Kinetics of T Helper Subsets and Associated Cytokines Correlate Well with the Clinical Activity of Graft-Versus-Host Disease

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Yeh, Su Peng ^a,b   Liao, Yu Min ^a   Lo, Wen Jyi ^a   Lin, Chiao Lin ^a   Bai, Li Yuan ^a,b   Lin, Chen Yuan ^a   Hsieh, Ching Yun ^a   Chang, Yu Chien ^a   Huang, Yu Ting ^a   Chiu, Chang Fang ^a,b  

^a CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4;

ALLOGENEIC PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; DISEASE COURSE; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GRAFT VERSUS HOST REACTION; HELPER CELL; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KINETICS; LIVER INJURY; LYMPHOCYTE SUBPOPULATION; NONHUMAN; PATHOGENESIS; PROSPECTIVE STUDY; TH1 CELL; TH2 CELL;

ANIMALS; BIOLOGICAL MARKERS; CYTOKINES; FLOW CYTOMETRY; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; INTERFERON-GAMMA; INTERFERONS; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-4; KINETICS; T-LYMPHOCYTES, HELPER-INDUCER; TH1 CELLS; TH2 CELLS; TIME FACTORS;

ANIMALIA;

EID: 84866027623     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0044416     Document Type: Article

References (43)

1. Korngold, B. & Sprent, (1978) J (1978) Lethal graft-versus-host disease after bone marrow transplantation across minor histocompatibility barriers in mice. Prevention by removing mature T cells from marrow. J Exp Med 148: 1687-1698.
2. Kernan NA, Collins NH, Juliano LL, Cartagena TT, Dupont BB, et al. (1986) Clonable T lymphocytes in T cell-depleted bone marrow transplants correlate with development of graft-v-host disease. Blood 68: 770-773.
3. Antin JH, Ferrara JLM, (1992) Cytokine dysregulation in acute graft-versus-host disease. Blood 80: 2964-8.
4. Abbas AK, Murphy KM, Sher A, (1996) Functional diversity of helper T lymphocytes. Nature 383: 787-793.
5. Abdallah AN, Boiron JM, Attia Y, Cassaigne A, Reiffers J, et al. (1997) Plasma cytokines in graft vs host disease and complications following bone marrow transplantation. Hematol Cell Ther 3: 27-32.
6. De Wit D, Van Mechelen M, Zanin C, Doutrelepont JM, Velu T, et al. (1993) Preferential activation of Th2 cells in chronic graft-versus-host reaction. J Immunol 150: 361-6.
7. Allen RD, Staley TH, Sidman CL, (1993) Differential cytokine expression in acute and chronic murine graft-versus-host-disease, Eur J Immunol. 23: 333-7.
8. Morel PA, Oriss TB, (1998) Crossregulation between Th1 and Th2 cells. Critical Reviews in Immunol 18: 275-303.
9. Murphy KM, Reiner SL, (2002) The lineage decisions of helper T cells. Nature Review Immunol 2: 933-944.
10. Tanaka J, Imamura M, Kasai M, Hashino S, Kobayashi S, et al. (1997) The important balance between cytokines derived from type 1 and type 2 helper T cells in the control of graft-versus-host disease. Bone Marrow Transplant 19(6): 571-6.
11. Sakata N, Yasui M, Okamura T, Inoue M, Yumura-Yagi K, et al. (2001) Kinetics of plasma cytokines after hematopoietic stem cell transplantation from unrelated donors: the ratio of plasma IL-10/sTNFR level as a potential prognostic marker in severe acute graft-versus-host disease. Bone Marrow Transplant 27(11): 1153-1161.
12. Min CK, Lee WY, Min DJ, Lee DG, Kim YJ, et al. (2001) The kinetics of circulating cytokines including IL-6, TNF-alpha, IL-8 and IL-10 following allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 28(10): 935-940.
13. Chik KW, Li K, Pong H, Shing MM, Li CK, et al. (2003) Elevated serum interleukin-15 level in acute graft-versus-host disease after hematopoietic cell transplantation. J Pediatr Hematol Oncol. 25(12): 960-964.
14. Visentainer JE, Lieber SR, Persoli LB, Vigorito AC, Aranha FJ, et al. (2003) Serum cytokine levels and acute graft-versus-host disease after HLA-identical hematopoietic stem cell transplantation. Exp Hematol. 31(11): 1044-1150.
15. Remberger M, Jaksch M, Uzunel M, Mattsson J, (2003) Serum levels of cytokines correlate to donor chimerism and acute graft-vs.-host disease after haematopoietic stem cell transplantation. Eur J Haematol. 70(6): 384-391.
16. Fujii N, Hiraki A, Aoe K, Murakami T, Ikeda K, et al. (2006) Serum cytokine concentrations and acute graft-versus-host disease after allogeneic peripheral blood stem cell transplantation: concurrent measurement of ten cytokines and their respective ratios using cytometric bead array. Int J Mol Med. 17(5): 881-885.
17. Imamura M, Hashino S, Kobayashi H, Kubayashi S, Hirano S, et al. (1994) Serum cytokine levels in bone marrow transplantation: synergistic interaction of interleukin-6, interferon-gamma, and tumor necrosis factor-alpha in graft-versus-host disease. Bone Marrow Transplant. 13(6): 745-751.
18. Nakamura H, Komatsu K, Ayaki M, Kawamoto S, Murakami M, et al. (2000) Serum levels of soluble IL-2 receptor, IL-12, IL-18, and IFN-gamma in patients with acute graft-versus-host disease after allogeneic bone marrow transplantation. J Allergy Clin Immunol 106(1 Pt 2): S45-50.
