Central hypothyroidism in a patient with pituitary autoimmunity: Evidence for TSH-independent thyroid hormone synthesis

Journal of Clinical Endocrinology and Metabolism

Volumn 97, Issue 2, 2012, Pages 345-350

  Barbesino, Giuseppe ^a   Sluss, Patrick M ^a   Caturegli, Patrizio ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; DIGOXIN; HYDROCORTISONE; LIOTHYRONINE; METOPROLOL; RADIOACTIVE IODINE; THYROGLOBULIN ANTIBODY; THYROID HORMONE; THYROTROPIN; THYROXINE; WARFARIN;

ADULT; ARTICLE; AUTOIMMUNITY; CARDIOVASCULAR SYSTEM EXAMINATION; CARDIOVERSION; CASE REPORT; ECHOGRAPHY; FEMALE; HEART ATRIUM FIBRILLATION; HUMAN; HYPOPHYSIS; HYPOTHYROIDISM; IMMUNOASSAY; LIOTHYRONINE BLOOD LEVEL; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYSICAL EXAMINATION; PRIORITY JOURNAL; THYROID FUNCTION TEST; THYROID GLAND; THYROID HORMONE SYNTHESIS; THYROIDITIS; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL;

AUTOIMMUNE DISEASES OF THE NERVOUS SYSTEM; AUTOIMMUNITY; FEMALE; HUMANS; HYPOTHYROIDISM; MIDDLE AGED; PITUITARY DISEASES; THYROID FUNCTION TESTS; THYROID HORMONES; THYROTROPIN;

EID: 84856809079     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2011-1591     Document Type: Article

References (21)

1. Patel YC, Burger HG 1973 Serum thyrotropin (TSH) in pituitary and/or hypothalamic hypothyroidism: normal or elevated basal levels and paradoxical responses to thyrotropin-releasing hormone. J Clin Endocrinol Metab 37:190-196
2. Persani L, Ferretti E, Borgato S, Faglia G, Beck-Peccoz P 2000 Circulating thyrotropin bioactivity in sporadic central hypothyroidism. J Clin Endocrinol Metab 85:3631-3635
3. van Tijn DA, de Vijlder JJ, Verbeeten Jr B, Verkerk PH, Vulsma T 2005 Neonatal detection of congenital hypothyroidism of central origin. J Clin Endocrinol Metab 90:3350-3359 (Pubitemid 41014297)
4. Yamada M, Mori M 2008 Mechanisms related to the pathophysiology and management of central hypothyroidism. Nat Clin Pract Endocrinol Metab 4:683-694
5. Yamamoto M, Iguchi G, Takeno R, Okimura Y, Sano T, Takahashi M, Nishizawa H, Handayaningshi AE, Fukuoka H, Tobita M, Saitoh T, Tojo K, Mokubo A, Morinobu A, Iida K, Kaji H, Seino S, Chihara K, Takahashi Y 2011 Adult combined GH, prolactin, and TSH deficiency associated with circulating PIT-1 antibody in humans. J Clin Invest 121:113-119
6. Oelkers W, Diederich S, Bähr V 1992 Diagnosis and therapy surveillance in Addison's disease: rapid adrenocorticotropin (ACTH) test and measurement of plasma ACTH, renin activity, and aldosterone. J Clin Endocrinol Metab 75:259-264
7. Bottazzo GF, Pouplard A, Florin-Christensen A, Doniach D 1975 Autoantibodies to prolactin-secreting cells of human pituitary. Lancet 2:97-101
8. Lania A, Persani L, Beck-Peccoz P 2008 Central hypothyroidism. Pituitary 11:181-186
9. Sylvia Vela B, Dorin RI 1991 Factitious triiodothyronine toxicosis. Am J Med 90:132-134
10. Agha A, Sherlock M, Brennan S, O'Connor SA, O'Sullivan E, Rogers B, Faul C, Rawluk D, Tormey W, Thompson CJ 2005 Hypothalamic-pituitary dysfunction after irradiation of nonpituitary brain tumors in adults. J Clin Endocrinol Metab 90:6355-6360 (Pubitemid 41759282)
11. Littley MD, Shalet SM, Beardwell CG, Ahmed SR, Applegate G, Sutton ML 1989 Hypopituitarism following external radiotherapy for pituitary tumours in adults. Q J Med 70:145-160 (Pubitemid 19115954)
12. Greenman Y, Stern N 2009 Non-functioning pituitary adenomas. Best Pract Res Clin Endocrinol Metab 23:625-638
13. Agha A, Rogers B, Sherlock M, O'Kelly P, Tormey W, Phillips J, Thompson CJ 2004 Anterior pituitary dysfunction in survivors of traumatic brain injury. J Clin Endocrinol Metab 89:4929-4936 (Pubitemid 39391430)
14. Carpinteri R, Patelli I, Casanueva FF, Giustina A 2009 Pituitary tumours: inflammatory and granulomatous expansive lesions of the pituitary. Best Pract Res Clin Endocrinol Metab 23:639-650
15. Bastenie PA, Bonnyns M, Neve P, Vanhaelst L, Chailly M 1967 Clinical and pathological significance of asymptomatic atrophic thyroiditis. A condition of latent hypothyroidism. Lancet 1:915-918
16. Gluck FB, Nusynowitz ML, Plymate S 1975 Chronic lymphocytic thyroiditis, thyrotoxicosis, and low radioactive iodine uptake. Report of four cases. N Engl J Med 293:624-628
17. Miyai K, Azukizawa M, Kumahara Y 1971 Familial isolated thyrotropin deficiency with cretinism. N Engl J Med 285:1043-1048
18. Borck G, Topaloglu AK, Korsch E, Martiné U, Wildhardt G, Onenli-Mungan N, Yuksel B, Aumann U, Koch G, Ozer G, Pfäffle R, Scherberg NH, Refetoff S, Pohlenz J 2004 Four new cases of congenital secondary hypothyroidism due to a splice site mutation in the thyrotropin-β gene: phenotypic variability and founder effect. J Clin Endocrinol Metab 89:4136-4141 (Pubitemid 39071524)
19. Haddad HM 1960 Rates of I 131-labeled thyroxine metabolism in euthyroid children. J Clin Invest 39:1590-1594
20. Dacou-Voutetakis C, Feltquate DM, Drakopoulou M, Kourides IA, Dracopoli NC 1990 Familial hypothyroidism caused by a nonsense mutation in the thyroid-stimulating hormone β-subunit gene. Am J Hum Genet 46:988-993
21. Van Sande J, Swillens S, Gerard C, Allgeier A, Massart C, Vassart G, Dumont JE 1995 In Chinese hamster ovary K1 cells dog and human thyrotropin receptors activate both the cyclic AMP and the phosphatidylinositol 4,5-bisphosphate cascades in the presence of thyrotropin and the cyclic AMP cascade in its absence. Eur J Biochem 229:338-343