Prox-1 promotes invasion of kaposiform hemangioendotheliomas

Journal of Investigative Dermatology

Volumn 128, Issue 12, 2008, Pages 2798-2806

  Dadras, Soheil S ^a,b,e   Skrzypek, Adrienne ^a   Nguyen, Lynh ^a   Shin, Jay W ^a,c   Schulz, Martin M P ^c   Arbiser, Jack ^d   Mihm, Martin C ^b   Detmar, Michael ^a,c  

^a Transplantation Biology Research Center   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c ETH ZURICH   (Switzerland)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN PROX 1; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANAPLASTIC CARCINOMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INVASION; CELL ADHESION; CELL MIGRATION; CONTROLLED STUDY; HEMANGIOENDOTHELIOMA; IN VITRO STUDY; IN VIVO STUDY; KAPOSI SARCOMA; KAPOSIFORM HEMANGIOENDOTHELIOMA; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TUMOR GROWTH; UPREGULATION;

ANIMALS; CELL LINE, TUMOR; CELL MOVEMENT; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HEMANGIOENDOTHELIOMA; HOMEODOMAIN PROTEINS; HUMANS; MEMBRANE GLYCOPROTEINS; MICE; NEOPLASM INVASIVENESS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SARCOMA, KAPOSI; TUMOR SUPPRESSOR PROTEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3;

EID: 57349166727     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2008.176     Document Type: Article

References (31)

1. Amatschek S, Kriehuber E, Bauer W, Reininger B, Meraner P, Wolpl A et al. (2007) Blood and lymphatic endothelial cell-specific differentiation programs are stringently controlled by the tissue environment. Blood 109:4777-85
2. Burke Z, Oliver G (2002) Prox1 is an early specific marker for the developing liver and pancreas in the mammalian foregut endoderm. Mech Dev 118:147-55
3. Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM et al. (1994) Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 266:1865-9
4. Cueni LN, Detmar M (2006) New insights into the molecular control of the lymphatic vascular system and its role in disease. J Invest Dermatol 126:2167-77
5. Dadras SS, North PE, Bertoncini J, Mihm MC, Detmar M (2004) Infantile hemangiomas are arrested in an early developmental vascular differentiation state. Mod Pathol 17:1068-79
6. Dadras SS, Paul T, Bertoncini J, Brown LF, Muzikansky A, Jackson DG et al. (2003) Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survival. Am J Pathol 162:1951-60
7. Detmar M, Tenorio S, Hettmannsperger U, Ruszczak Z, Orfanos CE (1992) Cytokine regulation of proliferation and ICAM-1 expression of human dermal microvascular endothelial cells in vitro. J Invest Dermatol 98:147-53
8. Dubois-Stringfellow N, Kolpack-Martindale L, Bautch VL, Azizkhan RG (1994) Mice with hemangiomas induced by transgenic endothelial cells. A model for the Kasabach-Merritt syndrome. Am J Pathol 144:796-806
9. Enjolras O, Mulliken JB, Wassef M, Frieden IJ, Rieu PN, Burrows PE et al. (2000) Residual lesions after Kasabach-Merritt phenomenon in 41 patients. J Am Acad Dermatol 42:225-35
10. Flanagan BP, Helwig EB (1977) Cutaneous lymphangioma. Arch Dermatol 113:24-30
11. Harvey NL, Srinivasan RS, Dillard ME, Johnson NC, Witte MH, Boyd K et al. (2005) Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity. Nat Genet 37:1072-81
12. Hirakawa S, Hong YK, Harvey N, Schacht V, Matsuda K, Libermann T et al. (2003) Identification of vascular lineage-specific genes by transcriptional profiling of isolated blood vascular and lymphatic endothelial cells. Am J Pathol 162:575-86
13. Hoak JC, Warner ED, Cheng HF, Fry GL, Hankenson RR (1971) Hemangioma with thrombocytopenia and microangiopathic anemia (Kasabach-Merritt syndrome): an animal model. J Lab Clin Med 77:941-50
14. Hong YK, Foreman K, Shin JW, Hirakawa S, Curry CL, Sage DR et al. (2004) Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus. Nat Genet 36:683-5
15. Hong Y-K, Harvey N, Noh Y-H, Schacht V, Hirakawa S, Detmar M et al. (2002) Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate. Dev Dyn 225:351-7
16. Laerm A, Helmbold P, Goldberg M, Dammann R, Holzhausen HJ, Ballhausen WG (2007) Prospero-related homeobox 1 (PROX1) is frequently inactivated by genomic deletions and epigenetic silencing in carcinomas of the biliary system. J Hepatol 46:89-97
17. Lavado A, Oliver G (2007) Prox1 expression patterns in the developing and adult murine brain. Dev Dyn 236:518-24
18. Nagai H, Li Y, Hatano S, Toshihito O, Yuge M, Ito E et al. (2003) Mutations and aberrant DNA methylation of the PROX1 gene in hematologic malignancies. Genes Chromosomes Cancer 38:13-21
19. Obeso J, Weber J, Auerbach R (1990) A hemangioendothelioma-derived cell line: its use as a model for the study of endothelial cell biology. Lab Invest 63:259-69
20. Petrova TV, Maekinen T, Maekelae TP, Saarela J, Virtanen I, Ferrell RE et al. (2002) Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor. EMBO J 21:4593-9
21. Sarkar M, Mulliken JB, Kozakewich HP, Robertson RL, Burrows PE (1997) Thrombocytopenic coagulopathy (Kasabach-Merritt phenomenon) is associated with Kaposiform hemangioendothelioma and not with common infantile hemangioma. Plast Reconstr Surg 100:1377-86
22. Shimoda M, Takahashi M, Yoshimoto T, Kono T, Ikai I, Kubo H (2006) A homeobox protein, prox1, is involved in the differentiation, proliferation, and prognosis in hepatocellular carcinoma. Clin Cancer Res 12:6005-11
23. Sosa-Pineda B, Wigle JT, Oliver G (2000) Hepatocyte migration during liver development requires Prox1. Nat Genet 25:254-5
24. Streit M, Riccardi L, Velasco P, Brown LF, Hawighorst T, Bornstein P et al. (1999) Thrombospondin-2: a potent endogenous inhibitor of tumor growth and angiogenesis. Proc Natl Acad Sci USA 96:14888-93
25. Su H, Reano A, Hesse S, Viac J, Thivolet J (1990) Modulation of bullous pemphigoid antigens by gamma interferon in cultured human keratinocytes. J Dermatol 17:16-23
26. Thurston G, Murphy TJ, Baluk P, Lindsey JR, McDonald DM (1998) Angiogenesis in mice with chronic airway inflammation: strain-dependent differences. Am J Pathol 153:1099-112
27. Wang HW, Trotter MW, Lagos D, Bourboulia D, Henderson S, Makinen T et al. (2004) Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma. Nat Genet 36:687-93
28. Wigle JT, Chowdhury K, Gruss P, Oliver G (1999) Prox1 function is crucial for mouse lens-fibre elongation. Nat Genet 21:318-22
29. Wigle JT, Oliver G (1999) Prox1 function is required for the development of the murine lymphatic system. Cell 98:769-78
30. Witte MH, Way DL, Witte CL, Bernas M (1997) Lymphangiogenesis: mechanisms, significance and clinical implications. EXS 79:65-112
31. Zukerberg LR, Nickoloff BJ, Weiss SW (1993) Kaposiform hemangioendothelioma of infancy and childhood. An aggressive neoplasm associated with Kasabach-Merritt syndrome and lymphangiomatosis. Am J Surg Pathol 17:321-8