Mapping and characterization of the interaction domains of human papillomavirus type 16 E1 and E2 proteins

Journal of Virology

Volumn 71, Issue 2, 1997, Pages 891-899

  Yasugi, Toshiharu ^a   Benson, John D ^a   Sakai, Hiroyuki ^a   Vidal, Marc ^b   Howley, Peter M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS DNA; VIRUS PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; DNA REPLICATION; GENE MAPPING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; VIRUS GENE; WART VIRUS;

EID: 0031016642     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.2.891-899.1997     Document Type: Article

References (58)

1. Benson, J. D., and P. M. Howley. 1995. Amino-terminal domains of the bovine papillomavirus type 1 E1 and E2 proteins participate in complex formation. J. Virol. 69:4364-1372.
2. Bernard, B. A., C. Bailly, M. C. Lenoir, M. Darmon, F. Thierry, and M. Yaniv. 1989. The human papillomavirus type 18 (HPV18) E2 gene product is a represser of the HPV18 regulatory region in human keratinocytes. J. Virol. 63:4317-4324.
3. Blitz, I. L., and L. A. Laimins. 1991. The 68-kilodalton E1 protein of bovine papillomavirus is a DNA-binding phosphoprolein which associates with the E2 transcriptional activator in vitro. J. Virol. 65:649-656.
4. Boeke, J. D., F. LaCroute, and G. R. Fink. 1984. A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance. Mol. Gen. Genet. 197:345-346.
5. Bream, G. L., C. A. Ohmstede, and W. C. Phelps. 1993. Characterization of human papillomavirus type 11 E1 and E2 proteins expressed in insect cells. J. Virol. 67:2655-2663.
6. Clertant, P., and L Seif. 1984. A common function for polyoma virus large-T and papillomavirus E1 proteins. Nature 311:276-279.
7. Cripe, T. P., T. H. Haugen, J. P. Turk, F. Tabatabai, P. G. Schmid, M. Dürst, L. Gissmann, A. Roman, and L. Turek. 1987. Transcriptional regulation of the human papillomavirus-16 E6-E7 promoter by a keratinocyte-dependent enhancer, and by viral E2 trans-activator and reprcssor gene products: implications for cervical carcinogenesis. EMBO J. 6:3745-3753.
8. Danos, O., I. Giri, F. Thierry, and M. Yaniv. 1984. Papillomavirus genomes: sequences and consequences. J. Invest. Dermatol. 83(Suppl. 1):7-11.
9. DiMaio, D., and J. Settleman. 1988. Bovine papillomavirus mutant temperature sensitive for transformation, replication and transactivation. EMBO J. 7:1197-1204.
10. Fields, S., and O. Song. 1989. A novel genetic system to detect protein-protein interaction. Nature 340:245-246.
11. Frattini, M. G., and L. A. Laimins. 1994. The role of the E1 and E2 proteins in the replication of human papillomavirus type 31b. Virology 204:799-804.
12. Giri, I., and M. Yaniv. 1988. Structural and mutational analysis of E2 transactivating proteins of papillomaviruses reveals three distinct functional domains. EMBO J. 7:2823-2829.
13. Golemis, E. A., J. Gyuris, and R. Brent. 1995. Interaction trap / two-hybrid system to identify interaction proteins, unit 20.1. In F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.), Current protocols in molecular biology. John Wiley & Sons. Inc., New York, N.Y.
14. Gopalakrishnan, V., and S. A. Khan. 1994. E1 protein of human papillomavirus type 1a is sufficient for initiation of viral DNA replication. Proc. Natl, Acad. Sci. USA 91:9597-9601.
15. Guarante, L. 1983. Yeast promoters and LacZ fusions designed to study expression of cloned genes in yeast. Methods Enzymol. 101:181-193.
16. Hawley-Nelson, P., E. J. Androphy, D. R. Lowy, and J. T. Schiller. 1988. The specific DNA recognition sequence of the bovine papillomavirus E2 protein is an E2-dependent enhancer. EMBO J. 7:525-531.
17. Haugen, T. H., T. P. Cripe, G. D. Ginder, M. Karin, and L. P. Turek. 1987. Trans-activation of an upstream early gene promoter of bovine papilloma virus-1 by a product of the viral E2 gene. EMBO J. 6:145-152.
