Association Study on Pathological Gambling and Polymorphisms of Dopamine D1, D2, D3, and D4 Receptor Genes in a Korean Population

Journal of Gambling Studies

Volumn 28, Issue 3, 2012, Pages 481-491

  Lim, Sewon ^a   Ha, Juwon ^a   Choi, Sam Wook ^b   Kang, Seung Gul ^c   Shin, Young Chul ^a  

^a School of Medicine   (South Korea)

^b Eulji University   (South Korea)

^c Catholic University of Daegu   (South Korea)

Author keywords

Dopamine receptor genes; Pathological gambling; Polymorphism

Indexed keywords

DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; DOPAMINE 4 RECEPTOR; DRD3 PROTEIN, HUMAN; DRD4 PROTEIN, HUMAN;

ADOLESCENT; ADULT; AGED; ARTICLE; CASE CONTROL STUDY; GENETIC EPISTASIS; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HUMAN; KOREA; MALE; MIDDLE AGED; PATHOLOGICAL GAMBLING;

ADOLESCENT; ADULT; AGED; CASE-CONTROL STUDIES; EPISTASIS, GENETIC; GAMBLING; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; KOREA; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; RECEPTORS, DOPAMINE D4; YOUNG ADULT;

EID: 84866104976     PISSN: 10505350     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10899-011-9261-1     Document Type: Article

References (47)

