Enhanced enzymatic stability and antitumor activity of daunorubicin-GnRH- III bioconjugates modified in position 4

Bioconjugate Chemistry

Volumn 22, Issue 7, 2011, Pages 1320-1329

  Manea, Marilena ^a   Leurs, Ulrike ^a   Orbán, Erika ^b   Baranyai, Zsuzsa ^b   Öhlschläger, Peter ^a,d   Marquardt, Andreas ^a   Schulcz, Ákos ^c   Tejeda, Miguel ^c   Kapuvári, Bence ^c   Tóvári, József ^c   Mezo, Gábor ^b  

^a UNIVERSITY OF KONSTANZ   (Germany)

^b EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^c NATIONAL INSTITUTE OF ONCOLOGY   (Hungary)

^d Division Juelich   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; DEGRADATION; DISEASES; ENZYMES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; STABILITY;

AMINO GROUP; ANTITUMOUR ACTIVITY; BIOCONJUGATES; CHEMOTHERAPEUTIC AGENTS; CYTOSTATIC; DAUNORUBICIN; ENZYMATIC STABILITY; GONADOTROPIN-RELEASING HORMONE; HUMAN SERUM; IN-VITRO;

BIOMOLECULES;

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; AMINOCAPROIC ACID; CHYMOTRYPSIN; DAUNORUBICIN; DAUNORUBICIN GONADORELIN 3; DOXORUBICIN; GONADORELIN; GONADORELIN 3; LYSINE; OXIME; PEPSIN A; SERINE; TRYPSIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL ASSAY; CELL STRAIN HT29; CELL STRAIN LNCAP; CELL STRAIN MCF 7; CIRCULAR DICHROISM; COLON CANCER; COLON CARCINOMA; CONTROLLED STUDY; CYTOSTASIS; DEPROTECTION REACTION; DRUG BLOOD LEVEL; DRUG CONJUGATION; DRUG DEGRADATION; DRUG STABILITY; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ANALYSIS; ENZYME DEGRADATION; ENZYME STABILITY; ENZYME STRUCTURE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; LIVER HOMOGENATE; LYSOSOME; MASS SPECTROMETRY; MOUSE; NONHUMAN; PROSTATE CANCER;

MURINAE; MUS; RATTUS;

EID: 79960579138     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc100547p     Document Type: Article

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