Impact of copper limitation on expression and function of multicopper oxidases (ferroxidases)

Advances in Nutrition

Volumn 2, Issue 2, 2011, Pages 89-95

  Prohaska, Joseph R ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CERULOPLASMIN; COPPER; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN;

ANIMAL; HUMAN; IRON DEFICIENCY ANEMIA; METABOLISM; MOUSE; RAT; REVIEW;

ANEMIA, HYPOCHROMIC; ANIMALS; CERULOPLASMIN; COPPER; GPI-LINKED PROTEINS; HUMANS; MICE; RATS;

EID: 84858275997     PISSN: 21618313     EISSN: 21565376     Source Type: Journal    
DOI: 10.3945/an.110.000208     Document Type: Article

References (61)

1. Banci L, Bertini I, Ciofi-Baffoni S, Kozyreva T, Zovo K, Palumaa P. Affinity gradients drive copper to cellular destinations. Nature. 2010; 465:645-8.
2. Lutsenko S. Human copper homeostasis: a network of interconnected pathways. Curr Opin Chem Biol. 2010;14:211-7.
3. Prohaska JR. Role of copper transporters in copper homeostasis. Am J Clin Nutr. 2008;88:S826-9.
4. Robinson NJ, Winge DR. Copper metallochaperones. Annu Rev Biochem. 2010;79:537-62.
5. Collins JF, Prohaska JR, Knutson MD. Metabolic crossroads of iron and copper. Nutr Rev. 2010;68:133-47.
6. Hart EB, Steenbock H, Waddell J, Elvehjem CA. Iron in nutrition. VII. Copper as a supplement to iron for hemoglobin building in the rat. J Biol Chem. 1928;77:797-812.
7. Fox PL. The copper-iron chronicles: the story of an intimate relationship. Biometals. 2003;16:9-40.
8. Chambers A, Krewski D, Birkett N, Plunkett L, Hertzberg R, Danzeisen R, Aggett PJ, Starr TB, Baker S, et al. An exposure-response curve for copper excess and deficiency. J Toxicol Environ Health B Crit Rev. 2010;13:546-78.
9. Kumar N, Butz JA, Burritt MF. Clinical significance of the laboratory determination of low serum copper in adults. Clin Chem Lab Med. 2007;45:1402-10.
10. Griffith DP, LiffDA, Ziegler TR, Esper GJ, Winton EF. Acquired copper deficiency: a potentially serious and preventable complication following gastric bypass surgery. Obesity (Silver Spring). 2009;17:827-31.
11. Hedera P, Peltier A, Fink JK, Wilcock S, London Z, Brewer GJ. Myelopolyneuropathy and pancytopenia due to copper deficiency and high zinc levels of unknown origin II. The denture cream is a primary source of excessive zinc. Neurotoxicology. 2009;30:996-9.
12. Holmberg CG, Laurell CB. Investigations in serum copper; nature of serum copper and its relation to the iron-binding protein in human serum. Acta Chem Scand. 1947;1:944-50.
13. Hellman NE, Gitlin JD. Ceruloplasmin metabolism and function. Annu Rev Nutr. 2002;22:439-58.
14. Osaki S, Johnson DA, Frieden E. The possible significance of the ferrous oxidase activity of ceruloplasmin in normal human serum. J Biol Chem. 1966;241:2746-51.
15. Lee GR, Nacht S, Lukens JN, Cartwright GE. Iron metabolism in copper-deficient swine. J Clin Invest. 1968;47:2058-69.
16. Meyer LA, Durley AP, Prohaska JR, Harris ZL. Copper transport and metabolism are normal in aceruloplasminemic mice. J Biol Chem. 2001;276:36857-61.
17. Harris ZL, Durley AP, Man TK, Gitlin JD. Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux. Proc Natl Acad Sci USA. 1999;96:10812-7.
18. Miyajima H, Nishimura Y, Mizoguchi K, Sakamoto M, Shimizu T, Honda N. Familial apoceruloplasmin deficiency associated with blepharospasm and retinal degeneration. Neurology. 1987;37:761-7.
19. Askwith C, Eide D, Van Ho A, Bernard PS, Li L, Davis-Kaplan S, Sipe DM, Kaplan J. The FET3 gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake. Cell. 1994;76:403-10.
20. Patel BN, David S. A novel glycosylphosphatidylinositol-anchored form of ceruloplasmin is expressed by mammalian astrocytes. J Biol Chem. 1997;272:20185-90.
