-
1
-
-
0036782277
-
Deregulated homeobox gene expression in cancer: Cause or consequence?
-
Abate-Shen C. 2002. Deregulated homeobox gene expression in cancer: Cause or consequence? Nat Rev Cancer 2: 777-785.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 777-785
-
-
Abate-Shen, C.1
-
2
-
-
33846883742
-
B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase CbetaII
-
Abrams ST, Lakum T, Lin K, Jones GM, Treweeke AT, Farahani M, Hughes M, Zuzel M, Slupsky JR. 2007. B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase CbetaII. Blood 109: 1193-1201.
-
(2007)
Blood
, vol.109
, pp. 1193-1201
-
-
Abrams, S.T.1
Lakum, T.2
Lin, K.3
Jones, G.M.4
Treweeke, A.T.5
Farahani, M.6
Hughes, M.7
Zuzel, M.8
Slupsky, J.R.9
-
3
-
-
33646027006
-
Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells
-
Betschinger J, Mechtler K, Knoblich JA. 2006. Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells. Cell 124: 1241-1253.
-
(2006)
Cell
, vol.124
, pp. 1241-1253
-
-
Betschinger, J.1
Mechtler, K.2
Knoblich, J.A.3
-
4
-
-
27144555447
-
Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster
-
Caussinus E, Gonzalez C. 2005. Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster. Nat Genet 37: 1125-1129.
-
(2005)
Nat Genet
, vol.37
, pp. 1125-1129
-
-
Caussinus, E.1
Gonzalez, C.2
-
5
-
-
33751330924
-
Prospero acts as a binary switch between self-renewal and differentiation in Drosophila neural stem cells
-
Choksi SP, Southall TD, Bossing T, Edoff K, de Wit E, Fischer BE, van Steensel B, Micklem G, Brand AH. 2006. Prospero acts as a binary switch between self-renewal and differentiation in Drosophila neural stem cells. Dev Cell 11: 775-789.
-
(2006)
Dev Cell
, vol.11
, pp. 775-789
-
-
Choksi, S.P.1
Southall, T.D.2
Bossing, T.3
Edoff, K.4
de Wit, E.5
Fischer, B.E.6
van Steensel, B.7
Micklem, G.8
Brand, A.H.9
-
6
-
-
0037942564
-
Distinction between color photoreceptor cell fates is controlled by Prospero in Drosophila
-
Cook T, Pichaud F, Sonneville R, Papatsenko D, Desplan C. 2003. Distinction between color photoreceptor cell fates is controlled by Prospero in Drosophila. Dev Cell 4: 853-864.
-
(2003)
Dev Cell
, vol.4
, pp. 853-864
-
-
Cook, T.1
Pichaud, F.2
Sonneville, R.3
Papatsenko, D.4
Desplan, C.5
-
7
-
-
57349166727
-
Prox-1 promotes invasion of kaposiform hemangioendotheliomas
-
Dadras SS, Skrzypek A, Nguyen L, Shin JW, Schulz MM, Arbiser J, Mihm MC, Detmar M. 2008. Prox-1 promotes invasion of kaposiform hemangioendotheliomas. J Investig Dermatol 128: 2798-2806.
-
(2008)
J Investig Dermatol
, vol.128
, pp. 2798-2806
-
-
Dadras, S.S.1
Skrzypek, A.2
Nguyen, L.3
Shin, J.W.4
Schulz, M.M.5
Arbiser, J.6
Mihm, M.C.7
Detmar, M.8
-
8
-
-
0038394537
-
Acyclic N-(azacycloalkyl)bisindolylmaleimides: Isozyme selective inhibitors of PKCbeta
-
Faul MM, Gillig JR, Jirousek MR, Ballas LM, Schotten T, Kahl A, Mohr M. 2003. Acyclic N-(azacycloalkyl)bisindolylmaleimides: Isozyme selective inhibitors of PKCbeta. Bioorg Med Chem Lett 13: 1857-1859.
