Suppression of Cancer Progression by MGAT1 shRNA Knockdown

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Beheshti Zavareh, Reza ^a   Sukhai, Mahadeo A ^a   Hurren, Rose ^a   Gronda, Marcela ^a   Wang, Xiaoming ^a   Simpson, Craig D ^b   Maclean, Neil ^a   Zih, Francis ^b   Ketela, Troy ^a   Swallow, Carol J ^b   Moffat, Jason ^a   Rose, David R ^c   Schachter, Harry ^d   Schimmer, Aaron D ^a   Dennis, James W ^b  

^a UNIVERSITY OF TORONTO   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

^c UNIVERSITY OF WATERLOO   (Canada)

^d HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA MANNOSIDASE; ALPHA MANNOSIDASE II; GLYCAN; N ACETYLGLUCOSAMINYLTRANSFERASE; N ACETYLGLUCOSAMINYLTRANSFERASE 1; SHORT HAIRPIN RNA; SWAINSONINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER THERAPY; CELL INVASION; CELL PROLIFERATION; CELL SURFACE; CONTROLLED STUDY; DRUG TARGETING; ENZYME ACTIVITY; FOCAL ADHESION; GENE SILENCING; HELA CELL; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LUNG METASTASIS; MALE; MICROFILAMENT; MIGRATION INHIBITION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PROSTATE CANCER; TUMOR XENOGRAFT;

ANIMALS; CELL LINE, TUMOR; CELL MEMBRANE; DISEASE PROGRESSION; ENZYME INHIBITORS; FEMALE; HELA CELLS; HUMANS; MALE; MICE; N-ACETYLGLUCOSAMINYLTRANSFERASES; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; NEOPLASMS; PHENOTYPE; POLYSACCHARIDES; PROSTATIC NEOPLASMS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SWAINSONINE;

TETRA;

EID: 84866027575     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0043721     Document Type: Article

References (38)

