Inhibition of HIV-1 tat-induced transactivation and apoptosis by the divalent metal chelators, fusaric acid and picolinic acid-Implications for HIV-1 dementia

Neuroscience Research

Volumn 74, Issue 1, 2012, Pages 59-63

  Ramautar, Atish ^a   Mabandla, Musa ^a   Blackburn, Jonathan ^b   Daniels, Willie M U ^a  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Apoptosis; Fusaric acid; HIV 1 dementia; Metal chelators; Picolinic acid; Tat protein

Indexed keywords

FUSARIC ACID; PICOLINIC ACID; RECOMBINANT PROTEIN; TRANSACTIVATOR PROTEIN;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CHELATION THERAPY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; FLOW CYTOMETRY; HIV ASSOCIATED DEMENTIA; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; TRANSACTIVATION; VIRUS INHIBITION; VIRUS TRANSCRIPTION;

AIDS DEMENTIA COMPLEX; APOPTOSIS; CELLS, CULTURED; CHELATING AGENTS; FLOW CYTOMETRY; FUSARIC ACID; HIV-1; HUMANS; METALS; PICOLINIC ACIDS; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; TRANSCRIPTIONAL ACTIVATION;

EID: 84865986486     PISSN: 01680102     EISSN: 18728111     Source Type: Journal    
DOI: 10.1016/j.neures.2012.05.014     Document Type: Article

References (28)

