Long-Term Bezafibrate Treatment Improves Skin and Spleen Phenotypes of the mtDNA Mutator Mouse

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Dillon, Lloye M ^a   Hida, Aline ^a   Garcia, Sofia ^a   Prolla, Tomas A ^b   Moraes, Carlos T ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BEZAFIBRATE; MITOCHONDRIAL DNA;

ANEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; FATTY ACID OXIDATION; GENE MUTATION; HAIR LOSS; HEPATOMEGALY; LIFESPAN; LIVER; LIVER TOXICITY; MALE; MOUSE; MUSCLE ATROPHY; MUSCLE FUNCTION; NONHUMAN; OSTEOPOROSIS; PREMATURE AGING; SKIN; SPLEEN;

AGING, PREMATURE; ANIMALS; BEZAFIBRATE; DNA, MITOCHONDRIAL; ENERGY METABOLISM; FATTY ACIDS; HEPATOMEGALY; HUMANS; HYPOLIPIDEMIC AGENTS; MALE; MICE; MICE, TRANSGENIC; MITOCHONDRIA; MUTATION; OXIDATION-REDUCTION; PHENOTYPE; PPAR GAMMA; SKIN; SPECIES SPECIFICITY; SPLEEN;

MUS; PRIMATES; RODENTIA;

EID: 84866020624     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0044335     Document Type: Article

References (23)

1. Dillon LM, Rebelo AP, Moraes CT, (2012) The role of PGC-1 coactivators in aging skeletal muscle and heart. IUBMB Life 64: 231-241.
2. Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, et al. (2004) Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429: 417-423.
3. Kujoth GC, Hiona A, Pugh TD, Someya S, Panzer K, et al. (2005) Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 309: 481-484.
4. Dillon LM, Williams SL, Hida A, Peacock JD, Prolla TA, et al. (2012) Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse. Hum Mol Genet 21: 2288-2297.
5. Tenenbaum A, Motro M, Fisman EZ, (2005) Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: the bezafibrate lessons. Cardiovasc Diabetol 4: 14.
6. Wang YX, (2010) PPARs: diverse regulators in energy metabolism and metabolic diseases. Cell Res 20: 124-137.
7. Kuenzli S, Saurat JH, (2003) Peroxisome proliferator-activated receptors in cutaneous biology. Br J Dermatol 149: 229-236.
8. Wenz T, Diaz F, Spiegelman BM, Moraes CT, (2008) Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype. Cell Metab 8: 249-256.
9. Johri A, Calingasan NY, Hennessey TM, Sharma A, Yang L, et al. (2012) Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington's disease. Hum Mol Genet 21: 1124-1137.
10. Yatsuga S, Suomalainen A (2011) Effect of bezafibrate treatment on late-onset mitochondrial myopathy in mice. Hum Mol Genet.
11. Viscomi C, Bottani E, Civiletto G, Cerutti R, Moggio M, et al. (2011) In vivo correction of COX deficiency by activation of the AMPK/PGC-1alpha axis. Cell Metab 14: 80-90.
12. Oikarinen A, (1994) Aging of the skin connective tissue: how to measure the biochemical and mechanical properties of aging dermis. Photodermatol Photoimmunol Photomed 10: 47-52.
13. Verrecchia F, Chu ML, Mauviel A, (2001) Identification of novel TGF-beta/Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach. J Biol Chem 276: 17058-17062.
14. Ham SA, Kim HJ, Kang ES, Eun SY, Kim GH, et al. (2010) PPARdelta promotes wound healing by up-regulating TGF-beta1-dependent or-independent expression of extracellular matrix proteins. J Cell Mol Med 14: 1747-1759.
15. Smaldone S, Olivieri J, Gusella GL, Moroncini G, Gabrielli A, et al. (2011) Ha-Ras stabilization mediates pro-fibrotic signals in dermal fibroblasts. Fibrogenesis Tissue Repair 4: 8.
16. Cesta MF, (2006) Normal structure, function, and histology of the spleen. Toxicol Pathol 34: 455-465.
17. Harries MJ, Paus R, (2009) Scarring alopecia and the PPAR-gamma connection. J Invest Dermatol 129: 1066-1070.
18. Hiona A, Sanz A, Kujoth GC, Pamplona R, Seo AY, et al. (2010) Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice. PLoS One 5: e11468.
19. De Souza AT, Cornwell PD, Dai X, Caguyong MJ, Ulrich RG, (2006) Agonists of the peroxisome proliferator-activated receptor alpha induce a fiber-type-selective transcriptional response in rat skeletal muscle. Toxicol Sci 92: 578-586.
20. Djouadi F, Bastin J (2011) Species differences in the effects of bezafibrate as a potential treatment of mitochondrial disorders. Cell Metab 14: 715-716; author reply 717.
21. Ahlqvist KJ, Hamalainen RH, Yatsuga S, Uutela M, Terzioglu M, et al. (2012) Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice. Cell Metab 15: 100-109.
22. Cheung MC, Spalding PB, Gutierrez JC, Balkan W, Namias N, et al. (2009) Body surface area prediction in normal, hypermuscular, and obese mice. J Surg Res 153: 326-331.
23. Pickrell AM, Fukui H, Wang X, Pinto M, Moraes CT, (2011) The striatum is highly susceptible to mitochondrial oxidative phosphorylation dysfunctions. J Neurosci 31: 9895-9904.