Phase II study of Ginkgo biloba in irradiated brain tumor patients: Effect on cognitive function, quality of life, and mood

Journal of Neuro-Oncology

Volumn 109, Issue 2, 2012, Pages 357-363

  Attia, Albert ^a   Rapp, Stephen R ^a   Case, L Doug ^a   D'Agostino, Ralph ^a   Lesser, Glenn ^a   Naughton, Michelle ^a   McMullen, Kevin ^b   Rosdhal, Robin ^a   Shaw, Edward G ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY   (United States)

Author keywords

Brain tumors; Cognitive function; Ginkgo biloba; Quality of life; Radiation

Indexed keywords

GINKGO BILOBA EXTRACT;

ADULT; AGED; ATTENTION; BRAIN HEMORRHAGE; BRAIN TUMOR; CALIFORNIA VERBAL LEARNING TEST PART II; CANCER RADIOTHERAPY; CANCER SURVIVOR; CLINICAL ARTICLE; COGNITION; COGNITIVE DEFECT; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIFFICULTY FINDING THE RIGHT WORDS; DRUG WITHDRAWAL; EXECUTIVE FUNCTION; F A S TEST; FATIGUE; FEMALE; FINGER SPAN TEST; FUNCTIONAL ASSESSMENT OF CANCER THERAPY BRAIN; GASTROINTESTINAL SYMPTOM; HUMAN; KARNOFSKY PERFORMANCE STATUS; LIFE EXPECTANCY; MALE; MEMORY; MEMORY DISORDER; MENTAL CONCENTRATION; MINI MENTAL STATE EXAMINATION; MODIFIED REY OSTERRIETH COMPLEX FIGURE; MOOD; NAUSEA; NEUROLOGIC DISEASE; PHASE 2 CLINICAL TRIAL; PROFILE OF MOOD STATES; PSYCHOLOGIC TEST; QUALITY OF LIFE; RATING SCALE; SPEECH DISORDER; TUMOR GROWTH;

ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; BRAIN NEOPLASMS; COGNITION DISORDERS; FEMALE; FOLLOW-UP STUDIES; GINKGO BILOBA; HUMANS; MALE; MIDDLE AGED; MOOD DISORDERS; NEUROPSYCHOLOGICAL TESTS; PHYTOTHERAPY; PLANT PREPARATIONS; QUALITY OF LIFE; SEVERITY OF ILLNESS INDEX; TIME FACTORS;

EID: 84866028077     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-012-0901-9     Document Type: Conference Paper

References (44)

