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Volumn 7, Issue 9, 2012, Pages

Some Novel Insights on HPV16 Related Cervical Cancer Pathogenesis Based on Analyses of LCR Methylation, Viral Load, E7 and E2/E4 Expressions

Author keywords

[No Author keywords available]

Indexed keywords

BISULFITE; MESSENGER RNA; PROTEIN E7; REPRESSOR PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS PROTEIN E2; VIRUS PROTEIN E4;

EID: 84866060807     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0044678     Document Type: Article
Times cited : (26)

References (39)
  • 1
    • 0037969847 scopus 로고    scopus 로고
    • Association of human papillomavirus viral load with HPV16 and high-grade intraepithelial lesion
    • Abba MC, Mourón SA, Gómez MA, Dulout FN, Golijow CD, (2003) Association of human papillomavirus viral load with HPV16 and high-grade intraepithelial lesion. Int J Gynecol Cancer 13: 154-158.
    • (2003) Int J Gynecol Cancer , vol.13 , pp. 154-158
    • Abba, M.C.1    Mourón, S.A.2    Gómez, M.A.3    Dulout, F.N.4    Golijow, C.D.5
  • 2
    • 34250818010 scopus 로고    scopus 로고
    • Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions: a meta-analysis update
    • Smith JS, Lindsay L, Hoots B, Keys J, Franceschi S, et al. (2007) Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions: a meta-analysis update. Int J Cancer 121: 621-632.
    • (2007) Int J Cancer , vol.121 , pp. 621-632
    • Smith, J.S.1    Lindsay, L.2    Hoots, B.3    Keys, J.4    Franceschi, S.5
  • 3
    • 33745105986 scopus 로고    scopus 로고
    • Human papillomavirus prevalence in postradiotherapy uterine cervical carcinoma patients: correlation with recurrence of the disease
    • Singh RK, Maulik S, Mitra S, Mondal RK, Basu PS, et al. (2006) Human papillomavirus prevalence in postradiotherapy uterine cervical carcinoma patients: correlation with recurrence of the disease. Int J Gynecol Cancer 16: 1048-1054.
    • (2006) Int J Gynecol Cancer , vol.16 , pp. 1048-1054
    • Singh, R.K.1    Maulik, S.2    Mitra, S.3    Mondal, R.K.4    Basu, P.S.5
  • 4
    • 29944447719 scopus 로고    scopus 로고
    • Prevalence and distribution of high-risk human papilloma virus (HPV) types in invasive squamous cell carcinoma of the cervix and in normal women in Andhra Pradesh, India
    • Sowjanya AP, Jain M, Poli UR, Padma S, Das M, et al. (2005) Prevalence and distribution of high-risk human papilloma virus (HPV) types in invasive squamous cell carcinoma of the cervix and in normal women in Andhra Pradesh, India. BMC Infect Dis 5: 116.
    • (2005) BMC Infect Dis , vol.5 , pp. 116
    • Sowjanya, A.P.1    Jain, M.2    Poli, U.R.3    Padma, S.4    Das, M.5
  • 5
    • 0036559896 scopus 로고    scopus 로고
    • Papillomaviruses and cancer: from basic studies to clinical application
    • zur Hausen H, (2002) Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer 2: 342-350.
    • (2002) Nat Rev Cancer , vol.2 , pp. 342-350
    • zur Hausen, H.1
  • 6
    • 0024423584 scopus 로고
    • Both episomal and integrated forms of human papillomavirus type 16 are involved in invasive cervical cancers
    • Matsukura T, Koi S, Sugase M, (1989) Both episomal and integrated forms of human papillomavirus type 16 are involved in invasive cervical cancers. Virology 172: 63-72.
    • (1989) Virology , vol.172 , pp. 63-72
    • Matsukura, T.1    Koi, S.2    Sugase, M.3
  • 7
    • 30444455306 scopus 로고    scopus 로고
    • HPV16 E2 gene disruption and polymorphisms of E2 and LCR: some significant associations with cervical cancer in Indian women
    • Bhattacharjee B, Sengupta S, (2006) HPV16 E2 gene disruption and polymorphisms of E2 and LCR: some significant associations with cervical cancer in Indian women. Gynecol Oncol 100: 372-378.
    • (2006) Gynecol Oncol , vol.100 , pp. 372-378
    • Bhattacharjee, B.1    Sengupta, S.2
  • 8
    • 7444264604 scopus 로고    scopus 로고
    • E2 sequence variations of HPV 16 among patients with cervical neoplasia seen in the Indian subcontinent
    • Sathish N, Abraham P, Peedicayil A, Sridharan G, Shaji RV, et al. (2004) E2 sequence variations of HPV 16 among patients with cervical neoplasia seen in the Indian subcontinent. Gynecol Oncol 95: 363-369.
