LC-MS/MS method using unbonded silica column and aqueous/methanol mobile phase for the simultaneous quantification of a drug candidate and co-administered metformin in rat plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 19, 2010, Pages 1583-1589

  Discenza, Lorell ^a   D'Arienzo, Celia ^a   Olah, Timothy ^a   Jemal, Mohammed ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

HILIC; LC MS MS; UPLC

Indexed keywords

2 MICRON; ACCEPTANCE CRITERIA; ANALYTICAL COLUMNS; BIOANALYTICAL METHODS; CHROMATOGRAPHIC CONDITIONS; DRUG CANDIDATES; DRUG DISCOVERY; GRADIENT ELUTION; HIGH-FLOW RATE; LC-MS/MS; LOWER LIMIT OF QUANTITATIONS; METFORMINS; MOBILE PHASE; MOBILE PHASIS; PEAK SHAPES; PERFORMANCE EVALUATION; PHARMACOKINETIC STUDIES; RAT PLASMA; RETENTION TIME; SILICA COLUMN;

SILICA;

BMS 754807; METFORMIN; METHANOL; NEW DRUG; SILICON DIOXIDE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; CHROMATOGRAPHY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG STRUCTURE; ELUTION; FLOW RATE; HYDROPHILIC INTERACTION CHROMATOGRAPHY; MASS SPECTROMETRY; MOBILE PHASE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; UNBONDED SILICA COLUMN;

ACETONITRILES; ANIMALS; BICARBONATES; CALIBRATION; CHROMATOGRAPHY, LIQUID; DRUG DISCOVERY; FORMIC ACIDS; HYDROPHOBICITY; METFORMIN; PYRAZOLES; RATS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; TRIAZINES;

RATTUS;

EID: 77952320994     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.04.018     Document Type: Article

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