Investigation of the serotonin transporter regulatory region polymorphism in bulimia nervosa: Relationships to harm avoidance, nutritional parameters, and psychiatric comorbidity

Psychosomatic Medicine

Volumn 68, Issue 1, 2006, Pages 99-103

  Monteleone, Palmiero ^a,e   Santonastaso, Paolo ^b   Mauri, Mauro ^a,c   Bellodi, Laura ^d   Erzegovesi, Stefano ^d   Fuschino, Antonio ^a,b   Favaro, Angela ^a,b   Rotondo, Alessandro ^c   Castaldo, Eloisa ^a   Maj, Mario ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c UNIVERSITY OF PISA   (Italy)

^d VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^e UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Bulimia nervosa; Comorbidity; Genetics; Harm avoidance; Polymorphism; Serotonin transporter

Indexed keywords

SEROTONIN TRANSPORTER;

ADULT; ARTICLE; AVOIDANCE BEHAVIOR; BLOOD SAMPLING; BODY COMPOSITION; BODY FAT; BODY MASS; BULIMIA; COMORBIDITY; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENE IDENTIFICATION; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MENTAL DISEASE; NEUROTRANSMISSION; NUTRITIONAL PARAMETERS; PRIORITY JOURNAL; PROMOTER REGION;

ADOLESCENT; ADULT; BULIMIA NERVOSA; CASE-CONTROL STUDIES; COMORBIDITY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HARM REDUCTION; HUMANS; NUTRITION PHYSIOLOGY; POLYMORPHISM, GENETIC; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 33644765339     PISSN: 00333174     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.psy.0000195746.52074.63     Document Type: Article

References (34)

