Suppressed hepcidin expression correlates with hypotransferrinemia in copper-deficient rat pups but not dams

Genes and Nutrition

Volumn 7, Issue 3, 2012, Pages 405-414

  Broderius, Margaret ^a   Mostad, Elise ^a   Prohaska, Joseph R ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Anemia; Copper deficiency; Hepcidin; Rats; Transferrin iron

Indexed keywords

HEPCIDIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; COPPER DEFICIENCY; DISEASE ASSOCIATION; FEMALE; GENE; GENE EXPRESSION; HAMP GENE; IRON METABOLISM; IRON METABOLISM DISORDER; MALE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; TRANSFERRIN DEFICIENCY;

RATTUS;

EID: 84866013221     PISSN: 15558932     EISSN: 18653499     Source Type: Journal    
DOI: 10.1007/s12263-012-0293-7     Document Type: Article

References (41)

1. Bartnikas TB, Andrews NC, Fleming MD (2011) Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice. Blood 117:630-637
2. Bastian TW, Prohaska JR, Georgieff MK, Anderson GW (2010) Perinatal iron and copper deficiencies alter neonatal rat circulating and brain thyroid hormone concentrations. Endocrinology 151:4055-4065
3. Bastian TW, Lassi KC, Anderson GW, Prohaska JR (2011) Maternal iron supplementation attenuates the impact of perinatal copper deficiency but does not eliminate hypotriiodothyroninemia nor impaired sensorimotor development. J Nutr Biochem 22:1084-1090
4. Broderius M, Mostad E, Wendroth K, Prohaska JR (2010) Levels of plasma ceruloplasmin protein are markedly lower following dietary copper deficiency in rodents. Comp Biochem Physiol C 151:473-479
5. Bustin SA, Benes V, Garson JA, Hellemans J, Huggett J, Kubista M, Mueller R, Nolan T, Pfaffl MW, Shipley GL, Vandesompele J, Wittwer CT (2009) The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin Chem 55:611-622
6. Cartwright GE, Gubler CJ, Bush JA, Wintrobe MM (1956) Studies of copper metabolism. XVII. Further observations on the anemia of copper deficiency in swine. Blood 11:143-153
7. Chen H, Huang G, Su T, Gao H, Attieh ZK, McKie AT, Anderson GJ, Vulpe CD (2006) Decreased hephaestin activity in the intestine of copper-deficient mice causes systemic iron deficiency. J Nutr 136:1236-1241
8. Chen H, Attieh ZK, Gao H, Huang G, Su T, Ke W, Vulpe CD (2009) Age-related changes in iron homeostasis in mouse ferroxidase mutants. Biometals 22:827-834
9. Chung J, Prohaska JR, Wessling-Resnick M (2004) Ferroportin-1 is not upregulated in copper-deficient mice. J Nutr 134:517-521 (Pubitemid 38298489)
10. Collins JF, Prohaska JR, Knutson MD (2010) Metabolic crossroads of iron and copper. Nutr Rev 68:133-147
11. De Domenico I, Ward DM, di Patti MC, Jeong SY, David S, Musci G, Kaplan J (2007) Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin. EMBO J 26:2823-2831 (Pubitemid 46975784)
12. Donovan A, Lima CA, Pinkus JL, Pinkus GS, Zon LI, Robine S, Andrews NC (2005) The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab 1:191-200 (Pubitemid 43960600)
13. Duce JA, Tsatsanis A, Cater MA, James SA, Robb E, Wikhe K, Leong SL, Perez K, Johanssen T, Greenough MA, Cho HH, Galatis D, Moir RD, Masters CL, McLean C, Tanzi RE, Cappai R, Barnham KJ, Ciccotosto GD, Rogers JT, Bush AI (2010) Iron-export ferroxidase activity of beta-amyloid precursor protein is inhibited by zinc in Alzheimer's disease. Cell 142:857-867
14. Fox PL (2003) The copper-iron chronicles: the story of an intimate relationship. Biometals 16:9-40 (Pubitemid 36140213)
15. Gao J, Chen J, Kramer M, Tsukamoto H, Zhang AS, Enns CA (2009) Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression. Cell Metab 9:217-227
16. Harris ZL, Durley AP, Man TK, Gitlin JD (1999) Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux. Proc Natl Acad Sci USA 96:10812-10817 (Pubitemid 29442226)
17. Hart EB, Steenbock H, Waddell J, Elvehjem CA (1928) Iron in nutrition. VII. Copper as a supplemment to iron for hemoglobin building in the rat. J Biol Chem 77:797-812