-
(2003)
Bioorg Med Chem Lett
, vol.13
, pp. 1857-1859
-
-
Faul, M.M.1
Gillig, J.R.2
Jirousek, M.R.3
Ballas, L.M.4
Schotten, T.5
Kahl, A.6
Mohr, M.7
-
9
-
-
0035866371
-
Elevated protein kinase C betaII is an early promotive event in colon carcinogenesis
-
Gokmen-Polar Y, Murray NR, Velasco MA, Gatalica Z, Fields AP. 2001. Elevated protein kinase C betaII is an early promotive event in colon carcinogenesis. Cancer Res 61: 1375-1381.
-
(2001)
Cancer Res
, vol.61
, pp. 1375-1381
-
-
Gokmen-Polar, Y.1
Murray, N.R.2
Velasco, M.A.3
Gatalica, Z.4
Fields, A.P.5
-
10
-
-
23844521568
-
The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts
-
Graff JR, McNulty AM, Hanna KR, Konicek BW, Lynch RL, Bailey SN, Banks C, Capen A, Goode R, Lewis JE, Sams L, Huss KL, Campbell RM, Iversen PW, Neubauer BL, Brown TJ, Musib L, Geeganage S, Thornton D. 2005. The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts. Cancer Res 65: 7462-7469.
-
(2005)
Cancer Res
, vol.65
, pp. 7462-7469
-
-
Graff, J.R.1
McNulty, A.M.2
Hanna, K.R.3
Konicek, B.W.4
Lynch, R.L.5
Bailey, S.N.6
Banks, C.7
Capen, A.8
Goode, R.9
Lewis, J.E.10
Sams, L.11
Huss, K.L.12
Campbell, R.M.13
Iversen, P.W.14
Neubauer, B.L.15
Brown, T.J.16
Musib, L.17
Geeganage, S.18
Thornton, D.19
-
11
-
-
12644317814
-
Prospero is a panneural transcription factor that modulates homeodomain protein activity
-
Hassan B, Li L, Bremer KA, Chang W, Pinsonneault J, Vaessin H. 1997. Prospero is a panneural transcription factor that modulates homeodomain protein activity. Proc Natl Acad Sci USA 94: 10991-10996.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 10991-10996
-
-
Hassan, B.1
Li, L.2
Bremer, K.A.3
Chang, W.4
Pinsonneault, J.5
Vaessin, H.6
-
12
-
-
48449097251
-
QUMA: Quantification tool for methylation analysis
-
Kumaki Y, Oda M, Okano M. 2008. QUMA: Quantification tool for methylation analysis. Nucleic Acids Res 36: W170-W175.
-
(2008)
Nucleic Acids Res
, vol.36
-
-
Kumaki, Y.1
Oda, M.2
Okano, M.3
-
13
-
-
33751530445
-
Prospero-related homeobox 1 (PROX1) is frequently inactivated by genomic deletions and epigenetic silencing in carcinomas of the bilary system
-
Laerm A, Helmbold P, Goldberg M, Dammann R, Holzhausen HJ, Ballhausen WG. 2007. Prospero-related homeobox 1 (PROX1) is frequently inactivated by genomic deletions and epigenetic silencing in carcinomas of the bilary system. J Hepatol 46: 89-97.
-
(2007)
J Hepatol
, vol.46
, pp. 89-97
-
-
Laerm, A.1
Helmbold, P.2
Goldberg, M.3
Dammann, R.4
Holzhausen, H.J.5
Ballhausen, W.G.6
-
14
-
-
0034650760
-
Pan-neural Prospero terminates cell proliferation during Drosophila neurogenesis
-
Li L, Vaessin H. 2000. Pan-neural Prospero terminates cell proliferation during Drosophila neurogenesis. Genes Dev 14: 147-151.
-
(2000)
Genes Dev
, vol.14
, pp. 147-151
-
-
Li, L.1
Vaessin, H.2
-
15
-
-
33845732645
-
Protein kinase C beta enhances growth and expression of cyclin D1 in human breast cancer cells
-
Li H, Weinstein IB. 2006. Protein kinase C beta enhances growth and expression of cyclin D1 in human breast cancer cells. Cancer Res 66: 11399-11408.
