemid 23230046)
    • (1993) Journal of Clinical Endocrinology and Metabolism , vol.77 , Issue.2 , pp. 393-398
    • Papandreou, M.-J.1    Persani, L.2    Asteria, C.3    Ronin, C.4    Beck-Peccoz, P.5
  • 20
    • 0031786080 scopus 로고    scopus 로고
    • Changes in the degree of sialylation of carbohydrate chains modify the biological properties of circulating thyrotropin isoforms in various physiological and pathological states
    • DOI 10.1210/jc.83.7.2486
    • Persani L, Borgato S, Romoli R, Asteria C, Pizzocaro A, Beck-Peccoz P 1998 Changes in the degree of sialylation of carbohydrate chains modify the biological properties of circulating thyrotropin isoforms in various physiological and pathological states. J Clin Endocrinol Metab 83:2486-2492 (Pubitemid 28503051)
    • (1998) Journal of Clinical Endocrinology and Metabolism , vol.83 , Issue.7 , pp. 2486-2492
    • Persani, L.1    Borgato, S.2    Romoli, R.3    Asteria, C.4    Pizzocaro, A.5    Beck-Peccoz, P.6
  • 26
    • 79960091086 scopus 로고    scopus 로고
    • Consequences of craniopharyngioma surgery in children
    • Müller HL 2011 Consequences of craniopharyngioma surgery in children. J Clin Endocrinol Metab 96:1981-1991
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 1981-1991
    • Müller, H.L.1
  • 28
    • 0023139085 scopus 로고
    • Endocrine complications after radiotherapy for tumors of the head and neck
    • Samaan NA, Schultz PN, Yang KP, Vassilopoulou-Sellin R, Maor MH, Cangir A, Goepfert H 1987 Endocrine complications after radiotherapy for tumors of the head and neck. J Lab Clin Med 109:364-372 (Pubitemid 17034044)
    • (1987) Journal of Laboratory and Clinical Medicine , vol.109 , Issue.3 , pp. 364-372
    • Samaan, N.A.1    Schultz, P.N.2    Yang, K.-P.P.3
  • 34
    • 33744950951 scopus 로고    scopus 로고
    • High risk of hypopituitarism after traumatic brain injury: A prospective investigation of anterior pituitary function in the acute phase and 12 months after trauma
    • DOI 10.1210/jc.2005-2476
    • Tanriverdi F, Senyurek H, Unluhizarci K, Selcuklu A, Casanueva FF, Kelestimur F 2006 High risk of hypopituitarism after traumatic brain injury: a prospective investigation of anterior pituitary function in the acute phase and 12 months after trauma. J Clin Endocrinol Metab 91:2105-2111 (Pubitemid 43854990)
    • (2006) Journal of Clinical Endocrinology and Metabolism , vol.91 , Issue.6 , pp. 2105-2111
    • Tanriverdi, F.1    Senyurek, H.2    Unluhizarci, K.3    Selcuklu, A.4    Casanueva, F.F.5    Kelestimur, F.6
  • 37
  • 40
    • 58149522761 scopus 로고    scopus 로고
    • Hypogonadism, diabetes mellitus, hypothyroidism, hypoparathyroidism: Incidence and prevalence related to iron overload and chelation therapy in patients with thalassaemia major followed from 1980 to 2007 in the Ferrara Centre
    • Gamberini MR, De Sanctis V, Gilli G 2008 Hypogonadism, diabetes mellitus, hypothyroidism, hypoparathyroidism: incidence and prevalence related to iron overload and chelation therapy in patients with thalassaemia major followed from 1980 to 2007 in the Ferrara Centre. Pediatr Endocrinol Rev 6(Suppl 1):158-169
    • (2008) Pediatr Endocrinol Rev , vol.6 , Issue.SUPPL. 1 , pp. 158-169
    • Gamberini, M.R.1    De Sanctis, V.2    Gilli, G.3
  • 41
    • 67849104080 scopus 로고    scopus 로고
    • All patients with 'idiopathic'hypopituitarism should be screened for hemochromatosis
