Gene transfer of NAD(P)H oxidase inhibitor to the vascular adventitia attenuates medial smooth muscle hypertrophy

Circulation Research

Volumn 95, Issue 6, 2004, Pages 587-594

  Liu, Jianhua ^a   Ormsby, Adrian ^a   Oja Tebbe, Nancy ^a   Pagano, Patrick J ^a  

^a HENRY FORD HOSPITAL   (United States)

Author keywords

Angiotensin II; Gene therapy; Hypertrophy; NAD(P)H oxidase; Reactive oxygen species

Indexed keywords

4 HYDROXYNONENAL; ADENOVIRUS VECTOR; ANGIOTENSIN; ENZYME INHIBITOR; GLYCOPROTEIN GP 91; GLYCOPROTEIN GP 91 INHIBITOR; PROTEIN INHIBITOR; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL WALL; CISTRON; CONTROLLED STUDY; CYTOMEGALOVIRUS; DOSE TIME EFFECT RELATION; ENZYME INHIBITION; GENE TRANSFER; GENETIC TRANSFECTION; IMMUNOHISTOCHEMISTRY; INHIBITION KINETICS; LIPID PEROXIDATION; MACROPHAGE; MALE; MOUSE; MUSCLE HYPERTROPHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SYSTOLIC BLOOD PRESSURE;

ADENOVIRIDAE; ALDEHYDES; ANGIOTENSIN II; ANIMALS; BLOOD PRESSURE; CAROTID ARTERIES; DEFECTIVE VIRUSES; GENE THERAPY; GENES, REPORTER; GENETIC VECTORS; GLYCOPROTEINS; HYPERTROPHY; INJECTIONS, INTRA-ARTERIAL; LIPID PEROXIDATION; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MUSCLE, SMOOTH, VASCULAR; NADPH OXIDASE; OXIDATIVE STRESS; PHOSPHOPROTEINS; REACTIVE OXYGEN SPECIES; TUNICA MEDIA;

EID: 4644363091     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000142317.88591.e6     Document Type: Article

References (35)

