Liquid chromatography-tandem mass spectrometric assay for the ALK inhibitor crizotinib in mouse plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 905, Issue , 2012, Pages 150-154

  Sparidans, Rolf W ^a   Tang, Seng Chuan ^b   Nguyen, Luan N ^b   Schinkel, Alfred H ^b   Schellens, Jan H M ^a,b   Beijnen, Jos H ^a,b,c  

^a UTRECHT UNIVERSITY   (Netherlands)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

^c SLOTERVAART HOSPITAL   (Netherlands)

Author keywords

ALK inhibitor; Crizotinib; LC MS MS; Mouse plasma; Oxidative metabolites

Indexed keywords

ALK INHIBITOR; AMMONIUM HYDROXIDE; ANALYTES; ANALYTICAL CONDITIONS; BIOANALYTICAL; CHROMATOGRAPHIC SYSTEMS; CRIZOTINIB; ELECTROSPRAY INTERFACES; INTERNAL STANDARDS; LC-MS/MS; MOUSE PLASMA; OCTADECYL SILICA; PLASMA SAMPLES; PROTEIN PRECIPITATION; SELECTED REACTION MONITORING; TRIPLE-QUADRUPOLE MASS SPECTROMETER; WHOLE CALIBRATION;

ACETONITRILE; AMMONIUM COMPOUNDS; CALIBRATION; ELECTROSPRAY IONIZATION; LIQUID CHROMATOGRAPHY; MAMMALS; MASS SPECTROMETRY; METABOLITES; METHANOL; POSITIVE IONS; SILICA;

PLASMAS;

ACETONITRILE; AMMONIUM HYDROXIDE; CRIZOTINIB; DRUG METABOLITE; METHANOL; SILICON DIOXIDE; WATER;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; DILUTION; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG MONITORING; DRUG OXIDATION; DRUG STABILITY; ELECTROSPRAY MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETER; MOUSE; NONHUMAN; PARTICLE SIZE; PRECIPITATION; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

ANIMALS; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; LINEAR MODELS; MALE; MICE; PYRAZOLES; PYRIDINES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

MUS;

EID: 84865780038     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2012.08.021     Document Type: Article

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