Enhanced cellular uptake and in vitro antitumor activity of short-chain fatty acid acylated daunorubicin-GnRH-III bioconjugates

European Journal of Medicinal Chemistry

Volumn 56, Issue , 2012, Pages 155-165

  Hegedüs, Rózsa ^a   Manea, Marilena ^b   Orbán, Erika ^a   Szabó, Ildikó ^a   Kiss, Éva ^c   Sipos, Éva ^d   Halmos, Gábor ^d   Mez, Gábor ^a  

^a EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^b UNIVERSITY OF KONSTANZ   (Germany)

^c EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^d UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Antitumor activity; Daunorubicin; Gonadotropin releasing hormone; Receptor binding affinity; Short chain fatty acids; Targeted cancer chemotherapy

Indexed keywords

CHYMOTRYPSIN A; DAUNORUBICIN; DAUNORUBICIN DERIVATIVE; GONADORELIN DERIVATIVE; GONADORELIN RECEPTOR; LYSINE; SERINE; SHORT CHAIN FATTY ACID;

ACYLATION; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER CELL; CANCER CHEMOTHERAPY; CANCER INHIBITION; CONTROLLED STUDY; CYTOSTASIS; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; DRUG UPTAKE; ENZYME STABILITY; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN;

ACYLATION; ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; CIRCULAR DICHROISM; DAUNORUBICIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; FATTY ACIDS; GONADOTROPIN-RELEASING HORMONE; HT29 CELLS; HUMANS; MCF-7 CELLS; MOLECULAR STRUCTURE; PYRROLIDONECARBOXYLIC ACID; RECEPTORS, LHRH; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84865825675     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.08.014     Document Type: Article

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