The 5-HTTLPR polymorphism and eating disorders: A meta-analysis

International Journal of Eating Disorders

Volumn 44, Issue 3, 2011, Pages 191-199

  Calati, Raffaella ^a   De Ronchi, Diana ^a   Bellini, Maurizio ^a   Serretti, Alessandro ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

5 HTTLPR; Anorexia nervosa; Bulimia nervosa; Eating disorders; Serotonin transporter

Indexed keywords

PROTEIN 5 HTTLPR; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

ANOREXIA; ANOREXIA NERVOSA; BINGE EATING DISORDER; BULIMIA; DNA POLYMORPHISM; EATING DISORDER; GENE FREQUENCY; GENOTYPE; HUMAN; PRIORITY JOURNAL; REVIEW;

ALLELES; EATING DISORDERS; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; POLYMORPHISM, GENETIC; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 79952673018     PISSN: 02763478     EISSN: 1098108X     Source Type: Journal    
DOI: 10.1002/eat.20811     Document Type: Review

References (44)

1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Revised. Washington DC: American Psychiatric Association, 2002.
2. Monteleone P, Maj M. Genetic susceptibility to eating disorders: Associated polymorphisms and pharmacogenetic suggestions. Pharmacogenomics 2008;9:1487-1520.
3. Mazzeo SE, Bulik CM. Environmental and genetic risk factors for eating disorders: What the clinician needs to know. Child Adolesc Psychiatr Clin N Am 2009;18:67-82.
4. Kaye WH, Fudge JL, Paulus M. New insights into symptoms and neurocircuit function of anorexia nervosa. Nat Rev Neurosci 2009;10:573-584.
5. Kaye W. Neurobiology of anorexia and bulimia nervosa. Physiol Behav 2008;94:121-135. (Pubitemid 351506510)
6. Lesch KP, Balling U, Gross J, Strauss K, Wolozin BL, Murphy DL, et al. Organization of the human serotonin transporter gene. J Neural Transm Gen Sect 1994;95:157-162.
7. Heils A, Teufel A, Petri S, Stöber G, Riederer P, Bengel D, et al. Allelic variation of human serotonin trasporter gene expression. J Neurochem 1996;66:2621-2624. (Pubitemid 26159101)
8. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996;274:1527-1531. (Pubitemid 26403928)
9. Gorwood P. Eating disorders, serotonin transporter polymorphisms and potential treatment response. Am J Pharmacogenomics 2004;4:9-17. (Pubitemid 38325701)
10. Steiger H, Bruce KR. Phenotypes, endophenotypes, and genotypes in bulimia spectrum eating disorders. Can J Psychiatry 2007;52:220-227. (Pubitemid 46743468)
11. Lee Y, Lin PY. Association between serotonin transporter gene polymorphism and eating disorders: A meta-analytic study. Int J Eat Disord (in press).
12. Wells GA, Shea B, O'Connell D, Peterson J, Welch V, Losos M, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of non-randomised studies in meta-analysis. [cited 2009 January]; Available at:http://www.ohri.ca/ programs/clinical-epidemiology/oxford.htm.
13. Egger M, Smith GD, Phillips AN. Meta-analysis: Principles and procedures. BMJ 1997;315:1533-1537. (Pubitemid 27517188)
14. Serretti A, Chiesa A. Treatment-emergent sexual dysfunction related to antidepressants: A meta-analysis. J Clin Psychopharmacol 2009;29:259-266.
15. Matsushita S, Nakamura T, Nishiguchi N, Higuchi S. Association of serotonin transporter regulatory region polymorphism and abnormal eating behaviors. Mol Psychiatry 2002;7:538-540.
16. Urwin RE, Bennetts BH, Wilcken B, Beumont PJ, Russell JD, Nunn KP. Investigation of epistasis between the serotonin transporter and norepinephrine transporter genes in anorexia nervosa. Neuropsychopharmacology 2003;28:1351-1355. (Pubitemid 41070906)
17. Steiger H, Joober R, Israel M, Young SN, Ng Ying Kin NM, Gauvin L, et al. The 5HTTLPR polymorphism, psychopathologic symptoms, and platelet [3H-] paroxetine binding in bulimic syndromes. Int J Eat Disord 2005;37:57-60. (Pubitemid 40262175)
18. Steiger H, Richardson J, Joober R, Gauvin L, Israel M, Bruce KR, et al. The 5HTTLPR polymorphism, prior maltreatment and dramatic-erratic personality manifestations in women with bulimic syndromes. J Psychiatry Neurosci 2007;32:354-362. (Pubitemid 47492760)
19. Richardson J, Steiger H, Schmitz N, Joober R, Bruce KR, Israel M, et al. Relevance of the 5-HTTLPR polymorphism and childhood abuse to increased psychiatric comorbidity in women with bulimia-spectrum disorders. J Clin Psychiatry 2008;69:981-990. (Pubitemid 351944954)
20. Steiger H, Richardson J, Joober R, Israel M, Bruce KR, Ng Ying Kin NM, et al. Dissocial behavior, the 5HTTLPR polymorphism, and maltreatment in women with bulimic syndromes. Am J Med Genet B Neuropsychiatr Genet B 2008;147:128-130.
21. Akkermann K, Nordquist N, Oreland L, Harro J. Serotonin transporter gene promoter polymorphism affects the severity of binge eating in general population. Prog Neuropsychopharmacol Biol Psychiatry (in press).
22. Steiger H, Joober R, Gauvin L, Bruce KR, Richardson J, Israel M, et al. Serotonin-system polymorphisms (5-HTTLPR and -1438G/A) and responses of patients with bulimic syndromes to multimodal treatments. J Clin Psychiatry 2008;69:1565-1571.