-
(2006)
Cancer Res
, vol.66
, pp. 11399-11408
-
-
Li, H.1
Weinstein, I.B.2
-
16
-
-
34249746834
-
Protein kinase C inhibitor enzastaurin induces in vitro and in vivo antitumor activity in Waldenstrom macroglobulinemia
-
Moreau AS, Jia X, Ngo HT, Leleu X, O'Sullivan G, Alsayed Y, Leontovich A, Podar K, Kutok J, Daley J, Lazo-Kallanian S, Hatjiharissi E, Raab MS, Xu L, Treon SP, Hideshima T, Anderson KC, Ghobrial IM. 2007. Protein kinase C inhibitor enzastaurin induces in vitro and in vivo antitumor activity in Waldenstrom macroglobulinemia. Blood 109: 4964-4972.
-
(2007)
Blood
, vol.109
, pp. 4964-4972
-
-
Moreau, A.S.1
Jia, X.2
Ngo, H.T.3
Leleu, X.4
O'Sullivan, G.5
Alsayed, Y.6
Leontovich, A.7
Podar, K.8
Kutok, J.9
Daley, J.10
Lazo-Kallanian, S.11
Hatjiharissi, E.12
Raab, M.S.13
Xu, L.14
Treon, S.P.15
Hideshima, T.16
Anderson, K.C.17
Ghobrial, I.M.18
-
17
-
-
38949178850
-
A phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory mantle cell lymphoma
-
Morschhauser F, Seymour JF, Kluin-Nelemans HC, Grigg A, Wolf M, Pfreundschuh M, Tilly H, Raemaekers J, van 't Veer MB, Milpied N, Cartron G, Pezzutto A, Spencer A, Reyes F, Dreyling M. 2008. A phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory mantle cell lymphoma. Ann Oncol 19: 247-253.
-
(2008)
Ann Oncol
, vol.19
, pp. 247-253
-
-
Morschhauser, F.1
Seymour, J.F.2
Kluin-Nelemans, H.C.3
Grigg, A.4
Wolf, M.5
Pfreundschuh, M.6
Tilly, H.7
Raemaekers, J.8
van 't Veer, M.B.9
Milpied, N.10
Cartron, G.11
Pezzutto, A.12
Spencer, A.13
Reyes, F.14
Dreyling, M.15
-
18
-
-
0033577858
-
Overexpression of protein kinase C betaII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis
-
Murray NR, Davidson LA, Chapkin RS, Clay Gustafson W, Schattenberg DG, Fields AP. 1999. Overexpression of protein kinase C betaII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis. J Cell Biol 145: 699-711.
-
(1999)
J Cell Biol
, vol.145
, pp. 699-711
-
-
Murray, N.R.1
Davidson, L.A.2
Chapkin, R.S.3
Clay Gustafson, W.4
Schattenberg, D.G.5
Fields, A.P.6
-
19
-
-
0041520652
-
Mutations and aberrant DNA methylation of the PROX1 gene in hematologic malignancies
-
Nagai H, Li Y, Hatano S, Toshihito O, Yuge M, Ito E, Utsumi M, Saito H, Kinoshita T. 2003. Mutations and aberrant DNA methylation of the PROX1 gene in hematologic malignancies. Genes Chromosomes Cancer 38: 13-21.
-
(2003)
Genes Chromosomes Cancer
, vol.38
, pp. 13-21
-
-
Nagai, H.1
Li, Y.2
Hatano, S.3
Toshihito, O.4
Yuge, M.5
Ito, E.6
Utsumi, M.7
Saito, H.8
Kinoshita, T.9
-
20
-
-
0026739568
-
Positive and negative regulation of the transcription of the human protein kinase C beta gene
-
Niino YS, Ohno S, Suzuki K. 1992. Positive and negative regulation of the transcription of the human protein kinase C beta gene. J Biol Chem 267: 6158-6163.
-
(1992)
J Biol Chem
, vol.267
, pp. 6158-6163
-
-
Niino, Y.S.1
Ohno, S.2
Suzuki, K.3
-
21
-
-
0026781998
-
Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters
-
Obeid LM, Blobe GC, Karolak LA, Hannun YA. 1992. Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters. J Biol Chem 267: 20804-20810.
