Delayed white matter growth trajectory in young nonpsychotic siblings of patients with childhood-onset schizophrenia

Archives of General Psychiatry

Volumn 69, Issue 9, 2012, Pages 875-884

  Gogtay, Nitin ^a   Hua, Xue ^b   Stidd, Reva ^a   Boyle, Christina P ^b   Lee, Suh ^b   Weisinger, Brian ^a   Chavez, Alex ^a   Giedd, Jay N ^a   Clasen, Liv ^a   Toga, Arthur W ^b   Rapoport, Judith L ^a   Thompson, Paul M ^b  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; AGE; ARTICLE; BRAIN GROWTH; BRAIN MAPPING; CHILD; CHILDHOOD ONSET SCHIZOPHRENIA; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOPHENOTYPE; FEMALE; GRAY MATTER; GROWTH RATE; HUMAN; LONGITUDINAL STUDY; MALE; MORPHOMETRICS; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PARIETAL LOBE; SCHIZOPHRENIA; SIBLING; TENSOR BASED MORPHOMETRY; WHITE MATTER;

ADOLESCENT; ADULT; ALGORITHMS; BRAIN MAPPING; CEREBRAL CORTEX; CHILD; DIFFUSION TENSOR IMAGING; FEMALE; HUMANS; IMAGE ENHANCEMENT; IMAGE INTERPRETATION, COMPUTER-ASSISTED; IMAGING, THREE-DIMENSIONAL; LEUKOENCEPHALOPATHIES; LONGITUDINAL STUDIES; MALE; ORGAN SIZE; REFERENCE VALUES; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; YOUNG ADULT;

EID: 84866046475     PISSN: 0003990X     EISSN: 15383636     Source Type: Journal    
DOI: 10.1001/archgenpsychiatry.2011.2084     Document Type: Article

References (50)