1. Aksenov M.Y., Aksenova M.V., Mactutus C.F., Booze R.M. Attenuated neurotoxicity of the transactivation-defective HIV-1 tat protein in hippocampal cell cultures. Exp. Neurol. 2009, 219:586-590.
2. Bonavia R., Bajetto A., Barbero S., Albini A., Noonan D.M., Schettini G. HIV-1 tat causes apoptotic death and calcium homeostasis alterations in rat neurons. Biochem. Biophys. Res. Commun. 2001, 288:301-308.
3. Buckner C., Luers A., Calderon T., Eugenin E., Berman J. Neuroimmunity and the blood-brain barrier: molecular regulation of leukocyte transmigration and viral entry into the nervous system with a focus on NeuroAIDS. J. Neuroimmune Pharmacol. 2006, 1:160-181.
4. Campbell G.R., Watkins J.D., Esquieu D., Pasquier E., Loret E.P., Spector S.A. The C terminus of HIV-1 tat modulates the extent of CD178-mediated apoptosis of T cells. J. Biol. Chem. 2005, 280:38376-38382.
5. Chase T.N. Fusaric acid in Parkinson's disease. Neurology 1974, 24:637-639.
6. Debebe Z., Ammosova T., Jerebtsova M., Kurantsin-Mills J., Niu X., Charles S., Richardson D.R., Ray P.E., Gordeuk V.R., Nekhai S. Iron chelators ICL670 and 311 inhibit HIV-1 transcription. Virology 2007, 367:324-333.
7. Fernandez-Pol J.A., Hamilton P.D., Klos D.J. Essential viral and cellular zinc and iron containing metalloproteins as targets for novel antiviral and anticancer agents: implications for prevention and therapy of viral diseases and cancer. Anticancer Res. 2001, 21(2A):931-957.
8. Fernandez-Pol J.A., Johnson G.S. Selective toxicity induced by picolinic acid in simian virus 40 transformed cells in tissue culture. Cancer Res. 1977, 37:4276-4279.
9. Fernandez-Pol J.A., Klos D.J., Hamilton P.D. Antiviral, cytotoxic and apoptotic activities of picolinic acid on human immunodeficiency virus-1 and human herpes simplex virus-2 infected cells. Anticancer Res. 2001, 21:3773-3776.
10. Ferris M.J., Mactutus C.F., Booze R.M. Neurotoxic profiles of HIV, psychostimulant drugs of abuse, and their concerted effect on the brain: current status of dopamine system vulnerability in NeuroAIDS. Neurosci. Biobehav. Rev. 2008, 32:883-909.
11. Grant R.S., Coggan S.E., Smythe G.A. The physiological action of picolinic acid in the human brain. Int. J. Tryptophan Res. 2009, 2:71-79.
12. Jaglowski J.R., Stack B.C. Enhanced growth inhibition of squamous cell carcinoma of the head and neck by combination therapy of fusaric acid and paclitaxel or carboplatin. Cancer Lett. 2006, 243:58-63.
13. Kashanchi F., Agbottah E.T., Pise-Masison C.A., Mahieux R., Duvall J., Kumar A., Brady J.N. Cell cycle-regulated transcription by the human immunodeficiency virus type 1 tat transactivator. J. Virol. 2000, 74:652-660.
14. King J.E., Eugenin E.A., Buckner C.M., Berman J.W. HIV tat and neurotoxicity. Microbes Infect. 2006, 8:1347-1357.
15. Kruman I.I., Nath A., Mattson M.P. HIV-1 protein tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stress. Exp. Neurol. 1998, 154:276-288.
16. Lopez-Huertas M.R., Callejas S., Abia D., Mateos E., Dopazo A., Alcami{dotless} J., Coiras M. Modifications in host cell cytoskeleton structure and function mediated by intracellular HIV-1 Tat protein are greatly dependent on the second coding exon. Nucleic Acids Res. 2010, 38:3287-3307.
17. Nath A., Sacktor N. Influence of HAART on persistence of HIV in the central nervous system. Curr. Opin. Neurol. 2006, 19:358-361.
18. Pocernich C.B., Sultana R., Mohmmad-Abdul H., Nath A., Butterfield D.A. HIV-dementia, tat-induced oxidative stress, and antioxidant therapeutic considerations. Brain Res. Rev. 2005, 50:14-26.
19. Romani B., Engelbrecht S., Glashoff R.H. Functions of tat: the versatile protein of human immunodeficiency virus type 1. J. Gen. Virol. 2010, 91:1-12.
20. Ruffman R., Schlick R., Chirigos M.A., Budzynsky W., Varesio L. Antiproliferative activity of picolinic acid due to macrophage activation. Drugs Exp. Clin. Res. 1987, 13:604-614.
21. Siddappa N.B., Venkatramanan M., Venkatesh P., Janki M.V., Jayasuryan N., Desai A., Ravi V., Ranga U. Transactivation and signaling functions of tat are not correlated: biological and immunological characterization of HIV-1 subtype-C tat protein. Retrovirology 2006, 3. Article 53.
22. Sharma D., Bhattacharya J. Cellular and molecular basis of HIV-assocviated neuro pathogenesis. Indian J. Med. Res. 2009, 129:637-651.
23. Stack J.R., Hansen B.C., Ruda J.P., Jaglowski J.M., Shvidler J., Hollenbeak C.S. Fusaric acid: a novel agent and mechanism to treat HNSCC. Otolaryngol. Head Neck Surg. 2004, 131:54-60.
24. Tahirov T.H., Babayeva N.D., Varzavand K., Cooper J.J., Sedore S.C., Price D.H. Crystal structure of HIV-1 tat complexed with human P-TEFb. Nature 2010, 465:747-752.
25. Varesio L., Clayton M., Blasi E., Ruffman R., Radzioch D. Picolinic acid, a catabolite of tryptophan, as the second signal in the activation of IFN-γ-primed macrophages. J. Immunol. 1990, 145:4265-4271.
26. Wang H., Ng T.B. Pharmacological activities of fusaric acid (5-butylpicolinic acid). Life Sci. 1999, 65:849-856.
27. Wiley C.A., Baldwin M., Achim C.L. Expression of HIV regulatory and structural mRNA in the central nervous system. AIDS 1996, 10:843-847.
28. Woods S.P., Moore D.J., Weber E., Grant I. Cognitive neuropsychology of HIV-associated neurocognitive disorders. Neuropsychol. Rev. 2009, 19:152-168.