1. Brunelleschi S, Penengo L, Santoro MM, Gaudino G, (2002) Receptor tyrosine kinases as target for anti-cancer therapy. Curr Pharm Des 8: 1959-1972.
2. Schachter H, (1986) Biosynthetic controls that determine the branching and microheterogeneity of protein-bound oligosaccharides. Biochemistry and Cell Biology 64: 163-181.
3. Yamashita K, Tachibana Y, Ohkura T, Kobata A, (1985) Enzymatic basis for the structural changes of asparagine-linked sugar chains of membrane glycoproteins of baby hamster kidney cells induced by polyoma transformation. Journal of Biological Chemistry 260: 3963-3969.
4. Kang R, Saito H, Ihara Y, Miyoshi E, Koyama N, et al. (1996) Transcriptional regulation of the N-acetylglucosaminyltranserase V gene in human bile duct carcinoma cells (HuCC-T1) is mediated by Ets-1. Journal of Biological Chemistry 271: 26706-26712.
5. Buckhaults P, Chen L, Fregien N, Pierce M, (1997) Transcriptional regulation of N-acetylglucosaminyltransferase V by the src Oncogene. Journal of Biological Chemistry 272: 19575-19581.
6. Demetriou M, Nabi IR, Coppolino M, Dedhar S, Dennis JW, (1995) Reduced contact-inhibition and substratum adhesion in epithelial cells expressing GlcNAc-transferase V. Journal of Cell Biology 130: 383-392.
7. Fernandes B, Sagman U, Auger M, Demetriou M, Dennis JW, (1991) beta1-6 branched oligosaccharides as a marker of tumor progression in human breast and colon neoplasia. Cancer Research 51: 718-723.
8. Seelentag WK, Li WP, Schmitz SF, Metzger U, Aeberhard P, et al. (1998) Prognostic value of beta1,6-branched oligosaccharides in human colorectal carcinoma. Cancer Research 58: 5559-5564.
9. Granovsky M, Fata J, Pawling J, Muller WJ, Khokha R, et al. (2000) Suppression of tumor growth and metastasis in Mgat5-deficient mice. Nature Medicine 6: 306-312.
10. Cheung P, Dennis JW, (2007) Mgat5 and Pten interact to regulate cell growth and polarity. Glycobiology 17: 767-773.
11. Goss PE, Baptiste J, Fernandes B, Baker M, Dennis JW, (1994) A study of swainsonine in patients with advanced malignancies. Cancer Research 54: 1450-1457.
12. Goss PE, Reid CL, Bailey D, Dennis JW, (1997) Phase IB clinical trial of the oligosaccharide processing inhibitor swainsonine in patients with advanced malignancies. Clinical cancer research 3: 1077-1086.
13. Lau K, Partridge EA, Silvescu CI, Grigorian A, Pawling J, et al. (2007) Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation. Cell 129: 123-124.
14. Partridge EA, Le Roy C, Di Guglielmo GM, Pawling J, Cheung P, et al. (2004) Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis. Science 306: 120-124.
15. Lajoie P, Partridge EA, Guay G, Goetz JG, Pawling J, et al. (2007) Plasma membrane domain organization regulates EGFR signaling in tumor cells. J Cell Biol 179: 341-356.
16. Markowska AI, Jefferies KC, Panjwani N, (2011) Galectin-3 protein modulates cell surface expression and activation of vascular endothelial growth factor receptor 2 in human endothelial cells. The Journal of biological chemistry 286: 29913-29921.
17. Cha SK, Ortega B, Kurosu H, Rosenblatt KP, Kuro OM, et al. (2008) Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1. Proc Natl Acad Sci U S A 105: 9805-9810.
18. Ohtsubo K, Takamatsu S, Minowa MT, Yoshida A, Takeuchi M, et al. (2005) Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes. Cell 123: 1307-1321.
19. Lagana A, Goetz JG, Cheung P, Raz A, Dennis JW, et al. (2006) Galectin binding to Mgat5-modified N-glycans regulates fibronectin matrix remodeling in tumor cells. Mol Cell Biol 26: 3181-3193.
20. Guo HB, Johnson H, Randolph M, Pierce M, (2009) Regulation of homotypic cell-cell adhesion by branched N-glycosylation of N-cadherin extracellular EC2 and EC3 domains. The Journal of biological chemistry 284: 34986-34997.
21. Terao M, Ishikawa A, Nakahara S, Kimura A, Kato A, et al. (2011) Enhanced epithelial-mesenchymal transition-like phenotype in N-acetylglucosaminyltransferase V transgenic mouse skin promotes wound healing. The Journal of biological chemistry 286: 28303-28311.
22. DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, et al. (2007) Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci U S A 104: 19345-19350.
23. Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, et al. (2009) Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature 457: 910-914.
24. Lau KS, Dennis JW, (2008) N-Glycans in cancer progression. Glycobiology 18: 750-760.
25. Ioffe E, Stanley P, (1994) Mice lacking N-acetylglucosaminyltransferase I activity die at mid-gestation, revealing an essential role for complex or hybrid N-linked carbohydrates. Proceedings of the National Academy of Sciences of the United States of America 91: 728-732.
26. Metzler M, Gertz A, Sarkar M, Schachter H, Schrader JW, et al. (1994) Complex asparagine-linked oligosaccharides are required for morphogenic events during post-implantation development. The EMBO Journal 13: 2056-2065.
27. Glinsky GV, Glinskii AB, Berezovskaya O, Smith BA, Jiang P, et al. (2006) Dual-color-coded imaging of viable circulating prostate carcinoma cells reveals genetic exchange between tumor cells in vivo, contributing to highly metastatic phenotypes. Cell Cycle 5: 191-197.
28. Moffat J, Grueneberg DA, Yang X, Kim SY, Kloepfer AM, et al. (2006) A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell 124: 1283-1298.
29. Korczak B, Le T, Elowe S, Donavan R, Datti A, et al. (2000) Minimal Catalytic Domain of N-Acetylglucosaminyltransferase V. Glycobiology 10: 595-599.
30. Beheshti Zavareh R, Lau KS, Hurren R, Datti A, Ashline DJ, et al. (2008) Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function. Cancer Research 68: 6688-6697.
31. Xu GW, Mawji IA, Macrae CJ, Koch CA, Datti A, et al. (2008) A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization. Apoptosis: an international journal on programmed cell death 13: 413-422.
32. Cummings RD, Kornfeld S, (1982) Characterization of the structural determinants required for the high affinity interaction of asparagine-linked oligosaccharides with immobilized Phaseolus vulgaris leukoagglutinating and erythroagglutinating lectin. Journal of Biological Chemistry 257: 11230-11234.
33. Yagel S, Feinmesser R, Waghorne C, Lala PK, Breitman ML, et al. (1989) Evidence that beta 1-6 branched Asn-linked oligosaccharides on metastatic tumor cells facilitate invasion of basement membranes. International Journal of Cancer 44: 685-690.
34. Dennis JW, Koch K, Yousefi S, VanderElst I, (1990) Growth inhibition of human melanoma tumor xenografts in athymic nude mice by swainsonine. Cancer Research 50: 1867-1872.
35. Palecek SP, Loftus JC, Ginsberg MH, Lauffenburger DA, Horwitz AF, (1997) Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness. Nature 385: 537-540.
36. Hall A, (2009) The cytoskeleton and cancer. Cancer Metastasis Rev 28: 5-14.
37. Takamatsu S, Antonopoulos A, Ohtsubo K, Ditto D, Chiba Y, et al. (2010) Physiological and glycomic characterization of N-acetylglucosaminyltransferase-IVa and-IVb double deficient mice. Glycobiology 20: 485-497.
38. Takamatsu S, Oguri S, Minowa MT, Yoshida A, Nakamura K, et al. (1999) Unusually high expression of N-acetylglucosaminyltransferase-IV a in human choriocarcinoma cell lines: a possible enzymatic basis of the formaiton of abnormal biantennary sugar chain. Cancer Research 59: 3949-3953.