Th2 cytokine-mediated methimazole-induced acute liver injury in mice

Journal of Applied Toxicology

Volumn 32, Issue 10, 2012, Pages 823-833

  Kobayashi, Masanori ^a,b   Higuchi, Satonori ^a   Ide, Mika ^b   Nishikawa, Satomi ^b   Fukami, Tatsuki ^a   Nakajima, Miki ^a   Yokoi, Tsuyoshi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Cytokines; Drug induced liver injury; Eotaxin; Helper T cells; IL 4

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BINDING PROTEIN; BUTHIONINE SULFOXIMINE; CHEMOKINE; GLUTATHIONE; INTERLEUKIN 4; INTERLEUKIN 4 ANTIBODY; MACROPHAGE INFLAMMATORY PROTEIN 2; MESSENGER RNA; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; THIAMAZOLE; TRANSCRIPTION FACTOR GATA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FEMALE; GENE; HISTOPATHOLOGY; LIVER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TH2 CELL; TOXIC HEPATITIS;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; ANTIMETABOLITES; ANTITHYROID AGENTS; BUTHIONINE SULFOXIMINE; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; FEMALE; GATA3 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; GLUTATHIONE; INTERLEUKIN-4; LIVER; METHIMAZOLE; MICE; MICE, INBRED BALB C; RNA, MESSENGER; TH2 CELLS;

MUS;

EID: 84865830744     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.2731     Document Type: Article

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