1. Sullivan PF, Kendler KS, Neale MC. Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch Gen Psychiatry. 2003;60(12):1187-1192.
2. Gogtay N. Cortical brain development in schizophrenia: insights from neuroimaging studies in childhood-onset schizophrenia. Schizophr Bull. 2008;34(1):30-36.
3. Rapoport JL, Gogtay N. Childhood onset schizophrenia: support for a progressive neurodevelopmental disorder. Int J Dev Neurosci. 2011;29(3):251-258.
4. Wright IC, Rabe-Hesketh S, Woodruff PW, David AS, Murray RM, Bullmore ET. Meta-analysis of regional brain volumes in schizophrenia. Am J Psychiatry. 2000;157(1):16-25.
5. Lawrie SM, Abukmeil SS. Brain abnormality in schizophrenia: a systematic and quantitative review of volumetric magnetic resonance imaging studies. Br J Psychiatry. 1998;172:110-120.
6. Honea R, Crow TJ, Passingham D, Mackay CE. Regional deficits in brain volume in schizophrenia: a meta-analysis of voxel-based morphometry studies. Am J Psychiatry. 2005;162(12):2233-2245.
7. Shenton ME, Dickey CC, Frumin M, McCarley RW. A review of MRI findings in schizophrenia. Schizophr Res. 2001;49(1-2):1-52.
8. Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry. 2003;160(4):636-645.
9. Meyer-Lindenberg A, Weinberger DR. Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nat Rev Neurosci. 2006;7(10):818-827.
10. Boos HB, Aleman A, Cahn W, Hulshoff Pol H, Kahn RS. Brain volumes in relatives of patients with schizophrenia: ameta-analysis. Arch Gen Psychiatry. 2007;64(3):297-304.
11. Gogtay N, Ordonez A, Herman DH, Hayashi KM, Greenstein D, Vaituzis C, Lenane M, Clasen L, Sharp W, Giedd JN, Jung D, Nugent TF III, Toga AW, Leibenluft E, Thompson PM, Rapoport JL. Dynamic mapping of cortical development before and after the onset of pediatric bipolar illness. J Child Psychol Psychiatry. 2007;48(9):852-862.
12. Gogtay N, Greenstein D, Lenane M, Clasen L, Sharp W, Gochman P, Butler P, Evans A, Rapoport J. Cortical brain development in nonpsychotic siblings of patients with childhood-onset schizophrenia. Arch Gen Psychiatry. 2007;64(7):772-780.
13. Mattai AA, Weisinger B, Greenstein D, Stidd R, Clasen L, Miller R, Tossell JW, Rapoport JL, Gogtay N. Normalization of cortical gray matter deficits in nonpsychotic siblings of patients with childhood-onset schizophrenia. J Am Acad Child Adolesc Psychiatry. 2011;50(7):697-704.
14. Gogtay N, Vyas NS, Testa R, Wood SJ, Pantelis C. Age of onset of schizophrenia: perspectives from structural neuroimaging studies. Schizophr Bull. 2011;37(3):504-513.
15. Makris N, Seidman LJ, Ahern T, Kennedy DN, Caviness VS, Tsuang MT, Goldstein JM. White matter volume abnormalities and associations with symptomatology in schizophrenia. Psychiatry Res. 2010;183(1):21-29.
16. Skudlarski P, Jagannathan K, Anderson K, Stevens MC, Calhoun VD, Skudlarska BA, Pearlson G. Brain connectivity is not only lower but different in schizophrenia: a combined anatomical and functional approach. Biol Psychiatry. 2010;68(1):61-69.
17. Peters BD, Blaas J, de Haan L. Diffusion tensor imaging in the early phase of schizophrenia: what have we learned? J Psychiatr Res. 2010;44(15):993-1004.
18. Pérez-Iglesias R, Tordesillas-Gutiérrez D, Barker GJ, McGuire PK, Roiz-Santiañez R, Mata I, de Lucas EM, Quintana F, Vazquez-Barquero JL, Crespo-Facorro B. White matter defects in first episode psychosis patients: a voxelwise analysis of diffusion tensor imaging. Neuroimage. 2010;49(1):199-204.
19. Pérez-Iglesias R, Tordesillas-Gutiérrez D, McGuire PK, Barker GJ, Roiz-Santiañez R, Mata I, de Lucas EM, Rodríguez- Sánchez JM, Ayesa-Arriola R, Vazquez-Barquero JL, Crespo-Facorro B. White matter integrity and cognitive impairment in first-episode psychosis. Am J Psychiatry. 2010;167(4):451-458.
20. Kubicki M, McCarley R, Westin CF, Park HJ, Maier S, Kikinis R, Jolesz FA, Shenton ME. A review of diffusion tensor imaging studies in schizophrenia. J Psychiatr Res. 2007;41(1-2):15-30.
21. Ashtari M, Cottone J, Ardekani BA, Cervellione K, Szeszko PR, Wu J, Chen S, Kumra S. Disruption of white matter integrity in the inferior longitudinal fasciculus in adolescents with schizophrenia as revealed by fiber tractography. Arch Gen Psychiatry. 2007;64(11):1270-1280.
22. Gogtay N, Lu A, Leow AD, Klunder AD, Lee AD, Chavez A, Greenstein D, Giedd JN, Toga AW, Rapoport JL, Thompson PM. Three-dimensional brain growth abnormalities in childhood-onset schizophrenia visualized by using tensor-based morphometry. Proc Natl Acad Sci U S A. 2008;105(41):15979-15984.
23. Hulshoff Pol HE, Schnack HG, Mandl RC, Brans RG, van Haren NE, Baaré WF, van Oel CJ, Collins DL, Evans AC, Kahn RS. Gray and white matter density changes in monozygotic and same-sex dizygotic twins discordant for schizophrenia using voxel-based morphometry. Neuroimage. 2006;31(2):482-488.
24. Brans RG, van Haren NE, van Baal GC, Schnack HG, Kahn RS, Hulshoff Pol HE. Heritability of changes in brain volume over time in twin pairs discordant for schizophrenia. Arch Gen Psychiatry. 2008;65(11):1259-1268.
25. Brans RG, van Haren NE, van Baal GC, Staal WG, Schnack HG, Kahn RS, Hulshoff Pol HE. Longitudinal MRI study in schizophrenia patients and their healthy siblings. Br J Psychiatry. 2008;193(5):422-423.
26. Boos HB, Mandl RC, van Haren NE, Cahn W, van Baal GC, Kahn RS, Hulshoff Pol H. Tract-based diffusion tensor imaging in patients with schizophrenia and their non-psychotic siblings. Eur Neuropsychopharmacol. In press.