    • (2004) Gynecol Oncol , vol.95 , pp. 363-369
    • Sathish, N.1    Abraham, P.2    Peedicayil, A.3    Sridharan, G.4    Shaji, R.V.5
  • 9
    • 33749537658 scopus 로고    scopus 로고
    • CpG methylation of HPV 16 LCR at E2 binding site proximal to P97 is associated with cervical cancer in presence of intact E2
    • Bhattacharjee B, Sengupta S, (2006) CpG methylation of HPV 16 LCR at E2 binding site proximal to P97 is associated with cervical cancer in presence of intact E2. Virology 354: 280-285.
    • (2006) Virology , vol.354 , pp. 280-285
    • Bhattacharjee, B.1    Sengupta, S.2
  • 10
    • 44949235994 scopus 로고    scopus 로고
    • Characterization of sequence variations within HPV16 isolates among Indian women: prediction of causal role of rare non-synonymous variations within intact isolates in cervical cancer pathogenesis
    • Bhattacharjee B, Mandal NR, Roy S, Sengupta S, (2008) Characterization of sequence variations within HPV16 isolates among Indian women: prediction of causal role of rare non-synonymous variations within intact isolates in cervical cancer pathogenesis. Virology 377: 143-150.
    • (2008) Virology , vol.377 , pp. 143-150
    • Bhattacharjee, B.1    Mandal, N.R.2    Roy, S.3    Sengupta, S.4
  • 11
    • 34548346853 scopus 로고    scopus 로고
    • Predisposition to HPV16/18-related cervical cancer because of proline homozygosity at codon 72 of p53 among Indian women is influenced by HLA-B*07 and homozygosity of HLA-DQB1*03
    • Bhattacharya P, Sengupta S, (2007) Predisposition to HPV16/18-related cervical cancer because of proline homozygosity at codon 72 of p53 among Indian women is influenced by HLA-B*07 and homozygosity of HLA-DQB1*03. Tissue Antigens 70: 283-293.
    • (2007) Tissue Antigens , vol.70 , pp. 283-293
    • Bhattacharya, P.1    Sengupta, S.2
  • 12
    • 77952565850 scopus 로고    scopus 로고
    • Association of viral load with HPV16 positive cervical cancer pathogenesis: causal relevance in isolates harboring intact viral E2 gene
    • Das D, Bhattacharjee B, Sen S, Mukhopadhyay I, Sengupta S, (2010) Association of viral load with HPV16 positive cervical cancer pathogenesis: causal relevance in isolates harboring intact viral E2 gene. Virology 402: 197-202.
    • (2010) Virology , vol.402 , pp. 197-202
    • Das, D.1    Bhattacharjee, B.2    Sen, S.3    Mukhopadhyay, I.4    Sengupta, S.5
  • 13
    • 0034659729 scopus 로고    scopus 로고
    • Separate domains in E1 and E2 proteins serve architectural and productive roles for cooperative DNA binding
    • Gillitzer E, Chen G, Stenlund A, (2000) Separate domains in E1 and E2 proteins serve architectural and productive roles for cooperative DNA binding. EMBO J 19: 3069-3079.
    • (2000) EMBO J , vol.19 , pp. 3069-3079
    • Gillitzer, E.1    Chen, G.2    Stenlund, A.3
  • 14
    • 0030971469 scopus 로고    scopus 로고
    • Functional interactions between papillomavirus E1 and E2 proteins
    • Berg M, Stenlund A, (1997) Functional interactions between papillomavirus E1 and E2 proteins. J Virol 71: 3853-3863.
    • (1997) J Virol , vol.71 , pp. 3853-3863
    • Berg, M.1    Stenlund, A.2
  • 15
    • 0031016642 scopus 로고    scopus 로고
    • Mapping and characterization of the interaction domains of human papillomavirus type 16 E1 and E2 proteins
    • Yasugi T, Benson JD, Sakai H, Vidal M, Howley PM, (1997) Mapping and characterization of the interaction domains of human papillomavirus type 16 E1 and E2 proteins. J Virol 71: 891-899.
