Gender specific drug metabolism of PF-02341066 in rats - Role of sulfoconjugation

Current Drug Metabolism

Volumn 11, Issue 4, 2010, Pages 296-306

  Zhong, Wei Zhu ^a   Zhan, Jenny ^a,b   Kang, Ping ^a   Yamazaki, Shinji ^a  

^a PFIZER INC   (United States)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Excretion; Gender differences; Hepatocytes; Human; Liver S9; Metabolic profile; Pharmacokinetics; Rat; Sulfotransferase

Indexed keywords

3 [1 (2,6 DICHLORO 3 FLUOROPHENYL)ETHOXY] 5 [1 (4 PIPERIDINYL) 1H PYRAZOL 4 YL] 2 PYRIDINYLAMINE; CIPROFLOXACIN; CYTOCHROME P450 3A; DESIPRAMINE; GARENOXACIN; METOCLOPRAMIDE; MOXIFLOXACIN; QUINOLONE DERIVATIVE; SULFATE; SULFOTRANSFERASE;

AEROBIC METABOLISM; DRUG CONJUGATION; DRUG EFFICACY; DRUG EXCRETION; DRUG EXPOSURE; DRUG METABOLISM; DRUG TRANSFORMATION; FECES; GENE EXPRESSION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIVER; NONHUMAN; RADIOACTIVITY; REVIEW; SEX DIFFERENCE; TOXICOKINETICS;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; DOGS; FEMALE; HUMANS; MACACA FASCICULARIS; MALE; OXIDATION-REDUCTION; PROTEIN KINASE INHIBITORS; PYRAZOLES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; SEX FACTORS; SPECIES SPECIFICITY; SULFATES; SULFOTRANSFERASES;

EID: 77953309039     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920010791514207     Document Type: Review

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