Transplantation of bone marrow cells decreases tumor necrosis factor-α production and blood-brain barrier permeability and improves survival in a mouse model of acetaminophen-induced acute liver disease

Cytotherapy

Volumn 14, Issue 8, 2012, Pages 1011-1021

  De Freitas Souza, Bruno Solano ^a,b   Nascimento, Ramon Campos ^a,c   De Oliveira, Sheilla Andrade ^a   Vasconcelos, Juliana Fraga ^a,b   Kaneto, Carla Martins ^b   De Carvalho, Lian Felipe Paiva Pontes ^b   Ribeiro Dos Santos, Ricardo ^a,b   Soares, Milena Botelho Pereira ^a,b   De Freitas, Luiz Antonio Rodrigues ^a,c  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b HOSPITAL SÃO RAFAEL   (Brazil)

^c FEDERAL UNIVERSITY OF BAHIA   (Brazil)

Author keywords

Acetaminophen; Acute liver failure; Bone marrow mononuclear cells; Brain edema; Cell therapy; Tumor necrosis factor

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; ENHANCED GREEN FLUORESCENT PROTEIN; GELATINASE B; INTERLEUKIN 10; INTERLEUKIN 6; MESSENGER RNA; PARACETAMOL; TUMOR NECROSIS FACTOR ALPHA;

ACUTE LIVER FAILURE; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL CONSUMPTION; AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD BRAIN BARRIER; BONE MARROW; BONE MARROW TRANSPLANTATION; C57BL 6 MOUSE; CONTROLLED STUDY; HYPERAMMONEMIA; LIVER CELL; LIVER LEVEL; LIVER NECROSIS; MALE; MEMBRANE DAMAGE; MEMBRANE PERMEABILITY; MONONUCLEAR CELL; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SPLEEN; TRANSGENIC MOUSE;

EID: 84865765919     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.3109/14653249.2012.684445     Document Type: Article

References (29)