-
(1992)
J Biol Chem
, vol.267
, pp. 20804-20810
-
-
Obeid, L.M.1
Blobe, G.C.2
Karolak, L.A.3
Hannun, Y.A.4
-
22
-
-
0027718106
-
Prox 1, a prospero-related homeobox gene expressed during mouse development
-
Oliver G, Sosa-Pineda B, Geisendorf S, Spana EP, Doe CQ, Gruss P. 1993. Prox 1, a prospero-related homeobox gene expressed during mouse development. Mech Dev 44: 3-16.
-
(1993)
Mech Dev
, vol.44
, pp. 3-16
-
-
Oliver, G.1
Sosa-Pineda, B.2
Geisendorf, S.3
Spana, E.P.4
Doe, C.Q.5
Gruss, P.6
-
23
-
-
0023278635
-
Expression and properties of two types of protein kinase C: Alternative splicing from a single gene
-
Ono Y, Kikkawa U, Ogita K, Fujii T, Kurokawa T, Asaoka Y, Sekiguchi K, Ase K, Igarashi K, Nishizuka Y. 1987. Expression and properties of two types of protein kinase C: Alternative splicing from a single gene. Science 236: 1116-1120.
-
(1987)
Science
, vol.236
, pp. 1116-1120
-
-
Ono, Y.1
Kikkawa, U.2
Ogita, K.3
Fujii, T.4
Kurokawa, T.5
Asaoka, Y.6
Sekiguchi, K.7
Ase, K.8
Igarashi, K.9
Nishizuka, Y.10
-
24
-
-
42949112116
-
Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype
-
Petrova TV, Nykanen A, Norrmen C, Ivanov KI, Andersson LC, Haglund C, Puolakkainen P, Wempe F, von Melchner H, Gradwohl G, Vanharanta S, Aaltonen LA, Saharinen J, Gentile M, Clarke A, Taipale J, Oliver G, Alitalo K. 2008. Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype. Cancer cell 13: 407-419.
-
(2008)
Cancer cell
, vol.13
, pp. 407-419
-
-
Petrova, T.V.1
Nykanen, A.2
Norrmen, C.3
Ivanov, K.I.4
Andersson, L.C.5
Haglund, C.6
Puolakkainen, P.7
Wempe, F.8
von Melchner, H.9
Gradwohl, G.10
Vanharanta, S.11
Aaltonen, L.A.12
Saharinen, J.13
Gentile, M.14
Clarke, A.15
Taipale, J.16
Oliver, G.17
Alitalo, K.18
-
25
-
-
34249075706
-
Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell lymphoma
-
Robertson MJ, Kahl BS, Vose JM, de Vos S, Laughlin M, Flynn PJ, Rowland K, Cruz JC, Goldberg SL, Musib L, Darstein C, Enas N, Kutok JL, Aster JC, Neuberg D, Savage KJ, LaCasce A, Thornton D, Slapak CA, Shipp MA. 2007. Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell lymphoma. J Clin Oncol 25: 1741-1746.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1741-1746
-
-
Robertson, M.J.1
Kahl, B.S.2
Vose, J.M.3
de Vos, S.4
Laughlin, M.5
Flynn, P.J.6
Rowland, K.7
Cruz, J.C.8
Goldberg, S.L.9
Musib, L.10
Darstein, C.11
Enas, N.12
Kutok, J.L.13
Aster, J.C.14
Neuberg, D.15
Savage, K.J.16
LaCasce, A.17
Thornton, D.18
Slapak, C.A.19
Shipp, M.A.20
more..