27. Hua X, Leow AD, Levitt JG, Caplan R, Thompson PM, Toga AW. Detecting brain growth patterns in normal children using tensor-based morphometry. Hum Brain Mapp. 2009;30(1):209-219.
28. Andreasen NC. Methods for assessing positive and negative symptoms. Mod Probl Pharmacopsychiatry. 1990;24:73-88.
29. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed, text revision. Washington, DC: American Psychiatric Association; 2000.
30. Hollingshead AB. Four Factor Index for Social Status. New Haven, CT: Yale University; 1975.
31. Leung K, Parker DS, Cunha A, Dinov I, Toga AW. IRMA: An image registration meta-algorithm evaluating alternative algorithms with multiple metrices. Sci Stat Database Manag. 2008;5069(Lecture Notes in Computer Science):612-617. doi:10.1007/978-3-540-69497-7-46.
32. Dinov I, Lozev K, Petrosyan P, Liu Z, Eggert P, Pierce J, Zamanyan A, Chakrapani S, Van Horn J, Parker DS, Magsipoc R, Leung K, Gutman B, Woods R, Toga A. Neuroimaging study designs, computational analyses and data provenance using the LONI pipeline. PLoS One. 2010;5(9). doi:10.1371/journal.pone.0013070.
33. Sled JG, Zijdenbos AP, Evans AC. A nonparametric method for automatic correction of intensity nonuniformity in MRI data. IEEE Trans Med Imaging. 1998;17(1):87-97.
34. Holmes CJ, Hoge R, Collins L, Woods R, Toga AW, Evans AC. Enhancement of MR images using registration for signal averaging. J Comput Assist Tomogr. 1998;22(2):324-333.
35. Leow A, Huang SC, Geng A, Becker J, Davis S, Toga A, Thompson P. Inverse consistent mapping in 3D deformable image registration: its construction and statistical properties. Inf Process Med Imaging. 2005;19:493-503.
36. Kochunov P, Lancaster J, Thompson P, Toga AW, Brewer P, Hardies J, Fox P. An optimized individual target brain in the Talairach coordinate system. Neuroimage. 2002;17(2):922-927.
37. Leow AD, Klunder AD, Jack CR Jr, Toga AW, Dale AM, Bernstein MA, Britson PJ, Gunter JL, Ward CP, Whitwell JL, Borowski BJ, Fleisher AS, Fox NC, Harvey D, Kornak J, Schuff N, Studholme C, Alexander GE, Weiner MW, Thompson PM; ADNI Preparatory Phase Study. Longitudinal stability of MRI for mapping brain change using tensor-based morphometry. Neuroimage. 2006;31(2):627-640.
38. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Series B Stat Methodol. 1995;57:289-300.
39. Mitelman SA, Brickman AM, Shihabuddin L, Newmark RE, Hazlett EA, Haznedar MM, Buchsbaum MS. A comprehensive assessment of gray and white matter volumes and their relationship to outcome and severity in schizophrenia. Neuroimage. 2007;37(2):449-462.
40. Tanskanen P, Haapea M, Veijola J, Miettunen J, Järvelin MR, Pyhtinen J, Jones PB, Isohanni M. Volumes of brain, grey and white matter and cerebrospinal fluid in schizophrenia in the Northern Finland 1966 Birth Cohort: an epidemiological approach to analysis. Psychiatry Res. 2009;174(2):116-120.
41. Bartzokis G, Nuechterlein KH, Lu PH, Gitlin M, Rogers S, Mintz J. Dysregulated brain development in adult men with schizophrenia: a magnetic resonance imaging study. Biol Psychiatry. 2003;53(5):412-421.
42. Boos HB, Cahn W, van Haren NE, Derks EM, Brouwer RM, Schnack HG, Hulshoff Pol HE, Kahn RS. Focal and global brain measurements in siblings of patients with schizophrenia [published online January 17, 2011]. Schizophr Bull. doi:10.1093/schbul/sbq147.
43. Cannon TD, van Erp TG, Huttunen M, Lönnqvist J, Salonen O, Valanne L, Poutanen VP, Standertskjöld-Nordenstam CG, Gur RE, Yan M. Regional gray matter, white matter, and cerebrospinal fluid distributions in schizophrenic patients, their siblings, and controls. Arch Gen Psychiatry. 1998;55(12):1084-1091.
44. Goldman AL, Pezawas L, Mattay VS, Fischl B, Verchinski BA, Zoltick B, Weinberger DR, Meyer-Lindenberg A. Heritability of brain morphology related to schizophrenia: a large-scale automated magnetic resonance imaging segmentation study. Biol Psychiatry. 2008;63(5):475-483.
45. Staal WG, Hulshoff Pol HE, Schnack HG, Hoogendoorn ML, Jellema K, Kahn RS. Structural brain abnormalities in patients with schizophrenia and their healthy siblings. Am J Psychiatry. 2000;157(3):416-421.
46. Calabrese DR, Wang L, Harms MP, Ratnanather JT, Barch DM, Cloninger CR, Thompson PA, Miller MI, Csernansky JG. Cingulate gyrus neuroanatomy in schizophrenia subjects and their non-psychotic siblings. Schizophr Res. 2008;104(1-3):61-70.
47. Hao Y, Yan Q, Liu H, Xu L, Xue Z, Song X, Kaneko Y, Jiang T, Liu Z, Shan B. Schizophrenia patients and their healthy siblings share disruption of white matter integrity in the left prefrontal cortex and the hippocampus but not the anterior cingulate cortex. Schizophr Res. 2009;114(1-3):128-135.
48. Greenstein D, Lerch J, Shaw P, Clasen L, Giedd J, Gochman P, Rapoport J, Gogtay N. Childhood onset schizophrenia: cortical brain abnormalities as young adults. J Child Psychol Psychiatry. 2006;47(10):1003-1012.
49. Gutman B, Svarer C, Leow AD, Yanovsky I, Toga AW, Thompson PM. Creating Unbiased Minimal Deformation Templates for Brain Volume Registration. Barcelona, Spain: Organization for Human Brain Mapping; 2010.
50. Kochunov P, Lancaster JL, Thompson P, Woods R, Mazziotta J, Hardies J, Fox P. Regional spatial normalization: toward an optimal target. J Comput Assist Tomogr. 2001;25(5):805-816.