    • Lewis AS, Courtney CH, Atkinson AB 2009 All patients with 'idiopathic'hypopituitarism should be screened for hemochromatosis. Pituitary 12:273-275
    • (2009) Pituitary , vol.12 , pp. 273-275
    • Lewis, A.S.1    Courtney, C.H.2    Atkinson, A.B.3
  • 42
    • 71749102435 scopus 로고    scopus 로고
    • Drugs that suppress TSH or cause central hypothyroidism
    • Haugen BR 2009 Drugs that suppress TSH or cause central hypothyroidism. Best Pract Res Clin Endocrinol Metab 23:793-800
    • (2009) Best Pract Res Clin Endocrinol Metab , vol.23 , pp. 793-800
    • Haugen, B.R.1
  • 45
    • 53549129976 scopus 로고    scopus 로고
    • Postnatal administration of dexamethasone for weaning off the ventilator affects thyroid function
    • Buimer M, van Wassenaer AG, Kok JH 2008 Postnatal administration of dexamethasone for weaning off the ventilator affects thyroid function. Neonatology 94:164-169
    • (2008) Neonatology , vol.94 , pp. 164-169
    • Buimer, M.1    Van Wassenaer, A.G.2    Kok, J.H.3
  • 46
    • 25144501183 scopus 로고    scopus 로고
    • Central hypothyroidism in infants who were born to mothers with thyrotoxicosis before 32 weeks' gestation: 3 Cases
    • DOI 10.1542/peds.2004-2128
    • Higuchi R, Miyawaki M, Kumagai T, Okutani T, Shima Y, Yoshiyama M, Ban H, Yoshikawa N 2005 Central hypothyroidism in infants who were born to mothers with thyrotoxicosis before 32 weeks' gestation: 3 cases. Pediatrics 115:e623-e625 (Pubitemid 43843222)
    • (2005) Pediatrics , vol.115 , Issue.5
    • Higuchi, R.1    Miyawaki, M.2    Kumagai, T.3    Okutani, T.4    Shima, Y.5    Yoshiyama, M.6    Ban, H.7    Yoshikawa, N.8
  • 47
    • 0016757873 scopus 로고
    • Recovery of pituitary thyrotropic function after withdrawal of prolonged thyroid-suppression therapy
    • Vagenakis AG, Braverman LE, Azizi F, Portinay GI, Ingbar SH 1975 Recovery of pituitary thyrotropic function after withdrawal of prolonged thyroid-suppression therapy.N Engl J Med 293:681-684
    • (1975) N Engl J Med , vol.293 , pp. 681-684
    • Vagenakis, A.G.1    Braverman, L.E.2    Azizi, F.3    Portinay, G.I.4    Ingbar, S.H.5
  • 49
    • 77949511133 scopus 로고    scopus 로고
    • Mechanisms behind the non-thyroidal illness syndrome: An update
    • Warner MH, Beckett GJ 2010 Mechanisms behind the non-thyroidal illness syndrome: an update. J Endocrinol 205:1-13
    • (2010) J Endocrinol , vol.205 , pp. 1-13
    • Warner, M.H.1    Beckett, G.J.2
  • 50
    • 0035109662 scopus 로고    scopus 로고
    • Thyroid function in the intensive care unit setting
    • Burman KD, Wartofsky L 2001 Thyroid function in the intensive care unit setting. Crit Care Clin 17:43-57 (Pubitemid 32163178)
    • (2001) Critical Care Clinics , vol.17 , Issue.1 , pp. 43-57
    • Burman, K.D.1    Wartofsky, L.2
  • 51
    • 1542376030 scopus 로고    scopus 로고
    • "Non-thyroidal illness syndrome" is functional central hypothyroidism, and if severe, hormone replacement is appropriate in light of present knowledge
    • DeGroot LJ 2003 "Nonthyroidal illness syndrome" is functional central hypothyroidism, and if severe, hormone replacement therapy is appropriate in light of present knowledge. J Endocrinol Invest 26:1163-1170 (Pubitemid 38324731)
    • (2003) Journal of Endocrinological Investigation , vol.26 , Issue.12 , pp. 1163-1170
    • DeGroot, L.J.1
  • 52
    • 34548401257 scopus 로고    scopus 로고
    • Nonthyroidal illness: To treat or not to treat?
