The aldehyde dehydrogenase 2 gene is associated with heroin dependence

Drug and Alcohol Dependence

Volumn 120, Issue 1-3, 2012, Pages 220-224

  Wang, Tzu Yun ^a,d   Lee, Sheng Yu ^a,b   Chen, Shiou Lan ^a   Chen, Shih Heng ^a   Chu, Chun Hsien ^a   Huang, San Yuan ^c   Tzeng, Nian Sheng ^c   Chang, Yun Hsuan ^a   Wang, Chen Lin ^b   Lee, I Hui ^a,b   Yeh, Tzung Lieh ^a,b   Yang, Yen Kuang ^a,b   Lu, Ru Band ^a,b  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

^c TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^d Tainan Hospital   (Taiwan)

Author keywords

Addition; ALDH2; DRD2; Han Chinese in Taiwan; Heroin dependence

Indexed keywords

ALDEHYDE DEHYDROGENASE ISOENZYME 2; ANKYRIN REPEAT AND KINASE DOMAIN CONTAINING 1; DIAMORPHINE; DOPAMINE 2 RECEPTOR; PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGE; ALDEHYDE DEHYDROGENASE 2 GENE; ANKYRIN REPEAT AND KINASE DOMAIN CONTAINING 1 GENE; ARTICLE; CHINESE; CONTROLLED STUDY; DOPAMINE 2 RECEPTOR GENE; FEMALE; GENDER; GENE; GENE FREQUENCY; GENE INTERACTION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HAN CHINESE; HEROIN DEPENDENCE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK ASSESSMENT;

ADULT; ALDEHYDE DEHYDROGENASE; ALLELES; CASE-CONTROL STUDIES; FEMALE; GENETIC ASSOCIATION STUDIES; GENOTYPE; HEROIN DEPENDENCE; HUMANS; LOGISTIC MODELS; MALE; POLYMORPHISM, GENETIC; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, DOPAMINE D2;

EID: 84155172969     PISSN: 03768716     EISSN: 18790046     Source Type: Journal    
DOI: 10.1016/j.drugalcdep.2011.06.008     Document Type: Article

References (44)