    • (1997) J Virol , vol.71 , pp. 891-899
    • Yasugi, T.1    Benson, J.D.2    Sakai, H.3    Vidal, M.4    Howley, P.M.5
  • 16
    • 1642447776 scopus 로고    scopus 로고
    • Human papillomavirus (HPV) origin-binding protein associates with mitotic spindles to enable viral DNA partitioning
    • Van Tine BA, Dao LD, Wu SY, Sonbuchner TM, Lin BY, et al. (2004) Human papillomavirus (HPV) origin-binding protein associates with mitotic spindles to enable viral DNA partitioning. Proc Natl Acad Sci U S A 101: 4030-4035.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 4030-4035
    • van Tine, B.A.1    Dao, L.D.2    Wu, S.Y.3    Sonbuchner, T.M.4    Lin, B.Y.5
  • 17
    • 12344269394 scopus 로고    scopus 로고
    • The mitotic chromosome binding activity of the papillomavirus E2 protein correlates with interaction with the cellular chromosomal protein, Brd4
    • Baxter MK, McPhillips MG, Ozato K, McBride AA, (2005) The mitotic chromosome binding activity of the papillomavirus E2 protein correlates with interaction with the cellular chromosomal protein, Brd4. J Virol 79: 4806-4818.
    • (2005) J Virol , vol.79 , pp. 4806-4818
    • Baxter, M.K.1    McPhillips, M.G.2    Ozato, K.3    McBride, A.A.4
  • 18
    • 8644243891 scopus 로고    scopus 로고
    • Conserved methylation patterns of human papillomavirus type 16 DNA in asymptomatic infection and cervical neoplasia
    • Kalantari M, Calleja-Macias IE, Tewari D, Hagmar B, Lie K, et al. (2004) Conserved methylation patterns of human papillomavirus type 16 DNA in asymptomatic infection and cervical neoplasia. J Virol 78: 12762-12772.
    • (2004) J Virol , vol.78 , pp. 12762-12772
    • Kalantari, M.1    Calleja-Macias, I.E.2    Tewari, D.3    Hagmar, B.4    Lie, K.5
  • 19
    • 0033572319 scopus 로고    scopus 로고
    • Detection of high-risk cervical intraepithelial neoplasia and cervical cancer by amplification of transcripts derived from integrated papillomavirus oncogenes
    • Klaes R, Woerner SM, Ridder R, Wentzensen N, Duerst M, et al. (1999) Detection of high-risk cervical intraepithelial neoplasia and cervical cancer by amplification of transcripts derived from integrated papillomavirus oncogenes. Cancer Res 59: 6132-6136.
    • (1999) Cancer Res , vol.59 , pp. 6132-6136
    • Klaes, R.1    Woerner, S.M.2    Ridder, R.3    Wentzensen, N.4    Duerst, M.5
  • 20
    • 33646596267 scopus 로고    scopus 로고
    • Human papillomavirus type 16 integration in cervical carcinoma in situ and in invasive cervical cancer
    • Arias-Pulido H, Peyton CL, Joste NE, Vargas H, Wheeler CM, (2006) Human papillomavirus type 16 integration in cervical carcinoma in situ and in invasive cervical cancer. J Clin Microbiol 44: 1755-1762.
    • (2006) J Clin Microbiol , vol.44 , pp. 1755-1762
    • Arias-Pulido, H.1    Peyton, C.L.2    Joste, N.E.3    Vargas, H.4    Wheeler, C.M.5
  • 21
    • 42649098924 scopus 로고    scopus 로고
    • Effects of cellular differentiation, chromosomal integration and 5-aza-2′-deoxycytidine treatment on human papillomavirus-16 DNA methylation in cultured cell lines
    • Kalantari M, Lee D, Calleja-Macias IE, Lambert PF, Bernard HU, (2008) Effects of cellular differentiation, chromosomal integration and 5-aza-2′-deoxycytidine treatment on human papillomavirus-16 DNA methylation in cultured cell lines. Virology 374: 292-303.
    • (2008) Virology , vol.374 , pp. 292-303
    • Kalantari, M.1    Lee, D.2    Calleja-Macias, I.E.3    Lambert, P.F.4    Bernard, H.U.5
  • 22
    • 0028267328 scopus 로고
    • Genome amplification of human papillomavirus types 16 and 18 in cervical carcinomas is related to the retention of E1/E2 genes
    • Berumen J, Casas L, Segura E, Amezcua JL, Garcia-Carranca A, (1994) Genome amplification of human papillomavirus types 16 and 18 in cervical carcinomas is related to the retention of E1/E2 genes. Int J Cancer 56: 640-645.