    • Paris
    • Peeters RP 2007 Nonthyroidal illness: to treat or not to treat? Ann Endocrinol (Paris) 68:224-228
    • (2007) Ann Endocrinol , vol.68 , pp. 224-228
    • Peeters, R.P.1
  • 53
    • 77953946006 scopus 로고    scopus 로고
    • New cases of isolated congenital central hypothyroidism due to homozygous thyrotropin β gene mutations: A pitfall to neonatal screening
    • Ramos HE, Labedan I, Carré A, Castanet M, Guemas I, Tron E, Madhi F, Delacourt C, Maciel RM, Polak M 2010 New cases of isolated congenital central hypothyroidism due to homozygous thyrotropin β gene mutations: a pitfall to neonatal screening. Thyroid 20:639-645
    • (2010) Thyroid , vol.20 , pp. 639-645
    • Ramos, H.E.1    Labedan, I.2    Carré, A.3    Castanet, M.4    Guemas, I.5    Tron, E.6    Madhi, F.7    Delacourt, C.8    Maciel, R.M.9    Polak, M.10
  • 55
    • 79952199857 scopus 로고    scopus 로고
    • Newborn screening strategies for congenital hypothyroidism: An update
    • LaFranchi SH 2010 Newborn screening strategies for congenital hypothyroidism: an update. J Inherit Metab Dis 33(Suppl 2):S225-S233
    • (2010) J Inherit Metab Dis , vol.33 , Issue.SUPPL. 2
    • LaFranchi, S.H.1
  • 56
    • 39049113461 scopus 로고    scopus 로고
    • Role of the thyrotropin-releasing hormone stimulation test in diagnosis of congenital central hypothyroidism in infants
    • DOI 10.1210/jc.2006-2656
    • van Tijn DA, de Vijlder JJ, Vulsma T 2008 Role of the thyrotropin-releasing hormone stimulation test in diagnosis of congenital central hypothyroidism in infants. J Clin Endocrinol Metab 93:410-419 (Pubitemid 351240810)
    • (2008) Journal of Clinical Endocrinology and Metabolism , vol.93 , Issue.2 , pp. 410-419
    • Van Tijn, D.A.1    De Vijlder, J.J.M.2    Vulsma, T.3
  • 57
    • 79952501538 scopus 로고    scopus 로고
    • Pituitary transcription factors in the aetiology of combined pituitary hormone deficiency
    • Pfäffle R, Klammt J 2011 Pituitary transcription factors in the aetiology of combined pituitary hormone deficiency. Best Pract Res Clin Endocrinol Metab 25:43-60
    • (2011) Best Pract Res Clin Endocrinol Metab , vol.25 , pp. 43-60
    • Pfäffle, R.1    Klammt, J.2
  • 58
    • 78049513746 scopus 로고    scopus 로고
    • Constitutively active thyrotropin and thyrotropin-releasing hormone receptors and their inverse agonists
    • Neumann S, Raaka BM, Gershengorn MC 2010 Constitutively active thyrotropin and thyrotropin-releasing hormone receptors and their inverse agonists. Methods Enzymol 485:147-160
    • (2010) Methods Enzymol , vol.485 , pp. 147-160
    • Neumann, S.1    Raaka, B.M.2    Gershengorn, M.C.3
  • 59
    • 84856809079 scopus 로고    scopus 로고
    • Central hypothyroidism in a patient with pituitary autoimmunity: Evidence for TSH-independent thyroid hormone synthesis
    • Barbesino G, Sluss PM, Caturegli P 2012 Central hypothyroidism in a patient with pituitary autoimmunity: evidence for TSH-independent thyroid hormone synthesis. J Clin Endocrinol Metab 97:345-350
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 345-350
    • Barbesino, G.1    Sluss, P.M.2    Caturegli, P.3
  • 61
    • 0742289429 scopus 로고    scopus 로고
    • Clinical and hormonal characteristics of central hypothyroidism at diagnosis and during follow-up in adult patients
    • DOI 10.1530/eje.0.1500001
    • Alexopoulou O, Beguin C, De Nayer P, Maiter D 2004 Clinical and hormonal characteristics of central hypothyroidism at diagnosis and during follow-up in adult patients. Eur J Endocrinol 150:1-8 (Pubitemid 38159735)
    • (2004) European Journal of Endocrinology , vol.150 , Issue.1 , pp. 1-8
    • Alexopoulou, O.1    Belguin, C..2    De Nayer, P..3    Maiter, D.4