1. Agarwal D.P., Goedde H.W. Pharmacogenetics of alcohol metabolism and alcoholism. Pharmacogenetics 1992, 2:48-62.
2. American Psychiatry Association, 1994. Diagnostic and Statistical Manual of Mental Disorders. Washington, DC.
3. Barratt D.T., Coller J.K., Somogyi A.A. Association between the DRD2 A1 allele and response to methadone and buprenorphine maintenance treatments. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 2006, 141B:323-331.
4. Beaver K.M., Gibson C.L., Jennings W.G., Ward J.T. A gene X environment interaction between DRD2 and religiosity in the prediction of adolescent delinquent involvement in a sample of males. Biodemography Soc. Biol. 2009, 55:71-81.
5. Blum K., Noble E.P., Sheridan P.J., Montgomery A., Ritchie T., Jagadeeswaran P., Nogami H., Briggs A.H., Cohn J.B. Allelic association of human dopamine D2 receptor gene in alcoholism. JAMA 1990, 263:2055-2060.
6. Brooner R.K., King V.L., Kidorf M., Schmidt C.W., Bigelow G.E. Psychiatric and substance use comorbidity among treatment-seeking opioid abusers. Arch. Gen. Psychiatry 1997, 54:71-80.
7. Cesura A.M., Pletscher A. The new generation of monoamine oxidase inhibitors. Prog. Drug Res. 1992, 38:171-297.
8. Chen C.C., Lu R.B., Chen Y.C., Wang M.F., Chang Y.C., Li T.K., Yin S.J. Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism. Am. J. Hum. Genet. 1999, 65:795-807.
9. Comings D.E., Ferry L., Bradshaw-Robinson S., Burchette R., Chiu C., Muhleman D. The dopamine D2 receptor (DRD2) gene: a genetic risk factor in smoking. Pharmacogenetics 1996, 6:73-79.
10. Crabb D.W., Edenberg H.J., Bosron W.F., Li T.K. Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant. J. Clin. Invest. 1989, 83:314-316.
11. Crettol S., Besson J., Croquette-Krokar M., Hammig R., Gothuey I., Monnat M., Deglon J.J., Preisig M., Eap C.B. Association of dopamine and opioid receptor genetic polymorphisms with response to methadone maintenance treatment. Prog. Neuropsychopharmacol. Biol. Psychiatry 2008, 32:1722-1727.
12. Dandre F., Cassaigne A., Iron A. The frequency of the mitochondrial aldehyde dehydrogenase I2 (atypical) allele in Caucasian, Oriental and African black populations determined by the restriction profile of PCR-amplified DNA. Mol. Cell Probes 1995, 9:189-193.
13. Elmer G.I., Pieper J.O., Rubinstein M., Low M.J., Grandy D.K., Wise R.A. Failure of intravenous morphine to serve as an effective instrumental reinforcer in dopamine D2 receptor knock-out mice. J. Neurosci. 2002, 22:RC224.
14. Endicott J., Spitzer R.L. A diagnostic interview: the schedule for affective disorders and schizophrenia. Arch. Gen. Psychiatry 1978, 35:837-844.
15. Faul F., Erdfelder E., Buchner A., Lang A.G. Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav. Res. Methods 2009, 41:1149-1160.
16. Grandy D.K., Zhang Y., Civelli O. PCR detection of the TaqA RFLP at the DRD2 locus. Hum. Mol. Genet. 1993, 2:2197.
17. Hou Q.F., Li S.B. Potential association of DRD2 and DAT1 genetic variation with heroin dependence. Neurosci. Lett. 2009, 464:127-130.
18. Huang S.Y., Lin W.W., Ko H.C., Lee J.F., Wang T.J., Chou Y.H., Yin S.J., Lu R.B. Possible interaction of alcohol dehydrogenase and aldehyde dehydrogenase genes with the dopamine D2 receptor gene in anxiety-depressive alcohol dependence. Alcohol. Clin. Exp. Res. 2004, 28:374-384.
19. Keung W.M., Vallee B.L. Daidzin: a potent, selective inhibitor of human mitochondrial aldehyde dehydrogenase. Proc. Natl. Acad. Sci. U. S. A. 1993, 90:1247-1251.
20. Kidorf M., Disney E.R., King V.L., Neufeld K., Beilenson P.L., Brooner R.K. Prevalence of psychiatric and substance use disorders in opioid abusers in a community syringe exchange program. Drug Alcohol Depend. 2004, 74:115-122.
21. Lamensdorf I., Eisenhofer G., Harvey-White J., Nechustan A., Kirk K., Kopin I.J. 3,4-Dihydroxyphenylacetaldehyde potentiates the toxic effects of metabolic stress in PC12 cells. Brain Res. 2000, 868:191-201.
22. Lawford B.R., Young R.M., Noble E.P., Sargent J., Rowell J., Shadforth S., Zhang X., Ritchie T. The D(2) dopamine receptor A(1) allele and opioid dependence: association with heroin use and response to methadone treatment. Am. J. Med. Genet. 2000, 96:592-598.
23. Lee H.S. Gender-specific molecular heterosis and association studies: dopamine D2 receptor gene and smoking. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 2003, 118B:55-59.
24. Lee S.Y., Hahn C.Y., Lee J.F., Chen S.L., Chen S.H., Yeh T.L., Kuo P.H., Lee I.H., Yang Y.K., Huang S.Y., Ko H.C., Lu R.B. MAOA-uVNTR polymorphism may modify the protective effect of ALDH2 gene against alcohol dependence in antisocial personality disorder. Alcohol. Clin. Exp. Res. 2009, 33:985-990.
