Vasodilatory and hypoglycaemic effects of two pyrano-isoflavone extractives from Eriosema kraussianum N. E. Br. [Fabaceae] rootstock in experimental rat models

Phytochemistry

Volumn 67, Issue 6, 2006, Pages 610-617

  Ojewole, John A O ^a   Drewes, Siegfried E ^a   Khan, Fatima ^a  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

Author keywords

Eriosema kraussianum; Hypoglycaemic and vasodilatory properties; K1 and K2; Pyrano isoflavones; Rat model

Indexed keywords

ANTIDIABETIC AGENT; ISOFLAVONE DERIVATIVE; KRAUSSIANONE 1; KRAUSSIANONE 2; KRAUSSIANONE-1; KRAUSSIANONE-2; PLANT EXTRACT; VASODILATOR AGENT;

ANIMAL; ANIMAL MODEL; ARTICLE; CHEMICAL STRUCTURE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DISEASE MODEL; DRUG EFFECT; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; HYPOGLYCEMIA; LEGUME; MALE; MEDICINAL PLANT; METABOLISM; PLANT ROOT; RAT; VASODILATATION; WISTAR RAT;

ANIMALS; BLOOD GLUCOSE; DISEASE MODELS, ANIMAL; FABACEAE; GLUCOSE TOLERANCE TEST; HYPOGLYCEMIA; HYPOGLYCEMIC AGENTS; ISOFLAVONES; MALE; MODELS, ANIMAL; MOLECULAR STRUCTURE; PLANT EXTRACTS; PLANT ROOTS; PLANTS, MEDICINAL; RATS; RATS, WISTAR; VASODILATION; VASODILATOR AGENTS;

ANIMALIA; ERIOSEMA; FABACEAE;

EID: 32644458203     PISSN: 00319422     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phytochem.2005.11.019     Document Type: Article

References (27)

1. B. Adzu, S. Amos, S.D. Kapu, and K.S. Gamaniel Anti-inflammatory and anti-nociceptive effects of Sphaeranthus senegalensis Journal of Ethnopharmacology 84 2003 169 173
2. P.A. Akah, and C.L. Okafor Blood sugar lowering effect of Vernonia amygdalina (Del) in an experimental rabbit model Phytotherapy Research 6 1992 171 173
3. A.T. Bryant Zulu Medicine and Medicine-Men 1966 Centaur Struik Cape Town
4. C.R. Conti, C.J. Pepine, and M. Sweeney Efficacy and safety of sildenafil citrate in the treatment of erectile dysfunction in patients with ischaemic heart disease American Journal of Cardiology 83 1999 29C 34C
5. F.A. Derry, W.W. Dinsmore, and M. Fraser Efficacy and safety of oral sildenafil (VIAGRA™) in men with erectile dysfunction caused by spinal cord injury Neurology 51 1998 1629 1633
6. S.E. Drewes, M.M. Horn, O.Q. Munro, J.T.B. Dhlamini, J.J.M. Meyer, and N.C. Rakuambo Pyrano-isoflavones with erectile-dysfunction activity from Eriosema kraussianum Phytochemistry 59 2002 739 747
7. S.E. Drewes, J. George, and F. Khan Recent findings on natural products with erectile-dysfunction activity Phytochemistry 62 2003 1019 1025
8. A.B. Dongmo, A. Kamanyi, G. Dzikouk, B. Chungag-Anye Nkeh, P.V. Tan, T. Nguelefack, T. Nole, M. Bopelet, and H. Wagner Anti-inflammatory and analgesic properties of the stem-bark extract of Mitragyna ciliata (Rubiaceae) Aubrev. and Pellegr Journal of Ethnopharmacology 84 2003 17 21
9. H.A. Feldman, I. Goldstein, D.G. Hatzichristou, R.I. Krane, and J.B. McKinlay Impotence and its medical and psychological correlates: results of the Massachusetts male aging study Journal of Urology 151 1994 54 61
10. I. Goldstein, T.F. Lue, H. Padma-Nathan, R.C. Rosen, W.D. Steers, and P.A. Wicker Oral sildenafil in the treatment of erectile dysfunction New England Journal of Medicine 339 1998 59
11. M.M. Hulme Wild Flowers of Natal 1954 Shuter & Shooter Pietermaritzburg
12. A. Hutchings, A.H. Scott, G. Lewis, and A. Cunningham Zulu Medicinal Plants - An Inventory 1996 University of Natal Press Pietermaritzburg pp. 145-146
13. J.E. Jackson, and R. Bressler Clinical pharmacology of sulphonylurea hypoglycaemic agents. Part I Drugs 22 1981 211 245
14. J.P. Jarow, A.L. Burnett, and A.M. Geringer Clinical efficacy of sildenafil citrate based on aetiology and response to prior treatment American Journal of Urology 162 1999 722 725
15. R.W. Li, G.D. Lin, S.P. Myers, and D.N. Leach Anti-inflammatory activity of Chinese medicinal vine plants Journal of Ethnopharmacology 85 2003 61 67
16. T.F. Luscher, and P.M. Vanhoutte Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat Hypertension 8 1986 344 348
17. R.J. Marles, and N.R. Farnsworth Antidiabetic plants and their active constituents Phytomedicine 2 1995 137 189
18. Ojewole, J.A.O., 1977. Studies on the Pharmacology of Some Antimalarial Drugs. PhD Thesis, University of Strathclyde, Glasgow, Scotland, UK.
19. J.A.O. Ojewole Hypoglycaemic effect of Clausena anisata (Willd) Hook methanolic root extract in rats Journal of Ethnopharmacology 81 2002 231 237
20. J.A.O. Ojewole Evaluation of the anti-inflammatory properties of Sclerocarya birrea (A. Rich.) Hochst. (family: Anacardiaceae) stem-bark extracts in rats Journal of Ethnopharmacology 85 2003 217 220
21. M.S. Rendell, J. Rajfer, P.A. Wicker, and M.D. Smith Sildenafil for treatment of erectile dysfunction in men with diabetes Journal of American Medical Association 281 1999 421 426
22. T. Taesotiku, A. Panthong, D. Kanjanapothi, R. Verpoorte, and J.J.C. Scheffer Anti-inflammatory, antipyretic and antinociceptive activities of Tabernaemontana pandacaqui Poir Journal of Ethnopharmacology 84 2003 31 35
23. J.M. Watt, and M.G. Breyer-Brandwijk The Medicinal and Poisonous Plants of Southern and Eastern Africa Second ed. 1962 E. & S Livingstone Ltd. Edinburgh and London pp. 600-601
24. D.J. Webb, S. Freestone, M.J. Allen, and G.J. Muirhead Sildenafil citrate and blood-pressure-lowering drugs: results of drug interaction studies with an organic nitrate and a calcium antagonist American Journal of Cardiology 83 1999 21C 28C
25. M.H. Yin, D.G. Kang, D.H. Choi, T.O. Kwon, and H.S. Lee Screening of vasorelaxant activity of some medicinal plants used in Oriental medicines Journal of Ethnopharmacology 99 2005 113 117
26. J.V. Zawadzki, P.D. Cherry, and R.F. Furchgott Comparison of endothelium-dependent relaxations of rabbit aorta by A23187 and acetylcholine Pharmacologist 22 1980 271
27. R.M. Zusman, A. Morales, D.B. Glasser, and I.H. Osterloh Overall cardiovascular profile of sildenafil citrate American Journal of Cardiology 83 1999 35C 44C