The effect of kraussianone-2 (Kr2), a natural pyrano-isoflavone from eriosema kraussianum, in an L-NAME-induced pre-eclamptic rat model

Phytotherapy Research

Volumn 26, Issue 9, 2012, Pages 1375-1380

  Ramesar, S V ^a   Drewes, S E ^a   Gathiram, P ^b   Moodley, J ^b   MacKraj, I ^a  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

^b UNIVERSITY OF KWAZULU NATAL   (South Africa)

Author keywords

Eriosema kraussianum; Kraussianone 2; pre eclampsia; soluble endoglin; soluble fms like tyrosine kinase1

Indexed keywords

ENDOGLIN; ERIOSEMA KRAUSSIANUM EXTRACT; ISOFLAVONE DERIVATIVE; KRAUSSIANONE 2; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PLACENTAL GROWTH FACTOR; PLANT EXTRACT; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIRTH WEIGHT; BLOOD ANALYSIS; BLOOD PRESSURE REGULATION; BLOOD SAMPLING; CONTROLLED STUDY; DRUG EFFICACY; DRUG ISOLATION; DRUG MECHANISM; ERIOSEMA KRAUSSIANUM; FABACEAE; FEMALE; FETUS; FETUS MORTALITY; FETUS OUTCOME; GESTATION PERIOD; LAPAROTOMY; LITTER SIZE; NONHUMAN; PLACENTA WEIGHT; PLANT ROOT; PREECLAMPSIA; PROTEIN BLOOD LEVEL; RAT; SYSTOLIC BLOOD PRESSURE; UTERINE ARTERY; UTERUS BLOOD FLOW;

ANIMALS; BIRTH WEIGHT; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; FABACEAE; FEMALE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ISOFLAVONES; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

ANIMALIA; ERIOSEMA KRAUSSIANUM; FABACEAE; RATTUS;

EID: 84866061742     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3697     Document Type: Article

References (33)