-
26
-
-
33750733603
-
A homeobox protein, prox1, is involved in the differentiation, proliferation, and prognosis in hepatocellular carcinoma
-
Shimoda M, Takahashi M, Yoshimoto T, Kono T, Ikai I, Kubo H. 2006. A homeobox protein, prox1, is involved in the differentiation, proliferation, and prognosis in hepatocellular carcinoma. Clin Cancer Res 12: 6005-6011.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 6005-6011
-
-
Shimoda, M.1
Takahashi, M.2
Yoshimoto, T.3
Kono, T.4
Ikai, I.5
Kubo, H.6
-
27
-
-
18244409933
-
Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning
-
Shipp MA, Ross KN, Tamayo P, Weng AP, Kutok JL, Aguiar RC, Gaasenbeek M, Angelo M, Reich M, Pinkus GS, Ray TS, Koval MA, Last KW, Norton A, Lister TA, Mesirov J, Neuberg DS, Lander ES, Aster JC, Golub TR. 2002. Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning. Nat Med 8: 68-74.
-
(2002)
Nat Med
, vol.8
, pp. 68-74
-
-
Shipp, M.A.1
Ross, K.N.2
Tamayo, P.3
Weng, A.P.4
Kutok, J.L.5
Aguiar, R.C.6
Gaasenbeek, M.7
Angelo, M.8
Reich, M.9
Pinkus, G.S.10
Ray, T.S.11
Koval, M.A.12
Last, K.W.13
Norton, A.14
Lister, T.A.15
Mesirov, J.16
Neuberg, D.S.17
Lander, E.S.18
Aster, J.C.19
Golub, T.R.20
more..
-
28
-
-
0033932899
-
Hepatocyte migration during liver development requires Prox1
-
Sosa-Pineda B, Wigle JT, Oliver G. 2000. Hepatocyte migration during liver development requires Prox1. Nat Genet 25: 254-255.
-
(2000)
Nat Genet
, vol.25
, pp. 254-255
-
-
Sosa-Pineda, B.1
Wigle, J.T.2
Oliver, G.3
-
29
-
-
33845576594
-
Loss of function of the candidate tumor suppressor prox1 by RNA mutation in human cancer cells
-
Takahashi M, Yoshimoto T, Shimoda M, Kono T, Koizumi M, Yazumi S, Shimada Y, Doi R, Chiba T, Kubo H. 2006. Loss of function of the candidate tumor suppressor prox1 by RNA mutation in human cancer cells. Neoplasia 8: 1003-1010.
-
(2006)
Neoplasia
, vol.8
, pp. 1003-1010
-
-
Takahashi, M.1
Yoshimoto, T.2
Shimoda, M.3
Kono, T.4
Koizumi, M.5
Yazumi, S.6
Shimada, Y.7
Doi, R.8
Chiba, T.9
Kubo, H.10
-
30
-
-
34250891865
-
Epigenetic silencing of the candidate tumor suppressor gene PROX1 in sporadic breast cancer
-
Versmold B, Felsberg J, Mikeska T, Ehrentraut D, Kohler J, Hampl JA, Rohn G, Niederacher D, Betz B, Hellmich M, Pietsch T, Schmutzler RK, Waha A. 2007. Epigenetic silencing of the candidate tumor suppressor gene PROX1 in sporadic breast cancer. Int J Cancer 121: 547-554.
-
(2007)
Int J Cancer
, vol.121
, pp. 547-554
-
-
Versmold, B.1
Felsberg, J.2
Mikeska, T.3
Ehrentraut, D.4
Kohler, J.5
Hampl, J.A.6
Rohn, G.7
Niederacher, D.8
Betz, B.9
Hellmich, M.10
Pietsch, T.11
Schmutzler, R.K.12
Waha, A.13
-
31
-
-
0033578853
-
Prox1 function is required for the development of the murine lymphatic system
-
Wigle JT, Oliver G. 1999. Prox1 function is required for the development of the murine lymphatic system. Cell 98: 769-778.
-
(1999)
Cell
, vol.98
, pp. 769-778
-
-
Wigle, J.T.1
Oliver, G.2
-
32
-
-
0033018615
-
Prox1 function is crucial for mouse lens-fibre elongation
-
Wigle JT, Chowdhury K, Gruss P, Oliver G. 1999. Prox1 function is crucial for mouse lens-fibre elongation. Nat Genet 21: 318-322.
-
(1999)
Nat Genet
, vol.21
, pp. 318-322
-
-
Wigle, J.T.1
Chowdhury, K.2
Gruss, P.3
Oliver, G.4
|