  • 62
    • 0035978067 scopus 로고    scopus 로고
    • Pitfalls in the use of thyrotropin concentration as a first-line thyroid-function test
    • DOI 10.1016/S0140-6736(00)04248-3
    • Wardle CA, Fraser WD, Squire CR 2001 Pitfalls in the use of thyrotropin concentration as a first-line thyroid-function test. Lancet 357:1013-1014 (Pubitemid 32285397)
    • (2001) Lancet , vol.357 , Issue.9261 , pp. 1013-1014
    • Wardle, C.A.1    Fraser, W.D.2    Squire, C.R.3
  • 63
    • 0037262989 scopus 로고    scopus 로고
    • Laboratory medicine practice guidelines for the diagnosis and monitoring of thyroid disease
    • Consensus guidelines for thyroid testing in the new millennium (monograph)
    • Demers LM, Spencer CA 2003 Laboratory medicine practice guidelines for the diagnosis and monitoring of thyroid disease. In: Consensus guidelines for thyroid testing in the new millennium (monograph). Thyroid 13:2-125
    • (2003) Thyroid , vol.13 , pp. 2-125
    • Demers, L.M.1    Spencer, C.A.2
  • 64
    • 79955814333 scopus 로고    scopus 로고
    • What should be done when thyroid function tests do not make sense?
    • Oxf
    • Gurnell M, Halsall DJ, Chatterjee VK 2011 What should be done when thyroid function tests do not make sense? Clin Endocrinol (Oxf) 74:673-678
    • (2011) Clin Endocrinol , vol.74 , pp. 673-678
    • Gurnell, M.1    Halsall, D.J.2    Chatterjee, V.K.3
  • 67
    • 28744458626 scopus 로고    scopus 로고
    • Circadian and stimulated thyrotropin secretion in cranially irradiated adult cancer survivors
    • DOI 10.1210/jc.2005-1593
    • Darzy KH, Shalet SM 2005 Circadian and stimulated thyrotropin secretion in cranially irradiated adult cancer survivors. J Clin Endocrinol Metab 90:6490-6497 (Pubitemid 41759304)
    • (2005) Journal of Clinical Endocrinology and Metabolism , vol.90 , Issue.12 , pp. 6490-6497
    • Darzy, K.H.1    Shalet, S.M.2
  • 68
    • 0035051072 scopus 로고    scopus 로고
    • Usefulness of thyrotropin (TSH)-releasing hormone test and nocturnal surge of TSH for diagnosis of isolated deficit of TSH secretion
    • DOI 10.1210/jc.86.3.1054
    • Yamakita N, Komaki T, Takao T, Murai T, Hashimoto K, Yasuda K 2001 Usefulness of thyrotropin (TSH)-releasing hormone test and nocturnal surge of TSH for diagnosis of isolated deficit of TSH secretion. J Clin Endocrinol Metab 86:1054-1060 (Pubitemid 32322981)
    • (2001) Journal of Clinical Endocrinology and Metabolism , vol.86 , Issue.3 , pp. 1054-1060
    • Yamakita, N.1    Komaki, T.2    Takao, T.3    Murai, T.4    Hashimoto, K.5    Yasuda, K.6
  • 69
    • 0015137931 scopus 로고
    • Effect of thyrotropin-releasing factor on serum thyroid-stimulating hormone. An approach to distinguishing hypothalamic from pituitary forms of idiopathic hypopituitary dwarfism
    • Costom BH, Grumbach MM, Kaplan SL 1971 Effect of thyrotropin-releasing factor on serum thyroid-stimulating hormone. An approach to distinguishing hypothalamic from pituitary forms of idiopathic hypopituitary dwarfism. J Clin Invest 50:2219-2225
    • (1971) J Clin Invest , vol.50 , pp. 2219-2225
    • Costom, B.H.1    Grumbach, M.M.2    Kaplan, S.L.3
  • 70
    • 0031733874 scopus 로고    scopus 로고
    • The clinical impact of the thyrotropin-releasing hormone test
    • Faglia G 1998 The clinical impact of the thyrotropin-releasing hormone test. Thyroid 8:903-908 (Pubitemid 28514182)
    • (1998) Thyroid , vol.8 , Issue.10 , pp. 903-908
    • Faglia, G.1
  • 73
    • 0036959745 scopus 로고    scopus 로고
    • 3 in normal subjects: A clue to the understanding of subclinical thyroid disease
    • DOI 10.1210/jc.87.3.1068