1. Loeffler JS, Patchell RA, Sawaya R (1999) Metastatic brain cancer. In: DeVita VT, JR, Hellman S, Rosenberg SA (eds) Cancer principles and practice of oncology, 5th edn. Lippencott, Raven, pp 2523-2535
2. Patchell RA (1997) Brain metastases. In: Black Peter McL, Loeffler JS (eds) Cancer of the nervous system. Blackwell, Cambridge, pp 653-663
3. Siegel R, Naishadham D, Jemal A (2012) Cancer statistics, 2012. CA Cancer J Clin 62(1):10-29
4. DeAngelis LM, Delattre J, Posner JB (1989) Radiation-induced dementia in patients cured of metastases. Neurology 39:789-796 (Pubitemid 19150153)
5. Crossen JR, Garwood D, Glatstein E, Neuwelt E (1994) Neurobehavioral sequelae of cranial irradiation in adults: a review of radiation-induced encephalopathy. J Clin Oncol 12(3):627-642 (Pubitemid 24079908)
6. Laukkanen E, Klonof H, Allan B et al (1988) The role of prophylactic brain irradiation in limited stage small-cell lung cancer: clinical, neuropsychological, and CT sequelae. Int J Radiat Oncol Biol Phys 14:1109-1117
7. Johnson BE, Becker B, Goff WB et al (1985) Neurologic, neuropsychologic, and computed cranial tomography scan abnormalities in 2-to 10-year survivors of small-cell lung cancer. J Clin Oncol 3:1659-1667 (Pubitemid 16199217)
8. Kiebert GM, Curran D, Aaronson NK et al (1998) Quality of life after radiation therapy of cerebral low-grade gliomas of the adult: results of randomized phase III trial on dose response (EORTC trial 22844). EORTC radiotherapy co-operative group. Eur J Cancer 34(12):1902-1909 (Pubitemid 28535439)
9. Archibald YM, Lunn D, Ruttan LA et al (1994) Cognitive functioning in long-term survivors of high-grade glioma. J Neurosurg 80:247-253 (Pubitemid 24036495)
10. Meyers CA, Boake C (1993) Neurobehavioral disorders in brain tumor patients: rehabilitation strategies. Cancer Bull 45:362-364 (Pubitemid 23262154)
11. Imperato JP, Paleologos NA, Vick NA (1990) Effects of treatment on long term survivors with malignant astrocytomas. Ann Neurol 28:818-822
12. Chang EL, Wefel JS, Hess KR et al (2009) Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial. Lancet Oncol 10:1037-1044
13. Weitzner MA, Meyers CA (1977) Cognitive functioning and quality of life in malignant glioma patients: a review of the literature. Psycho-Oncol 6(3):169-177
14. Corn BW, Yousem D, Scott CB et al (1994) White matter changes are correlated significantly with radiation dose: observations from randomized dose-escalation trial for malignant glioma (radiation therapy oncology group 83-02). Cancer 74:2828-2835 (Pubitemid 24340551)
15. Fazekas F, Chawluk JB, Alavi A et al (1987) MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. Am J Roentgenol 8:421-426 (Pubitemid 17075726)
16. Rogers SL, Doody RS, Mohs RC et al (1998) Donepezil improves cognition and global function in Alzheimer's disease. Arch Int Med 158:1021-1031
17. Le Bars PL, Katz MM, Berman N et al (1997) A placebo-controlled, double-blinded, randomized trial of an extract of Ginkgo biloba for dementia. JAMA 278:1327-1332 (Pubitemid 27449692)
18. Jorm AF, Rodgers B, Christensen H (2004) Use of medications to enhance memory in a large community sample of 60-64 year olds. Int Psychogeriatr 16:209-217 (Pubitemid 38963107)
19. DeKosky ST, Williamson JD, Fitzpatrick AL et al (2008) Ginkgo biloba for prevention of dementia: a randomized controlled trial. JAMA 300(19):2253-2262
20. Snitz BE, O'Meara ES, Carlson MC et al (2009) Ginkgo biloba for preventing cognitive decline in older adults: a randomized trial. JAMA 302:2663-2670
21. Folstein MF, Folstein SE, McHugh PR (1975) "Mini Mental State": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189-198
22. Reitan R (1958) Validity of the Trail Making Test as an indicator of organic brain damage. Percept Mot Skills 8:271-276
23. Wechsler D (1981) Wechsler adult intelligence scale-revised. Psychological Corporation, New York
24. Fastenau PS, Denburg NL, Hufford BJ (1999) Adult norms for the Rey-Osterrieth Complex Figure Test and for supplemental recognition and matching trials from the Extended Complex Figure Test. Clin Neuropsychol 13:30-47 (Pubitemid 29391492)
25. Benton AL, Hamsher K (1983) Multilingual aphasia examination. AJA Associates, Iowa City
26. Delis DC, Kramer JH, Kaplan E et al (2000) California Verbal Learning Test-II. Psychological Corporation, New York
27. Weitzner MA, Meyers CA, Gelke CK et al (1995) The Functional Assessment of Cancer Therapy (FACT) scale: development of a brain subscale and revalidation of the general version (FACT-G) in patients with primary brain tumors. Cancer 75:1151-1161
28. McNair DM, Lorr M, Droppleman LF (1992) Profile of mood states manual. Educational and Industrial Testing Service, San Diego
29. Bak JS, Green RL (1980) Changes in neuropsychological functioning in an aging population. J Consult Clin Psychol 48:395-399 (Pubitemid 10058424)
30. Dupont WD, Plummer WD Jr (1990) Power and sample size calculations: a review and computer program. Control Clin Trials 11:116-128 (Pubitemid 20136185)
31. Kleijnen J, Knipschild P (1992) Ginkgo biloba. Lancet 340:1136-1474
32. Cott J (1995) Natural product formulations available in Europe for psychotropic indications. Psychopharmacol Bull 31:745-751 (Pubitemid 26094430)
33. Ni Y, Zhao B, Hou J, Xin W (1996) Preventative effects of Ginkgo biloba extract on apoptosis in rats cerebellar neuronal cells induced by hydroxyl radicals. Neurosci Lett 214:115-118 (Pubitemid 26284445)
34. Oyama Y, Chikahisa L, Ueha T et al (1996) Ginkgo biloba extract protects brain neurons against oxidative stress induced by hydrogen peroxide. Brain Res 712:349-352 (Pubitemid 26106099)
35. Klein J, Chatterjee SS, Löffelholz K (1997) Phospholipid breakdown and choline release under hypoxic conditions: inhibition by bilobalide, a constituent of Ginkgo biloba. Brain Res 755:347-350 (Pubitemid 27196343)
36. Emerit I, Arutyunyan R, Oganesian N et al (1995) Radiationinduced clastogenic factors: anti-clastogenic effect of Ginkgo biloba extract. Free Radical Biol Med 18:985-991
37. Dumont E, Petit E, Tarrade T et al (1992) UV-C irradiationinduced peroxidative degradation of microsomal fatty acids in proteins: protection by an extract of Ginkgo biloba. Free Radical Biol Med 13:197-203
38. Regine WF, Schmitt FA, Scott CB et al (2004) Feasibility of neurocognitive outcome evaluations in patients with brain metastases in a multi-institutional cooperative group setting: results of Radiation Therapy Oncology Group trial BR-0018. Int J Radiat Oncol Biol Phys 58:1346-1352 (Pubitemid 38438293)
39. Kondziolka D, Niranjan A, Flickinger JC et al (2005) Radiosurgery with or without whole-brain radiotherapy for brain metastases: the patients' perspective regarding complications. Am J Clin Oncol 28:173-179
40. Duffner PK (2004) Long-term effects of radiation therapy on cognitive and endocrine function in children with leukemia and brain tumors. Neurologist 10:293-310 (Pubitemid 39492075)
41. Levin VA, Yung WK, Bruner J et al (2002) Phase II study of accelerated fractionation radiation therapy with carboplatin followed by PCV chemotherapy for the treatment of anaplastic gliomas. Int J Radiat Oncol Biol Phys 53:58-66 (Pubitemid 34465808)
42. Weitzner MA, Meyers CA, Valentine AD (1995) Methylphenidate in the treatment of neurobehavioral slowing associated with cancer and cancer treatment. J Neuropsychiatry Clin Neurosci 7:347-350
43. Meyers CA, Weitzner MA, Valentine AD et al (1998) Methylphenidate therapy improves cognition, mood, and function of brain tumor patients. J Clin Oncol 16:2522-2527 (Pubitemid 28309050)
44. McCaffrey RJ, Westervelt HJ (1995) Issues associated with repeated neuropsychological assessments. Neuropsychol Rev 5:203-221 (Pubitemid 26114648)