Regulating the TRAIL of destruction: How A20 protects glioblastomas from TRAIL-mediated death

Cancer Discovery

Volumn 2, Issue 2, 2012, Pages 112-114

  Verbrugge, Inge ^a   Johnstone, Ricky W ^a,b  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

A20 PROTEIN; CASPASE 8; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEIN; DEATH RECEPTOR 4; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FLICE INHIBITORY PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROCASPASE 8; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN MDM2; PROTEIN P53; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UBIQUITIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; GLIOBLASTOMA; HUMAN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; ZINC FINGER MOTIF;

BRAIN NEOPLASMS; CASPASE 8; DNA-BINDING PROTEINS; GLIOBLASTOMA; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NUCLEAR PROTEINS; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; TNF-RELATED APOPTOSIS-INDUCING LIGAND; UBIQUITIN-PROTEIN LIGASES;

EID: 84865770460     PISSN: 21598274     EISSN: 21598290     Source Type: Journal    
DOI: 10.1158/2159-8290.CD-11-0350     Document Type: Article

References (12)

1. Johnstone RW, Frew AJ, Smyth MJ. The TRAIL apoptotic pathway in cancer onset, progression and therapy. Nat Rev Cancer 2008;8:782-98.
2. Verbrugge I, Johnstone RW, Smyth MJ. SnapShot: extrinsic apoptosis pathways. Cell 2010;143:1192e1-2.
3. Jin Z, Li Y, Pitti R, Lawrence D, Pham VC, Lill JR, et al. Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. Cell 2009;137:721-35.
4. Srinivasula SM, Ashwell JD. A20: more than one way to skin a cat. Mol Cell 2011;44:511-2.
5. Wertz IE, O'Rourke KM, Zhou H, Eby M, Aravind L, Seshagiri S, et al. De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature 2004;430:694-9.
6. Ea CK, Deng L, Xia ZP, Pineda G, Chen ZJ. Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol Cell 2006;22:245-57.
7. Declercq W, Vanden Berghe T, Vandenabeele P. RIP kinases at the crossroads of cell death and survival. Cell 2009;138:229-32.
8. Bellail AC, Olson JJ, Yang X, Chen ZJ, Hao C. A20 ubiquitin ligasemediated polyubiquitination of RIP1 inhibits caspase-8 cleavage and TRAIL-induced apoptosis in glioblastoma. Cancer Discovery 2012;2:140-55.
9. Hsu H, Shu HB, Pan MG, Goeddel DV. TRADD-TRAF2 and TRADDFADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 1996;84:299-308.
10. Skaug B, Chen J, Du F, He J, Ma A, Chen ZJ. Direct, noncatalytic mechanism of IKK inhibition by A20. Mol Cell 2011;44:559-71.
11. Kapuria V, Peterson LF, Fang D, Bornmann WG, Talpaz M, Donato NJ. Deubiquitinase inhibition by small-molecule WP1130 triggers aggresome formation and tumor cell apoptosis. Cancer Res 2010;70:9265-76.
12. Smolewski P, Robak T. Inhibitors of apoptosis proteins (IAPs) as potential molecular targets for therapy of hematological malignancies. Curr Mol Med 2011;11:633-49.