    • Andersen S, Pedersen KM, Bruun NH, Laurberg P 2002 Narrow individual variations in serum T4 and T3 in normal subjects: a clue to understanding of subclinical thyroid disease. J Clin Endocrinol Metab 87:1068-1072 (Pubitemid 36121067)
    • (2002) Journal of Clinical Endocrinology and Metabolism , vol.87 , Issue.3 , pp. 1068-1072
    • Andersen, S.1    Pedersen, K.M.2    Bruun, N.H.3    Laurberg, P.4
  • 75
    • 0028090633 scopus 로고
    • Growth hormone administration stimulates energy expenditure and extrathyroidal conversion of thyroxine to triiodothyronine in a dose-dependent manner and suppresses circadian thyrotrophin levels studies in GH-deficient adults
    • Jørgensen JO, Møller J, Laursen T, Orskov H, Christiansen JS, Weeke J 1994 Growth hormone administration stimulates energy expenditure and extrathyroidal conversion of thyroxine to triiodothyronine in a dose-dependent manner and suppresses circadian thyrotrophin levels: studies in GH-deficient adults. Clin Endocrinol (Oxf) 41:609-614 (Pubitemid 24336863)
    • (1994) Clinical Endocrinology , vol.41 , Issue.5 , pp. 609-614
    • Jorgensen, J.O.L.1    Moller, J.2    Laursen, T.3    Orskov, H.4    Christiansen, J.S.5    Weeke, J.6
  • 76
    • 84859403304 scopus 로고    scopus 로고
    • Diagnosis of subclinical central hypothyroidism in patients with hypothalamic-pituitary disease by Doppler echocardiography
    • Doin FC, Rosa-Borges M, Martins MR, Moisés VA, Abucham J 2012 Diagnosis of subclinical central hypothyroidism in patients with hypothalamic-pituitary disease by Doppler echocardiography. Eur J Endocrinol 166:631-640
    • (2012) Eur J Endocrinol , vol.166 , pp. 631-640
    • Doin, F.C.1    Rosa-Borges, M.2    Martins, M.R.3    Moisés, V.A.4    Abucham, J.5
  • 77
    • 84859104026 scopus 로고    scopus 로고
    • Subclinical thyroid disease
    • Cooper DS, Biondi B 2012 Subclinical thyroid disease. Lancet 379:1142-1154
    • (2012) Lancet , vol.379 , pp. 1142-1154
    • Cooper, D.S.1    Biondi, B.2
  • 78
    • 49649087985 scopus 로고    scopus 로고
    • Exploring the use of recombinant human TSH in the diagnosis of central hypothyroidism
    • Filipsson H, Nyström E, Johannsson G 2008 Exploring the use of recombinant human TSH in the diagnosis of central hypothyroidism. Eur J Endocrinol 159:153-160
    • (2008) Eur J Endocrinol , vol.159 , pp. 153-160
    • Filipsson, H.1    Nyström, E.2    Johannsson, G.3
  • 79
    • 77952876422 scopus 로고    scopus 로고
    • Genetics and phenomics of thyroid hormone transport by MCT8
    • Friesema EC, Visser WE, Visser TJ 2010 Genetics and phenomics of thyroid hormone transport by MCT8. Mol Cell Endocrinol 322:107-113
    • (2010) Mol Cell Endocrinol , vol.322 , pp. 107-113
    • Friesema, E.C.1    Visser, W.E.2    Visser, T.J.3
  • 82
    • 79955854785 scopus 로고    scopus 로고
    • Treatment of central hypothyroidism
    • Oxf
    • Beck-Peccoz P 2011 Treatment of central hypothyroidism. Clin Endocrinol (Oxf) 74:671-672
    • (2011) Clin Endocrinol , vol.74 , pp. 671-672
    • Beck-Peccoz, P.1
  • 87
    • 0036737156 scopus 로고    scopus 로고
    • Thyrotropin suppression by thyroid hormone replacement is correlated with thyroxine level normalization in central hypothyroidism
    • Shimon I, Cohen O, Lubetsky A, Olchovsky D 2002 Thyrotropin suppression by thyroid hormone replacement is correlated with thyroxine level normalization in central hypothyroidism. Thyroid 12:823-827
    • (2002) Thyroid , vol.12 , pp. 823-827
    • Shimon, I.1    Cohen, O.2    Lubetsky, A.3    Olchovsky, D.4
  • 88
    • 58149466267 scopus 로고    scopus 로고
    • Optimal free thyroxine levels for thyroid hormone replacement in hypothyroidism