1. American Psychiatric Association. (1980). Diagnostic and statistical manual of mental disorders. Washington, DC: American Psychiatric Association.
2. Bergh, C., Eklund, T., Sodersten, P., & Nordin, C. (1997). Altered dopamine function in pathological gambling. Psychological Medicine, 27, 473-475.
3. Berlin, I., de Brettes, B., Aymard, G., Diquet, B., Arnulf, I., & Puech, A. J. (2000). Dopaminergic drug response and the genotype (Taq IA polymorphism) of the dopamine D2 receptor. The International Journal of Neuropsychopharmacology, 3, 35-43.
4. Blanco, C., Petkova, E., Ibanez, A., & Saiz-Ruiz, J. (2002). A pilot placebo-controlled study of fluvoxamine for pathological gambling. Annals of Clinical Psychiatry, 14, 9-15.
5. Blaszczynski, A., & Nower, L. (2002). A pathways model of problem and pathological gambling. Addiction, 97, 487-499.
6. Blaszczynski, A. P., Wilson, A. C., & McConaghy, N. (1986). Sensation seeking and pathological gambling. British Journal of Addiction, 81, 113-117.
7. Choi, W. C., Kim, K. B., Oh, D. W., & Lee, T. K. (2001). A preliminary study on standardization of Korean form of South Oak Gambling Screening. Journal of Korean Academy of Addiction Psychiatry, 5, 46-52.
8. Cichon, S., Nothen, M. M., Stober, G., Schroers, R., Albus, M., Maier, W., et al. (1996). Systematic screening for mutations in the 5'-regulatory region of the human dopamine D1 receptor (DRD1) gene in patients with schizophrenia and bipolar affective disorder. American Journal of Medical Genetics, 67, 424-428.
9. Comings, D. E., Ferry, L., Bradshaw-Robinson, S., Burchette, R., Chiu, C., & Muhleman, D. (1996a). The dopamine D2 receptor (DRD2) gene: A genetic risk factor in smoking. Pharmacogenetics, 6, 73-79.
10. Comings, D. E., Muhleman, D., & Gysin, R. (1996b). Dopamine D2 receptor (DRD2) gene and susceptibility to posttraumatic stress disorder: A study and replication. Biological Psychiatry, 40, 368-372.
11. Comings, D. E., Gade, R., Wu, S., Chiu, C., Dietz, G., Muhleman, D., et al. (1997). Studies of the potential role of the dopamine D1 receptor gene in addictive behaviors. Molecular Psychiatry, 2, 44-56.
12. Comings, D. E., Gonzalez, N., Wu, S., Gade, R., Muhleman, D., Saucier, G., et al. (1999). Studies of the 48 bp repeat polymorphism of the DRD4 gene in impulsive, compulsive, addictive behaviors: Tourette syndrome, ADHD, pathological gambling, and substance abuse. American Journal of Medical Genetics, 88, 358-368.
13. Crocq, M. A., Mant, R., Asherson, P., Williams, J., Hode, Y., Mayerova, A., et al. (1992). Association between schizophrenia and homozygosity at the dopamine D3 receptor gene. Journal of Medical Genetics, 29, 858-860.
14. Cunningham-Williams, R. M., & Cottler, L. B. (2001). The epidemiology of pathological gambling. Seminars in Clinical Neuropsychiatry, 6, 155-166.
15. da Silva Lobo, D. S., Vallada, H. P., Knight, J., Martins, S. S., Tavares, H., Gentil, V., et al. (2007). Dopamine genes and pathological gambling in discordant sib-pairs. Journal of Gambling Studies, 23, 421-433.
16. Drevets, W. C., Videen, T. O., Price, J. L., Preskorn, S. H., Carmichael, S. T., & Raichle, M. E. (1992). A functional anatomical study of unipolar depression. Journal of Neuroscience, 12, 3628-3641.
17. Ebstein, R. P., Novick, O., Umansky, R., Priel, B., Osher, Y., Blaine, D., et al. (1996). Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking. Nature Genetics, 12, 78-80.
18. Gallagher, D. A., O'Sullivan, S. S., Evans, A. H., Lees, A. J., & Schrag, A. (2007). Pathological gambling in Parkinson's disease: Risk factors and differences from dopamine dysregulation. An analysis of published case series. Movement Disorders, 22, 1757-1763.
19. Grandy, D. K., Zhang, Y., & Civelli, O. (1993). PCR detection of the TaqA RFLP at the DRD2 locus. Human Molecular Genetics, 2, 2197.
20. Hwang, N.-Y., Yun, K.-W., Joo, Y. H., Kim, C. Y., Jung, S. H., Kim, B., et al. (2004). Association between schizophrenia and the genetic polymorphism of DRD3, DRD4 and HTR2A. Korean Journal of Laboratory Medicine, 24, 446-451.
21. Jellinger, K. A. (1991). Pathology of Parkinson's disease. Changes other than the nigrostriatal pathway. Molecular and Chemical Neuropathology, 14, 153-197.
22. Kim, J. W., Park, C. S., Hwang, J. W., Shin, M. S., Hong, K. E., Cho, S. C., et al. (2006). Clinical and genetic characteristics of Korean male alcoholics with and without attention deficit hyperactivity disorder. Alcohol and Alcoholism, 41, 407-411.
23. Kotler, M., Cohen, H., Segman, R., Gritsenko, I., Nemanov, L., Lerer, B., et al. (1997). Excess dopamine D4 receptor (D4DR) exon III seven repeat allele in opioid-dependent subjects. Molecular Psychiatry, 2, 251-254.