23. Steiger H, Richardson J, Schmitz N, Joober R, Israel M, Bruce KR, et al. Association of trait-defined, eating-disorder sub-phenotypes with (biallelic and triallelic) 5HTTLPR variations. J Psychiatr Res 2009;43:1086-1094.
24. Di Bella DD, Catalano M, Cavallini MC, Riboldi C, Bellodi L. Serotonin transporter linked polymorphic region in anorexia nervosa and bulimia nervosa. Mol Psychiatry 2000;5:233-234. (Pubitemid 30438394)
25. Fumeron F, Betoulle D, Aubert R, Herbeth B, Siest G, Rigaud D. Association of a functional 5-HT transporter gene polymorphism with anorexia nervosa and food intake. Mol Psychiatry 2001;6:9-10. (Pubitemid 32096059)
26. Hinney A, Barth N, Ziegler A, von Prittwitz S, Hamann A, Hennighausen K, et al. Serotonin transporter gene-linked polymorphic region: allele distributions in relationship to body weight and in anorexia nervosa. Life Sci 1997;61:295-303.
27. Matsushita S, Suzuki K, Murayama M, Nishiguchi N, Hishimoto A, Takeda A, et al. Serotonin transporter regulatory region polymorphism is associated with anorexia nervosa. Am J Med Genet B Neuropsychiatr Genet 2004;128:114-117. (Pubitemid 38849929)
28. Ribases M, Fernandez-Aranda F, Gratacos M, Mercader JM, Casasnovas C, Nunez A, et al. Contribution of the serotoninergic system to anxious and depressive traits that may be partially responsible for the phenotypical variability of bulimia nervosa. J Psychiatr Res 2008;42:50-57. (Pubitemid 47562431)
29. Rybakowski F, Slopien A, Dmitrzak-Weglarz M, Czerski P, Rajewski A, Hauser J. The 5-HT2A -1438 A/G and 5-HTTLPR polymorphisms and personality dimensions in adolescent anorexia nervosa: Association study. Neuropsychobiology 2006;53:33-39. (Pubitemid 43254175)
30. Sundaramurthy D, Pieri LF, Gape H, Markham AF, Campbell DA. Analysis of the serotonin transporter gene linked polymorphism (5-HTTLPR) in anorexia nervosa. Am J Med Genet 2000; 96:53-55. (Pubitemid 30077650)
31. Urwin RE, Nunn KP. Epistatic interaction between the monoamine oxidase A and serotonin transporter genes in anorexia nervosa. Eur J Hum Genet 2005;13:370-375. (Pubitemid 40360793)
32. Lauzurica N, Hurtado A, Escarti A, Delgado M, Barrios V, Morande G, et al. Polymorphisms within the promoter and the intron 2 of the serotonin transporter gene in a population of bulimic patients. Neurosci Lett 2003;352:226-230. (Pubitemid 38367608)
33. Monteleone P, Santonastaso P, Mauri M, Bellodi L, Erzegovesi S, Fuschino A, et al. Investigation of the serotonin transporter regulatory region polymorphism in bulimia nervosa: Relationships to harm avoidance, nutritional parameters, and psychiatric comorbidity. Psychosom Med 2006;68:99-103. (Pubitemid 43803222)
34. Wonderlich SA, Crosby RD, Joiner T, Peterson CB, Bardone-Cone A, Klein M, et al. Personality subtyping and bulimia nervosa: Psychopathological and genetic correlates. Psychol Med 2005;35:649-657. (Pubitemid 40716428)
35. Frieling H, Romer KD, Wilhelm J, Hillemacher T, Kornhuber J, de Zwaan M, et al. Association of catecholamine-O-methyltransferase and 5-HTTLPR genotype with eating disorderrelated behavior and attitudes in females with eating disorders. Psychiatr Genet 2006;16:205-208. (Pubitemid 44401260)
36. Monteleone P, Tortorella A, Castaldo E, Maj M. Association of a functional serotonin transporter gene polymorphism with binge eating disorder. Am J Med Genet B Neuropsychiatr Genet B 2006;141:7-9. (Pubitemid 43062535)
37. Kendler KS. Reflections on the relationship between psychiatric genetics and psychiatric nosology. Am J Psychiatry 2006;163:1138-1146. (Pubitemid 44464439)
38. Steiger H, Puentes-Neuman G, Leung FY. Personality and family features of adolescent girls with eating symptoms: Evidence for restricter/binger differences in a nonclinical population. Addict Behav 1991;16:303-314.
39. Steiger H, Jabalpurwala S, Champagne J, Stotland S. A controlled study of trait narcissism in anorexia and bulimia nervosa. Int J Eat Disord 1997;22:173-178. (Pubitemid 27328392)
40. Schinka JA, Busch RM, Robichaux-Keene N. A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety. Mol Psychiatry 2004;9:197-202. (Pubitemid 38299534)
41. Gillihan SJ, Farah MJ, Sankoorikal GM, Breland J, Brodkin ES. Association between serotonin transporter genotype and extraversion. Psychiatr Genet 2007;17:351-354. (Pubitemid 351339819)
42. Serretti A, Mandelli L, Lorenzi C, Landoni S, Calati R, Insacco C, et al. Temperament and character in mood disorders: Influence of DRD4, SERTPR, TPH and MAO-A polymorphisms. Neuropsychobiology 2006;53:9-16. (Pubitemid 43254171)
43. Hu X, Oroszi G, Chun J, Smith TL, Goldman D, Schuckit MA. An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. Alcohol Clin Exp Res 2005;29:8-16. (Pubitemid 40129206)
44. Zintzaras E, Lau J. Trends in meta-analysis of genetic association studies. J Hum Genet 2008;53:1-9.