Multi-layer polymeric implants for sustained release of chemopreventives

Cancer Letters

Volumn 326, Issue 1, 2012, Pages 33-40

  Aqil, Farrukh ^a   Jeyabalan, Jeyaprakash ^a   Kausar, Hina ^a   Bansal, Shyam S ^a   Sharma, Ram J ^c   Singh, Inder P ^c   Vadhanam, Manicka V ^a   Gupta, Ramesh C ^a,b  

^a UNIVERSITY OF LOUISVILLE   (United States)

^b University of Louisville School of Medicine   (United States)

^c NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

Bioavailability; Curcumin; Curcuminoids; DNA adducts; Drug delivery; Lung tumor xenograft; Oltipraz; Polycaprolactone; Withaferin A

Indexed keywords

ANTINEOPLASTIC AGENT; CURCUMIN; CURCUMIN I; CURCUMIN II; CURCUMIN III; DIBENZO[A,L]PYRENE; DICHLOROMETHANE; OLTIPRAZ; POLYCAPROLACTONE; UNCLASSIFIED DRUG; WITHAFERIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BRAIN; CONTROLLED STUDY; DNA ADDUCT; DRUG COATING; DRUG EFFICACY; DRUG FORMULATION; DRUG IMPLANT; DRUG TISSUE LEVEL; FEMALE; FLUORESCENCE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER; LUNG; LUNG CANCER; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; SUSTAINED DRUG RELEASE; TOXICITY TESTING; TUMOR XENOGRAFT; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ANIMALS; ANTICARCINOGENIC AGENTS; BIOLOGICAL AVAILABILITY; COATED MATERIALS, BIOCOMPATIBLE; CURCUMIN; DNA ADDUCTS; FEMALE; HUMANS; INFUSION PUMPS, IMPLANTABLE; MICE; MICE, NUDE; POLYESTERS; POLYMERS; PYRAZINES; TISSUE DISTRIBUTION; WITHANOLIDES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MUS; MUS MUSCULUS;

EID: 84866148275     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2012.07.017     Document Type: Article

References (27)

