5-HTTLPR polymorphism in bulimia nervosa: A multiple-model meta-analysis

Psychiatric Genetics

Volumn 22, Issue 5, 2012, Pages 219-225

  Polsinelli, Gina N ^a   Levitan, Robert N ^a   De Luca, Vincenzo ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

5 HTTLPR; bulimia; eating disorder; polymorphism; serotonin; SERT

Indexed keywords

SEROTONIN TRANSPORTER;

ALLELE; BULIMIA; GENE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HUMAN; MENTAL DISEASE; META ANALYSIS; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SEROTONIN TRANSPORTER GENE;

BULIMIA NERVOSA; CONFIDENCE INTERVALS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MODELS, GENETIC; ODDS RATIO; POLYMORPHISM, GENETIC; PUBLICATION BIAS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 84865772662     PISSN: 09558829     EISSN: 14735873     Source Type: Journal    
DOI: 10.1097/YPG.0b013e32835669b3     Document Type: Review

References (33)

1. Akkermann K, Nordquist N, Oreland L, Harro J (2010). Serotonin transporter gene promoter polymorphism affects the severity of binge eating in general population. Prog Neuropsychopharmacol Biol Psychiatry 34:111-114.
2. American Psychiatric Association (2000). Diagnostic and statistical manual of mental disorders. 4th ed, text revision Washington, DC: American Psychiatric Association.
3. Calati R, De Ronchi D, Bellini M, Serretti A (2011). The 5-HTTLPR polymorphism and eating disorders: A meta analysis. Int J Eat Disord 44:191-199.
4. De Luca V, Levitan RD, Kaplan AS, Tharmalingam S, Lipson N, Mackenzie B, et al. (2003). Serotonin system genes in bulimia nervosa: Analysis of two samples from Canada and Italy. Am J Med Genet B Neuropsychiatr enet 122B:93.
5. Di Bella DD, Catalano M, Cavallini MC, Riboldi C, Bellodi L (2000). Serotonin transporter linked polymorphic region in anorexia nervosa and bulimia nervosa. Mol Psychiatry 5:233-234.
6. Fuemmeler BF, Agurs-Collins TD, Mcclernon FJ, Kollins SH, Kail ME, Bergen AW, et al. (2008). Genes implicated in serotonergic and dopaminergic functioning predict BMI categories. Obesity 16:348-355.
7. Heils A, Teufel A, Petri S, Stöber G, Riederer P, Bengel D, Lesch KP (1996). Allelic variation of human serotonin transporter gene expression. J Neurochem 66:2621-2624.
8. Helder SG, Collier DA (2010). The genetics of eating disorders. Curr Top Behav Neurosci 6:157-175.
9. Hinney A, Barth N, Ziegler A, von Prittwitz S, Hamann A, Hennighausen K, et al. (1997). Serotonin transporter gene-linked polymorphic region: Allele distributions in relationship to body weight and in anorexia nervosa. Life Sci 61: PL295-PL303.
10. Karwautz AF, Wagner G, Waldherr K, Nader IW, Fernandez-Aranda F, Estivill X, et al. (2011). Gene-environment interaction in anorexia nervosa: Relevance of non-shared environment and the serotonin transporter gene. Mol Psychiatry 16:590-592.
11. Kaye GK, Frank GK, Bailer UF, Henry SE, Meltzer CC, Price JC, et al. (2005). Serotonin alterations in anorexia and bulimia nervosa: New insights from imaging studies. Physiol Behav 85:73-81.
12. Krug I, Root T, Bulik C, Granero R, Penelo E, Jimé nez-Murcia S, et al. (2011). Redefining phenotypes in eating disorders based on personality: A latent profile analysis. Psychiatry Res 188:439-445.
13. Kuikka JT, Tammela L, Karhunen L, Rissanen A, Bergström KA, Naukkarinen H, et al. (2001). Reduced serotonin transporter binding in binge eating women. Psychopharmacology (Berl) 155:310-314.
14. Lauzurica N, Hurtado A, Escartí A, Delgado M, Barrios V, Morandé G, et al. (2003). Polymorphisms within the promoter and the intron 2 of the serotonin transporter gene in a population of bulimic patients. Neurosci Lett 352:226-230.