18. Hibma, M. H., K. Raj, S. J. Ely, M. Stanley, and L. Crawford. 1995. The interaction between human papillomavirus type 16 E1 and E2 proteins is blocked by an antibody to the N-terminal region of E2. Eur. J. Biochem. 229:517-525.
19. Howley, P. M. 1996. Papillomaviruses and their replication, p. 2045-2076. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), virology, 3rd ed. Lippincott-Raven Press, New York, N.Y.
20. Hughes, F. J., and M. A. Romanos. 1993. E1 protein of human papillomavirus is a DNA helicase/ATPase. Nucleic Acids Res. 21:5817-5823.
21. Huibregtse, J. M., M. Scheffner, and P. M. Howley. 1993. Cloning and expression of the cDNA for E6-AP: a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53. Mol. Cell. Biol. 13:775-784.
22. Kamens, J., P. Richardson, G. Mosialos, R. Brent, and T. Gilmore. 1990. Oncogenic transformation by v-rel requires an amino-terminal activation domain. Mol. Cell. Biol. 10:2840-2847.
23. Kuo, S. R., J. S. Liu, T. R. Broker, and L. T. Chow. 1994. Cell-free replication of the human papillomavirus DNA with homologous viral E1 and E2 proteins and human cell extracts. J. Biol. Chem. 269:24058-24065.
24. Le Moal, M. A., M. Yaniv, and F. Thierry. 1994. The bovine papillomavirus type 1 (BPV1) replication protein E1 modulates transcriptional activation by interacting with BPV1 E2. J. Virol. 68:1085-1093.
25. cdc2 phosphorylation site. J. Virol. 67:1414-1423.
26. Lusky, M., and E. Fontane. 1991. Formation of the complex of bovine papillomavirus E1 and E2 proteins is modulated by E2 phosphorylation and depends upon sequences within the carboxyl terminus of E1. Proc. Natl. Acad. Sci. USA 88:6363-6367.
27. McBride, A. A., H. Romanczuk, and P. M. Howley. 1991. The papillomavirus E2 regulatory proteins. J. Biol. Chem. 266:18411-18414.
28. McBride, A. A., J. C. Byrne, and P. M. Howley. 1989. E2 polypeptides encoded by bovine papillomavirus type 1 form dimers through the common carboxyl-terminal domain: transactivation is mediated by the conserved amino-terminal domain. Proc. Natl. Acad. Sci. USA 86:510-514.
29. McBride, A. A., R. Schlegel, and P. M. Howley. 1988. The carboxy-terminal domain shared by the bovine papillomavirus E2 transactivation and repressor proteins contains a specific DNA binding activity. EMBO J. 7:533-539.
30. Mohr, I. J., R. Clark, S. Sun, E. J. Androphy, P. MacPherson, and M. R. Botchan. 1990. Targeting the E1 replication protein to the papillomavirus origin of replication by complex formation with the E2 transactivator. Science 250:1694-1699.
31. Müller, F., and M. Sapp. 1996. Domains of the E1 protein of human papillomavirus type 33 involved in binding to the E2 protein. Virology 219:247-256.
32. Muller, F., Y. S. Seo, and J. Hurwitz. 1994. Replication of bovine papillmavirus type 1 origin-containing DNA in crude extracts and with purified proteins. J. Biol. Chem. 269:17086-17094.
33. Phelps, W. C., and P. M. Howley. 1987. Transcriptional transactivation by the human papillomavirus type 16 E2 gene product. J. Virol. 61:1630-1638.
34. Rabson, M. S., C. Yet, Y.-C. Yang, and P. M. Howley. 1986. Analysis of the bovine papillomavirus type 1 3′ early region transformation and plasmid maintenance functions. J. Virol. 60:626-634.
35. Romanczuk, H., F. Thierry, and P. M. Howley. 1990. Mutational analysis of cis elements involved in E2 modulation of human papillomavirus type 16 P97 and type 18 P105 promoters. J. Virol. 64:2849-2859.
36. Sakai, H., T. Yasugi, J. D. Benson, J. J. Dowhanick, and P. M. Howley. 1996. Targeted mutagenesis of the human papillomavirus type 16 E2 transactivation domain reveals separable transcriptional activation and DNA replication functions. J. Virol. 70:1602-1611.
37. Sandler, A. B., S. B. Vande Pol, and B. A. Spalholz. 1993. Repression of bovine papillomavirus type 1 transcription by the E1 replication protein. J. Virol. 67:5079-5087.