21. Patel BN, Dunn RJ, David S. Alternative RNA splicing generates a glycosylphosphatidylinositol-anchored form of ceruloplasmin in mammalian brain. J Biol Chem. 2000;275:4305-10.
22. Mostad E, Prohaska JR. Glycosylphosphatidylinositol-linked ceruloplasmin is expressed in multiple rodent organs and is lower following dietary copper deficiency. Exp Biol Med. 2011; in press.
23. Vulpe CD, Kuo YM, Murphy TL, Cowley L, Askwith C, Libina N, Gitschier J, Anderson GJ. Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nat Genet. 1999;21:195-9.
24. Donovan A, Lima CA, Pinkus JL, Pinkus GS, Zon LI, Robine S, Andrews NC. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab. 2005;1:191-200.
25. Andersen HS, Gambling L, Holtrop G, Mcardle HJ. Effect of dietary copper deficiency on iron metabolism in the pregnant rat. Br J Nutr. 2007;97:239-46.
26. Pyatskowit JW, Prohaska JR. Multiple mechanisms account for lower plasma iron in young copper deficient rats. Biometals. 2008;21: 343-52.
27. Danzeisen R, Ponnambalam S, Lea RG, Page K, Gambling L, Mcardle HJ. The effect of ceruloplasmin on iron release from placental (BeWo) cells; evidence for an endogenous Cu oxidase. Placenta. 2000;21: 805-12.
28. Chen H, Attieh ZK, Syed BA, Kuo YM, Stevens V, Fuqua BK, Andersen HS, Naylor CE, Evans RW, et al. Identification of zyklopen, a new member of the vertebrate multicopper ferroxidase family, and characterization in rodents and human cells. J Nutr. 2010;140:1728-35.
29. Ragan HA, Nacht S, Lee GR, Bishop CR, Cartwright GE. Effect of ceruloplasmin on plasma iron in copper-deficient swine. Am J Physiol. 1969;217:1320-3.
30. Evans JL, Abraham PA. Anemia, iron storage and ceruloplasmin in copper nutrition in the growing rat. J Nutr. 1973;103:196-201.
31. Harris ZL, Klomp LW, Gitlin JD. Aceruloplasminemia: an inherited neurodegenerative disease with impairment of iron homeostasis. Am J Clin Nutr. 1998;67:S972-7.
32. Patel BN, Dunn RJ, Jeong SY, Zhu Q, Julien JP, David S. Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury. J Neurosci. 2002;22:6578-86.
33. Yamamoto K, Yoshida K, Miyagoe Y, Ishikawa A, Hanaoka K, Nomoto S, Kaneko K, Ikeda S, Takeda S. Quantitative evaluation of expression of iron-metabolism genes in ceruloplasmin-deficient mice. Biochim Biophys Acta. 2002;1588:195-202.
34. De Domenico I, Ward DM, di Patti MC, Jeong SY, David S, Musci G, Kaplan J. Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin. EMBO J. 2007;26: 2823-31.
35. Reeves PG, Demars LC, Johnson WT, Lukaski HC. Dietary copper deficiency reduces iron absorption and duodenal enterocyte hephaestin protein in male and female rats. J Nutr. 2005;135:92-8.
36. Chen H, Huang G, Su T, Gao H, Attieh ZK, Mckie AT, Anderson GJ, Vulpe CD. Decreased hephaestin activity in the intestine of copper-deficient mice causes systemic iron deficiency. J Nutr. 2006;136:1236-41.
37. Holtzman NA, Gaumnitz BM. Identification of an apoceruloplasminlike substance in the plasma of copper-deficient rats. J Biol Chem. 1970;245:2350-3.
38. Holtzman NA, Gaumnitz BM. Studies on the rate of release and turnover of ceruloplasmin and apoceruloplasmin in rat plasma. J Biol Chem. 1970;245:2354-8.
39. Matsuda I, Pearson T, Holtzman NA. Determination of apoceruloplasmin by radioimmunoassay in nutritional copper deficiency, Menkes' kinky hair syndrome, Wilson's disease, and umbilical cord blood. Pediatr Res. 1974;8:821-4.
40. Gitlin JD, Schroeder JJ, Lee-Ambrose LM, Cousins RJ. Mechanisms of caeruloplasmin biosynthesis in normal and copper-deficient rats. Biochem J. 1992;282:835-9.