24. Lang, A. E., & Obeso, J. A. (2004). Challenges in Parkinson's disease: Restoration of the nigrostriatal dopamine system is not enough. Lancet Neurology, 3, 309-316.
25. Lee, M. S., & Ryu, S. H. (2002). No association between the dopamine D3 receptor gene and Korean alcohol dependence. Psychiatric Genetics, 12, 173-176.
26. Lee, S. H., Ham, B. J., Cho, Y. H., Lee, S. M., & Shim, S. H. (2007). Association study of dopamine receptor D2 TaqI A polymorphism and reward-related personality traits in healthy Korean young females. Neuropsychobiology, 56, 146-151.
27. Linnet, J., Peterson, E., Doudet, D. J., Gjedde, A., & Moller, A. (2010). Dopamine release in ventral striatum of pathological gamblers losing money. Acta Psychiatrica Scandinavica, 122, 326-333.
28. Liu, H.-C., Chen, C.-K., Leu, S.-J., Wu, H.-T., & Lin, S.-K. (2006). Association between dopamine receptor D1 A-48G polymorphism and methamphetamine abuse. Psychiatry and Clinical Neurosciences, 60, 226-231.
29. Miller, R. D., Phillips, M. S., Jo, I., Donaldson, M. A., Studebaker, J. F., Addleman, N., et al. (2005). High-density single-nucleotide polymorphism maps of the human genome. Genomics, 86, 117-126.
30. Moore, J. H. (2004). Computational analysis of gene-gene interactions using multifactor dimensionality reduction. Expert Review of Molecular Diagnostics, 4, 795-803.
31. Motsinger, A. A., & Ritchie, M. D. (2006). Multifactor dimensionality reduction: An analysis strategy for modelling and detecting gene-gene interactions in human genetics and pharmacogenomics studies. Human Genomics, 2, 318-328.
32. Nanko, S., Hattori, M., Ikeda, K., Sasaki, T., Kazamatsuri, H., & Kuwata, S. (1993). Dopamine D4 receptor polymorphism and schizophrenia. Lancet, 341, 689-690.
33. Nestler, E. J. (2004). Molecular mechanisms of drug addiction. Neuropharmacology, 47(Suppl 1), 24-32.
34. Noble, E. P., Blum, K., Khalsa, M. E., Ritchie, T., Montgomery, A., Wood, R. C., et al. (1993). Allelic association of the D2 dopamine receptor gene with cocaine dependence. Drug and Alcohol Dependence, 33, 271-285.
35. Noble, E. P., St Jeor, S. T., Ritchie, T., Syndulko, K., St Jeor, S. C., Fitch, R. J., et al. (1994). D2 dopamine receptor gene and cigarette smoking: A reward gene? Medical Hypotheses, 42, 257-260.
36. Ono, Y., Manki, H., Yoshimura, K., Muramatsu, T., Mizushima, H., Higuchi, S., et al. (1997). Association between dopamine D4 receptor (D4DR) exon III polymorphism and novelty seeking in Japanese subjects. American Journal of Medical Genetics, 74, 501-503.
37. O'Sullivan, S. S., & Lees, A. J. (2007). Pathological gambling in Parkinson's disease. Lancet Neurology, 6, 384-386.
38. Perez de Castro, I., Ibanez, A., Torres, P., Saiz-Ruiz, J., & Fernandez-Piqueras, J. (1997). Genetic association study between pathological gambling and a functional DNA polymorphism at the D4 receptor gene. Pharmacogenetics, 7, 345-348.
39. Procopio, M. (2005). Pathological gambling and cross-addiction. Canadian Journal of Psychiatry, 50, 302-303. author reply 303.
40. Quickfall, J., & Suchowersky, O. (2007). Pathological gambling associated with dopamine agonist use in restless legs syndrome. Parkinsonism and Related Disorders, 13, 535-536.
41. Ritchie, M. D., Hahn, L. W., & Moore, J. H. (2003). Power of multifactor dimensionality reduction for detecting gene-gene interactions in the presence of genotyping error, missing data, phenocopy, and genetic heterogeneity. Genetic Epidemiology, 24, 150-157.
42. Shi, J., Gershon, E. S., & Liu, C. (2008). Genetic associations with schizophrenia: Meta-analyses of 12 candidate genes. Schizophrenia Research, 104, 96-107.
43. Smith, D., Harvey, P., Battersby, M., Pols, R., Oakes, J., & Baigent, M. (2010). Treatment outcomes and predictors of drop out for problem gamblers in South Australia: A cohort study. Australian and New Zealand Journal of Psychiatry, 44, 911-920.
44. Sokoloff, P., Giros, B., Martres, M. P., Bouthenet, M. L., & Schwartz, J. C. (1990). Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics. Nature, 347, 146-151.
45. Wang, T. Y., Lee, S. Y., Chen, S. L., Chen, S. H., Chu, C. H., Huang, S. Y., et al. (2011). The aldehyde dehydrogenase 2 gene is associated with heroin dependence. Drug Alcohol Depend. doi: 10. 1016/j. drugalcdep. 2011. 06. 008.
46. Wiesbeck, G. A., Dursteler-MacFarland, K. M., Wurst, F. M., Walter, M., Petitjean, S., Muller, S., et al. (2006). No association of dopamine receptor sensitivity in vivo with genetic predisposition for alcoholism and DRD2/DRD3 gene polymorphisms in alcohol dependence. Addiction Biology, 11, 72-75.
47. Woo, S. I., Kim, J. W., Rha, E., Han, S. H., Hahn, K. H., Park, C. S., et al. (2002). Association of the Ser9Gly polymorphism in the dopamine D3 receptor gene with tardive dyskinesia in Korean schizophrenics. Psychiatry and Clinical Neurosciences, 56, 469-474.