    • Iverson JF, Mariash CN 2008 Optimal free thyroxine levels for thyroid hormone replacement in hypothyroidism. Endocr Pract 14:550-555
    • (2008) Endocr Pract , vol.14 , pp. 550-555
    • Iverson, J.F.1    Mariash, C.N.2
  • 89
    • 79955795773 scopus 로고    scopus 로고
    • Diagnosis and treatment of hypothyroidism in TSH deficiency compared to primary thyroid disease: Pituitary patients are at risk of underreplacement with levothyroxine
    • Oxf
    • Koulouri O, Auldin MA, Agarwal R, Kieffer V, Robertson C, Falconer Smith J, Levy MJ, Howlett TA 2011 Diagnosis and treatment of hypothyroidism in TSH deficiency compared to primary thyroid disease: pituitary patients are at risk of underreplacement with levothyroxine. Clin Endocrinol (Oxf) 74:744-749
    • (2011) Clin Endocrinol , vol.74 , pp. 744-749
    • Koulouri, O.1    Auldin, M.A.2    Agarwal, R.3    Kieffer, V.4    Robertson, C.5    Falconer Smith, J.6    Levy, M.J.7    Howlett, T.A.8
  • 91
    • 0025059736 scopus 로고
    • Monitoring therapy in patients taking levothyroxine
    • Helfand M, Crapo LM 1990 Monitoring therapy in patients taking levothyroxine. Ann Int Med 113:450-454 (Pubitemid 20333454)
    • (1990) Annals of Internal Medicine , vol.113 , Issue.6 , pp. 450-454
    • Helfand, M.1    Crapo, L.M.2
  • 92
    • 0035821989 scopus 로고    scopus 로고
    • Increased need for thyroxine in women with hypothyroidism during estrogen therapy
    • DOI 10.1056/NEJM200106073442302
    • Arafah BM 2001 Increased need for thyroxine in women with hypothyroidism during estrogen therapy. N Engl J Med 344:1743-1749 (Pubitemid 32497028)
    • (2001) New England Journal of Medicine , vol.344 , Issue.23 , pp. 1743-1749
    • Arafah, B.M.1
  • 93
    • 0023619315 scopus 로고
    • Reduced clearance rate of thyroxine-binding globulin (TBG) with increased sialylation: A mechanism for estrogen-induced elevation of serum TBG concentration
    • Ain KB, Mori Y, Refetoff S 1987 Reduced clearance rate of thyroxine-binding globulin (TBG) with increased sialylation: a mechanism for estrogen-induced elevation of serum TBG concentration. J Clin Endocrinol Metab 65:689-696 (Pubitemid 17157386)
    • (1987) Journal of Clinical Endocrinology and Metabolism , vol.65 , Issue.4 , pp. 689-696
    • Ain, K.B.1    Mori, Y.2    Refetoff, S.3
  • 95
    • 33845631286 scopus 로고    scopus 로고
    • Unmasking of central hypothyroidism following growth hormone replacement in adult hypopituitary patients
    • DOI 10.1111/j.1365-2265.2006.02688.x
    • Agha A, Walker D, Perry L, Drake WM, Chew SL, Jenkins PJ, Grossman AB, Monson JP 2007 Unmasking of central hypothyroidism following growth hormone replacement in adult hypopituitary patients. Clin Endocrinol (Oxf) 66:72-77 (Pubitemid 44952497)
    • (2007) Clinical Endocrinology , vol.66 , Issue.1 , pp. 72-77
    • Agha, A.1    Walker, D.2    Perry, L.3    Drake, W.M.4    Chew, S.L.5    Jenkins, P.J.6    Grossman, A.B.7    Monson, J.P.8
  • 96
    • 57449083988 scopus 로고    scopus 로고
    • Long-term effects of growth hormone replacement therapy on thyroid function in adults with growth hormone deficiency
    • Losa M, Scavini M, Gatti E, Rossini A, Madaschi S, Formenti I, Caumo A, Stidley CA, Lanzi R 2008 Long-term effects of growth hormone replacement therapy on thyroid function in adults with growth hormone deficiency. Thyroid 18:1249-1254
    • (2008) Thyroid , vol.18 , pp. 1249-1254
    • Losa, M.1    Scavini, M.2    Gatti, E.3    Rossini, A.4    Madaschi, S.5    Formenti, I.6    Caumo, A.7    Stidley, C.A.8    Lanzi, R.9
  • 97
    • 84866159517 scopus 로고    scopus 로고
    • Thyroid hormone replacement in central hypothyroidism
    • Ross R, Erfurth EM, eds. Bristol, UK: Bioscientifica Ltd.