1. Larson AM, Polson J, Fontana RJ, Davern TJ, Lalani E, Hynan LS, et al. Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Hepatology. 2005;42:1364-72.
2. Slattery JT, Nelson SD, Thummel KE. The complex interaction between ethanol and acetaminophen. Clin Pharmacol Ther. 1996;60:241-6.
3. Whitcomb DC, Block GD. Association of acetaminophen hepatotoxicity with fasting and ethanol use. J AM MED ASSOC. 1994;272:1845-50.
4. Potter WZ, Davis DC, Mitchell JR, Jollow DJ, Gillette JR, Brodie BB. Acetaminophen-induced hepatic necrosis. III. Cytochrome P-450-mediated covalent binding in vitro. J Pharmacol Exp Ther. 1973;187:203-10.
5. Masubuchi Y, Suda C, Horie T. Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice. J Hepatol. 2005;42:110-16.
6. Kosenko E, Kaminsky Y, Lopata O, Muravyov N, Kaminsky A, Hermenegildo C, et al. Nitroarginine, an inhibitor of nitric oxide synthase, prevents changes in superoxide radical and antioxidant enzymes induced by ammonia intoxication. Metab Brain Dis. 1998;13:29-41.
7. Chung C, Gottstein J, Blei AT. Indomethacin prevents the development of experimental ammonia-induced brain edema in rats after portacaval anastomosis. Hepatology. 2001;34:249-54.
8. Odeh M. Pathogenesis of hepatic encephalopathy: the tumour necrosis factor-alpha theory. Eur J Clin Invest. 2007;37:291-304.
9. Bernal W, Wendon J. Liver transplantation in adults with acute liver failure. J Hepatol. 2004;40:192-7.
10. Jalan R. Acute liver failure: current management and future prospects. J Hepatol. 2005;42(Suppl):S115-23.
11. Simpson K, Hogaboam CM, Kunkel SL, Harrison DJ, Bone-Larson C, Lukacs NW. Stem cell factor attenuates liver damage in a murine model of acetaminophen-induced hepatic injury. Lab Invest. 2003;83:199-206.
12. van Poll D, Parekkadan B, Cho CH, Berthiaume F, Nahmias Y, Tilles AW, et al. Mesenchymal stem cell-derived molecules directly modulate hepatocellular death and regeneration in vitro and in vivo. Hepatology. 2008;47:1634-43.
13. Abraham CS, Deli MA, Joo F, Megyeri P, Torpier G. Intracarotid tumor necrosis factor-alpha administration increases the blood - brain barrier permeability in cerebral cortex of the newborn pig: quantitative aspects of double-labelling studies and confocal laser scanning analysis. Neurosci Lett. 1996;208:85-8.
14. Van Lint P, Wielockx B, Puimège L, Noël A, López-Otin C, Libert C. Resistance of collagenase-2 (matrix metalloproteinase-8)-deficient mice to TNF-induced lethal hepatitis. J Immunol. 2005;175:7642-9.
15. Wielockx B, Lannoy K, Shapiro SD, Itoh T, Itohara S, Vandekerckhove J, Libert C. Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy. Nat Med. 2001;7:1202-8.
16. Nguyen JH, Yamamoto S, Steers J, Sevlever D, Lin W, Shimojima N, et al. Matrix metalloproteinase-9 contributes to brain extravasation and edema in fulminant hepatic failure mice. J Hepatol. 2006;44:1105-14.
17. Kis B, Chen L, Ueta Y, Busija DW. Autocrine peptide mediators of cerebral endothelial cells and their role in the regulation of blood - brain barrier. Peptides. 2006;27:211-22.
18. Belardinelli MC, Pereira F, Baldo G, Vicente Tavares AM, Kieling CO, da Silveira TR, et al. Adult derived mononuclear bone marrow cells improve survival in a model of acetaminopheninduced acute liver failure in rats. Toxicology. 2008;247:1-5.
19. Soares MB, Lima RS, Souza BS, Vasconcelos JF, Rocha LL, Dos Santos RR, et al. Reversion of gene expression alterations in hearts of mice with chronic chagasic cardiomyopathy after transplantation of bone marrow cells. Cell Cycle. 2011;10:1448-55.
20. Costa-Ferro ZS, Souza BS, Leal MM, Kaneto CM, Azevedo CM, da Silva IC, et al. Transplantation of bone marrow mononuclear cells decreases seizure incidence, mitigates neuronal loss and modulates pro-inflammatory cytokine production in epileptic rats. Neurobiol Dis. 2012;46:302-13.
21. de Oliveira SA, de Freitas Souza BS, Barreto EP, Kaneto CM, Neto HA, Azevedo CM, et al. Reduction of galectin-3 expression and liver fibrosis after cell therapy in a mouse model of cirrhosis. Cytotherapy. 2012;14:339-49.
22. Streetz K, Leifeld L, Grundmann D, Ramakers J, Eckert K, Spengler U, et al. Tumor necrosis factor alpha in the pathogenesis of human and murine fulminant hepatic failure. Gastroenterology. 2000;119:446-60.
23. Nagaki M, Iwai H, Naiki T, Ohnishi H, Muto Y, Moriwaki H. High levels of serum interleukin-10 and tumor necrosis factoralpha are associated with fatality in fulminant hepatitis. J Infect Dis. 2000;182:1103-8.
24. Idriss HT, Naismith JH. TNF alpha and the TNF receptor superfamily: structure-function relationship (s). Microsc Res Tech. 2000;50:184-95.
25. Odeh M. Pathogenesis of hepatic encephalopathy: the tumour necrosis factor-alpha theory. Eur J Clin Invest. 2007;37:291-304.
26. Wang W, Lv S, Zhou Y, Fu J, Li C, Liu P. Tumor necrosis factor-α affects blood - brain barrier permeability in acetaminopheninduced acute liver failure. Eur J Gastroenterol Hepatol. 2011;23:552-8.
27. Bemeur C, Qu H, Desjardins P, Butterworth RF. IL-1 or TNF receptor gene deletion delays onset of encephalopathy and attenuates brain edema in experimental acute liver failure. Neurochem Int. 2010;56:213-15.
28. Aizawa S, Tavassoli T. Molecular basis of the recognition of intravenously transplanted hemopoietic cells by bone marrow. Proc Natl Acad Sci USA 1988;85:3180-3183.
29. Burchfield JS, Iwasaki M, Koyanagi M, Urbich C, Rosenthal N, Zeiher AM, Dimmeler S. Interleukin-10 from transplanted bone marrow mononuclear cells contributes to cardiac protection after myocardial infarction. Circ Res. 2008;103:203-11.