Determination of metformin in rat plasma by HILIC-MS/MS combined with Tecan automation and direct injection

Biomedical Chromatography

Volumn 26, Issue 10, 2012, Pages 1163-1169

  Zhang, Wei ^a   Han, Futian ^a   Zhao, Harry ^a   Lin, Zhongping John ^a   Huang, Qingtao Mike ^b   Weng, Naidong ^b  

^a Frontage Laboratories Inc ^*  (United States)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Direct injection; HILIC MS MS; Metformin

Indexed keywords

BODY FLUIDS; DRUG DOSAGE; DRUG PRODUCTS; HYDROPHILICITY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; RATS; ROOM TEMPERATURE; SILICA;

BIOLOGICAL FLUIDS; CHROMATOGRAPHIC COLUMN; HILIC-MS/MS; METFORMINS; MOLECULAR SIZE; PHASE LIQUIDS; RAT PLASMA; REVERSED PHASE; TYPE II; VALIDATED METHODS;

DIRECT INJECTION;

METFORMIN; SILICON DIOXIDE;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOMATION; BLOOD ANALYSIS; CALIBRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ISOLATION; HYDROPHILIC INTERACTION CHROMATOGRAPHY; LOW TEMPERATURE; MALE; MASS SPECTROMETRY; NONHUMAN; RAT; ROOM TEMPERATURE; THAWING;

RATTUS;

EID: 84865786042     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.2673     Document Type: Article

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