Synthesis and QSAR analysis of chalcone derivatives as nitric oxide inhibitory agent

Medicinal Chemistry Research

Volumn 21, Issue 8, 2012, Pages 1953-1966

  Lam, Kok Wai ^a   Uddin, Reaz ^b   Liew, Choi Yi ^a   Tham, Chau Ling ^a   Israf, Daud A ^a   Syahida, Ahmad ^a   Rahman, Mohd Basyaruddin Abdul ^a   Ul Haq, Zaheer ^b   Lajis, Nordin H ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^b UNIVERSITY OF KARACHI   (Pakistan)

Author keywords

3D QSAR; Chalcone analogues; CoMFA; Nitric oxide inhibition; RAW 264.7

Indexed keywords

1 (2,5 DIMETHYLFURAN 3 YL) 3 (2 HYDROXYPHENYLPROP 2 EN 1 ONE; 1 (2,5 DIMETHYLFURAN 3 YL) 3 (3 HYDROXYPHENYLPROP 2 EN 1 ONE; 1 (5 METHYLFURAN 2 YL) 3 (2,3,4 TRIEMTHOXYPHENYL)PROP 2 EN 1 ONE; 1 (5 METHYLFURAN 2 YL) 3 (2,4,6 TRIEMTHOXYPHENYL)PROP 2 EN 1 ONE; 1 (5 METHYLFURAN 2 YL) 3 (4 NITROPHENYL)PROP 2 EN 1 ONE; 1 (FURAN 2 YL) 3 (2 HYDROXYPHENYL)PROP 2 EN 1 ONE; 1 (FURAN 2 YL) 3 (3 HYDROXYPHENYL)PROP 2 EN 1 ONE; 1 (FURAN 2 YL) 3 (4 HYDROXYPHENYL)PROP 2 EN 1 ONE; 2 [2 [3 (5 METHYLFURAN 2 YL) 3 OXOPROP 1 ENYL]PHENOXY]ACETIC ACID; 3 (2 CHLOROPHENYL) 1 (5 METHYLFURAN 2 YL)PROP 2 EN 1 ONE; 3 (2 FLUORO 4 METHOXYPHENYL) 1 (5 METHYLFURAN 2 YL)PROP 2 EN 1 ONE; 3 (2 FLUOROPHENYL) 1 (5 METHYLFURAN 2 YL)PROP 2 EN 1 ONE; 3 (2 HYDROXYPHENYL) 1 (5 METHYLFURAN 2 YL)PROP 2 EN 1 ONE; 3 (2,3 DIMETHOXYPHENYL) 1 (5 METHYLFURAN 2 YL)PROP 2 EN 1 ONE; 3 (2,5 DIMETHOXYPHENYL) 1 (5 METHYLFURAN 2 YL)PROP 2 EN 1 ONE; 3 (2,5 DIMETHOXYPHENYL) 1 (FURAN 2 YL)PROP 2 EN 1 ONE; 3 (2,6 DIMETHOXYPHENYL) 1 (5 METHYLFURAN 2 YL)PROP 2 EN 1 ONE; 3 (3 CHLOROPHENYL) 1 (5 METHYLFURAN 2 YL)PROP 2 EN 1 ONE; 3 (3 FLUOROPHENYL) 1 (5 METHYLFURAN 2 YL)PROP 2 EN 1 ONE; 3 (3 HYDROXYPHENYL) 1 (5 METHYLFURAN 2 YL)PROP 2 EN 1 ONE; 3 (4 CHLOROPHENYL) 1 (5 METHYLFURAN 2 YL)PROP 2 EN 1 ONE; 3 (4 FLUOROPHENYL) 1 (5 METHYLFURAN 2 YL)PROP 2 EN 1 ONE; 3 (4 HYDROXYPHENYL) 1 (5 METHYLFURAN 2 YL)PROP 2 EN 1 ONE; 3 (FURAN 2 YL) 1 (5 METHYLFURAN 2 YL)PROP 2 EN 1 ONE; ANTIINFLAMMATORY AGENT; CHALCONE DERIVATIVE; GAMMA INTERFERON; LIPOPOLYSACCHARIDE; NITRIC OXIDE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL LINE; COMPARATIVE MOLECULAR FIELD ANALYSIS; DRUG POTENCY; DRUG SYNTHESIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

EID: 84866065946     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-011-9706-1     Document Type: Article

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