38. Sarafi, T. R., and A. A. McBride. 1995. Domains of the BPV-1 E1 replication protein required for origin-specific DNA binding and interaction with the E2 transactivator. Virology 211:385-396.
39. Sardet, C., M. Vidal, D. Cobrinik, Y. Geng, C. Onufryk, A. Chen, and R. A. Weinberg. 1995. E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. Proc. Natl. Acad. Sci. USA 92:2403-2407.
40. Seo, Y. S., F. Muller, M. Lusky, E. Gibbs, H. Y. Kim, B. Phillips, and J. Hurwitz. 1993. Bovine papillomavirus (BPV)-encoded E2 protein enhances binding of E1 protein to the BPV DNA replication origin. Proc. Natl. Acad. Sci. USA 90:2865-2869.
41. Seo, Y. S., F. Muller, M. Lusky, and J. Hurwitz. 1993. Bovine papillomavirus (BPV)-encoded E1 protein contains multiple activities required for BPV DNA replication. Proc. Natl. Acad. Sci. USA 90:702-706.
42. Shah, K. V., and P. M. Howley. 1996. Papillomaviruses, p. 2077-2110. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Virology, 3rd ed. Lippincott-Raven Press, New York, N.Y.
43. Smith, D. B., and L. M. Corcoran. 1995. Protein expression, p. 16.7.1-16.7.8. In F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.), Current protocols in molecular biology. John Wiley & Sons, Inc., New York, N.Y.
44. Spalholz, B. A., A. A. McBride, T. Sarafi, and J. Quintero. 1993. Binding of bovine papillomavirus E1 to the origin is not sufficient for DNA replication. Virology 193:201-212.
45. Spalholz, B. A., P. F. Lambert, C. L. Yee, and P. M. Howley. 1987. Bovine papillomavirus transcriptional regulation: localization of the E2-responsive elements of the long control region. J. Virol. 61:2128-2137.
46. Storey, A., A. Piccini, P. Massima, V. Bouvard, and L. Banks. 1995. Mutations in the human papillomavirus type 16 E2 protein identify a region of the protein involved in binding to E1 protein. J. Gen. Virol. 76:819-826.
47. Sun, S., L. Thorner, M. lentz, P. MacPherson, and M. Botchan. 1990. Identification of a 68-kilodalton nuclear ATP-binding phosphoprotein encoded by bovine papillomavirus type 1. J. Virol. 64:5093-5105.
48. Thierry, F., N. Dostatni, F. Arnos, and M. Yaniv. 1990 Cooperative activation of transcription by bovine papillomavirus type 1 E2 can occur over a large distance. Mol. Cell. Biol. 10:4431-1437.
49. Thierry, F., and M. Yaniv. 1987. The BPV1-E2 trans-acting protein can be either an activator or a repressor of the HPV18 regulatory region. EMBO J. 6:3391-3397.
50. Thorner, L. K., D. A. Lim, and M. R. Botchan. 1993. DNA-binding domain of bovine papillomavirus type 1 E1 helicase: structural and functional aspects. J. Virol. 67:6000-6014.
51. Treco, D. A., and F. Winston. 1995. Growth and manipulation of yeast, unit 13.2. In F. M. Ausubet, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.), Current protocols in molecular biology. John Wiley & Sons, Inc., New York, N.Y.
52. Ustav, M., and A. Stenlund. 1991. Transient replication of BPV-1 requires two viral polypeptides encoded by the E1 and E2 open reading frames. EMBO J. 10:449-457.
53. Ustav, M., E. Ustav, P. Szymanski, and A. Stenlund. 1991. Identification of the origin of replication of bovine papillomavirus and characterization of the viral origin recognition factor E1. EMBO J. 10:4321-4329.
54. Wilson, V. G., and J. Ludes-Meyers. 1991. A bovine papillomavirus E1-related protein binds specifically to bovine papillomavirus DNA. J. Virol. 65:5314-5322.
55. Yang, L., R. Li, I. J. Mohr, R. Clark, and M. R. Botchan. 1991. Activation of BPV-1 replication in vitro by the transcription factor E2. Nature 353:628-633.
56. Yang, L., I. Mohr, E. Fouts, D. A. Lim, M. Nohile, and M. Botchan. 1993. The E1 protein of the papillomavirus BPV-1 is an ATP dependent DNA helicase. Proc. Natl. Acad. Sci. USA 90:5086-5090.
57. Yasugi, T., J. D. Benson, H. Sakai, and P. M. Howley. Unpublished data.
58. Zervos, A. S., J. Gyuris, and R. Brent. 1993. Mxil, a protein that specifically interacts with Max to bind Myc-Max recognition sites. Cell 72:223-232.