25. Lee S.Y., Chen S.L., Chang Y.H., Chen S.H., Chu C.H., Huang S.Y., Tzeng N.S., Wang C.L., Lee I.H., Yeh T.L., Yang Y.K., Lu R.B. The ALDH2 and DRD2/ANKK1 genes interacted in bipolar II but not bipolar I disorder. Pharmacogenet. Genomics 2010, 20:500-506.
26. Li T., Liu X., Zhao J., Hu X., Ball D.M., Loh el W., Sham P.C., Collier D.A. Allelic association analysis of the dopamine D2, D3, 5-HT2A, and GABA(A)gamma2 receptors and serotonin transporter genes with heroin abuse in Chinese subjects. Am. J. Med. Genet. 2002, 114:329-335.
27. Lu R.B., Ko H.C., Lee J.F., Lin W.W., Huang S.Y., Wang T.J., Wu Y.S., Lu T.E., Chou Y.H. No alcoholism-protection effects of ADH1B*2 allele in antisocial alcoholics among Han Chinese in Taiwan. Alcohol. Clin. Exp. Res. 2005, 29:2101-2107.
28. Lu R.B., Lee J.F., Huang S.Y., Lee S.Y., Chang Y.H., Kuo P.H., Chen S.L., Chen S.H., Chu C.H., Lin W.W., Wu P.L., Ko H.C. Interaction between ALDH2*1*1 and DRD2/ANKK1 TaqI A1A1 genes may be associated with antisocial personality disorder not comorbid with alcoholism. Addict. Biol. 2010, (Epub ahead of print).
29. Maldonado R., Saiardi A., Valverde O., Samad T.A., Roques B.P., Borrelli E. Absence of opiate rewarding effects in mice lacking dopamine D2 receptors. Nature 1997, 388:586-589.
30. Noble E.P. D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 2003, 116B:103-125.
31. Noble E.P., St Jeor S.T., Ritchie T., Syndulko K., St Jeor S.C., Fitch R.J., Brunner R.L., Sparkes R.S. D2 dopamine receptor gene and cigarette smoking: a reward gene?. Med. Hypotheses 1994, 42:257-260.
32. Perez de los Cobos J., Baiget M., Trujols J., Sinol N., Volpini V., Banuls E., Calafell F., Luquero E., del Rio E., Alvarez E. Allelic and genotypic associations of DRD2 TaqI A polymorphism with heroin dependence in Spanish subjects: a case control study. Behav. Brain Funct. 2007, 3:25.
33. Ponce G., Hoenicka J., Jimenez-Arriero M.A., Rodriguez-Jimenez R., Aragues M., Martin-Sune N., Huertas E., Palomo T. DRD2 and ANKK1 genotype in alcohol-dependent patients with psychopathic traits: association and interaction study. Br. J. Psychiatry 2008, 193:121-125.
34. Robbins T.W., Everitt B.J. Drug addiction: bad habits add up. Nature 1999, 398:567-570.
35. Sheehan D.V., Lecrubier Y., Sheehan K.H., Amorim P., Janavs J., Weiller E., Hergueta T., Baker R., Dunbar G.C. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J. Clin. Psychiatry 1998, 59(Suppl. 20):22-33. (quiz 34-57).
36. Thomasson H.R., Edenberg H.J., Crabb D.W., Mai X.L., Jerome R.E., Li T.K., Wang S.P., Lin Y.T., Lu R.B., Yin S.J. Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. Am. J. Hum. Genet. 1991, 48:677-681.
37. Tsuang M.T., Lyons M.J., Eisen S.A., Goldberg J., True W., Lin N., Meyer J.M., Toomey R., Faraone S.V., Eaves L. Genetic influences on DSM-III-R drug abuse and dependence: a study of 3,372 twin pairs. Am. J. Med. Genet. 1996, 67:473-477.
38. Tsuang M.T., Lyons M.J., Meyer J.M., Doyle T., Eisen S.A., Goldberg J., True W., Lin N., Toomey R., Eaves L. Co-occurrence of abuse of different drugs in men: the role of drug-specific and shared vulnerabilities. Arch. Gen. Psychiatry 1998, 55:967-972.
39. Westerink B.H., de Vries J.B. On the origin of dopamine and its metabolite in predominantly noradrenergic innervated brain areas. Brain Res. 1985, 330:164-166.
40. Wise R.A. Dopamine, learning and motivation. Nat. Rev. Neurosci. 2004, 5:483-494.
41. Wurst F.M., Tabakoff B., Alling C., Aradottir S., Wiesbeck G.A., Muller-Spahn F., Pragst F., Johnson B., Javors M., Ait-Daoud N., Skipper G.E., Spies C., Nachbar Y., Lesch O., Ramskogler K., Hartmann S., Wolfersdorf M., Dresen S., Weinmann W., Hines L., Kaiser A., Lu R.B., Ko H.C., Huang S.Y., Wang T.J., Wu Y.S., Whitfield J., Snell L.D., Wu C., Hoffman P.L. World Health Organization/International Society for Biomedical Research on Alcoholism study on state and trait markers of alcohol use and dependence: back to the future. Alcohol. Clin. Exp. Res. 2005, 29:1268-1275.
42. Xu K., Lichtermann D., Lipsky R.H., Franke P., Liu X., Hu Y., Cao L., Schwab S.G., Wildenauer D.B., Bau C.H., Ferro E., Astor W., Finch T., Terry J., Taubman J., Maier W., Goldman D. Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations. Arch. Gen. Psychiatry 2004, 61:597-606.
43. Yoshida A., Hsu L.C., Yasunami M. Genetics of human alcohol-metabolizing enzymes. Prog. Nucleic Acid Res. Mol. Biol. 1991, 40:255-287.
44. Young R.M., Lawford B.R., Nutting A., Noble E.P. Advances in molecular genetics and the prevention and treatment of substance misuse: implications of association studies of the A1 allele of the D2 dopamine receptor gene. Addict. Behav. 2004, 29:1275-1294.