1. Blundell JE. Serotonin manipulations and the structure of feeding behavior. Appetite 1986;7(suppl):39-56.
2. Barr LC, Goodman WK, Price LH, McDougle CJ, Charney DS. The serotonin hypothesis of obsessive compulsive disorder: implications of pharmacologic challenge studies. J Clin Psychiatry 1992;53:17-28.
3. Higley JD, Linnoila M. Low central nervous system serotonergic activity is trait-like and correlates with impulsive behavior. A nonhuman primate model investigating genetic and environmental influences on neurotransmission. Ann NY Acad Sci 1997;836:39-56.
4. Lucki I. The spectrum of behaviors influenced by serotonin. Biol Psychiatry 1998;44:151-62.
5. Mann JJ. Role of serotonergic system in the pathogenesis of major depression and suicidal behavior. Neuropsychopharmacology 1999;21:99S-105S.
6. Cloninger CR, Svrakic DM, Przbeck TR. A psychobiological model of temperament and characters. Arch Gen Psychiatry 1993;50:975-90.
7. Bulik CM, Sullivan PF, Carter F, Joyce P. Temperament, character, and personality disorder in bulimia nervosa. J Nerv Ment Dis 1995;183:593-8.
8. Halmi KA, Kleifield EI, Braun DL, Sunday SR. Personality correlates of eating disorder subtypes. In: Cloninger CR, ed. Personality and Psychopathology. Washington, DC: American Psychiatric Press; 1999:67-98.
9. Diaz-Marsa M, Carrasco JL, Sàiz J. A study of temperament and personality in anorexia and bulimia nervosa. J Pers Disord 2000;4:352-9.
10. Monteleone P, Brambilla F, Bortolotti F, Ferraro C, Maj M. Plasma prolactin response to d-fenfluramine is blunted in bulimic patients with frequent binge episodes. Psychol Med 1998;28:975-83.
11. Monteleone P, Brambilla F, Bortolotti F, Maj M. Serotonergic dysfunction across the eating disorders: relationship to eating behaviour, nutritional status and general psychopathology. Psychol Med 2000;30:1099-110.
12. Kaye WH, Greeno CG, Moss H, Fernstrom J, Fernstrom M, Lilenfeld LR, Weltzin TE, Mann JJ. Alterations in serotonin activity and psychiatric symptomatology after recovery from bulimia nervosa. Arch Gen Psychiatry 1998;55:927-35.
13. Kaye WH, Frank GK, Meltzer CC, Price JC, McConaha CW, Crossan PJ, Klump KL, Rhodes L. Altered serotonin 2A receptor activity in women who have recovered from bulimia nervosa. Am J Psychiatry 2001;158:1152-5.
14. Tauscher J, Pirker W, Willelt M, de Zwaan M, Bailer U, Neumeister A, Asenbaum S, Lennkh C, Praschak-Rieder N, Brucket T, Kaper S. [123]Beta-CIT and single photon emission computed tomography level reduced brain serotonin transporter availability in bulimia nervosa. Biol Psychiatry 2001;49:326-32.
15. De Zwaan M, Roerig J. Pharmacological treatment of eating disorders: a review. In: Maj M, Halmi K, Lopez-Ibor JJ, Sartorius N, eds. Eating Disorders. Chichester: John Wiley & Sons Ltd; 2003:223-85.
16. Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D, Lesch KP. Allelic variation of human serotonin transporter gene expression. J Neurochem 1999;66:2621-4.
17. Greenberg BD, Tolliver TJ, Huang SJ, Li Q, Bengel D, Murphy DL. Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. Am J Med Genet 1999;88:83-7.
18. Di Bella D, Catalano M, Cavallini MC, Riboldi C, Bellodi L. Serotonin transporter linked polymorphic region in anorexia nervosa and bulimia nervosa. Mol Psychiatry 2000;5:233-4.
19. Lauzurica N, Hurtado A, Escarti A, Delgado M, Barrios V, Morande G, Soriano J, Jauregui I, Gonzales-Valdemoro MI, Garcia-Camba E, Fuentes JA. Polymorphisms within the promoter and the intron 2 of the serotonin transporter gene in a population of bulimic patients. Neurosci Lett 2003;352:226-30.
20. Matsushita S, Suzuki K, Murayama M, Nishiguchi N, Hishimoto A, Takeda A, Shirakawa O, Higuchi S. Serotonin transporter regulatory region polymorphism is associated with anorexia nervosa. Am J Med Genet 2004;128B:114-7.
21. Halmi KA. Classification, diagnosis and comorbidities of eating disorders. In: Maj M, Halmi K, Lopez-Ibor JJ, Sartorius N, eds. Eating Disorders. Chichester: John Wiley & Sons Ltd; 2003:1-33.
22. First MB, Spitzer RL, Gibbon M, Williams JB. Structured Clinical Interview for DSM-IV Axis I Disorders SCID-I. New York: Research Version Biometrics, Research Department, New York State Psychiatric Institute; 1995.
23. First MB, Gibbon M, Spitzer RL, Gibbon M, Williams JB. Structured Clinical Interview for DSM-IV Axis II Personality Disorders SCID-II. Washington, DC: American Psychiatric Press; 1997.
24. Cloninger CR, Przybeck TR, Svrakic DM, Wetzel RD. The Temperament and Character Inventory (TCI): A Guide to Its Development and Use. St. Louis: Center for Psychobiology and Personality, Washington University; 1994.
25. Lecrubier Y, Sheehan D, Weller E, Amorim P, Bonora I, Sheehan K, Janavs J, Dunbar GC. The Mini International Neuropsychiatric Interview MINI. A short diagnostic structured interview: reliability and validity according to the CIDI. Eur Psychiatry 1997;12:224-31.
26. Deckert J, Catalano M, Heils A, Di Bella D, Fries F, Politi E, Franke P, Nothen MM, Maier W, Bellodi L, Lesch HP. Functional promoter polymorphism of the human serotonin transporter: lack of association with panic disorder. Psychiatr Genet 1997;2:45-7.
27. Dixon J. BMDP Statistical Software. Berkeley, CA: University of California Press; 1985.
28. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin S, Muller CR, Hamer DH, Murphy DL. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene. Science 1996;274:1527-31.
29. Matsushita S, Nakamura T, Nishiguchi N, Higuchi S. Association of serotonin transporter regulatory region polymorphism and abnormal eating behaviors. Mol Psychiatry 2002;7:538-40.
30. 3[H]paroxetine binding in bulimic syndromes. Int J Eat Disord 2005;37:57-60.
31. Gorwood P. Eating disorders, serotonin transporter polymorphisms and potential treatment response. American Journal of Pharmacogenomics 2004;4:9-17.
32. Moffitt TE, Caspi A, Rutter M. Strategy for investigating interaction between measured genes and measured environments. Arch Gen Psychiatry 2005;62:473-81.
33. Bouchard TJ Jr. Genes, environment, and personality. Science 1994;264:1700-1.
34. Sen S, Burmeister M, GhoshD. Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits. Am J Med Genet 2004;127B:85-9.