    • Persani L 2004 Thyroid hormone replacement in central hypothyroidism. Ross R, Erfurth EM, eds. Pituitary function through the ages. Bristol, UK: Bioscientifica Ltd.; 111-124
    • (2004) Pituitary Function Through the Ages , pp. 111-124
    • Persani, L.1
  • 98
    • 0033871562 scopus 로고    scopus 로고
    • Changes in serum thyroid hormones levels and their mechanisms during long-term growth hormone (GH) replacement therapy in GH deficient children
    • DOI 10.1046/j.1365-2265.2000.01071.x
    • Portes ES, Oliveira JH, MacCagnan P, Abucham J 2000 Changes in serum thyroid hormones levels and their mechanisms during long-term growth hormone (GH) replacement therapy in GH deficient children. Clin Endocrinol (Oxf) 53:183-189 (Pubitemid 30643452)
    • (2000) Clinical Endocrinology , vol.53 , Issue.2 , pp. 183-189
    • Portes, E.S.1    Oliveira, J.H.A.2    Maccagnan, P.3    Abucham, J.4
  • 99
    • 0344513888 scopus 로고    scopus 로고
    • Recombinant hGH replacement therapy and the hypothalamus-pituitary- thyroid axis in children with GH deficiency: When should we be concerned about the occurrence of central hypothyroidism?
    • DOI 10.1046/j.1365-2265.2003.01892.x
    • Giavoli C, Porretti S, Ferrante E, Cappiello V, Ronchi CL, Travaglini P, Epaminonda P, Arosio M, Beck-Peccoz P 2003 Recombinant hGH replacement therapy and the hypothalamus-pituitarythyroid axis in children with GH deficiency: when should we be concerned about the occurrence of central hypothyroidism? Clin Endocrinol (Oxf) 59:806-810 (Pubitemid 37491588)
    • (2003) Clinical Endocrinology , vol.59 , Issue.6 , pp. 806-810
    • Giavoli, C.1    Porretti, S.2    Ferrante, E.3    Cappiello, V.4    Ronchi, C.L.5    Travaglini, P.6    Epaminonda, P.7    Arosio, M.8    Beck-Peccoz, P.9
  • 103
    • 0034768038 scopus 로고    scopus 로고
    • The spectrum of thyroid diseases in childhood and its evolution during transition to adulthood: Natural history, diagnosis, differential diagnosis and management
    • Koch CA, Sarlis NJ 2001 The spectrum of thyroid diseases in childhood and its evolution during transition to adulthood: natural history, diagnosis, differential diagnosis and management. J Endocrinol Invest 24:659-675 (Pubitemid 32982336)
    • (2001) Journal of Endocrinological Investigation , vol.24 , Issue.9 , pp. 659-675
    • Koch, C.A.1    Sarlis, N.J.2
  • 105
    • 79961006122 scopus 로고    scopus 로고
    • Pituitary stem cell update and potential implications for treating hypopituitarism
    • Castinetti F, Davis SW, Brue T, Camper SA 2011 Pituitary stem cell update and potential implications for treating hypopituitarism. Endocr Rev 32:453-471
    • (2011) Endocr Rev , vol.32 , pp. 453-471
    • Castinetti, F.1    Davis, S.W.2    Brue, T.3    Camper, S.A.4


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