Maternal iron supplementation attenuates the impact of perinatal copper deficiency but does not eliminate hypotriiodothyroninemia nor impaired sensorimotor development

Journal of Nutritional Biochemistry

Volumn 22, Issue 11, 2011, Pages 1084-1090

  Bastian, Thomas W ^a   Lassi, Katie C ^b   Anderson, Grant W ^a   Prohaska, Joseph R ^b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Brain iron; Copper deficient; Rat; Sensorimotor behavior; Triiodothyronine

Indexed keywords

COPPER PROTEIN; HEMOGLOBIN; IRON; LIOTHYRONINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; COPPER DEFICIENCY; DIET SUPPLEMENTATION; FEMALE; HEMOGLOBIN BLOOD LEVEL; HYPOTRIIODOTHYRONINEMIA; IRON BLOOD LEVEL; IRON DEFICIENCY; IRON THERAPY; MALE; MATERNAL NUTRITION; NONHUMAN; PERINATAL PERIOD; RAT; SENSORIMOTOR NEUROPATHY; THYROID DISEASE;

ANIMAL FEED; ANIMALS; BRAIN; BRAIN CHEMISTRY; COPPER; DIETARY SUPPLEMENTS; FEMALE; IRON; IRON, DIETARY; MALE; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; THYROID HORMONES; TRIIODOTHYRONINE;

RATTUS;

EID: 80054087488     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2010.09.007     Document Type: Article

References (37)

