Phospholipid breakdown and choline release under hypoxic conditions: Inhibition by bilobalide, a constituent of Ginkgo biloba

Brain Research

Volumn 755, Issue 2, 1997, Pages 347-350

  Klein, Jochen ^a   Chatterjee, Shyam S ^b   Löffelholz, Konrad ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b Section of Pharmacology   (Germany)

Author keywords

bilobalide; choline; Ginkgo biloba; hippocampal slice; hypoxia

Indexed keywords

BILOBALIDE; GINKGO BILOBA EXTRACT;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; HIPPOCAMPUS; HYPOXIA; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PHOSPHOLIPID METABOLISM; PRIORITY JOURNAL; RAT;

ANIMALS; CHOLINE; CYCLOPENTANES; DITERPENES; DRUG EVALUATION, PRECLINICAL; FURANS; GINKGOLIDES; HIPPOCAMPUS; HYPOXIA, BRAIN; LOGISTIC MODELS; MALE; PHOSPHOLIPIDS; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, WISTAR;

EID: 0030907753     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00239-4     Document Type: Article

References (26)

1. N.G. Bazan Jr., Effects of ischemia and electroconvulsic shock on free fatty acid pool in the brain, Biochim. Biophys. Acta 218 (1970) 1-10.
2. A. Beley, N. Bertrand, P. Beley, Cerebral ischemia: changes in brain choline, acetylcholine, and other monoamines as related to energy metabolism, Neurochem. Res. 16 (1991) 555-561.
3. P. Braquet, M. Braquet, M. Koltai, R. Bourgain, F. Bussolino, D. Hosford, Is there a case for PAF antagonists in the treatment of ischemic states?, Trends Pharmacol. Sci. 10 (1989) 23-30.
4. Chatterjee, S.S., Gabard, B.L. and Jaggy, H.E.W., Pharmaceutical compositions containing bilobalide for the treatment of neuropathies, US patent No. 4,571,407 (Feb 18, 1986).
5. DeFeudis, F.V., Ginkgo biloba Extract (EGb761): Pharmacological Activities and Clinical Applications, Elsevier, Paris, 1991.
6. B. Djuricic, S.R. Olson, H.M. Assaf, T.S. Whittingham, W.D. Lust, L.R. Drewes, Formation of free choline in brain tissue during in vitro energy deprivation, J. Cereb. Blood Flow Metab. 11 (1991) 308-313.
7. A. Dumuis, M. Sebben, L. Haynes, J.-P. Pin, J. Bockaert, NMDA receptors activate the arachidonic acid cascade system in striatal neurons, Nature 336 (1988) 68-70.
8. J.B. Fourtillan, A.M. Brisson, J. Girault, I. Ingrand, J.P. Decourt, K. Drieu, P. Jouenne, A. Biber, Pharmacokinetic properties of Bilobalide and Ginkogolides A and B in healthy subjects after intravenous and oral administration of Gingko biloba extract (EGb 761), Therapie 50 (1995) 137-144.
9. T. Holler, E. Cappel, J. Klein, K. Löffelholz, Glutamate activates phospholipase D in hippocampal slices of newborn and adult rats, J. Neurochem. 61 (1993) 1569-1572.
10. M. Israel, B. Lesbats, Application to mammalian tissues of the chemiluminescent method for detecting acetylcholine, J. Neurochem 39 (1982) 248-250.
11. D. Janssens, C. Michiels, E. Delaive, F. Eliaers, K. Drieu, J. Remacle, Protection of hypoxia-induced ATP decrease in endothelial cells by Ginkgo biloba extract and bilobalide, Biochem. Pharmacol. 50 (1995) 991-999.
12. L. Karcher, P. Zagermann, J. Krieglstein, Effect of an extract of Ginkgo biloba on rat brain energy metabolism in hypoxia, Naunyn-Schmiedeberg's Arch. Pharmacol. 327 (1984) 31-35.
13. 2 and C activation during ischemia, J. Neurochem. 61 (1993) 1677-1684.
14. J. Klein, R. Gonzalez, A. Köppen, K. Löffelholz, Free choline and choline metabolites in rat brain and body fluids: sensitive determination and implications for choline supply to the brain, Neurochem. Int. 22 (1993) 293-300.
15. 2 but not from phospholipase D, Brain Res. 630 (1993) 337-340.
16. M. Kozuka, Changes in brain energy metabolism, neuotransmitters, and choline during and after incomplete cerebral ischemia in spontaneously hypertensive rats, Neurochem. Res. 20 (1995) 23-30.
17. J. Krieglstein, T. Beck, A. Seibert, Influence of an extract of Ginkgo biloba on cerebral blood flow and metabolism, Life Sci. 39 (1986) 2327-2334.
18. Y. Kumagae, Y. Matsui, Output, tissue levels, and synthesis of acetylcholine during and after transient forebrain ischemia in the rat, J. Neurochem. 56 (1991) 1169-1173.
19. H. Ladinsky, S. Consolo, A. Zatta, A. Vezzani, Mode of action of gamma-butyrolactone on the central cholinergic system, Naunyn-Schmiedeberg's Arch. Pharmacol. 332 (1983) 42-48.
20. H. Oberpichler, T. Beck, M.M. Abdel-Rahman, B.W. Bielenberg, J. Krieglstein, Effects of Ginkgo biloba constituents related to protection against brain damage caused by hypoxia, Pharmacol. Res. Commun. 20 (1988) 349-368.
21. H. Oberpichler, D. Sauer, C. Rossberg, H.D. Mennel, J. Krieglstein, PAF-antagonist ginkgolide B reduces postischemic neuronal damage in rat brain hippocampus, J. Cereb. Blood Flow Metab. 10 (1990) 133-135.
22. M. Otani, S.S. Chatterjee, B. Gabara, G.W. Kreutzberg, Effect of an extract of Ginkgo biloba on triethyltin-induced cerebral edema, Acta Neuropathol. 69 (1986) 54-65.
23. 2) activity in gerbil brain: enhanced activities of cytosolic, mitochondrial, and microsomal forms after ischemia and reperfusion, J. Neurosci. 11 (1991) 1829-1836.
24. O.U. Scremin, D.J. Jenden, Focal ischemia enhances choline output and decreases acetylcholine output from rat cerebral cortex, Stroke 20 (1989) 92-95.
25. Siesjö, B.K., Katsura, K., Pahlmark, K. and Smith, M.-L., The multiple causes of ischemic brain damage: a speculative synthesis. In J. Krieglstein and H. Oberpichler-Schwenk (Eds.), Pharmacology of Cerebral Ischemia 1992, Wissenschaftliche Verlagsgesellschaft, Stuttgart, 1992, pp. 511-525.
26. 2 by cyanide in PC12 cells, Toxicol. Appl. Pharmacol. 124 (1994) 262-267.