1. Ceiler DL, Nelissen-Vrancken HJMG, Smits JFM, De Mey JGR. Pressure but not angiotensin II-induced increases in wall mass or tone influences static and dynamic aortic mechanics. J Hypertens. 1999;17:1109-1116.
2. Parker SB, Wade SS, Prewitt RL. Pressure mediates angiotensin II-induced arterial hypertrophy and PDGF-A expression. Hypertension. 1998;32:452-458.
3. Cifuentes ME, Pagano PJ. c-Src and smooth muscle NAD(P)H oxidase: assembling a path to hypertrophy [editorial]. Arterioscler Thromb Vasc Biol. 2003;23:919-921.
4. Geisterfer AAT, Peach MJ, Owens GK. Angiotensin II induces hypertrophy, not hyperplasia, of cultured rat aortic smooth muscle cells. Circ Res. 1988;62:749-756.
5. Griffin SA, Brown WCB, MacPherson F, McGrath JC, Wilson VG, Korsgaard N, Mulvany MJ, Lever AF. Angiotensin II causes vascular hypertrophy in part by a non-pressor mechanism. Hypertension. 1991;17: 626-635.
6. Engeli S, Negrel R, Sharma AM. Physiology and pathophysiology of the adipose tissue renin-angiotensin system. Hypertension. 2000;35: 1270-1277.
7. Cassis LA, Lynch KR, Peach MJ. Localization of angiotensinogen messenger RNA in rat aorta. Circ Res. 1988;62:1259-1262.
8. Berk BC, Vekshtein V, Gordon HM, Tsuda T. Angiotensin II-stimulated protein synthesis in cultured vascular smooth muscle cells. Hypertension. 1989;13:305-314.
9. Griendling KK, Minieri CA, Ollerenshaw JD, Alexander RW. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res. 1994;74:1141-1148.
10. Rao GN, Berk BC. Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression. Circ Res. 1992;70: 593-599.
11. Ushio-Fukai M, Alexander RW, Akers M, Yin Q, Fujio Y, Walsh K, Griendling KK. Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells. J Biol Chem. 1999;274:22699-22704.
12. Griendling KK, Sorescu D, Lassègue B, Ushio-Fukai M. Modulation of protein kinase activity and gene expression by reactive oxygen species and their role in vascular physiology and pathophysiology. Arterioscler Thromb Vasc Biol. 2000;20:2175-2183.
13. Touyz RM, Yao G, Schiffrin EL. c-Src induces phosphorylation and translocation of p47phox. Role in superoxide generation by angiotensin II in human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2003;23:981-987.
14. Pagano PJ, Clark JK, Cifuentes-Pagano ME, Clark SM, Callis GM, Quinn MT. Localization of a constitutively active, phagocyte-like NADPH oxidase in rabbit aortic adventitia: enhancement by angiotensin II. Proc Natl Acad Sci USA. 1997;94:14483-14488.
15. phox mRNA expression and NADPH oxidase superoxide generation in rabbit aortic adventitial fibroblasts. Hypertension. 1998;32: 331-337.
16. phox in human coronary arteries. Circulation. 1999;100:1494-1498.
17. Shi Y, Niculescu R, Wang D, Patel S, Davenpeck KL, Zalewski A. Increased NAD(P)H oxidase and reactive oxygen species in coronary arteries after balloon injury. Arterioscler Thromb Vasc Biol. 2001;21: 739-745.
18. Capers Q, IV, Alexander RW, Lou P, de Leon H, Wilcox JN, Ishizaka N, Howard AB, Taylor WR. Monocyte chemoattractant protein-1 expression in aortic tissues of hypertensive rats. Hypertension. 1997;30:1397-1402.
19. phox. Circulation. 2002; 106:2497-2502.
20. Wang HD, Xu S, Johns DG, Du Y, Quinn MT, Cayatte AJ, Cohen RA. Role of NADPH oxidase in the vascular hypertrophic and oxidative stress response to angiotensin II in mice. Circ Res. 2001;88:947-953.
21. Liao D-F, Jin Z-G, Baas AS, Daum G, Gygi SP, Aebersold R, Berk BC. Purification and identification of secreted oxidative stress-induced factors from vascular smooth muscle cells. J Biol Chem. 2000;275:189-196.
22. Jin Z-G, Melaragno MG, Liao D-F, Yan C, Haendeler J, Suh Y-A, Lambeth JD, Berk BC. Cyclophilin A is a secreted growth factor induced by oxidative stress. Circ Res. 2000;87:789-796.
23. 2-and systolic blood pressure in mice. Circ Res. 2001;89:408-414.
24. Jacobson GM, Dourron HM, Liu J, Carretero OA, Reddy DJ, Andrzejewski T, Pagano PJ. Novel NAD(P)H oxidase inhibitor suppresses angioplasty-induced superoxide and neointimal hyperplasia of rat carotid artery. Circ Res. 2003;92:637-643.
25. Vaziri C, Faller DV. Down-regulation of platelet-derived growth factor receptor expression during terminal differentiation of 3T3-L1 preadipocyte fibroblasts. J Biol Chem. 1996;271:13642-13648.
26. Ballagi AE, Ishizaki A, Nehlin J-O, Funa K. Isolation and characterization of the mouse PDGF β-receptor promoter. Biochem Biophys Res Commun. 1995;210:165-173.
27. Mulvany MJ, Baumbach GL, Aalkjaer C, Heagerty AM, Korsgaard N, Schiffrin EL, Heistad DD. Vascular remodeling [letter]. Hypertension. 1996;28:505-506.
28. Bush E, Maeda N, Kuziel WA, Dawson TC, Wilcox JN, DeLeon H, Taylor WR. CC chemokine receptor 2 is required for macrophage infiltration and vascular hypertrophy in angiotensin II-induced hypertension. Hypertension. 2000;36:360-363.
29. Liu JH, Yang F, Yang X-P, Jankowski M, Pagano PJ. Angiotensin II-induced vascular macrophage infiltration and remodeling are mediated by NAD(P)H oxidase. Arterioscler Thromb Vasc Biol. 2003;23:776-782.
30. Ushio-Fukai M, Zafari AM, Fukui T, Ishizaka N, Griendling KK. p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells. J Biol Chem. 1996;271: 23317-23321.
31. Dourron HM, Jacobson GM, Reddy DJ, Pagano PJ. Adventitial gene transfer of NAD(P)H oxidase inhibitor suppresses increased superoxide following balloon angioplasty in the rat carotid artery. Hypertension. 2002;40:383. Abstract.
32. Nakamura K, Kusano K, Nakamura Y, Kakishita M, Ohta K, Nagase S, Yamamoto M, Miyaji K, Saito H, Morita H, Emori T, Matsubara H, Toyokuni S, Ohe T. Carvedilol decreases elevated oxidative stress in human failing myocardium. Circulation. 2002;105:2867-2871.
33. Touyz RM, Chen X, Tabet F, Yao G, He G, Quinn MT, Pagano PJ, Schiffrin EL. Expression of a functionally active gp91phox-containing neutrophil-type NAD(P)H oxidase in smooth muscle cells from human resistance arteries. Regulation by angiotensin II. Circ Res. 2002;90: 1205-1213.
34. Halliwell B, Gutteridge JMC. Oxidative stress: adaptation, damage, repair and death. In: Halliwell B, Gutteridge JMC, eds. Free Radicals in Biology and Medicine. 3rd ed. New York: Oxford University Press; 1999: pp. 246-350.
35. Touyz RM, El Mabrouk M, He G, Wu X-H, Schiffrin EL. Mitogen-activated protein/extracellular signal-regulated kinase inhibition attenuates angiotensin II-mediated signaling and contraction in spontaneously hypertensive rat vascular smooth muscle cells. Circ Res. 1999; 84:505-515.