19. Kayaba H, Hirokawa M, Watanabe A, Saitoh N, Changhao C, et al. (2000) Serum markers of graft-versus-host disease after bone marrow transplantation. J Allergy Clin Immunol. 106(1 Pt 2): S40-45.
20. Couper KN, Blount DG, Riley EM, (2008) IL-10: the master regulator of immunity to infection. J Immunol 180(9): 5771-7.
21. S-P Yeh, C-F Chiu, W-J Lo, C-L Lin, Y-M Liao, et al. (2006) Cytokines and T cell subsets change in patients having graft-versus-host disease. Haematologica: 91, supplement No.1; a0309.
22. Glucksberg H, Storb R, Fefer A, Buckner CD, Neiman PE, et al. (1974) Clinical manifestations of graft-versus-host disease in human recipients of marrow from HLA-matched sibling donors. Transplantation. 18(4): 295-304.
23. Shulman HM, Sullivan KM, Weiden PL, McDonald GB, Striker GE, et al. (1980) Chronic graft-versus-host syndrome in man. A long-term clinicopathologic study of 20 Seattle patients. Am J Med. 69: 204-217.
24. Picker LJ, Singh MK, Zdraveski Z, Treer JR, Waldrop SL, et al. (1995) Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry. Blood 86: 1408-19.
25. Groux H, O'Garra A, Bigler M, Rouleau M, Antonenko S, et al. (1997) A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389: 737-42.
26. Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A, (2001) Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 19: 683-765.
27. MacNeil IA, Suda T, Moore KW, Mosmann TR, Zlotnik A, (1990) IL-10, a novel growth cofactor for mature and immature T cells. J Immunol 145: 4167-73.
28. Go NF, Castle BE, Barrett R, Kastelein R, Dang W, et al. (1990) Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells. J Exp Med 172: 1625-31.
29. Defrance T, Vanbervliet B, Briere F, Durand I, Rousset F, et al. (1992) Interleukin 10 and transforming growth factor beta cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin A. J Exp Med. 175: 671-82.
30. Rowe V, Banovic T, MacDonald KP, Kuns R, Don AL, et al. (2006) Host B cells produce IL-10 following TBI and attenuate acute GVHD after allogeneic bone marrow transplantation. Blood 2006 108(7): 2485-92.
31. Holler E, Roncarolo MG, Hintermeier-Knabe R, Eissner G, Ertl B, et al. (2000) Prognostic significance of increased IL-10 production in patients prior to allogeneic bone marrow transplantation. Bone Marrow Transplant. 25(3): 237-41.
32. Miura Y, Thoburn CJ, Bright EC, Chen W, Nakao S, et al. (2002) Cytokine and chemokine profiles in autologous graft-versus-host disease (GVHD): interleukin 10 and interferon gamma may be critical mediators for the development of autologous GVHD. Blood 100: 2650-8.
33. Fowler DH, Kurasawa K, Husebekk A, Cohen PA, Gress RE, (1994) Cells of Th2 cytokine phenotype prevent LPS-induced lethality during murine graft-versus-host reaction. Regulation of cytokines and CD8+ lymphoid engraftment. J Immunol 152: 1004-13.
34. Fowler DH, Kurasawa K, Smith R, Eckhaus MA, Gress RE, (1994) Donor CD4-enriched cells of Th2 cytokine phenotype regulate graft-versus-host disease without impairing allogeneic engraftment in sublethally irradiated mice. Blood 84: 3540-9.
35. Krenger W, Cooke KR, Crawford JM, Sonis ST, Simmons R, et al. (1996) Transplantation of polarized type 2 donor T cells reduces mortality caused by experimental graft-versus-host disease. Transplantation 62: 1278-85.
36. Spolski R, Kim HP, Zhu W, Levy DE, Leonard WJ, (2009) IL-21 mediates suppressive effects via its induction of IL-10. J Immunol 182(5): 2859-67.
37. Monteleone G, Monteleone I, Fina D, Vavassori P, Del Vecchio Blanco G, et al. (2005). Interleukin-21 enhances T-helper cell type I signaling and interferon- gamma production in Crohn's disease. Gastroenterology 128, 687-94.
38. Wang T, Diaz-Rosales P, Costa MM, Campbell S, Snow M, et al. (2011) Functional characterization of a nonmammalian IL-21: rainbow trout Oncorhynchus mykiss IL-21 upregulates the expression of the Th cell signature cytokines IFN-gamma, IL-10, and IL-22. J Immunol. 186(2): 708-21.
39. Strengell M, Sareneva T, Foster D, Julkunen I, and Matikainen S, (2002). IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response. J. Immunol. 169(7), 3600-05.
40. Terrier B, Geri G, Chaara W, Allenbach Y, Rosenzwajg M, et al. (2012) IL-21 modulates Th1 and Th17 responses in Giant Cell Arterits. Arthritis & Rheumatism Dec 6. doi: 10.1002/art.34327. [Epub ahead of print].
41. Fröhlich A, Marsland BJ, Sonderegger I, Kurrer M, Hodge MR, et al. (2007) IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo. Blood 109(5): 2023-31.
42. Bucher C, Koch L, Vogtenhuber C, Goren E, Munger M, et al. (2009) IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation. Blood 114(26): 5375-84.
43. Hanash AM, Kappel LW, Yim NL, Nejat RA, Goldberg GL, et al. (2011) Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL. Blood 118(2): 446-55.