1. Bdolah Y, Sukhatme VP, Karumanchi SA,. 2004. Angiogenic imbalance in the pathophysiology of preeclampsia: newer insights. Sem Nephrol 24 (6): 548-556.
2. Boolell M, Gepi-Attee S, Gingell JC, Allen MJ,. 1996. Sildenafil, a novel effective oral therapy for male erectile dysfunction. Br J Urol 78 (2): 257-261.
3. Bryant AT,. 1966. Zulu Medicine and Medicine-Men. Centaur Struik: Cape Town.
4. Buhimschi CS, Garfield RE, Weiner CP, Buhimschi IA,. 2004. The presence and function of phosphodiesterase type 5 in the rat myometrium. Am J Obstet Gynecol 190 (1): 268-274.
5. Drewes SE, Horn MM, Munro OQ, Dhlamini JTB, Meyer JJM, Rakuambo NC,. 2002. Pyrano-isoflavones with erectile-dysfunction activity from Eriosema kraussianum. Phytochemistry 59: 739-747.
6. Drewes SE, George J, Khan F,. 2003. Recent findings on natural products with erectile-dysfunction activity, Phytochemistry 62: 1019-1025.
7. He Y, Smith SK, Day KA, Clark DE, Licence DR, Charnock-Jones DS,. 1999. Alternative splicing of vascular endothelial growth factor (VEGF)-R1 (FLT-1) pre-mRNA is important for the regulation of VEGF activity. Mol Endocrinol 13 (4): 537-545.
8. Hulme MM,. 1954. Wild Flowers of Natal. Shuter & Shooter: Pietermaritzburg.
9. Hutchings A, Scott AH, Lewis G, Cunningham A,. 1996. Zulu Medicinal Plants-An Inventory. University of Natal Press: Pietermaritzburg; 145-146.
10. Karumanchi SA, Bdolah Y,. 2004. Hypoxia and sFlt-1 in preeclampsia: the 'chicken-and-egg' question. Endocrinology 145 (11): 4835-4837.
11. Kendall RL, Thomas KA,. 1993. Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. Proc Natl Acad Sci USA 90 (22): 10705-10709.
12. Khalil RA, Granger JP,. 2002. Vascular mechanisms of increased arterial pressure in preeclampsia: lessons from animal models. Am J Physiol Regul Integr Comp Physiol 283: R29-R45.
13. Lopez-Jaramillo P, Casas JP, Serrano N,. 2001. Pre eclampsia: from epidemiological observations to molecular mechanisms. Braz J Med Biol Res 34 (10): 1227-1235.
14. Maynard SE, Min JY, Merchan J, et al,. 2003. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 111 (5): 649-658.
15. Maynard SE, Venkatesha S, Thadhani R, Karumanchi SA,. 2005. Soluble fms-like tyrosine kinase 1 and endothelial dysfunction in the pathogenesis of preeclampsia. Pediatr Res 57 (5 Pt 2): 1R-7R.
16. Noris M, Perico N, Remuzzi G,. 2005. Mechanisms of disease. Nat Clin Pract Nephrol 1 (2): 98-114.
17. Ojewole JAO, Drewes SE, Khan F,. 2006. Vasodilatory and hypoglycaemic effects of two pyrano-isoflavone extractives from Eriosema kraussianum N. E. Br. [Fabaceae] rootstock in experimental rat models. Phytochemistry 67: 610-617.
18. Olatunji-Bello II, Nwachukwu D, Adegunloye BJ,. 2001. Blood pressure and heart rate changes during pregnancy in fructose-fed Sprague-Dawley rats. Afr J Med Med Sci 30: 187-190.
19. Osol G, Celia G, Gokina NI,. 2005. Beneficial effects of Viagra on fetal and vascular parameters in hypertensive pregnancy in the rat. FASEB J 19 (5): A1597-A.
20. Pijnenborg R, Anthony J, Davey DA,. 1991. Placental bed spiral arteries in the hypertensive disorders of pregnancy. Brit J Obstet Gynaecol 98 (7): 648-655.
21. Raijmakers MT, Dechend R, Poston L,. 2004. Oxidative stress and preeclampsia: rationale for antioxidant clinical trials. Hypertension 44: 374-380.
22. Ramesar SV, Mackraj I, Gathiram P, Moodley J,. 2009. Sildenafil citrate improves fetal outcomes in pregnant, l-NAME treated, Sprague-Dawley rats. Eur J Obstet Gynecol Reprod Biol 149 (1): 22-26.
23. Redman CWG, Sargent IL,. 2000. Placental debris, oxidative stress and preeclampsia. Placenta 21 (7): 597-602.
24. Regan CL, Levine R, Baird DD, et al,. 2001. No evidence for lipid peroxidation in severe preeclampsia. Am J Obstet Gynecol 185: 572-578
25. Roberts J, Hubel, CA,. 1999. Is oxidative stress the link in the two-stage model of pre-eclampsia? Lancet 354 (9181): 788-789.
26. Roberts JM, Gammill HS,. 2005. Preeclampsia: recent insights. Hypertension 46 (6): 1243-1249.
27. Sher G, Fisch JD,. 2000. Vaginal sildenafil (Viagra): a preliminary report of a novel method to improve uterine artery blood flow and endometrial development in patients undergoing IVF. Hum Reprod 15 (4): 806-809.
28. Sibai BM,. 2003. Diagnosis and management of gestational hypertension and pre eclampsia. Obstet Gynecol 102 (1): 181-192.
29. Sibai BM, Dekker G, Kupferminc M,. 2005. Pre-eclampsia. Lancet 365: 785-799.
30. Thadhani RI, Johnson RJ, Karumanchi SA,. 2005. Hypertension during pregnancy: A disorder begging for pathophysiological support. Hypertension 46: 1250-1251.
31. Valdés G, Kaufmann P, Corthorn J, Erices R, Brosnihan KB, Joyner-Grantham J,. 2009. Vasodilator factors in the systemic and local adaptations to pregnancy. Reprod Biol Endocrinol 7: 79.
32. Venkatesha S, Toporsian M, Lam C, et al,. 2006. Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med 12 (6): 642-649.
33. Wareing M, Myers JE, O'Hara M, Baker PN,. 2005. Sildenafil citrate (Viagra) enhances vasodilatation in fetal growth restriction. J Clin Endocrinol Metab 90 (5): 2550-2555.