1. Georgieff M.K. Nutrition and the developing brain: nutrient priorities and measurement. Am J Clin Nutr 2007, 85:614S-620S.
2. Pop V.J., Kuijpens J.L., van Baar A.L., Verkerk G., van Son M.M., de Vijlder J.J., et al. Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy. Clin Endocrinol 1999, 50:149-155.
3. Anderson G.W., Schoonover C.M., Jones S.A. Control of thyroid hormone action in the developing rat brain. Thyroid 2003, 13:1039-1056.
4. Felt B.T., Beard J.L., Schallert T., Shao J., Aldridge J.W., Connor J.R., et al. Persistent neurochemical and behavioral abnormalities in adulthood despite early iron supplementation for perinatal iron deficiency anemia in rats. Behav Brain Res 2006, 171:261-270.
5. Penland J.G., Prohaska J.R. Abnormal motor function persists following recovery from perinatal copper deficiency in rats. J Nutr 2004, 134:1984-1988.
6. Prohaska J.R., Hoffman R.G. Auditory startle response is diminished in rats after recovery from perinatal copper deficiency. J Nutr 1996, 126:618-627.
7. Zimmermann M., Adou P., Torresani T., Zeder C., Hurrell R. Persistence of goiter despite oral iodine supplementation in goitrous children with iron deficiency anemia in Cote d'Ivoire. Am J Clin Nutr 2000, 71:88-93.
8. Hess S.Y., Zimmermann M.B., Arnold M., Langhans W., Hurrell R.F. Iron deficiency anemia reduces thyroid peroxidase activity in rats. J Nutr 2002, 132:1951-1955.
9. Pyatskowit J.W., Prohaska J.R. Iron injection restores brain iron and hemoglobin deficits in perinatal copper-deficient rats. J Nutr 2008, 138:1880-1886.
10. Bastian T.W., Prohaska J.R., Georgieff M.K., Anderson G.W. Perinatal iron and copper deficiencies alter neonatal rat circulating and brain thyroid hormone concentrations. Endocrinology 2010, 151:4055-4065.
11. Beard J., Tobin B., Green W. Evidence for thyroid hormone deficiency in iron-deficient anemic rats. J Nutr 1989, 119:772-778.
12. Lukaski H.C. Body temperature and thyroid hormone metabolism of copper-deficient rats. J Nutr Biochem 1995, 6:445-451.
13. Olin K.L., Walter R.M., Keen C.L. Copper deficiency affects selenoglutathione peroxidase and selenodeiodinase activities and antioxidant defense in weanling rats. Am J Clin Nutr 1994, 59:654-658.
14. Prohaska J.R., Gybina A.A. Rat brain iron concentration is lower following perinatal copper deficiency. J Neurochem 2005, 93:698-705.
15. Ward K.L., Tkac I., Jing Y., Felt B., Beard J., Connor J., et al. Gestational and lactational iron deficiency alters the developing striatal metabolome and associated behaviors in young rats. J Nutr 2007, 137:1043-1049.
16. Pyatskowit J.W., Prohaska J.R. Copper deficient rats and mice both develop anemia but only rats have lower plasma and brain iron levels. Comp Biochem Physiol C 2008, 147:316-323.
17. Prohaska J.R. Changes in Cu,Zn-superoxide dismutase, cytochrome c oxidase, glutathione peroxidase and glutathione transferase activities in copper-deficient mice and rats. J Nutr 1991, 121:355-363.
18. Morreale de Escobar G., Pastor R., Obregon M.J., Escobar del Rey F. Effects of maternal hypothyroidism on the weight and thyroid hormone content of rat embryonic tissues, before and after onset of fetal thyroid function. Endocrinology 1985, 117:1890-1900.
19. Prohaska J.R., Wells W.W. Copper deficiency in the developing rat brain: a possible model for Menkes' steely-hair disease. J Neurochem 1974, 23:91-98.
20. Vega-Nunez E., Menendez-Hurtado A., Garesse R., Santos A., Perez-Castillo A. Thyroid hormone-regulated brain mitochondrial genes revealed by differential cDNA cloning. J Clin Invest 1995, 96:893-899.
21. Prohaska J.R., Broderius M., Brokate B. Metallochaperone for Cu,Zn-superoxide dismutase (CCS) protein but not mRNA is higher in organs from copper-deficient mice and rats. Arch Biochem Biophys 2003, 417:227-234.
22. Broderius M.A., Prohaska J.R. Differential impact of copper deficiency in rats on blood cuproproteins. Nutr Res 2009, 29:494-502.
23. Balcells-Olivero M., Cousins M.S., Seiden L.S. Holtzman and Harlan Sprague-Dawley rats: differences in DRL 72-sec performance and 8-hydroxy-di-propylamino tetralin-induced hypothermia. J Pharmacol Exp Ther 1998, 286:742-752.
24. Gybina A.A., Prohaska J.R. Variable response of selected cuproproteins in rat choroid plexus and cerebellum following perinatal copper deficiency. Genes Nutr 2006, 1:51-60.
25. Uriu-Adams J.Y., Scherr R.E., Lanoue L., Keen C.L. Influence of copper on early development: prenatal and postnatal considerations. BioFactors 2010, 36:136-152.
26. Prohaska J.R., Wells W.W. Copper deficiency in the developing rat brain: evidence for abnormal mitochondria. J Neurochem 1975, 25:221-228.
27. Gybina A.A., Prohaska J.R. Fructose-2,6-bisphosphate is lower in copper deficient rat cerebellum despite higher content of phosphorylated AMP-activated protein kinase. Exp Biol Med 2008, 233:1262-1270.
28. Prohaska J.R., Bailey W.R. Alterations of rat brain peptidylglycine α-amidating monooxygenase and other cuproenzyme activities following perinatal copper deficiency. Proc Soc Exp Biol Med 1995, 210:107-116.
29. Bousquet-Moore D., Prohaska J.R., Nillni E.A., Czyzyk T., Wetsel W.C., Mains R.E., et al. Interactions of peptide amidation and copper: novel biomarkers and mechanisms of neural dysfunction. Neurobiol Dis 2010, 37:130-140.
30. Gybina A.A., Tkac I., Prohaska J.R. Copper deficiency alters the neurochemical profile of developing rat brain. Nutr Neurosci 2009, 12:114-122.
31. Oliver J.W. Interrelationships between athyreotic and copper-deficient states in rats. Am J Vet Res 1975, 36:1649-1653.
32. Eipper B.A., Stoffers D.A., Mains R.E. The biosynthesis of neuropeptides: peptide alpha-amidation. Annu Rev Neurosci 1992, 15:57-85.
33. Prohaska J.R., Bailey W.R., Lear P.M. Copper deficiency alters rat peptidylglycine α-amidating monooxygenase activity. J Nutr 1995, 125:1447-1454.
34. Bousquet-Moore D., Ma X.M., Nillni E.A., Czyzyk T.A., Pintar J.E., Eipper B.A., et al. Reversal of physiological deficits caused by diminished levels of peptidylglycine alpha-amidating monooxygenase by dietary copper. Endocrinology 2009, 150:1739-1747.
35. Allen D.K., Hassel C.A., Lei K.Y. Function of pituitary-thyroid axis in copper-deficient rats. J Nutr 1982, 112:2043-2046.
36. Prohaska J.R., Sunde R.A., Zinn K. Livers from copper-deficient rats have lower glutathione peroxidase activity and mRNA levels but normal liver selenium levels. J Nutr Biochem 1992, 3:429-436.
37. Kralik A., Kirchgessner M., Eder K. Concentrations of thyroid hormones in serum and activity of hepatic 5' monodeiodinase in copper-deficient rats. Z Ernahrungswiss 1996, 35:288-291.