18. Jenkitkasemwong S, Broderius M, Nam H, Prohaska JR, Knutson MD (2010) Anemic copper-deficient rats, but not mice, display low hepcidin expression and high ferroportin levels. J Nutr 140:723-730
19. Karimbakas J, Langkamp-Henken B, Percival SS (1998) Arrested maturation of granulocytes in copper deficient mice. J Nutr 128:1855-1860 (Pubitemid 28509846)
20. Knutson MD (2010) Iron-sensing proteins that regulate hepcidin and enteric iron absorption. Annu Rev Nutr 30:149-171
21. Kono S, Yoshida K, Tomosugi N, Terada T, Hamaya Y, Kanaoka S, Miyajima H (2010) Biological effects of mutant ceruloplasmin on hepcidin-mediated internalization of ferroportin. Biochim Biophys Acta 1802:968-975
22. Mostad EJ, Prohaska JR (2011) Glycosylphosphatidylinositol-linked ceruloplasmin is expressed in multiple rodent organs and is lower following dietary copper deficiency. Exp Biol Med 236:298-308
23. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306:2090-2093 (Pubitemid 40007660)
24. Osaki S, Johnson DA, Frieden E (1966) The possible significance of the ferrous oxidase activity of ceruloplasmin in normal human serum. J Biol Chem 241:2746-2751
25. Prohaska JR (1991) Changes in Cu, Zn-superoxide dismutase, cytochrome c oxidase, glutathione peroxidase and glutathione transferase activities in copper-deficient mice and rats. J Nutr 121:355-363
26. Prohaska JR (2011) Impact of copper limitation on expression and function of multicopper oxidases (ferroxidases). Adv Nutr 2:129-137
27. Prohaska JR (2012) Copper. In: Erdman J, Macdonald I, Zeisel S (eds) Present knowledge in nutrition, 10th edn. International Life Sciences Institute, Washington, DC (in press)
28. Prohaska JR, Broderius M (2012) Copper deficiency has minimal impact on ferroportin expression or function. Biometals 25 (in press)
29. Prohaska JR, Brokate B (1999) Copper deficiency alters rat dopamine b-monooxygenase mRNA and activity. J Nutr 129:2147-2153
30. Prohaska J, Bailey W, Cox D (1985) Failure of iron injection to reverse copper-dependent anemia in mice. In: Mills CF, Bremner I, Chesters JK (eds) Trace elements in man and animals, TEMA 5. Commonwealth Agricultural Bureaux, Farnham Royal, pp 27-32
31. Pyatskowit JW, Prohaska JR (2008a) Copper deficient rats and mice both develop anemia but only rats have lower plasma and brain iron levels. Comp Biochem Physiol C 147:316-323
32. Pyatskowit JW, Prohaska JR (2008b) Iron injection restores brain iron and hemoglobin deficits in perinatal copper-deficient rats. J Nutr 138:1880-1886
33. Pyatskowit JW, Prohaska JR (2008c) Multiple mechanisms account for lower plasma iron in young copper deficient rats. Biometals 21:343-352
34. Reeves PG, DeMars LC (2006) Signs of iron deficiency in copperdeficient rats are not affected by iron supplements administered by diet or by injection. J Nutr Biochem 17:635-642 (Pubitemid 44205443)
35. Reeves PG, Demars LC, Johnson WT, Lukaski HC (2005) Dietary copper deficiency reduces iron absorption and duodenal enterocyte hephaestin protein in male and female rats. J Nutr 135:92-98 (Pubitemid 40094327)
36. Schmidt PJ, Toran PT, Giannetti AM, Bjorkman PJ, Andrews NC (2008) The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression. Cell Metab 7:205-214 (Pubitemid 351285524)
37. Schulz K, Vulpe CD, Harris LZ, David S (2011) Iron efflux from oligodendrocytes is differentially regulated in gray and white matter. J Neurosci 31:13301-13311
38. Torrance JD, Bothwell TH (1968) A simple technique for measuring storage iron concentrations in formalinised liver samples. S Afr J Med Sci 33:9-11
39. West EC, Prohaska JR (2004) Cu, Zn-superoxide dismutase is lower and copper chaperone CCS is higher in erythrocytes of copperdeficient rats and mice. Exp Biol Med 229:756-764 (Pubitemid 39166479)
40. Wilkins SJ, Frazer DM, Millard KN, McLaren GD, Anderson GJ (2006) Iron metabolism in the hemoglobin-deficit mouse: correlation of diferric transferrin with hepcidin expression. Blood 107:1659-1664 (Pubitemid 43242406)
41. Williams DM, Kennedy FS, Green BG (1983) Hepatic iron accumulation in copper-deficient rats. Br J Nutr 50:653-660