15. Lee Y, Lin PY (2010). Association between serotonin transporter gene polymorphism and eating disorders: A meta-analytic study. Int J Eat Disord 43:498-504.
16. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, et al. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527-1531.
17. Mata J, Gotlib IH (2010). 5-HTTLPR moderates the relation between changes in depressive and bulimic symptoms in adolescent girls: A longitudinal study. Int J Eat Disord 44:383-388.
18. Matsushita S, Suzuki K, Murayama M, Nishiguchi N, Hishimoto A, Takeda A, et al. (2004). Serotonin transporter regulatory region polymorphism is associated with anorexia nervosa. Am J Med Genet B Neuropsychiatr enet 28B: 114-117.
19. Monteleone P, Santonastaso P, Mauri M, Bellodi L, Erzegovesi S, Fuschino A, et al. (2006). Investigation of the serotonin transporter regulatory region polymorphism in bulimia nervosa: Relationships to harm avoidance, nutritional parameters, and psychiatric comorbidity. Psychosom Med 68:99-103.
20. Pezawas L, Meyer-Lindenberg A, Drabant EM, Verchinski BA, Munoz KE, Kolachana BS, et al. (2005). 5-HTTLPR polymorphism impacts human cingulated amygdale interactions: A genetic susceptibility mechanism for depression. Nat Neurosci 8:828-834.
21. Rask-Andersen M, Olszewski PK, Levine AS, Schiöth HB (2010). Molecular mechanisms underlying anorexia nervosa: Focus on human gene association studies and systems controlling food intake. Brain Res Rev 62:147-164.
22. Scherag S, Hebebrand J, Hinney A (2010). Eating disorders: The current status of molecular genetic research. Eur Child Adolesc Psychiatry 19: 211-226.
23. Schinka JA, Busch RM, Robichaux-Keene N (2004). A meta-analysis of the association between the serotonin transporter gene polymorphism (5- HTTLPR) and trait anxiety. Mol Psychiatry 9:197-202.
24. Sookoian S, Gemma C, Gianotti TF, Burgueno A, Castano G, Pirola CJ (2008). Genetic variants of Clock transcription factor are associated with individual susceptibility to obesity. Am J Clin Nutr 87:1606-1615.
25. Stamatakis EA, Hetherington MM (2003). Neuroimaging in eating disorders. Nutr Neurosci 6:325-334.
26. Steiger H, Young SN, Kin NM, Koerner N, Israel M, Lageix P, et al. (2001). Implications of impulsive and affective symptoms for serotonin function in bulimia nervosa. Psychol Med 31:85-95.
27. Steiger H, Richardson J, Schmitz N, Joober R, Israel M, Bruce KR, et al. (2009). Association of trait-defined, eating-disorder sub-phenotypes with (biallelic and triallelic) 5HTTLPR variations. J Psychiatr Res 43:1086-1094.
28. Steiger H, Bruce KR, Groleau P (2011a). Neural circuits, neurotransmitters, and behavior: serotonin and temperament in bulimic syndromes. Curr Top Behav Neurosci 6:125-138.
29. Steiger H, Fichter M, Bruce KR, Joober R, Badawi G, Richardson J, et al. (2011b). Molecular-genetic correlates of self-harming behaviors in eating disordered women: Findings from a combined Canadian-German mple. Prog Neuropsychopharmacol Biol Psychiatry 35:102-106.
30. Tallett AJ, Blundell JE, Rodgers RJ (2009). Sibutramine-induced anorexia: Potent, dose-dependent and behaviourally-selective profile in male rats. Behav Brain Res 198:359-365.
31. Tauscher J, PirkerW,Willeit M, de Zwaan M, Bailer U, Neumeister A, et al. (2001). [123I] beta-CIT and single photon emission computed tomography reveal reduced brain serotonin transporter availability in bulimia nervosa. Biol Psychiatry 49:326-332.
32. Uher R, McGuffin P (2008). The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: Review and methodological analysis. Mol Psychiatry 13:131-146.
33. Wendland JR, Kruse MR, Murphy DL (2006). Functional SLITRK1 var321, varCDfs and SLC6A4 G56A variants and susceptibility to obsessivecompulsive disorder. Mol Psychiatry 11:802-804.