    • (1994) Int J Cancer , vol.56 , pp. 640-645
    • Berumen, J.1    Casas, L.2    Segura, E.3    Amezcua, J.L.4    Garcia-Carranca, A.5
  • 23
    • 0035812307 scopus 로고    scopus 로고
    • Asian-American variants of human papillomavirus 16 and risk for cervical cancer: a case-control study
    • Berumen J, Ordoñez RM, Lazcano E, Salmeron J, Galvan SC, et al. (2001) Asian-American variants of human papillomavirus 16 and risk for cervical cancer: a case-control study. J Natl Cancer Inst 93: 1325-1330.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 1325-1330
    • Berumen, J.1    Ordoñez, R.M.2    Lazcano, E.3    Salmeron, J.4    Galvan, S.C.5
  • 24
    • 0029815037 scopus 로고    scopus 로고
    • CpG methylation directly inhibits binding of the human papillomavirus type 16 E2 protein to specific DNA sequences
    • Thain A, Jenkins O, Clarke AR, Gaston K, (1996) CpG methylation directly inhibits binding of the human papillomavirus type 16 E2 protein to specific DNA sequences. J Virol 70: 7233-7235.
    • (1996) J Virol , vol.70 , pp. 7233-7235
    • Thain, A.1    Jenkins, O.2    Clarke, A.R.3    Gaston, K.4
  • 25
    • 0242661842 scopus 로고    scopus 로고
    • Methylation patterns of papillomavirus DNA, its influence on E2 function, and implications in viral infection
    • Kim K, Garner-Hamrick PA, Fisher C, Lee D, Lambert PF, (2003) Methylation patterns of papillomavirus DNA, its influence on E2 function, and implications in viral infection. J Virol 77: 12450-12459.
    • (2003) J Virol , vol.77 , pp. 12450-12459
    • Kim, K.1    Garner-Hamrick, P.A.2    Fisher, C.3    Lee, D.4    Lambert, P.F.5
  • 26
    • 61849085358 scopus 로고    scopus 로고
    • The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer
    • Fernandez AF, Rosales C, Lopez-Nieva P, Graña O, Ballestar E, et al. (2009) The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer. Genome Res 19: 438-451.
    • (2009) Genome Res , vol.19 , pp. 438-451
    • Fernandez, A.F.1    Rosales, C.2    Lopez-Nieva, P.3    Graña, O.4    Ballestar, E.5
  • 27
    • 67349204495 scopus 로고    scopus 로고
    • Distinct human papillomavirus type 16 methylomes in cervical cells at different stages of premalignancy
    • Brandsma JL, Sun Y, Lizardi PM, Tuck DP, Zelterman D, et al. (2009) Distinct human papillomavirus type 16 methylomes in cervical cells at different stages of premalignancy. Virology 389: 100-107.
    • (2009) Virology , vol.389 , pp. 100-107
    • Brandsma, J.L.1    Sun, Y.2    Lizardi, P.M.3    Tuck, D.P.4    Zelterman, D.5
  • 28
    • 40449129515 scopus 로고    scopus 로고
    • Integration of the HPV16 genome does not invariably result in high levels of viral oncogene transcripts
    • Häfner N, Driesch C, Gajda M, Jansen L, Kirchmayr R, et al. (2008) Integration of the HPV16 genome does not invariably result in high levels of viral oncogene transcripts. Oncogene 27: 1610-1617.
    • (2008) Oncogene , vol.27 , pp. 1610-1617
    • Häfner, N.1    Driesch, C.2    Gajda, M.3    Jansen, L.4    Kirchmayr, R.5
  • 29
    • 18244415256 scopus 로고    scopus 로고
    • Enhanced oncogenicity of Asian-American human papillomavirus 16 is associated with impaired E2 repression of E6/E7 oncogene transcription
    • Ordóñez RM, Espinosa AM, Sánchez-González DJ, Armendáriz-Borunda J, Berumen J, (2004) Enhanced oncogenicity of Asian-American human papillomavirus 16 is associated with impaired E2 repression of E6/E7 oncogene transcription. J Gen Virol 85: 1433-1444.
    • (2004) J Gen Virol , vol.85 , pp. 1433-1444
    • Ordóñez, R.M.1    Espinosa, A.M.2    Sánchez-González, D.J.3    Armendáriz-Borunda, J.4    Berumen, J.5
  • 30
    • 0031052028 scopus 로고    scopus 로고
    • Human papillomavirus type 16 sequence variation in cervical cancers: a worldwide perspective
    • Yamada T, Manos MM, Peto J, Greer CE, Munoz N, et al. (1997) Human papillomavirus type 16 sequence variation in cervical cancers: a worldwide perspective. J Virol 71: 2463-2472.
    • (1997) J Virol , vol.71 , pp. 2463-2472
    • Yamada, T.1    Manos, M.M.2    Peto, J.3    Greer, C.E.4    Munoz, N.5
  • 31
    • 0032893038 scopus 로고    scopus 로고
    • The E2 protein of human papillomavirus type 16 is translated from a variety of differentially spliced polycistronic mRNAs
    • Alloul N, Sherman L, (1999) The E2 protein of human papillomavirus type 16 is translated from a variety of differentially spliced polycistronic mRNAs. J Gen Virol 80 (Pt 1): 29-37.
