Internally deleted human tRNA synthetase suggests evolutionary pressure for repurposing

Structure

Volumn 20, Issue 9, 2012, Pages 1470-1477

  Xu, Zhiwen ^a,b   Wei, Zhiyi ^a   Zhou, Jie J ^a,b   Ye, Fei ^a   Lo, Wing Sze ^a,b   Wang, Feng ^a,b   Lau, Ching Fun ^a,b   Wu, Jingjing ^a   Nangle, Leslie A ^c   Chiang, Kyle P ^c   Yang, Xiang Lei ^a   Zhang, Mingjie ^a   Schimmel, Paul ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^b Edinburgh Tower   (Hong Kong)

^c aTyr Pharma   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; AMINO ACID TRANSFER RNA LIGASE; AMINO TERMINAL TELOPEPTIDE; ANTICODON BINDING DOMAIN PROTEIN; BINDING PROTEIN; CARBOXY TERMINAL TELOPEPTIDE; HISTIDINE TRANSFER RNA LIGASE; HOMODIMER; MONOMER; UNCLASSIFIED DRUG; WHEP PROTEIN;

AMINO TERMINAL SEQUENCE; AMINOACYLATION; ANTICODON; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; GENE DELETION; GENETIC CONSERVATION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN QUATERNARY STRUCTURE; PROTEIN STRUCTURE; PROTEIN TERTIARY STRUCTURE; TRYPANOSOMA; X RAY CRYSTALLOGRAPHY;

ANTIBODIES; BASE SEQUENCE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DNA, COMPLEMENTARY; EVOLUTION, MOLECULAR; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HISTIDINE-TRNA LIGASE; HUMANS; LUNG DISEASES, INTERSTITIAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MYOSITIS; PROTEIN ISOFORMS; PROTEIN STRUCTURE, SECONDARY; SEQUENCE ANALYSIS, DNA; SEQUENCE DELETION; TRANSCRIPTOME;

EID: 84865802082     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2012.08.001     Document Type: Article

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