1. Wattenberg L.W. Chemoprophylaxis of carcinogenesis: a review. Cancer Res. 1966, 26:1520-1526.
2. Sporn M.B., Dunlop N.M., Newton D.L., Smith J.M. Prevention of chemical carcinogenesis by vitamin-a and its synthetic analogs (Retinoids). Fed. Proc. 1976, 35:1332-1338.
3. Ireson C.R., Jones D.J., Orr S., Coughtrie M.W., Boocock D.J., Williams M.L., Farmer P.B., Steward W.P., Gescher A.J. Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine. Cancer Epidemiol. Biomar. Prev. 2002, 11:105-111.
4. Wahlang B., Pawar Y.B., Bansal A.K. Identification of permeability-related hurdles in oral delivery of curcumin using the Caco-2 cell model. Eur. J. Pharm. Biopharm. 2011, 77:275-282.
5. Pan M.H., Huang T.M., Lin J.K. Biotransformation of curcumin through reduction and glucuronidation in mice. Drug Metab. Dispos. 1999, 27:486-494.
6. Bansal S.S., Goel M., Aqil F., Vadhanam M.V., Gupta R.C. Advanced drug delivery systems of curcumin for cancer chemoprevention. Cancer Prev. Res. (Phila) 2011, 4:1158-1171.
7. Hoffman A.S. The origins and evolution of " controlled" drug delivery systems. J. Control. Release 2008, 132:153-163.
8. Klitsch M. Hormonal implants - the next wave of contraceptives. Fam. Plann. Perspect 1983, 15:239.
9. Fulzele S.V., Satturwar P.M., Dorle A.K. Study of the biodegradation and in vivo biocompatibility of novel biomaterials. Eur. J. Pharm. Sci. 2003, 20:53-61.
10. Dickers K.J., Huatan H., Cameron R.E. Polyglycolide-based blends for drug delivery: a differential scanning calorimetry study of the melting behavior. J. Appl. Polym. Sci. 2003, 89:2937-2939.
11. Bansal S.S., Vadhanam M.V., Gupta R.C. Development and in vitro-in vivo evaluation of polymeric implants for continuous systemic delivery of curcumin. Pharm. Res. 2011, 28:1121-1130.
12. 32P-postlabeling for detection of DNA adducts. Technologies for Detection of DNA Damage and Mutations 1996, 45-61. Plenum Press, New York. G.P. Pfeifer (Ed.).
13. R.C. Gupta, S.S. Bansal, F. Aqil, J. Jeyabalan, P. Cao, H. Kauser, G.K. Russell, S. Ravoori, R. Munagala, M.V. Vadhanam, Controlled-release systemic delivery - a new concept in cancer chemoprevention. Carcinogenesis E-pub, 2012. doi: 10.1093/carcin/bgs209.
14. Jeyabalan J., Vadhanam M.V., Ravoori S., Gupta R.C. Sustained overexpression of CYP1A1 and 1B1 and steady accumulation of DNA adducts by low-dose, continuous exposure to benzo[a]pyrene by polymeric implants. Chem. Res. Toxicol. 2011, 24:1937-1943.
15. Ravoori S., Vadhanam M.V., Sahoo S., Srinivasan C., Gupta R.C. Mammary tumor induction in ACI rats exposed to low levels of 17beta-estradiol. Int. J. Oncol. 2007, 31:113-120.
16. Gupta R.C. 32P-postlabelling analysis of bulky aromatic adducts. IARC Sci. Publ. 1993, 11-23.
17. Anand P., Kunnumakkara A.B., Newman R.A., Aggarwal B.B. Bioavailability of curcumin: problems and promises. Mol. Pharm. 2007, 4:807-818.
18. Arif J.M., Gairola C.G., Glauert H.P., Kelloff G.J., Lubet R.A., Gupta R.C. Inhibition of cigarette smoke-related lipophilic DNA adducts in rat tissues by dietary oltipraz. Carcinogenesis 1998, 19:1515-1517.
19. Moon R., Rao K., Detrisac C., Kelloff G., Steele V., Doody L. Chemoprevention of respiratory-tract neoplasia in the hamster by oltipraz, alone and in combination. Int. J. Oncol. 1994, 4:661-667.
20. Sun H.F., Mei L., Song C.X., Cui X.M., Wang P.Y. The in vivo degradation, absorption and excretion of PCL-based implant. Biomaterials 2006, 27:1735-1740.
21. Arif J.M., Gupta R.C. Microsome-mediated bioactivation of dibenzo[a,l]pyrene and identification of DNA adducts by 32P-postlabeling. Carcinogenesis 1997, 18:1999-2007.
22. Ireson C.R., Jones D.J.L., Orr S., Coughtrie M.W.H., Boocock D.J., Williams M.L., Farmer P.B., Steward W.P., Gescher A.J. Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine. Cancer Epidemol. Biomar. 2002, 11:105-111.
23. Fiala M., Liu P.T., Espinosa-Jeffrey A., Rosenthal M.J., Bernard G., Ringman J.M., Sayre J., Zhang L., Zaghi J., Dejbakhsh S., Chiang B., Hui J., Mahanian M., Baghaee A., Hong P., Cashman J. Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin. Proc. Natl. Acad. Sci. USA 2007, 104:12849-12854.
24. Munagala R., Kausar H., Munjal C., Gupta R.C. Withaferin A induces p53-dependent apoptosis by repression of HPV oncogenes and upregulation of tumor suppressor proteins in human cervical cancer cells. Carcinogenesis 2011, 32:1697-1705.
25. Thaiparambil J.T., Bender L., Ganesh T., Kline E., Patel P., Liu Y., Tighiouart M., Vertino P.M., Harvey R.D., Garcia A., Marcus A.I. Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation. Int. J. Cancer 2011, 129:2744-2755.
26. Stan S.D., Hahm E.R., Warin R., Singh S.V. Withaferin A causes FOXO3a- and Bim-dependent apoptosis and inhibits growth of human breast cancer cells in vivo. Cancer Res. 2008, 68:7661-7669.
27. Oh J.H., Kwon T.K. Withaferin A inhibits tumor necrosis factor-alpha-induced expression of cell adhesion molecules by inactivation of Akt and NF-kappaB in human pulmonary epithelial cells. Int. Immunopharmacol. 2009, 9:614-619.