    • (1999) J Gen Virol , vol.80 , Issue.Pt 1 , pp. 29-37
    • Alloul, N.1    Sherman, L.2
  • 32
    • 0038677462 scopus 로고    scopus 로고
    • A comprehensive analysis of HPV integration loci in anogenital lesions combining transcript and genome-based amplification techniques
    • Ziegert C, Wentzensen N, Vinokurova S, Kisseljov F, Einenkel J, et al. (2003) A comprehensive analysis of HPV integration loci in anogenital lesions combining transcript and genome-based amplification techniques. Oncogene 22: 3977-3984.
    • (2003) Oncogene , vol.22 , pp. 3977-3984
    • Ziegert, C.1    Wentzensen, N.2    Vinokurova, S.3    Kisseljov, F.4    Einenkel, J.5
  • 33
    • 0026548255 scopus 로고
    • Disruption of either the E1 or the E2 regulatory gene of human papillomavirus type 16 increases viral immortalization capacity
    • Romanczuk H, Howley PM, (1992) Disruption of either the E1 or the E2 regulatory gene of human papillomavirus type 16 increases viral immortalization capacity. Proc Natl Acad Sci U S A 89: 3159-3163.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 3159-3163
    • Romanczuk, H.1    Howley, P.M.2
  • 34
    • 0042552760 scopus 로고
    • Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer-derived cell line and identification of the E7 protein
    • Smotkin D, Wettstein FO, (1986) Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer-derived cell line and identification of the E7 protein. Proc Natl Acad Sci U S A 83: 4680-4684.
    • (1986) Proc Natl Acad Sci U S A , vol.83 , pp. 4680-4684
    • Smotkin, D.1    Wettstein, F.O.2
  • 35
    • 0028900490 scopus 로고
    • Integration of human papillomavirus type 16 DNA into the human genome leads to increased stability of E6 and E7 mRNAs: implications for cervical carcinogenesis
    • Jeon S, Lambert PF, (1995) Integration of human papillomavirus type 16 DNA into the human genome leads to increased stability of E6 and E7 mRNAs: implications for cervical carcinogenesis. Proc Natl Acad Sci U S A 92: 1654-1658.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 1654-1658
    • Jeon, S.1    Lambert, P.F.2
  • 36
    • 0038365277 scopus 로고    scopus 로고
    • CpG methylation of human papillomavirus type 16 DNA in cervical cancer cell lines and in clinical specimens: genomic hypomethylation correlates with carcinogenic progression
    • Badal V, Chuang LS, Tan EH, Badal S, Villa LL, et al. (2003) CpG methylation of human papillomavirus type 16 DNA in cervical cancer cell lines and in clinical specimens: genomic hypomethylation correlates with carcinogenic progression. J Virol 77: 6227-6234.
    • (2003) J Virol , vol.77 , pp. 6227-6234
    • Badal, V.1    Chuang, L.S.2    Tan, E.H.3    Badal, S.4    Villa, L.L.5
  • 37
    • 0023144684 scopus 로고
    • Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines
    • Baker CC, Phelps WC, Lindgren V, Braun MJ, Gonda MA, et al. (1987) Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines. J Virol 61: 962-971.
    • (1987) J Virol , vol.61 , pp. 962-971
    • Baker, C.C.1    Phelps, W.C.2    Lindgren, V.3    Braun, M.J.4    Gonda, M.A.5
  • 38
    • 4644332773 scopus 로고    scopus 로고
    • Clonal selection for transcriptionally active viral oncogenes during progression to cancer
    • Van Tine BA, Kappes JC, Banerjee NS, Knops J, Lai L, et al. (2004) Clonal selection for transcriptionally active viral oncogenes during progression to cancer. J Virol 78: 11172-11186.
    • (2004) J Virol , vol.78 , pp. 11172-11186
    • van Tine, B.A.1    Kappes, J.C.2    Banerjee, N.S.3    Knops, J.4    Lai, L.5
  • 39
    • 33744756020 scopus 로고    scopus 로고
    • Papillomavirus genome structure, expression, and post-transcriptional regulation
    • Zheng ZM, Baker CC, (2006) Papillomavirus genome structure, expression, and post-transcriptional regulation. Front Biosci 11: 2286-2302.
    • (2006) Front Biosci , vol.11 , pp. 2286-2302
    • Zheng, Z.M.1    Baker, C.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.