41. Broderius M, Mostad E, Wendroth K, Prohaska JR. Levels of plasma ceruloplasmin protein are markedly lower following dietary copper deficiency in rodents. Comp Biochem Physiol C Toxicol Pharmacol. 2010; 151:473-9.
42. Kim H, Son HY, Bailey SM, Lee J. Deletion of hepatic Ctr1 reveals its function in copper acquisition and compensatory mechanisms for copper homeostasis. Am J Physiol Gastrointest Liver Physiol. 2009;296: G356-64.
43. Nose Y, Kim BE, Thiele DJ. Ctr1 drives intestinal copper absorption and is essential for growth, iron metabolism, and neonatal cardiac function. Cell Metab. 2006;4:235-44.
44. Huster D, Finegold MJ, Morgan CT, Burkhead JL, Nixon R, Vanderwerf SM, Gilliam CT, Lutsenko S. Consequences of copper accumulation in the livers of the Atp7b2/2 (Wilson disease gene) knockout mice. Am J Pathol. 2006;168:423-34.
45. Hamza I, Faisst A, Prohaska J, Chen J, Gruss P, Gitlin JD. The metallochaperone Atox1 plays a critical role in perinatal copper homeostasis. Proc Natl Acad Sci USA. 2001;98:6848-52.
46. Nittis T, Gitlin JD. Role of copper in the proteosome-mediated degradation of the multicopper oxidase hephaestin. J Biol Chem. 2004;279: 25696-702.
47. Cherukuri S, Potla R, Sarkar J, Nurko S, Harris ZL, Fox PL. Unexpected role of ceruloplasmin in intestinal iron absorption. Cell Metab. 2005;2: 309-19.
48. Logan JI, Harveyson KB, Wisdom GB, Hughes AE, Archbold GP. Hereditary caeruloplasmin deficiency, dementia and diabetes mellitus. QJM. 1994;87:663-70.
49. Morita H, Ikeda S, Yamamoto K, Morita S, Yoshida K, Nomoto S, Kato M, Yanagisawa N. Hereditary ceruloplasmin deficiency with hemosiderosis: a clinicopathological study of a Japanese family. Ann Neurol. 1995;37:646-56.
50. Pyatskowit JW, Prohaska JR. Copper deficient rats and mice both develop anemia but only rats have lower plasma and brain iron levels. Comp Biochem Physiol C Toxicol Pharmacol. 2008;147: 316-23.
51. Gray LW, Kidane TZ, Nguyen A, Akagi S, Petrasek K, Chu YL, Cabrera A, KantardjieffK, Mason AZ, et al. Copper proteins and ferroxidases in human plasma and that of wild-type and ceruloplasmin knockout mice. Biochem J. 2009;419:237-45.
52. Prohaska JR. Comparison between dietary and genetic copper deficiency in mice: copper-dependent anemia. Nutr Res. 1981;1:159-67.
53. Jenkitkasemwong S, Broderius M, Nam H, Prohaska JR, Knutson MD. Anemic copper-deficient rats, but not mice, display low hepcidin expression and high ferroportin levels. J Nutr. 2010;140:723-30.
54. Prohaska JR. Changes in tissue growth, concentrations of copper, iron, cytochrome oxidase and superoxide dismutase subsequent to dietary or genetic copper deficiency in mice. J Nutr. 1983;113:2048-58.
55. Prohaska JR. Effect of dietary copper deficiency on heterozygous female brindled mice. Nutr Res. 1988;8:1079-84.
56. Reeves PG, Demars LC. Signs of iron deficiency in copper-deficient rats are not affected by iron supplements administered by diet or by injection. J Nutr Biochem. 2006;17:635-42.
57. Prohaska J, Bailey W, Cox D. Failure of iron injection to reserve copperdependent anemia in mice. In: Mills CF, Bremner I, Chesters JK, editors. Trace elements in man and animals. Farnham Royal, Slough (UK): Commonwealth Agricultural Bureaux; 1985. p. 27-32.
58. Prohaska JR. Repletion of copper-deficient mice and brindled mice with copper or iron. J Nutr. 1984;114:422-30.
59. Pyatskowit JW, Prohaska JR. Iron injection restores brain iron and hemoglobin deficits in perinatal copper-deficient rats. J Nutr. 2008;138: 1880-6.
60. Cohen NL, Keen CL, Hurley LS, Lonnerdal B. Determinants of copperdeficiency anemia in rats. J Nutr. 1985;115:710-25.
61. Prohaska JR. Effect of diet on milk copper and iron content of normal and heterozygous brindled mice. Nutr Res. 1989;9:353-6.